Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
March-2016 Volume 35 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2016 Volume 35 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Analysis of novel microRNA targets in drug-sensitive and -insensitive small cell lung cancer cell lines

  • Authors:
    • Lijie Ma
    • Peipei Li
    • Ruixuan Wang
    • Yandong Nan
    • Xueying Liu
    • Faguang Jin
  • View Affiliations / Copyright

    Affiliations: Department of Respiration, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Respiration, Harrison International Peace Hospital, Hengshui, Hebei 053000, P.R. China, Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China
  • Pages: 1611-1621
    |
    Published online on: December 16, 2015
       https://doi.org/10.3892/or.2015.4487
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Advances in chemotherapy have failed to improve the long-term survival rate of small cell lung cancer (SCLC) patients due to multidrug resistance (MDR). The mechanisms of MDR are complex involving multiple genes and a variety of mechanisms. MicroRNAs (miRNAs) are non-coding RNAs theoretically involved in gene regulation. The aim of the present study was to explore the role of miRNAs in SCLC occurrence and multidrug resistance. Expression levels of known miRNAs in SCLC cell line H446 and its multidrug-resistant cell line H446/CDDP were analyzed using the next generation high through-put Illumina Solexa sequencing technology, and expression of a group of specific miRNAs was validated by quantitative polymerase chain reaction (qPCR). Furthermore, novel miRNAs and their putative target genes in the two SCLC cell lines were predicted with the help of software developed by Beijing Genomics Institute and analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. The results revealed a set of known miRNAs with altered expression in the H446 and H446/CDDP cells which may be associated with multidrug resistance of SCLC. Biological information analysis of the novel miRNAs and their putative target genes further elucidated the role of miRNAs in MDR. In addition, the pathway prediction by KEGG analysis may provide clues for further research on MDR of SCLC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Pillai RN and Owonikoko TK: Small cell lung cancer: Therapies and targets. Semin Oncol. 41:133–142. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Rutledge MR, Waddell JA and Solimando DA Jr: Carboplatin (renally dosed) and etoposide regimen for small-cell lung cancer. Hosp Pharm. 48:274–279. 2013. View Article : Google Scholar

3 

Chen YT, Feng B and Chen LB: Update of research on drug resistance in small cell lung cancer chemotherapy. Asian Pac J Cancer Prev. 13:3577–3581. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Xia B, Hong LZ, Cai XW, Zhu ZF, Liu Q, Zhao KL, Fan M, Mao JF, Yang HJ, Wu KL, et al: Phase 2 study of accelerated hypofractionated thoracic radiation therapy and concurrent chemotherapy in patients with limited-stage small-cell lung cancer. Int J Radiat Oncol Biol Phys. 91:517–523. 2015. View Article : Google Scholar

5 

Rule WG, Foster NR, Meyers JP, Ashman JB, Vora SA, Kozelsky TF, Garces YI, Urbanic JJ, Salama JK and Schild SE: Prophylactic cranial irradiation in elderly patients with small cell lung cancer: Findings from a North Central Cancer Treatment Group pooled analysis. J Geriatr Oncol. 6:119–126. 2015. View Article : Google Scholar

6 

Zhu H, Guo H, Shi F, Zhu K, Luo J, Liu X, Kong L and Yu J: Prophylactic cranial irradiation improved the overall survival of patients with surgically resected small cell lung cancer, but not for stage I disease. Lung Cancer. 86:334–338. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Schabath MB, Nguyen A, Wilson P, Sommerer KR, Thompson ZJ and Chiappori AA: Temporal trends from 1986 to 2008 in overall survival of small cell lung cancer patients. Lung Cancer. 86:14–21. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Knez L, Sodja E, Kern I, Košnik M and Cufer T: Predictive value of multidrug resistance proteins, topoisomerases II and ERCC1 in small cell lung cancer: A systematic review. Lung Cancer. 72:271–279. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Kinehara Y, Minami T, Kijima T, Hoshino S, Morimura O, Otsuka T, Hayama Y, Fukushima K, Takeuchi Y, Higashiguchi M, et al: Favorable response to trastuzumab plus irinotecan combination therapy in two patients with HER2-positive relapsed small-cell lung cancer. Lung Cancer. 87:321–325. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Ushijima R, Takayama K, Izumi M, Harada T, Horiuchi Y, Uchino J, Hara N and Nakanishi Y: Immunohistochemical expression of MRP2 and clinical resistance to platinum-based chemotherapy in small cell lung cancer. Anticancer Res. 27:4351–4358. 2007.

11 

Eda A, Tamura Y, Yoshida M and Hohjoh H: Systematic gene regulation involving miRNAs during neuronal differentiation of mouse P19 embryonic carcinoma cell. Biochem Biophys Res Commun. 388:648–653. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Tindall MJ and Clerk A: Modelling negative feedback networks for activating transcription factor 3 predicts a dominant role for miRNAs in immediate early gene regulation. PLOS Comput Biol. 10:e10035972014. View Article : Google Scholar : PubMed/NCBI

13 

Zhang R, Marshall D, Bryan GJ and Hornyik C: Identification and characterization of miRNA transcriptome in potato by high-throughput sequencing. PLoS One. 8:e572332013. View Article : Google Scholar : PubMed/NCBI

14 

Zha W, Cao L, Shen Y and Huang M: Roles of miR-144-ZFX pathway in growth regulation of non-small-cell lung cancer. PLoS One. 8:e741752013. View Article : Google Scholar : PubMed/NCBI

15 

Yoshikawa M: Biogenesis of trans-acting siRNAs, endogenous secondary siRNAs in plants. Genes Genet Syst. 88:77–84. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Schwab R, Palatnik JF, Riester M, Schommer C, Schmid M and Weigel D: Specific effects of microRNAs on the plant transcriptome. Dev Cell. 8:517–527. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Altermann E and Klaenhammer TR: PathwayVoyager: Pathway mapping using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. BMC Genomics. 6:602005. View Article : Google Scholar : PubMed/NCBI

18 

Wrzodek C, Dräger A and Zell A: KEGGtranslator: Visualizing and converting the KEGG PATHWAY database to various formats. Bioinformatics. 27:2314–2315. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Fukunaga R, Han BW, Hung JH, Xu J, Weng Z and Zamore PD: Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Cell. 151:533–546. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Blake JA and Harris MA: The Gene Ontology (GO) project: Structured vocabularies for molecular biology and their application to genome and expression analysis. Curr Protoc Bioinformatics Chapter. 7:2–7. 2008.

21 

Smid M and Dorssers LC: GO-Mapper: Functional analysis of gene expression data using the expression level as a score to evaluate Gene Ontology terms. Bioinformatics. 20:2618–2625. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Wang G, Zhang H, He H, Tong W, Wang B, Liao G, Chen Z and Du C: Up-regulation of microRNA in bladder tumor tissue is not common. Int Urol Nephrol. 42:95–102. 2010. View Article : Google Scholar

23 

Chen YH, Wang SQ, Wu XL, Shen M, Chen ZG, Chen XG, Liu YX, Zhu XL, Guo F, Duan XZ, et al: Characterization of microRNAs expression profiling in one group of Chinese urothelial cell carcinoma identified by Solexa sequencing. Urol Oncol. 31:219–227. 2013. View Article : Google Scholar

24 

Li P, Ma L, Zhang Y, Ji F and Jin F: MicroRNA-137 down-regulates KIT and inhibits small cell lung cancer cell proliferation. Biomed Pharmacother. 68:7–12. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Bier A, Giladi N, Kronfeld N, Lee HK, Cazacu S, Finniss S, Xiang C, Poisson L, deCarvalho AC, Slavin S, et al: Micro-RNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1. Oncotarget. 4:665–676. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Li L, Li Z, Kong X, Xie D, Jia Z, Jiang W, Cui J, Du Y, Wei D, Huang S, et al: Down-regulation of microRNA-494 via loss of SMAD4 increases FOXM1 and β-catenin signaling in pancreatic ductal adenocarcinoma cells. Gastroenterology. 147:485–497.e18. 2014. View Article : Google Scholar

27 

Yang H, Li Q, Zhao W, Yuan D, Zhao H and Zhou Y: miR-329 suppresses the growth and motility of neuroblastoma by targeting KDM1A. FEBS Lett. 588:192–197. 2014. View Article : Google Scholar

28 

Xiao B, Tan L, He B, Liu Z and Xu R: MiRNA-329 targeting E2F1 inhibits cell proliferation in glioma cells. J Transl Med. 11:1722013. View Article : Google Scholar : PubMed/NCBI

29 

Senanayake U, Das S, Vesely P, Alzoughbi W, Fröhlich LF, Chowdhury P, Leuschner I, Hoefler G and Guertl B: miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms. Carcinogenesis. 33:1014–1021. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Song B, Wang Y, Titmus MA, Botchkina G, Formentini A, Kornmann M and Ju J: Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. Mol Cancer. 9:962010. View Article : Google Scholar : PubMed/NCBI

31 

Götz S, García-Gómez JM, Terol J, Williams TD, Nagaraj SH, Nueda MJ, Robles M, Talón M, Dopazo J and Conesa A: High-throughput functional annotation and data mining with the Blast2GO suite. Nucleic Acids Res. 36:3420–3435. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Nagaraju GP, Dontula R, El-Rayes BF and Lakka SS: Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesis. Carcinogenesis. 35:967–973. 2014. View Article : Google Scholar : PubMed/NCBI

33 

de Cremoux P and Robert J: Cell signalling and cancer: Characterisation of therapeutic targets. Pathol Biol (Paris). 60:217–222. 2012.In French. View Article : Google Scholar

34 

Allard B, Turcotte M and Stagg J: CD73-generated adenosine: Orchestrating the tumor-stroma interplay to promote cancer growth. J Biomed Biotechnol. 2012:4851562012. View Article : Google Scholar : PubMed/NCBI

35 

Dollé L, Depypere HT and Bracke ME: Anti-invasive/anti-metastasis strategies: New roads, new tools and new hopes. Curr Cancer Drug Targets. 6:729–751. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Lee JW, Bae SH, Jeong JW, Kim SH and Kim KW: Hypoxia-inducible factor (HIF-1)alpha: Its protein stability and biological functions. Exp Mol Med. 36:1–12. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Huang G, Nishimoto K, Yang Y and Kleinerman ES: Participation of the Fas/FasL signaling pathway and the lung microenvironment in the development of osteosarcoma lung metastases. Adv Exp Med Biol. 804:203–217. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Giubellino A, Burke TR Jr and Bottaro DP: Grb2 signaling in cell motility and cancer. Expert Opin Ther Targets. 12:1021–1033. 2008. View Article : Google Scholar : PubMed/NCBI

39 

De Luca A, Maiello MR, D'Alessio A, Pergameno M and Normanno N: The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: Role in cancer pathogenesis and implications for therapeutic approaches. Expert Opin Ther Targets. 16(Suppl 2): S17–S27. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Miliani de Marval PL and Zhang Y: The RP-Mdm2-p53 pathway and tumorigenesis. Oncotarget. 3:234–238. 2011. View Article : Google Scholar

41 

Cai Y, Cai T and Chen Y: Wnt pathway in osteosarcoma, from oncogenic to therapeutic. J Cell Biochem. 115:625–631. 2014. View Article : Google Scholar

42 

Li X, Jia Y, Zhang W, Zhang Y, Li B, Huang M, Bao F, Wu J and Lou Y: The research progress about Wnt pathway of lung cancer stem cells. Zhongguo Fei Ai Za Zhi. 14:695–698. 2011.In Chinese. PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ma L, Li P, Wang R, Nan Y, Liu X and Jin F: Analysis of novel microRNA targets in drug-sensitive and -insensitive small cell lung cancer cell lines. Oncol Rep 35: 1611-1621, 2016.
APA
Ma, L., Li, P., Wang, R., Nan, Y., Liu, X., & Jin, F. (2016). Analysis of novel microRNA targets in drug-sensitive and -insensitive small cell lung cancer cell lines. Oncology Reports, 35, 1611-1621. https://doi.org/10.3892/or.2015.4487
MLA
Ma, L., Li, P., Wang, R., Nan, Y., Liu, X., Jin, F."Analysis of novel microRNA targets in drug-sensitive and -insensitive small cell lung cancer cell lines". Oncology Reports 35.3 (2016): 1611-1621.
Chicago
Ma, L., Li, P., Wang, R., Nan, Y., Liu, X., Jin, F."Analysis of novel microRNA targets in drug-sensitive and -insensitive small cell lung cancer cell lines". Oncology Reports 35, no. 3 (2016): 1611-1621. https://doi.org/10.3892/or.2015.4487
Copy and paste a formatted citation
x
Spandidos Publications style
Ma L, Li P, Wang R, Nan Y, Liu X and Jin F: Analysis of novel microRNA targets in drug-sensitive and -insensitive small cell lung cancer cell lines. Oncol Rep 35: 1611-1621, 2016.
APA
Ma, L., Li, P., Wang, R., Nan, Y., Liu, X., & Jin, F. (2016). Analysis of novel microRNA targets in drug-sensitive and -insensitive small cell lung cancer cell lines. Oncology Reports, 35, 1611-1621. https://doi.org/10.3892/or.2015.4487
MLA
Ma, L., Li, P., Wang, R., Nan, Y., Liu, X., Jin, F."Analysis of novel microRNA targets in drug-sensitive and -insensitive small cell lung cancer cell lines". Oncology Reports 35.3 (2016): 1611-1621.
Chicago
Ma, L., Li, P., Wang, R., Nan, Y., Liu, X., Jin, F."Analysis of novel microRNA targets in drug-sensitive and -insensitive small cell lung cancer cell lines". Oncology Reports 35, no. 3 (2016): 1611-1621. https://doi.org/10.3892/or.2015.4487
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team