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Article

MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1

Corrigendum in: /10.3892/or.2022.8317
  • Authors:
    • Qian Jiang
    • Miao He
    • Meng-Tao Ma
    • Hui-Zhe Wu
    • Zhao-Jin Yu
    • Shu Guan
    • Long-Yang Jiang
    • Yan Wang
    • Da-Di Zheng
    • Feng Jin
    • Min-Jie Wei
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning 110122, P.R. China, Department of Surgical Oncology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, P.R. China
  • Pages: 1425-1432
    |
    Published online on: December 21, 2015
       https://doi.org/10.3892/or.2015.4502
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Abstract

Wnt/β-catenin signaling pathway influences embryonic development, cell polarity and adhesion, apoptosis and tumorigenesis. MicroRNAs (miRNAs) function as important regulators of the tumorigenesis and metastasis. In the present study, we aimed to find novel targets and mechanisms of microRNA-148a (miR-148a) in regulating the migration and invasion of breast cancer cells. In the present study, miR-148a was found downregulated in human breast cancer tissues and cell lines. The ectopic miR-148a expression inhibited the migration and invasion of MCF-7 and MDA-MB-231 breast cancer cells. Furthermore, we demonstrated that WNT-1, one of the ligands of Wnt/β-catenin signaling pathway, was a direct target of miR-148a. The overexpression of miR-148a reduced the mRNA and protein expression levels of WNT-1, also decreased the expression levels of the key components of Wnt/β-catenin pathway, including β-catenin, metalloproteinase-7 (MMP-7) and T-cell factor-4 (TCF-4) in MCF-7 and MDA-MB-231 cells. In addition, the data showed that the expression of WNT-1 was significantly higher in human breast cancer tissues compared with the adjacent normal tissues and the expression of miR-148a was negatively correlated with the WNT-1 expression in human breast cancer tissues. Taken together, our results suggest that miR-148a can suppress the migration and invasion of breast cancer cells by targeting WNT-1 and inhibiting Wnt/β-catenin signaling pathway and this will provide new insights into the molecular mechanisms of breast cancer metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang Q, He M, Ma M, Wu H, Yu Z, Guan S, Jiang L, Wang Y, Zheng D, Jin F, Jin F, et al: MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1 Corrigendum in /10.3892/or.2022.8317. Oncol Rep 35: 1425-1432, 2016.
APA
Jiang, Q., He, M., Ma, M., Wu, H., Yu, Z., Guan, S. ... Wei, M. (2016). MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1 Corrigendum in /10.3892/or.2022.8317. Oncology Reports, 35, 1425-1432. https://doi.org/10.3892/or.2015.4502
MLA
Jiang, Q., He, M., Ma, M., Wu, H., Yu, Z., Guan, S., Jiang, L., Wang, Y., Zheng, D., Jin, F., Wei, M."MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1 Corrigendum in /10.3892/or.2022.8317". Oncology Reports 35.3 (2016): 1425-1432.
Chicago
Jiang, Q., He, M., Ma, M., Wu, H., Yu, Z., Guan, S., Jiang, L., Wang, Y., Zheng, D., Jin, F., Wei, M."MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1 Corrigendum in /10.3892/or.2022.8317". Oncology Reports 35, no. 3 (2016): 1425-1432. https://doi.org/10.3892/or.2015.4502
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Q, He M, Ma M, Wu H, Yu Z, Guan S, Jiang L, Wang Y, Zheng D, Jin F, Jin F, et al: MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1 Corrigendum in /10.3892/or.2022.8317. Oncol Rep 35: 1425-1432, 2016.
APA
Jiang, Q., He, M., Ma, M., Wu, H., Yu, Z., Guan, S. ... Wei, M. (2016). MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1 Corrigendum in /10.3892/or.2022.8317. Oncology Reports, 35, 1425-1432. https://doi.org/10.3892/or.2015.4502
MLA
Jiang, Q., He, M., Ma, M., Wu, H., Yu, Z., Guan, S., Jiang, L., Wang, Y., Zheng, D., Jin, F., Wei, M."MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1 Corrigendum in /10.3892/or.2022.8317". Oncology Reports 35.3 (2016): 1425-1432.
Chicago
Jiang, Q., He, M., Ma, M., Wu, H., Yu, Z., Guan, S., Jiang, L., Wang, Y., Zheng, D., Jin, F., Wei, M."MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1 Corrigendum in /10.3892/or.2022.8317". Oncology Reports 35, no. 3 (2016): 1425-1432. https://doi.org/10.3892/or.2015.4502
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