A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma

  • Authors:
    • Yanan Jiang
    • Qiong Wu
    • Xiawen Yang
    • Jimin Zhao
    • Yuxi Jin
    • Ke Li
    • Yihui Ma
    • Xinhuan Chen
    • Fang Tian
    • Song Zhao
    • Jinglong Xu
    • Jing Lu
    • Xueshan Yin
    • Kangdong Liu
    • Ziming Dong
  • View Affiliations

  • Published online on: November 26, 2015     https://doi.org/10.3892/or.2015.4459
  • Pages: 785-792
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Esophageal squamous cell carcinoma (ESCC) is the predominant histological type of esophageal carcinoma in China. The overall 5-year survival rate of ESCC patients is in the low range of 15-25%. One important reason for the poor prognosis is that the underlying molecular mechanisms are unclear. Furthermore, the development of effective therapeutic strategies to improve patient outcome is needed. Animal models can be beneficial to analyze the molecular mechanisms as well as specific clinical therapeutic strategies for esophageal cancer. In recent years, patient-derived xenografts (PDXs) have been widely used in numerous types of cancers to investigate the basic mechanisms and to conduct preclinical research. Accumulating evidence indicates that the PDX model is an important tool for basic and clinical research. Herein, we successfully established 14 ESCC PDXs. These PDX models preserved the patient pathological characteristics and effectively reflected the patient biological heterogeneity. Cancers exhibit diverse growth rates and tumor texture, even more, they have different signaling pathways. The PDX model is a superior strategy for understanding the underlying molecular mechanisms of ESCC and for screening new therapeutic strategies for ESCC patients.
View Figures
View References

Related Articles

Journal Cover

February-2016
Volume 35 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Wu Q, Yang X, Zhao J, Jin Y, Li K, Ma Y, Chen X, Tian F, Zhao S, Zhao S, et al: A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma. Oncol Rep 35: 785-792, 2016
APA
Jiang, Y., Wu, Q., Yang, X., Zhao, J., Jin, Y., Li, K. ... Dong, Z. (2016). A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma. Oncology Reports, 35, 785-792. https://doi.org/10.3892/or.2015.4459
MLA
Jiang, Y., Wu, Q., Yang, X., Zhao, J., Jin, Y., Li, K., Ma, Y., Chen, X., Tian, F., Zhao, S., Xu, J., Lu, J., Yin, X., Liu, K., Dong, Z."A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma". Oncology Reports 35.2 (2016): 785-792.
Chicago
Jiang, Y., Wu, Q., Yang, X., Zhao, J., Jin, Y., Li, K., Ma, Y., Chen, X., Tian, F., Zhao, S., Xu, J., Lu, J., Yin, X., Liu, K., Dong, Z."A method for establishing a patient-derived xenograft model to explore new therapeutic strategies for esophageal squamous cell carcinoma". Oncology Reports 35, no. 2 (2016): 785-792. https://doi.org/10.3892/or.2015.4459