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Article

MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-β1

Retraction in: /10.3892/or.2022.8324
  • Authors:
    • Qizhuang Li
    • Quan Cheng
    • Zigui Chen
    • Renjun Peng
    • Rui Chen
    • Zhiming Ma
    • Xin Wan
    • Jincan Liu
    • Ming Meng
    • Zhigang Peng
    • Bing Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, Hunan 410078, P.R. China
  • Pages: 1125-1134
    |
    Published online on: November 17, 2015
       https://doi.org/10.3892/or.2015.4432
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Abstract

Cell migration and invasion are key processes involved during tumor metastasis. Recently, microRNAs (miRs) have been demonstrated to play important roles in the regulation of cancer metastasis. However, the underlying mechanisms remain unknown. Here, we aimed to investigate the exact role of miR-663 in the metastasis of glioblastoma as well as the underlying mechanisms. By performing quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis, we demonstrated that miR-663 was significantly downregulated in glioblastoma tissues (n=25), when compared to that in normal brain tissues (n=15). In addition, its expression levels were also reduced in human glioblastoma cell lines, A172 and U87. Furthermore, restoration of miR-663 expression led to a significant decrease in the cell proliferation, migration and invasion of human glioblastoma A172 and U87 cells. We further identified TGF-β1 as a direct target of miR-663, and found that the expression of TGF-β1 was negatively mediated by miR-663 at the post-transcriptional level in glioblastoma cells. Moreover, overexpression of TGF-β1 significantly reversed the inhibitory effects of miR-663 upregulation on the proliferation, migration and invasion in A172 and U87 cells. In addition, our data suggest that MMP2 and E-cadherin, a key factor in epithelial-mesenchymal transition (EMT), are involved in the miR-633/TGF-β1-mediated metastasis of glioblastoma. In summary, miR-663 plays an inhibitory role in the regulation of proliferation, migration and invasion of glioblastoma cells, partly at least, via direct mediation of TGF-β1 as well as downstream MMP2 and E-cadherin. Therefore, we suggest that miR-663 is a potential candidate for the prevention of glioblastoma metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Li Q, Cheng Q, Chen Z, Peng R, Chen R, Ma Z, Wan X, Liu J, Meng M, Peng Z, Peng Z, et al: MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-β1 Retraction in /10.3892/or.2022.8324. Oncol Rep 35: 1125-1134, 2016.
APA
Li, Q., Cheng, Q., Chen, Z., Peng, R., Chen, R., Ma, Z. ... Jiang, B. (2016). MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-β1 Retraction in /10.3892/or.2022.8324. Oncology Reports, 35, 1125-1134. https://doi.org/10.3892/or.2015.4432
MLA
Li, Q., Cheng, Q., Chen, Z., Peng, R., Chen, R., Ma, Z., Wan, X., Liu, J., Meng, M., Peng, Z., Jiang, B."MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-β1 Retraction in /10.3892/or.2022.8324". Oncology Reports 35.2 (2016): 1125-1134.
Chicago
Li, Q., Cheng, Q., Chen, Z., Peng, R., Chen, R., Ma, Z., Wan, X., Liu, J., Meng, M., Peng, Z., Jiang, B."MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-β1 Retraction in /10.3892/or.2022.8324". Oncology Reports 35, no. 2 (2016): 1125-1134. https://doi.org/10.3892/or.2015.4432
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Cheng Q, Chen Z, Peng R, Chen R, Ma Z, Wan X, Liu J, Meng M, Peng Z, Peng Z, et al: MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-β1 Retraction in /10.3892/or.2022.8324. Oncol Rep 35: 1125-1134, 2016.
APA
Li, Q., Cheng, Q., Chen, Z., Peng, R., Chen, R., Ma, Z. ... Jiang, B. (2016). MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-β1 Retraction in /10.3892/or.2022.8324. Oncology Reports, 35, 1125-1134. https://doi.org/10.3892/or.2015.4432
MLA
Li, Q., Cheng, Q., Chen, Z., Peng, R., Chen, R., Ma, Z., Wan, X., Liu, J., Meng, M., Peng, Z., Jiang, B."MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-β1 Retraction in /10.3892/or.2022.8324". Oncology Reports 35.2 (2016): 1125-1134.
Chicago
Li, Q., Cheng, Q., Chen, Z., Peng, R., Chen, R., Ma, Z., Wan, X., Liu, J., Meng, M., Peng, Z., Jiang, B."MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-β1 Retraction in /10.3892/or.2022.8324". Oncology Reports 35, no. 2 (2016): 1125-1134. https://doi.org/10.3892/or.2015.4432
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