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Article Open Access

Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo

  • Authors:
    • Tao Hu
    • Pei Li
    • Zhongguang Luo
    • Xiaoyu Chen
    • Jingyang Zhang
    • Chunyao Wang
    • Ping Chen
    • Ziming Dong
  • View Affiliations / Copyright

    Affiliations: College of Basic Medical Sciences, Zhengzhou University; Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou, Henan 450001, P.R. China, Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Laboratory Animal Center, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 43-49
    |
    Published online on: November 2, 2015
       https://doi.org/10.3892/or.2015.4380
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Abstract

Recently, chloroquine (CQ) has been widely used to improve the efficacy of different chemotherapy drugs to treat tumors. However, the effects of single treatment of CQ on liver cancer have not been investigated. In the present study, we examined the effects of CQ on the growth and viability of liver cancer cells in vitro and in vivo, and revealed that CQ treatment triggered G0/G1 cell cycle arrest, induced DNA damage and apoptosis in a dose- and time-dependent manner in liver cancer cells. Moreover, administration of CQ to tumor-bearing mice suppressed the tumor growth in an orthotopic xenograft model of liver cancer. These findings extend our understanding and suggest that CQ could be repositioned as a treatment option for liver cancer as a single treatment or in combination.
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Copy and paste a formatted citation
Spandidos Publications style
Hu T, Li P, Luo Z, Chen X, Zhang J, Wang C, Chen P and Dong Z: Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo. Oncol Rep 35: 43-49, 2016.
APA
Hu, T., Li, P., Luo, Z., Chen, X., Zhang, J., Wang, C. ... Dong, Z. (2016). Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo. Oncology Reports, 35, 43-49. https://doi.org/10.3892/or.2015.4380
MLA
Hu, T., Li, P., Luo, Z., Chen, X., Zhang, J., Wang, C., Chen, P., Dong, Z."Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo". Oncology Reports 35.1 (2016): 43-49.
Chicago
Hu, T., Li, P., Luo, Z., Chen, X., Zhang, J., Wang, C., Chen, P., Dong, Z."Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo". Oncology Reports 35, no. 1 (2016): 43-49. https://doi.org/10.3892/or.2015.4380
Copy and paste a formatted citation
x
Spandidos Publications style
Hu T, Li P, Luo Z, Chen X, Zhang J, Wang C, Chen P and Dong Z: Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo. Oncol Rep 35: 43-49, 2016.
APA
Hu, T., Li, P., Luo, Z., Chen, X., Zhang, J., Wang, C. ... Dong, Z. (2016). Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo. Oncology Reports, 35, 43-49. https://doi.org/10.3892/or.2015.4380
MLA
Hu, T., Li, P., Luo, Z., Chen, X., Zhang, J., Wang, C., Chen, P., Dong, Z."Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo". Oncology Reports 35.1 (2016): 43-49.
Chicago
Hu, T., Li, P., Luo, Z., Chen, X., Zhang, J., Wang, C., Chen, P., Dong, Z."Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo". Oncology Reports 35, no. 1 (2016): 43-49. https://doi.org/10.3892/or.2015.4380
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