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Review

The role of exosomes in tumor progression and metastasis (Review)

  • Authors:
    • Wiktoria M. Suchorska
    • Michal S. Lach
  • View Affiliations / Copyright

    Affiliations: Radiobiology Laboratory, Greater Poland Cancer Centre, 61-866 Poznan, Poland
  • Pages: 1237-1244
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    Published online on: December 22, 2015
       https://doi.org/10.3892/or.2015.4507
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Abstract

Tumor cells have developed various mechanisms in defense against applied treatment, which prevent their total elimination from an organism. One of the underestimated mechanisms of defense is secretion of highly specialized double-membrane structures called exosomes. They play a crucial role in the control of the local microenvironment and intracellular communication. It has been shown that the exosomes can be carriers of various proteins, lipids, miRNAs and mRNAs. There are extensive data concerning the influence and participation by exosomes in metastasis and cancer progression. It has been demonstrated that exosomes are involved in multidrug resistance mechanisms, radiation-induced bystander effect and epithelial-mesenchymal transition. Furthermore, exosomes are able to form a premetastatic niche and enable the escape of cancer cells from recognition by host immune cells. Moreover, exosomes are responsible for the formation of vessels. This indicates the significance of secreted extracellular vesicles in the development and prognosis of cancer. The aim of the present review is to briefly describe the role of exosomes in tumor biology.
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Copy and paste a formatted citation
Spandidos Publications style
Suchorska WM and Lach MS: The role of exosomes in tumor progression and metastasis (Review). Oncol Rep 35: 1237-1244, 2016.
APA
Suchorska, W.M., & Lach, M.S. (2016). The role of exosomes in tumor progression and metastasis (Review). Oncology Reports, 35, 1237-1244. https://doi.org/10.3892/or.2015.4507
MLA
Suchorska, W. M., Lach, M. S."The role of exosomes in tumor progression and metastasis (Review)". Oncology Reports 35.3 (2016): 1237-1244.
Chicago
Suchorska, W. M., Lach, M. S."The role of exosomes in tumor progression and metastasis (Review)". Oncology Reports 35, no. 3 (2016): 1237-1244. https://doi.org/10.3892/or.2015.4507
Copy and paste a formatted citation
x
Spandidos Publications style
Suchorska WM and Lach MS: The role of exosomes in tumor progression and metastasis (Review). Oncol Rep 35: 1237-1244, 2016.
APA
Suchorska, W.M., & Lach, M.S. (2016). The role of exosomes in tumor progression and metastasis (Review). Oncology Reports, 35, 1237-1244. https://doi.org/10.3892/or.2015.4507
MLA
Suchorska, W. M., Lach, M. S."The role of exosomes in tumor progression and metastasis (Review)". Oncology Reports 35.3 (2016): 1237-1244.
Chicago
Suchorska, W. M., Lach, M. S."The role of exosomes in tumor progression and metastasis (Review)". Oncology Reports 35, no. 3 (2016): 1237-1244. https://doi.org/10.3892/or.2015.4507
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