Hispolon inhibits breast cancer cell migration by reversal of epithelial-to-mesenchymal transition via suppressing the ROS/ERK/Slug/E-cadherin pathway

  • Authors:
    • Zhao Zhao
    • Yi-Sheng Sun
    • Wei Chen
    • Long-Xian Lv
    • Yong-Quan Li
  • View Affiliations

  • Published online on: November 25, 2015     https://doi.org/10.3892/or.2015.4445
  • Pages: 896-904
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Abstract

Hispolon has been shown to have anticancer effects on various tumors. However, whether hispolon exerts anti-migration activity in breast cancer cells and the underlying mechanisms, have not been elucidated yet. In the present study, our data demonstrated that hispolon inhibited TPA-induced breast cancer MCF-7 cell migration at sub-toxic concentrations in vitro. Hispolon decreased the level of cellular ROS significantly and repressed TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK), accompanied by upregulation of E-cadherin and downregulation of the transcriptional repressor Slug. Furthermore, N-acetyl-cysteine, an antioxidant agent, markedly suppressed TPA-induced epithelial-to-mesenchymal transition, cell migration and activation of ERK. Taken together, our results indicated that hispolon suppressed the migration of breast cancer cells via suppressing the ROS/ERK/Slug/E‑cadherin pathway. Hispolon may be developed as a potential antimetastasis agent to breast cancer.
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February-2016
Volume 35 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhao Z, Sun Y, Chen W, Lv L and Li Y: Hispolon inhibits breast cancer cell migration by reversal of epithelial-to-mesenchymal transition via suppressing the ROS/ERK/Slug/E-cadherin pathway. Oncol Rep 35: 896-904, 2016
APA
Zhao, Z., Sun, Y., Chen, W., Lv, L., & Li, Y. (2016). Hispolon inhibits breast cancer cell migration by reversal of epithelial-to-mesenchymal transition via suppressing the ROS/ERK/Slug/E-cadherin pathway. Oncology Reports, 35, 896-904. https://doi.org/10.3892/or.2015.4445
MLA
Zhao, Z., Sun, Y., Chen, W., Lv, L., Li, Y."Hispolon inhibits breast cancer cell migration by reversal of epithelial-to-mesenchymal transition via suppressing the ROS/ERK/Slug/E-cadherin pathway". Oncology Reports 35.2 (2016): 896-904.
Chicago
Zhao, Z., Sun, Y., Chen, W., Lv, L., Li, Y."Hispolon inhibits breast cancer cell migration by reversal of epithelial-to-mesenchymal transition via suppressing the ROS/ERK/Slug/E-cadherin pathway". Oncology Reports 35, no. 2 (2016): 896-904. https://doi.org/10.3892/or.2015.4445