Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A

Retraction in: /10.3892/or.2024.8717

  • Authors:
    • Yi Cai
    • Hanzhong Li
    • Yushi Zhang
  • View Affiliations

  • Published online on: December 30, 2015     https://doi.org/10.3892/or.2015.4538
  • Pages: 1778-1786
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Abstract

MicroRNA-206 (miR-206) has been discovered to have anticancer properties in different tissues. However, the role of miR-206 on renal carcinoma is still ambiguous. In the present study, we investigated the role of miR-206 on the development of renal carcinoma. The results indicated that miR-206 was significantly downregulated in 69 clear cell renal carcinoma (ccRCC) tissues and low-level of miR-206 related to shorter metastasis-free survival time for patients with ccRCC. The results indicated that vascular endothelial growth factor A (VEGFA) was a direct target of miR-206 in renal cancer cells. Further studies revealed that upregulation of miR-206 inhibited renal cancer cell proliferation, invasion and migration, suggesting that miR-206 functioned as a tumor suppressor. RNA interference targeting VEGFA mRNA could mimic the upregulation of miR-206 functions, and also suppressed tumor formation in vivo in nude mice. These results suggest that miR-206 plays an important role in ccRCC tumorigenesis by targeting VEGFA.
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March-2016
Volume 35 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cai Y, Li H and Zhang Y: Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A Retraction in /10.3892/or.2024.8717. Oncol Rep 35: 1778-1786, 2016
APA
Cai, Y., Li, H., & Zhang, Y. (2016). Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A Retraction in /10.3892/or.2024.8717. Oncology Reports, 35, 1778-1786. https://doi.org/10.3892/or.2015.4538
MLA
Cai, Y., Li, H., Zhang, Y."Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A Retraction in /10.3892/or.2024.8717". Oncology Reports 35.3 (2016): 1778-1786.
Chicago
Cai, Y., Li, H., Zhang, Y."Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A Retraction in /10.3892/or.2024.8717". Oncology Reports 35, no. 3 (2016): 1778-1786. https://doi.org/10.3892/or.2015.4538