Novel cellular and post-genomic technologies in the treatment of glioblastoma multiforme (Review)

  • Authors:
    • Igor Bryukhovetskiy
    • Andrey Bryukhovetskiy
    • Yuri Khotimchenko
    • Polina Mischenko
  • View Affiliations

  • Published online on: November 6, 2015     https://doi.org/10.3892/or.2015.4404
  • Pages: 639-648
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors. The majority of modern treatment methods for GBM are not sufficiently effective with a median survival varying from 9 to 14 months. One of the main reasons for the therapeutic resistance of GBM is attributed to cancer stem cells. Pharmaceuticals that can effectively eliminate cancer stem cells do not exist. Experimentally, we have shown that cancer stem cells can be specifically affected to arrest adhesion, proliferation and migration, and other key functions. The main target of this therapy involves membrane intracellular signaling pathways of cancer stem cells that are not subject to neoplastic transformation. An effect on such a complex target requires the development of innovative biotechnological approaches. The research analysis of modern approaches towards creating biomedical drugs for treating cancer stem cells of glioblastoma multiforme is based on advances in the latest cellular and post-genomic technologies. The combination of targeted therapy with regulation of the key functions of cancer stem cells using cell systems with a remodeled proteome is suggested.
View Figures
View References

Related Articles

Journal Cover

February-2016
Volume 35 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Bryukhovetskiy I, Bryukhovetskiy A, Khotimchenko Y and Mischenko P: Novel cellular and post-genomic technologies in the treatment of glioblastoma multiforme (Review). Oncol Rep 35: 639-648, 2016
APA
Bryukhovetskiy, I., Bryukhovetskiy, A., Khotimchenko, Y., & Mischenko, P. (2016). Novel cellular and post-genomic technologies in the treatment of glioblastoma multiforme (Review). Oncology Reports, 35, 639-648. https://doi.org/10.3892/or.2015.4404
MLA
Bryukhovetskiy, I., Bryukhovetskiy, A., Khotimchenko, Y., Mischenko, P."Novel cellular and post-genomic technologies in the treatment of glioblastoma multiforme (Review)". Oncology Reports 35.2 (2016): 639-648.
Chicago
Bryukhovetskiy, I., Bryukhovetskiy, A., Khotimchenko, Y., Mischenko, P."Novel cellular and post-genomic technologies in the treatment of glioblastoma multiforme (Review)". Oncology Reports 35, no. 2 (2016): 639-648. https://doi.org/10.3892/or.2015.4404