Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R Retraction in /10.3892/or.2022.8415

Li,Jieyan; Li,Dongmei; Zhang,Weiyuan

doi:10.3892/or.2015.4498

Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R

Retraction in: /10.3892/or.2022.8415

Authors:
- Jieyan Li
- Dongmei Li
- Weiyuan Zhang
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Affiliations: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, P.R. China, Special Education Department of Changchun University, Changchun, Jilin 130022, P.R. China
Published online on: December 18, 2015 https://doi.org/10.3892/or.2015.4498
Pages: 1671-1679

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Abstract

Accumulating evidence shows that microRNA-217 (miR-217) is frequently dysregulated in various cancers, and plays crucial roles in tumorigenesis and metastasis; however, the role and underlying molecular mechanism of miR-217 in human epithelial ovarian cancer (EOC) remains unclear. Here, we report that miR-217 expression was downregulated in EOC tissue and inversely correlated with advanced FIGO stage, high histological grading and lymph node metastasis (P<0.01). Function analysis revealed that the ectopic expression of miR-217 in EOC cells inhibited cell proliferation, migration and invasion in vitro, as well as suppressed tumor growth in vivo. Bioinformatics analysis and dual luciferase assays identified insulin-like growth factor 1 receptor (IGF1R) as a direct target of miR-217 in EOC cells. Western blot assay showed that overexpression of miR-217 in EOC cells inhibited IGF1R expression. In addition, downregulation of IGF1R mimicked the tumor-suppressive effects of miR-217 in EOC cells, whereas the reintroduction of IGF1R partially abrogated the suppression effect induced by miR-217 on EOC cells. Collectively, these results demonstrated that miR-217 plays a tumor suppressor role in human epithelial ovarian cancer by directly targeting IGF1R gene, suggesting a new potential therapeutic target in EOC.

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