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Article

Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R

Retraction in: /10.3892/or.2022.8415
  • Authors:
    • Jieyan Li
    • Dongmei Li
    • Weiyuan Zhang
  • View Affiliations / Copyright

    Affiliations: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, P.R. China, Special Education Department of Changchun University, Changchun, Jilin 130022, P.R. China
  • Pages: 1671-1679
    |
    Published online on: December 18, 2015
       https://doi.org/10.3892/or.2015.4498
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Abstract

Accumulating evidence shows that microRNA-217 (miR-217) is frequently dysregulated in various cancers, and plays crucial roles in tumorigenesis and metastasis; however, the role and underlying molecular mechanism of miR-217 in human epithelial ovarian cancer (EOC) remains unclear. Here, we report that miR-217 expression was downregulated in EOC tissue and inversely correlated with advanced FIGO stage, high histological grading and lymph node metastasis (P<0.01). Function analysis revealed that the ectopic expression of miR-217 in EOC cells inhibited cell proliferation, migration and invasion in vitro, as well as suppressed tumor growth in vivo. Bioinformatics analysis and dual luciferase assays identified insulin-like growth factor 1 receptor (IGF1R) as a direct target of miR-217 in EOC cells. Western blot assay showed that overexpression of miR-217 in EOC cells inhibited IGF1R expression. In addition, downregulation of IGF1R mimicked the tumor-suppressive effects of miR-217 in EOC cells, whereas the reintroduction of IGF1R partially abrogated the suppression effect induced by miR-217 on EOC cells. Collectively, these results demonstrated that miR-217 plays a tumor suppressor role in human epithelial ovarian cancer by directly targeting IGF1R gene, suggesting a new potential therapeutic target in EOC.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Li D and Zhang W: Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R Retraction in /10.3892/or.2022.8415. Oncol Rep 35: 1671-1679, 2016.
APA
Li, J., Li, D., & Zhang, W. (2016). Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R Retraction in /10.3892/or.2022.8415. Oncology Reports, 35, 1671-1679. https://doi.org/10.3892/or.2015.4498
MLA
Li, J., Li, D., Zhang, W."Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R Retraction in /10.3892/or.2022.8415". Oncology Reports 35.3 (2016): 1671-1679.
Chicago
Li, J., Li, D., Zhang, W."Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R Retraction in /10.3892/or.2022.8415". Oncology Reports 35, no. 3 (2016): 1671-1679. https://doi.org/10.3892/or.2015.4498
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Li D and Zhang W: Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R Retraction in /10.3892/or.2022.8415. Oncol Rep 35: 1671-1679, 2016.
APA
Li, J., Li, D., & Zhang, W. (2016). Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R Retraction in /10.3892/or.2022.8415. Oncology Reports, 35, 1671-1679. https://doi.org/10.3892/or.2015.4498
MLA
Li, J., Li, D., Zhang, W."Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R Retraction in /10.3892/or.2022.8415". Oncology Reports 35.3 (2016): 1671-1679.
Chicago
Li, J., Li, D., Zhang, W."Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R Retraction in /10.3892/or.2022.8415". Oncology Reports 35, no. 3 (2016): 1671-1679. https://doi.org/10.3892/or.2015.4498
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