Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
February-2016 Volume 35 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2016 Volume 35 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Uvangoletin induces mitochondria-mediated apoptosis in HL-60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Retraction in: /10.3892/or.2025.9015
  • Authors:
    • Zhuanzhen Zheng
    • Zhenhua Qiao
    • Rong Gong
    • Yalin Wang
    • Yiqun Zhang
    • Yanping Ma
    • Li Zhang
    • Yujin Lu
    • Bo Jiang
    • Guoxia Li
    • Chunxia Dong
    • Wenliang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, P.R. China, Shanxi Academy of Medical Sciences, Shanxi University Hospital, Taiyuan 030001, P.R. China, Department of Hematology, the Second People's Hospital of Shanxi Province, Taiyuan 030001, P.R. China
  • Pages: 1213-1221
    |
    Published online on: November 25, 2015
       https://doi.org/10.3892/or.2015.4443
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

This study investigated the cytotoxic effect of uvangoletin on HL-60 cells, and the effects of uvangoletin on myelosuppression, leucopenia, gastrointestinal tract disturbances and the possible cytotoxic mechanisms by using CCK-8, flow cytometry, western blot, xenograft, cyclophosphamide-induced leucopenia, copper sulfate-induced emesis and ethanol-induced gastric mucosal lesions assays. The results of CCK-8, flow cytometry and western blot assays indicated that uvangoletin showed the cytotoxic effect on HL-60 cells and induced the apoptosis of HL-60 cells by downregulating the expression levels of anti-apoptotic proteins (Survivin, Bcl-xl and Bcl-2), upregulating the expression levels of pro-apoptotic proteins (Smac, Bax, Bad, c-caspase-3 and c-caspase-9), and promoting the release of cytochrome c from mitochondria to cytoplasm. Further, the results of xenograft assay suggested that uvangoletin inhibited the HL-60-induced tumor growth without adverse effect on body weight of nude mice in vivo by regulating the expression levels of above apoptotic proteins. The results indicated that the reductions of WBCs count and thighbone marrow granulocytes percentage in cyclophosphamide-induced leucopenia assay, the incubation period and number of emesis in copper sulfate-induced emesis assay and the gastric mucosal lesions in ethanol-induced gastric mucosal lesions assay were not exacerbated or reversed by uvangoletin. In conclusion, the research preliminarily indicated that uvangoletin induced apoptosis of HL-60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances, and the pro-apoptotic mechanisms may be related to mitochondria-mediated apoptotic pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Cooke JV: The occurrence of leukemia. Blood. 9:340–347. 1954.PubMed/NCBI

2 

Kadia TM, Ravandi F, O'Brien S, Cortes J and Kantarjian HM: Progress in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 15:139–151. 2015. View Article : Google Scholar

3 

Robak T: Recent progress in the management of chronic lymphocytic leukemia. Cancer Treat Rev. 33:710–728. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Soni G and Yadav KS: Applications of nanoparticles in treatment and diagnosis of leukemia. Mater Sci Eng C. 47:156–164. 2015. View Article : Google Scholar

6 

Callera F, Callera AF and Rosa ES: Trends in mortality of adult patients diagnosed with myeloid leukemia from 1994 to 2011 in southeastern Brazil. Rev Bras Hematol Hemoter. 37:7–11. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Hahn A, Giri S, Yaghmour G and Martin MG: Early mortality in acute myeloid leukemia. Leuk Res. 39:505–509. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Kassar O, Kallel F, Ghorbel M, Bellaaj H, Mnif Z and Elloumi M: Acute acalculous cholecystitis complicating chemotherapy for acute myeloblastic leukemia. Leuk Res Rep. 4:39–41. 2015.PubMed/NCBI

9 

Saenz GJ, Hovanessian R, Gisis AD and Medh RD: Glucocorticoid-mediated co-regulation of RCAN1-1, E4BP4 and BIM in human leukemia cells susceptible to apoptosis. Biochem Biophys Res Commun. 463:1291–1296. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Pleimes D, Flechsig S and Meyer M: Effect of IEPA, a novel orally bioavaible small molecule, on chemotherapy-induced myelosuppression. 57th ASH Annual Meeting; December 6–9, 2014; https://ash.confex.com/ash/2014/webprogram/Paper76791.html.

11 

Choi TY, Lee MS and Ernst E: Moxibustion for the treatment of chemotherapy-induced leukopenia: A systematic review of randomized clinical trials. Support Care Cancer. 23:1819–1826. 2015. View Article : Google Scholar

12 

Roila F, Herrstedt J, Aapro M, Gralla RJ, Einhorn LH, Ballatori E, Bria E, Clark-Snow RA, Espersen BT, Feyer P, et al: ESMO/MASCC Guidelines Working Group: Guideline update for MASCC and ESMO in the prevention of chemotherapy-and radiotherapy-induced nausea and vomiting: Results of the Perugia consensus conference. Ann Oncol. 21(Suppl 5): v232–v243. 2010. View Article : Google Scholar

13 

Zhang Z, Liu W, Zheng Y, Jin L, Yao W and Gao X: SGP-2, an acidic polysaccharide from Sarcandra glabra, inhibits proliferation and migration of human osteosarcoma cells. Food Funct. 5:167–175. 2014. View Article : Google Scholar

14 

Zhang Z, Zheng Y, Zhu R, Zhu Y, Yao W, Liu W and Gao X: The ERK/eIF4F/Bcl-XL pathway mediates SGP-2 induced osteosarcoma cells apoptosis in vitro and in vivo. Cancer Lett. 352:203–213. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Zhou B, Liu KY, Chang J and Cheng CQ: Advances on chemical constituents and pharmacological activities of Sarcandra glabra. Chin JMAP. 26:982–986. 2009.

16 

Xu YQ, Liu XL, Huang XF and Ge F: Status and prospect of studies on Sarcandra glaba. Chin Tradit Herbal Drugs. 42:2552–2559. 2011.

17 

Wang F, Yuan ST and Zhu DN: Active components of antitumor fraction from Sarcandra glabra. Chin J Nat Med. 5:174–178. 2007.

18 

Wang HP, Zhao XX and Tian KY: Dynamic changes of leukocyte and myelogram in the rat leucopenia model. J Zhenzhou Univ. 37:439–440. 2002.

19 

Xu SY, Bian RL and Chen X: Methodology of pharmacological experiment. People's Medical Publishing House; Beijing: 2002

20 

Guth PH, Aures D and Paulsen G: Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine, and probanthine. Gastroenterology. 76:88–93. 1979.PubMed/NCBI

21 

Wang XB, Yang CS, Hua SZ and Kong LY: Chemical constituents from the seeds of Alpinia katsumadai Hayata. Chin J Nat Med. 8:419–421. 2010.

22 

Hufford CD and Oguntimein BO: Dihydrochalcones from Uvaria angolensis. Phytochemistry. 19:2036–2038. 1980. View Article : Google Scholar

23 

Yuan JL, Wang SM, Lan T, Liu JZ, Wang GH, Sun QS and Chen H: Studies on anti-hepatoma effect of Gan-Ai-Xiao decoction. Trop J Pharm Res. 14:1249–1255. 2015. View Article : Google Scholar

24 

Dong J, Zhao YP, Zhou L, Zhang TP and Chen G: Bcl-2 up regulation induced by miR-21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa-2 pancreatic cancer cells. Arch Med Res. 42:8–14. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Shi Y: A structural view of mitochondria-mediated apoptosis. Nat Struct Biol. 8:394–401. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Wang JL, Gao QL, Wang DC, Wang ZQ and Hu C: Metformin inhibits growth of lung adenocarcinoma cells by inducing apoptosis via the mitochondria-mediated pathway. Oncol Lett. 10:1343–1349. 2015.PubMed/NCBI

27 

Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, Tailor P, Morimoto RI, Cohen GM and Green DR: Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol. 2:469–475. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Chandele A, Prasad V, Jagtap JC, Shukla R and Shastry PR: Upregulation of survivin in G2/M cells and inhibition of caspase 9 activity enhances resistance in staurosporine-induced apoptosis. Neoplasia. 6:29–40. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Chi SP, Bai BK, Xie J, Chen HG, Du L, You LY and Cheng Y: Study of the effect and mechanism of Cyclophosphamide on antitumor in animal model. Chin Med Her. 9:20–22. 2012.

30 

Huang GC, Wu LS, Chen LG, Yang LL and Wang CC: Immuno-enhancement effects of Huang Qi Liu Yi Tang in a murine model of cyclophosphamide-induced leucopenia. J Ethnopharmacol. 109:229–235. 2007. View Article : Google Scholar

31 

Feng Y, He QS, Liu W, Zhang YL and Meng QH: Affection of Xiao Banxia plus Fuling grain on MTL in CINV pigef plasma. J Liaoning Univ TCM. 11:175–177. 2009.

32 

La Casa C, Villegas I, Alarcón de la Lastra C, Motilva V and Martín Calero MJ: Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol. 71:45–53. 2000. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng Z, Qiao Z, Gong R, Wang Y, Zhang Y, Ma Y, Zhang L, Lu Y, Jiang B, Li G, Li G, et al: Uvangoletin induces mitochondria-mediated apoptosis in HL-60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances Retraction in /10.3892/or.2025.9015. Oncol Rep 35: 1213-1221, 2016.
APA
Zheng, Z., Qiao, Z., Gong, R., Wang, Y., Zhang, Y., Ma, Y. ... Chen, W. (2016). Uvangoletin induces mitochondria-mediated apoptosis in HL-60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances Retraction in /10.3892/or.2025.9015. Oncology Reports, 35, 1213-1221. https://doi.org/10.3892/or.2015.4443
MLA
Zheng, Z., Qiao, Z., Gong, R., Wang, Y., Zhang, Y., Ma, Y., Zhang, L., Lu, Y., Jiang, B., Li, G., Dong, C., Chen, W."Uvangoletin induces mitochondria-mediated apoptosis in HL-60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances Retraction in /10.3892/or.2025.9015". Oncology Reports 35.2 (2016): 1213-1221.
Chicago
Zheng, Z., Qiao, Z., Gong, R., Wang, Y., Zhang, Y., Ma, Y., Zhang, L., Lu, Y., Jiang, B., Li, G., Dong, C., Chen, W."Uvangoletin induces mitochondria-mediated apoptosis in HL-60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances Retraction in /10.3892/or.2025.9015". Oncology Reports 35, no. 2 (2016): 1213-1221. https://doi.org/10.3892/or.2015.4443
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng Z, Qiao Z, Gong R, Wang Y, Zhang Y, Ma Y, Zhang L, Lu Y, Jiang B, Li G, Li G, et al: Uvangoletin induces mitochondria-mediated apoptosis in HL-60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances Retraction in /10.3892/or.2025.9015. Oncol Rep 35: 1213-1221, 2016.
APA
Zheng, Z., Qiao, Z., Gong, R., Wang, Y., Zhang, Y., Ma, Y. ... Chen, W. (2016). Uvangoletin induces mitochondria-mediated apoptosis in HL-60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances Retraction in /10.3892/or.2025.9015. Oncology Reports, 35, 1213-1221. https://doi.org/10.3892/or.2015.4443
MLA
Zheng, Z., Qiao, Z., Gong, R., Wang, Y., Zhang, Y., Ma, Y., Zhang, L., Lu, Y., Jiang, B., Li, G., Dong, C., Chen, W."Uvangoletin induces mitochondria-mediated apoptosis in HL-60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances Retraction in /10.3892/or.2025.9015". Oncology Reports 35.2 (2016): 1213-1221.
Chicago
Zheng, Z., Qiao, Z., Gong, R., Wang, Y., Zhang, Y., Ma, Y., Zhang, L., Lu, Y., Jiang, B., Li, G., Dong, C., Chen, W."Uvangoletin induces mitochondria-mediated apoptosis in HL-60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances Retraction in /10.3892/or.2025.9015". Oncology Reports 35, no. 2 (2016): 1213-1221. https://doi.org/10.3892/or.2015.4443
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team