Liver epithelial cells inhibit proliferation and invasiveness of hepatoma cells

  • Authors:
    • Kuo-Shyang Jeng
    • Chi-Juei Jeng
    • Wen-Juei Jeng
    • I-Shyan Sheen
    • Shih-Yun Li
    • Zih-Hang Hung
    • Hsin-I Hsiau
    • Ming-Che Yu
    • Chiung-Fang Chang
  • View Affiliations

  • Published online on: December 8, 2015     https://doi.org/10.3892/or.2015.4478
  • Pages: 1622-1628
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Abstract

Hepatocellular carcinoma (HCC) is a worldwide malignancy with poor prognosis. Liver progenitors or stem cells could be a potential therapy for HCC treatment since they migrate toward tumors. Rat liver epithelial (RLE) cells have both progenitor and stem cell-like properties. Therefore, our study elucidated the therapeutic effect of RLE cells in rat hepatoma cells. RLE cells were isolated from 10-day old rats and characterized for stem cell marker expression. RLE cells and rat hepatoma cells (H4-IIE-C3 cells) were co-cultured and divided into four groups with different ratios of RLE and hepatoma cells. Group A had only rat hepatoma cells as a control group. The ratios of rat hepatoma and RLE cells in group B, C and D were 5:1, 1:1 and 1:5, respectively. Effective inhibition of cell proliferation and migration was found in group D when compared to group A. There was a significant decrease in Bcl2 expression and increase in late apoptosis of rat hepatoma cells when adding more RLE cells. RLE cells reduced cell proliferation and migration of rat hepatoma cells. These results suggested that RLE cells could be used as a potential cell therapy.
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March-2016
Volume 35 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jeng K, Jeng C, Jeng W, Sheen I, Li S, Hung Z, Hsiau H, Yu M and Chang C: Liver epithelial cells inhibit proliferation and invasiveness of hepatoma cells. Oncol Rep 35: 1622-1628, 2016.
APA
Jeng, K., Jeng, C., Jeng, W., Sheen, I., Li, S., Hung, Z. ... Chang, C. (2016). Liver epithelial cells inhibit proliferation and invasiveness of hepatoma cells. Oncology Reports, 35, 1622-1628. https://doi.org/10.3892/or.2015.4478
MLA
Jeng, K., Jeng, C., Jeng, W., Sheen, I., Li, S., Hung, Z., Hsiau, H., Yu, M., Chang, C."Liver epithelial cells inhibit proliferation and invasiveness of hepatoma cells". Oncology Reports 35.3 (2016): 1622-1628.
Chicago
Jeng, K., Jeng, C., Jeng, W., Sheen, I., Li, S., Hung, Z., Hsiau, H., Yu, M., Chang, C."Liver epithelial cells inhibit proliferation and invasiveness of hepatoma cells". Oncology Reports 35, no. 3 (2016): 1622-1628. https://doi.org/10.3892/or.2015.4478