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Article

A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma

  • Authors:
    • Yanan Jiang
    • Qiong Wu
    • Xiawen Yang
    • Jimin Zhao
    • Yuxi Jin
    • Ke Li
    • Yihui Ma
    • Xinhuan Chen
    • Fang Tian
    • Song Zhao
    • Jinglong Xu
    • Jing Lu
    • Xueshan Yin
    • Kangdong Liu
    • Ziming Dong
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 785-792
    |
    Published online on: November 26, 2015
       https://doi.org/10.3892/or.2015.4459
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Abstract

Esophageal squamous cell carcinoma (ESCC) is the predominant histological type of esophageal carcinoma in China. The overall 5-year survival rate of ESCC patients is in the low range of 15-25%. One important reason for the poor prognosis is that the underlying molecular mechanisms are unclear. Furthermore, the development of effective therapeutic strategies to improve patient outcome is needed. Animal models can be beneficial to analyze the molecular mechanisms as well as specific clinical therapeutic strategies for esophageal cancer. In recent years, patient-derived xenografts (PDXs) have been widely used in numerous types of cancers to investigate the basic mechanisms and to conduct preclinical research. Accumulating evidence indicates that the PDX model is an important tool for basic and clinical research. Herein, we successfully established 14 ESCC PDXs. These PDX models preserved the patient pathological characteristics and effectively reflected the patient biological heterogeneity. Cancers exhibit diverse growth rates and tumor texture, even more, they have different signaling pathways. The PDX model is a superior strategy for understanding the underlying molecular mechanisms of ESCC and for screening new therapeutic strategies for ESCC patients.
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1 

Zhao P, Dai M, Chen W and Li N: Cancer trends in China. Jpn J Clin Oncol. 40:281–285. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, et al: The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma. Tumour Biol. 35:973–985. 2014. View Article : Google Scholar

3 

Belkhiri A and El-Rifai W: Advances in targeted therapies and new promising targets in esophageal cancer. Oncotarget. 6:1348–1358. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Honjo S, Ajani JA, Scott AW, Chen Q, Skinner HD, Stroehlein J, Johnson RL and Song S: Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer. Int J Oncol. 45:567–574. 2014.PubMed/NCBI

5 

Harb WA: Management of patients with hormone receptor-positive breast cancer with visceral disease: Challenges and treatment options. Cancer Manag Res. 7:37–46. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Geuna E, Milani A, Martinello R, Aversa C, Valabrega G, Scaltriti M and Montemurro F: Buparlisib, an oral pan-PI3K inhibitor for the treatment of breast cancer. Expert Opin Investig Drugs. 24:421–431. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Inoue A, Saijo Y, Maemondo M, Gomi K, Tokue Y, Kimura Y, Ebina M, Kikuchi T, Moriya T and Nukiwa T: Severe acute interstitial pneumonia and gefitinib. Lancet. 361:137–139. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Baselga J, Rischin D, Ranson M, Calvert H, Raymond E, Kieback DG, Kaye SB, Gianni L, Harris A, Bjork T, et al: Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J Clin Oncol. 20:4292–4302. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Marangoni E, Vincent-Salomon A, Auger N, Degeorges A, Assayag F, de Cremoux P, de Plater L, Guyader C, De Pinieux G, Judde JG, et al: A new model of patient tumor-derived breast cancer xenografts for preclinical assays. Clin Cancer Res. 13:3989–3998. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Moro M, Bertolini G, Tortoreto M, Pastorino U, Sozzi G and Roz L: Patient-derived xenografts of non small cell lung cancer: Resurgence of an old model for investigation of modern concepts of tailored therapy and cancer stem cells. J Biomed Biotechnol. 2012:5685672012. View Article : Google Scholar : PubMed/NCBI

11 

Siolas D and Hannon GJ: Patient-derived tumor xenografts: Transforming clinical samples into mouse models. Cancer Res. 73:5315–5319. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Tian H, Hou L, Xiong YM, Huang JX, She YJ, Bi XB and Song XR: miR-218 suppresses tumor growth and enhances the chemosensitivity of esophageal squamous cell carcinoma to cisplatin. Oncol Rep. 33:981–989. 2015.

13 

Napier KJ, Scheerer M and Misra S: Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities. World J Gastrointest Oncol. 6:112–120. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Uemura N and Kondo T: Current status of predictive biomarkers for neoadjuvant therapy in esophageal cancer. World J Gastrointest Pathophysiol. 5:322–334. 2014.PubMed/NCBI

15 

Morton CL and Houghton PJ: Establishment of human tumor xenografts in immunodeficient mice. Nat Protoc. 2:247–250. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Dong SW, Zhang H, Wang BL, Sun P, Wang YG and Zhang P: Effect of the downregulation of SMYD3 expression by RNAi on RIZ1 expression and proliferation of esophageal squamous cell carcinoma. Oncol Rep. 32:1064–1070. 2014.PubMed/NCBI

17 

Blobel GA, Moll R, Franke WW, Kayser KW and Gould VE: The intermediate filament cytoskeleton of malignant mesotheliomas and its diagnostic significance. Am J Pathol. 121:235–247. 1985.PubMed/NCBI

18 

Ye S, Lee KB, Park MH, Lee JS and Kim SM: p63 regulates growth of esophageal squamous carcinoma cells via the Akt signaling pathway. Int J Oncol. 44:2153–2159. 2014.PubMed/NCBI

19 

Thépot A, Hautefeuille A, Cros MP, Abedi-Ardekani B, Pétré A, Damour O, Krutovskikh V and Hainaut P: Intraepithelial p63-dependent expression of distinct components of cell adhesion complexes in normal esophageal mucosa and squamous cell carcinoma. Int J Cancer. 127:2051–2062. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Lin DC, Hao JJ, Nagata Y, Xu L, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, et al: Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat Genet. 46:467–473. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, et al: Identification of genomic alterations in oesophageal squamous cell cancer. Nature. 509:91–95. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Li B, Li J, Xu WW, Guan XY, Qin YR, Zhang LY, Law S, Tsao SW and Cheung AL: Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway. Oncotarget. 5:11576–11587. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Hou G, Yang S, Zhou Y, Wang C, Zhao W and Lu Z: Targeted inhibition of mTOR signaling improves sensitivity of esophageal squamous cell carcinoma cells to cisplatin. J Immunol Res. 2014:8457632014. View Article : Google Scholar : PubMed/NCBI

24 

Huang Y, Xi Q, Chen Y, Wang J, Peng P, Xia S and Yu S: A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin. Anticancer Drugs. 24:889–898. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Ciccarelli A and Giustetto M: Role of ERK signaling in activity-dependent modifications of histone proteins. Neuropharmacology. 80:34–44. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Bhalla S, Evens AM, Dai B, Prachand S, Gordon LI and Gartenhaus RB: The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma. Blood. 118:1052–1061. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Zhang J, Zhi H, Zhou C, Ding F, Luo A, Zhang X, Sun Y, Wang X, Wu M and Liu Z: Up-regulation of fibronectin in oesophageal squamous cell carcinoma is associated with activation of the Erk pathway. J Pathol. 207:402–409. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Sakamoto C: STAT1 and STAT3 might be regulated differently in esophageal squamous cell carcinoma. J Gastroenterol. 37:575–577. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Wang Z, Zhu S, Shen M, Liu J, Wang M, Li C, Wang Y, Deng A and Mei Q: STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1. Carcinogenesis. 34:678–688. 2013. View Article : Google Scholar

30 

Qing Y and Stark GR: Alternative activation of STAT1 and STAT3 in response to interferon-gamma. J Biol Chem. 279:41679–41685. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Regis G, Pensa S, Boselli D, Novelli F and Poli V: Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling. Semin Cell Dev Biol. 19:351–359. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang Y, Wu Q, Yang X, Zhao J, Jin Y, Li K, Ma Y, Chen X, Tian F, Zhao S, Zhao S, et al: A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma. Oncol Rep 35: 785-792, 2016.
APA
Jiang, Y., Wu, Q., Yang, X., Zhao, J., Jin, Y., Li, K. ... Dong, Z. (2016). A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma. Oncology Reports, 35, 785-792. https://doi.org/10.3892/or.2015.4459
MLA
Jiang, Y., Wu, Q., Yang, X., Zhao, J., Jin, Y., Li, K., Ma, Y., Chen, X., Tian, F., Zhao, S., Xu, J., Lu, J., Yin, X., Liu, K., Dong, Z."A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma". Oncology Reports 35.2 (2016): 785-792.
Chicago
Jiang, Y., Wu, Q., Yang, X., Zhao, J., Jin, Y., Li, K., Ma, Y., Chen, X., Tian, F., Zhao, S., Xu, J., Lu, J., Yin, X., Liu, K., Dong, Z."A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma". Oncology Reports 35, no. 2 (2016): 785-792. https://doi.org/10.3892/or.2015.4459
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Wu Q, Yang X, Zhao J, Jin Y, Li K, Ma Y, Chen X, Tian F, Zhao S, Zhao S, et al: A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma. Oncol Rep 35: 785-792, 2016.
APA
Jiang, Y., Wu, Q., Yang, X., Zhao, J., Jin, Y., Li, K. ... Dong, Z. (2016). A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma. Oncology Reports, 35, 785-792. https://doi.org/10.3892/or.2015.4459
MLA
Jiang, Y., Wu, Q., Yang, X., Zhao, J., Jin, Y., Li, K., Ma, Y., Chen, X., Tian, F., Zhao, S., Xu, J., Lu, J., Yin, X., Liu, K., Dong, Z."A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma". Oncology Reports 35.2 (2016): 785-792.
Chicago
Jiang, Y., Wu, Q., Yang, X., Zhao, J., Jin, Y., Li, K., Ma, Y., Chen, X., Tian, F., Zhao, S., Xu, J., Lu, J., Yin, X., Liu, K., Dong, Z."A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma". Oncology Reports 35, no. 2 (2016): 785-792. https://doi.org/10.3892/or.2015.4459
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