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Article

Genetic analysis in a patient with nine primary malignant neoplasms: a rare case of Li-Fraumeni syndrome

  • Authors:
    • Xiaoyuan Li
    • Juan Kang
    • Qi Pan
    • Weronika Sikora-Wohlfeld
    • Dachun Zhao
    • Changting Meng
    • Chunmei Bai
    • Anil Patwardhan
    • Richard Chen
    • Hong Ren
    • Atul J. Butte
    • Keyue Ding
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P.R. China, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education of China; Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China, Division of Systems Medicine, Department of Pediatrics, Stanford University, CA, USA, Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P.R. China, Personalis, Inc., Menlo Park, CA, USA
  • Pages: 1519-1528
    |
    Published online on: December 21, 2015
       https://doi.org/10.3892/or.2015.4501
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Abstract

To identify rare mutations and retrospectively estimate the cancer risk of a 45-year old female patient diagnosed with Li-Fraumeni syndrome (LFS), who developed nine primary malignant neoplasms in a period of 38 years, we conducted next-generation sequencing in this patient. Whole-genome and whole-exome sequencing were performed in DNA of whole blood obtained a year prior to the diagnosis of acute myeloid leukemia (AML) and at the time of diagnosis of AML, respectively. We analyzed rare mutations in cancer susceptibility genes using a candidate strategy and estimated cancer risk using the Risk-O-Gram algorithm. We found rare mutations in cancer susceptibility genes associated with an increased hereditary cancer risk in the patient. Notably, the number of mutated genes in p53 signaling pathway was significantly higher than expected (p=0.02). However, the phenotype of multiple malignant neoplasms of the studied patient was unlikely to be caused by accumulation of common cancer risk alleles. In conclusion, we established the mutation profile in a rare case of Li-Fraumeni syndrome, illustrating that the rare mutations rather than the cumulative of common risk alleles leading to an increased cancer risk in the patient.
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1 

Li FP and Fraumeni JF Jr: Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med. 71:747–752. 1969. View Article : Google Scholar : PubMed/NCBI

2 

Hisada M, Garber JE, Fung CY, Fraumeni JF Jr and Li FP: Multiple primary cancers in families with Li-Fraumeni syndrome. J Natl Cancer Inst. 90:606–611. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Olivier M, Hollstein M and Hainaut P: TP53 mutations in human cancers: Origins, consequences, and clinical use. Cold Spring Harb Perspect Biol. 2:a0010082010. View Article : Google Scholar : PubMed/NCBI

4 

Bell DW, Varley JM, Szydlo TE, Kang DH, Wahrer DC, Shannon KE, Lubratovich M, Verselis SJ, Isselbacher KJ, Fraumeni JF, et al: Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science. 286:2528–2531. 1999. View Article : Google Scholar

5 

Bachinski LL, Olufemi S-E, Zhou X, Wu CC, Yip L, Shete S, Lozano G, Amos CI, Strong LC and Krahe R: Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23. Cancer Res. 65:427–431. 2005.PubMed/NCBI

6 

Chen K, Wallis JW, McLellan MD, Larson DE, Kalicki JM, Pohl CS, McGrath SD, Wendl MC, Zhang Q, Locke DP, et al: BreakDancer: An algorithm for high-resolution mapping of genomic structural variation. Nat Methods. 6:677–681. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Boeva V, Popova T, Bleakley K, Chiche P, Cappo J, Schleiermacher G, Janoueix-Lerosey I, Delattre O and Barillot E: Control-FREEC: A tool for assessing copy number and allelic content using next-generation sequencing data. Bioinformatics. 28:423–425. 2012. View Article : Google Scholar :

8 

Cibulskis K, Lawrence MS, Carter SL, Sivachenko A, Jaffe D, Sougnez C, Gabriel S, Meyerson M, Lander ES and Getz G: Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol. 31:213–219. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Gilissen C, Hoischen A, Brunner HG and Veltman JA: Disease gene identification strategies for exome sequencing. Eur J Hum Genet. 20:490–497. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Garber JE and Offit K: Hereditary cancer predisposition syndromes. J Clin Oncol. 23:276–292. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Wood RD, Mitchell M, Sgouros J and Lindahl T: Human DNA repair genes. Science. 291:1284–1289. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Ramensky V, Bork P and Sunyaev S: Human non-synonymous SNPs: Server and survey. Nucleic Acids Res. 30:3894–3900. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Chen R, Davydov EV, Sirota M and Butte AJ: Non-synonymous and synonymous coding SNPs show similar likelihood and effect size of human disease association. PLoS One. 5:e135742010. View Article : Google Scholar : PubMed/NCBI

14 

Ashley EA, Butte AJ, Wheeler MT, Chen R, Klein TE, Dewey FE, Dudley JT, Ormond KE, Pavlovic A, Morgan AA, et al: Clinical assessment incorporating a personal genome. Lancet. 375:1525–1535. 2010. View Article : Google Scholar : PubMed/NCBI

15 

1000 Genomes Project Consortium; Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT and McVean GA: An integrated map of genetic variation from 1,092 human genomes. Nature. 491:56–65. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Mwenifumbo JC and Marra MA: Cancer genome-sequencing study design. Nat Rev Genet. 14:321–332. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Malkin D, Jolly KW, Barbier N, Look AT, Friend SH, Gebhardt MC, Andersen TI, Børresen AL, Li FP, Garber J, et al: Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. N Engl J Med. 326:1309–1315. 1992. View Article : Google Scholar : PubMed/NCBI

18 

Sugano K, Taniguchi T, Saeki M, Tsunematsu Y, Tomaru U and Shimoda T: Germline p53 mutation in a case of Li-Fraumeni syndrome presenting gastric cancer. Jpn J Clin Oncol. 29:513–516. 1999. View Article : Google Scholar

19 

Healey CS, Dunning AM, Teare MD, Chase D, Parker L, Burn J, Chang-Claude J, Mannermaa A, Kataja V, Huntsman DG, et al: A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability. Nat Genet. 26:362–364. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Masciari S, Larsson N, Senz J, Boyd N, Kaurah P, Kandel MJ, Harris LN, Pinheiro HC, Troussard A, Miron P, et al: Germline E-cadherin mutations in familial lobular breast cancer. J Med Genet. 44:726–731. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Kaurah P, MacMillan A, Boyd N, Senz J, De Luca A, Chun N, Suriano G, Zaor S, Van Manen L, Gilpin C, et al: Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA. 297:2360–2372. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Mohaghegh P and Hickson ID: DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. Hum Mol Genet. 10:741–746. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Kitao S, Shimamoto A, Goto M, Miller RW, Smithson WA, Lindor NM and Furuichi Y: Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome. Nat Genet. 22:82–84. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Ellis NA, Groden J, Ye TZ, Straughen J, Lennon DJ, Ciocci S, Proytcheva M and German J: The Bloom's syndrome gene product is homologous to RecQ helicases. Cell. 83:655–666. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Thompson ER, Doyle MA, Ryland GL, Rowley SM, Choong DY, Tothill RW, Thorne H, Barnes DR, Li J, Ellul J, et al: kConFab: Exome sequencing identifies rare deleterious mutations in DNA repair genes FANCC and BLM as potential breast cancer susceptibility alleles. PLoS Genet. 8:e10028942012. View Article : Google Scholar

26 

Kunkel TA and Erie DA: DNA mismatch repair. Annu Rev Biochem. 74:681–710. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Nakagawa H, Lockman JC, Frankel WL, Hampel H, Steenblock K, Burgart LJ, Thibodeau SN and de la Chapelle A: Mismatch repair gene PMS2: Disease-causing germline mutations are frequent in patients whose tumors stain negative for PMS2 protein, but paralogous genes obscure mutation detection and interpretation. Cancer Res. 64:4721–4727. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Hitchins MP, Wong JJL, Suthers G, Suter CM, Martin DIK, Hawkins NJ and Ward RL: Inheritance of a cancer-associated MLH1 germ-line epimutation. N Engl J Med. 356:697–705. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Forbes SA, Bindal N, Bamford S, Cole C, Kok CY, Beare D, Jia M, Shepherd R, Leung K, Menzies A, et al: COSMIC: Mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res. 39(Database): D945–D950. 2011. View Article : Google Scholar :

30 

Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, et al: MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell. 25:652–665. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Li WD, Li QR, Xu SN, Wei FJ, Ye ZJ, Cheng JK and Chen JP: Exome sequencing identifies an MLL3 gene germ line mutation in a pedigree of colorectal cancer and acute myeloid leukemia. Blood. 121:1478–1479. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Villani A, Tabori U, Schiffman J, Shlien A, Beyene J, Druker H, Novokmet A, Finlay J and Malkin D: Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: A prospective observational study. Lancet Oncol. 12:559–567. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Vogelstein B, Lane D and Levine AJ: Surfing the p53 network. Nature. 408:307–310. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Haferlach C, Dicker F, Herholz H, Schnittger S, Kern W and Haferlach T: Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype. Leukemia. 22:1539–1541. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Grochola LF, Zeron-Medina J, Mériaux S and Bond GL: Single-nucleotide polymorphisms in the p53 signaling pathway. Cold Spring Harb Perspect Biol. 2:a0010322010. View Article : Google Scholar : PubMed/NCBI

36 

Fitzgerald RC, Hardwick R, Huntsman D, Carneiro F, Guilford P, Blair V, Chung DC, Norton J, Ragunath K, Van Krieken JH, et al International Gastric Cancer Linkage Consortium: Hereditary diffuse gastric cancer: Updated consensus guidelines for clinical management and directions for future research. J Med Genet. 47:436–444. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Evans DGR and Ingham SL: Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors. Appl Clin Genet. 6:53–61. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Limacher JM, Frebourg T, Natarajan-Ame S and Bergerat JP: Two metachronous tumors in the radiotherapy fields of a patient with Li-Fraumeni syndrome. Int J Cancer. 96:238–242. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Heymann S, Delaloge S, Rahal A, Caron O, Frebourg T, Barreau L, Pachet C, Mathieu MC, Marsiglia H and Bourgier C: Radio-induced malignancies after breast cancer postoperative radiotherapy in patients with Li-Fraumeni syndrome. Radiat Oncol. 5:1042010. View Article : Google Scholar : PubMed/NCBI

40 

Godley LA and Larson RA: Therapy-related myeloid leukemia. Semin Oncol. 35:418–429. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Smith MA, Rubinstein L, Anderson JR, Arthur D, Catalano PJ, Freidlin B, Heyn R, Khayat A, Krailo M, Land VJ, et al: Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins. J Clin Oncol. 17:569–577. 1999.PubMed/NCBI

42 

Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr and Kinzler KW: Cancer genome landscapes. Science. 339:1546–1558. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Rausch T, Jones DTW, Zapatka M, Stütz AM, Zichner T, Weischenfeldt J, Jäger N, Remke M, Shih D, Northcott PA, et al: Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell. 148:59–71. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Kang J, Pan Q, Sikora-Wohlfeld W, Zhao D, Meng C, Bai C, Patwardhan A, Chen R, Ren H, Ren H, et al: Genetic analysis in a patient with nine primary malignant neoplasms: a rare case of Li-Fraumeni syndrome. Oncol Rep 35: 1519-1528, 2016.
APA
Li, X., Kang, J., Pan, Q., Sikora-Wohlfeld, W., Zhao, D., Meng, C. ... Ding, K. (2016). Genetic analysis in a patient with nine primary malignant neoplasms: a rare case of Li-Fraumeni syndrome. Oncology Reports, 35, 1519-1528. https://doi.org/10.3892/or.2015.4501
MLA
Li, X., Kang, J., Pan, Q., Sikora-Wohlfeld, W., Zhao, D., Meng, C., Bai, C., Patwardhan, A., Chen, R., Ren, H., Butte, A. J., Ding, K."Genetic analysis in a patient with nine primary malignant neoplasms: a rare case of Li-Fraumeni syndrome". Oncology Reports 35.3 (2016): 1519-1528.
Chicago
Li, X., Kang, J., Pan, Q., Sikora-Wohlfeld, W., Zhao, D., Meng, C., Bai, C., Patwardhan, A., Chen, R., Ren, H., Butte, A. J., Ding, K."Genetic analysis in a patient with nine primary malignant neoplasms: a rare case of Li-Fraumeni syndrome". Oncology Reports 35, no. 3 (2016): 1519-1528. https://doi.org/10.3892/or.2015.4501
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Kang J, Pan Q, Sikora-Wohlfeld W, Zhao D, Meng C, Bai C, Patwardhan A, Chen R, Ren H, Ren H, et al: Genetic analysis in a patient with nine primary malignant neoplasms: a rare case of Li-Fraumeni syndrome. Oncol Rep 35: 1519-1528, 2016.
APA
Li, X., Kang, J., Pan, Q., Sikora-Wohlfeld, W., Zhao, D., Meng, C. ... Ding, K. (2016). Genetic analysis in a patient with nine primary malignant neoplasms: a rare case of Li-Fraumeni syndrome. Oncology Reports, 35, 1519-1528. https://doi.org/10.3892/or.2015.4501
MLA
Li, X., Kang, J., Pan, Q., Sikora-Wohlfeld, W., Zhao, D., Meng, C., Bai, C., Patwardhan, A., Chen, R., Ren, H., Butte, A. J., Ding, K."Genetic analysis in a patient with nine primary malignant neoplasms: a rare case of Li-Fraumeni syndrome". Oncology Reports 35.3 (2016): 1519-1528.
Chicago
Li, X., Kang, J., Pan, Q., Sikora-Wohlfeld, W., Zhao, D., Meng, C., Bai, C., Patwardhan, A., Chen, R., Ren, H., Butte, A. J., Ding, K."Genetic analysis in a patient with nine primary malignant neoplasms: a rare case of Li-Fraumeni syndrome". Oncology Reports 35, no. 3 (2016): 1519-1528. https://doi.org/10.3892/or.2015.4501
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