miR-506 functions as a tumor suppressor in glioma by targeting STAT3

Retraction in: /10.3892/or.2021.8212

  • Authors:
    • Tao Peng
    • Lixiang Zhou
    • Ling Zuo
    • Yongxin Luan
  • View Affiliations

  • Published online on: November 9, 2015     https://doi.org/10.3892/or.2015.4406
  • Pages: 1057-1064
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Abstract

MicroRNA-506 (miR-506) has been reported to act as a tumor suppressive or an oncogenic miRNA in different types of tumors. However, the roles and underlying molecular mechanism of miR-506 in glioma remain unclear. In the present study, we performed quantitative PCR to investigate the level of miR-506 in 36 pairs of glioma tumor and matched adjacent tissues, and found that miR-506 was downregulated in the glioma tumors compared to the expression in the adjacent normal tissues. Furthermore, a functional assay found that ectopic expression of miR-506 in glioma cells markedly suppressed cell proliferation, colony formation, migration and invasion, and suppressed tumor growth in vivo. Moreover, signal transducer and activator of transcription 3 (STAT3) was identified as a direct target of miR-506. Western blot assay showed that overexpression of miR-506 not only induced changes in STAT3 expression but also altered expression of its downstream genes, including, Bcl2, cyclin D1 and matrix metalloproteinase 2 (MMP-2), in the human glioma cells. In addition, STAT3 mRNA expression was increased in the glioma tissues, and was inversely correlated with miR-506. Importantly, overexpression of STAT3 in glioma cells attenuated the suppressive effects of miR-506 on cell proliferation, colony formation, migration and invasion. These results showed that miR-506 functions as a tumor suppressor in glioma by targeting STAT3, suggesting that miR-506 may serve as a potential target in the treatment of human glioma.
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February-2016
Volume 35 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Peng T, Zhou L, Zuo L and Luan Y: miR-506 functions as a tumor suppressor in glioma by targeting STAT3 Retraction in /10.3892/or.2021.8212. Oncol Rep 35: 1057-1064, 2016
APA
Peng, T., Zhou, L., Zuo, L., & Luan, Y. (2016). miR-506 functions as a tumor suppressor in glioma by targeting STAT3 Retraction in /10.3892/or.2021.8212. Oncology Reports, 35, 1057-1064. https://doi.org/10.3892/or.2015.4406
MLA
Peng, T., Zhou, L., Zuo, L., Luan, Y."miR-506 functions as a tumor suppressor in glioma by targeting STAT3 Retraction in /10.3892/or.2021.8212". Oncology Reports 35.2 (2016): 1057-1064.
Chicago
Peng, T., Zhou, L., Zuo, L., Luan, Y."miR-506 functions as a tumor suppressor in glioma by targeting STAT3 Retraction in /10.3892/or.2021.8212". Oncology Reports 35, no. 2 (2016): 1057-1064. https://doi.org/10.3892/or.2015.4406