Protein-protein interactions among signaling pathways may become new therapeutic targets in liver cancer (Review)

  • Authors:
    • Xiao Zhang
    • Yulan Wang
    • Jiayi Wang
    • Fenyong Sun
  • View Affiliations

  • Published online on: November 27, 2015     https://doi.org/10.3892/or.2015.4464
  • Pages: 625-638
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Abstract

Numerous signaling pathways have been shown to be dysregulated in liver cancer. In addition, some protein-protein interactions are prerequisite for the uncontrolled activation or inhibition of these signaling pathways. For instance, in the PI3K/AKT signaling pathway, protein AKT binds with a number of proteins such as mTOR, FOXO1 and MDM2 to play an oncogenic role in liver cancer. The aim of the present review was to focus on a series of important protein-protein interactions that can serve as potential therapeutic targets in liver cancer among certain important pro-carcinogenic signaling pathways. The strategies of how to investigate and analyze the protein-protein interactions are also included in this review. A survey of these protein interactions may provide alternative therapeutic targets in liver cancer.
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February-2016
Volume 35 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang X, Wang Y, Wang J and Sun F: Protein-protein interactions among signaling pathways may become new therapeutic targets in liver cancer (Review). Oncol Rep 35: 625-638, 2016
APA
Zhang, X., Wang, Y., Wang, J., & Sun, F. (2016). Protein-protein interactions among signaling pathways may become new therapeutic targets in liver cancer (Review). Oncology Reports, 35, 625-638. https://doi.org/10.3892/or.2015.4464
MLA
Zhang, X., Wang, Y., Wang, J., Sun, F."Protein-protein interactions among signaling pathways may become new therapeutic targets in liver cancer (Review)". Oncology Reports 35.2 (2016): 625-638.
Chicago
Zhang, X., Wang, Y., Wang, J., Sun, F."Protein-protein interactions among signaling pathways may become new therapeutic targets in liver cancer (Review)". Oncology Reports 35, no. 2 (2016): 625-638. https://doi.org/10.3892/or.2015.4464