The roles of microRNAs in the pathogenesis and drug resistance of chronic myelogenous leukemia (Review)

  • Authors:
    • Carla Di Stefano
    • Giovanna Mirone
    • Stefania Perna
    • Gabriella Marfe
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  • Published online on: November 26, 2015     https://doi.org/10.3892/or.2015.4456
  • Pages: 614-624
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Abstract

Chronic myeloid leukemia (CML) is characterized by the accumulation of Philadelphia chromosome-positive (Ph+) myeloid cells. Ph+ cells occur via a reciprocal translocation between the long arms of chromosomes 9 and 22 resulting in constitutively active BCR-ABL fusion protein. Tyrosine kinase inhibitors (TKIs) are used against the kinase activity of BCR-ABL protein for the effective treatment of CML. However, the development of drug resistance, caused by different genetic mechanisms, is the major issue in the clinical application of TKIs. These mechanisms include changes in expression levels of microRNAs (miRNAs). miRNAs are short non-coding regulatory RNAs that control gene expression and play an important role in cancer development and progression. In the present review, we highlight the roles of miRNAs both in the progression and chemotherapy-resistance of CML. Our understanding of these mechanisms may lead to the use of this knowledge not only in the treatment of patients with CML, but also in other type of cancers.
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February-2016
Volume 35 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Di Stefano C, Mirone G, Perna S and Marfe G: The roles of microRNAs in the pathogenesis and drug resistance of chronic myelogenous leukemia (Review). Oncol Rep 35: 614-624, 2016
APA
Di Stefano, C., Mirone, G., Perna, S., & Marfe, G. (2016). The roles of microRNAs in the pathogenesis and drug resistance of chronic myelogenous leukemia (Review). Oncology Reports, 35, 614-624. https://doi.org/10.3892/or.2015.4456
MLA
Di Stefano, C., Mirone, G., Perna, S., Marfe, G."The roles of microRNAs in the pathogenesis and drug resistance of chronic myelogenous leukemia (Review)". Oncology Reports 35.2 (2016): 614-624.
Chicago
Di Stefano, C., Mirone, G., Perna, S., Marfe, G."The roles of microRNAs in the pathogenesis and drug resistance of chronic myelogenous leukemia (Review)". Oncology Reports 35, no. 2 (2016): 614-624. https://doi.org/10.3892/or.2015.4456