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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A

Retraction in: /10.3892/or.2024.8717
  • Authors:
    • Yi Cai
    • Hanzhong Li
    • Yushi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China
  • Pages: 1778-1786
    |
    Published online on: December 30, 2015
       https://doi.org/10.3892/or.2015.4538
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Abstract

MicroRNA-206 (miR-206) has been discovered to have anticancer properties in different tissues. However, the role of miR-206 on renal carcinoma is still ambiguous. In the present study, we investigated the role of miR-206 on the development of renal carcinoma. The results indicated that miR-206 was significantly downregulated in 69 clear cell renal carcinoma (ccRCC) tissues and low-level of miR-206 related to shorter metastasis-free survival time for patients with ccRCC. The results indicated that vascular endothelial growth factor A (VEGFA) was a direct target of miR-206 in renal cancer cells. Further studies revealed that upregulation of miR-206 inhibited renal cancer cell proliferation, invasion and migration, suggesting that miR-206 functioned as a tumor suppressor. RNA interference targeting VEGFA mRNA could mimic the upregulation of miR-206 functions, and also suppressed tumor formation in vivo in nude mice. These results suggest that miR-206 plays an important role in ccRCC tumorigenesis by targeting VEGFA.
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Copy and paste a formatted citation
Spandidos Publications style
Cai Y, Li H and Zhang Y: Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A Retraction in /10.3892/or.2024.8717. Oncol Rep 35: 1778-1786, 2016.
APA
Cai, Y., Li, H., & Zhang, Y. (2016). Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A Retraction in /10.3892/or.2024.8717. Oncology Reports, 35, 1778-1786. https://doi.org/10.3892/or.2015.4538
MLA
Cai, Y., Li, H., Zhang, Y."Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A Retraction in /10.3892/or.2024.8717". Oncology Reports 35.3 (2016): 1778-1786.
Chicago
Cai, Y., Li, H., Zhang, Y."Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A Retraction in /10.3892/or.2024.8717". Oncology Reports 35, no. 3 (2016): 1778-1786. https://doi.org/10.3892/or.2015.4538
Copy and paste a formatted citation
x
Spandidos Publications style
Cai Y, Li H and Zhang Y: Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A Retraction in /10.3892/or.2024.8717. Oncol Rep 35: 1778-1786, 2016.
APA
Cai, Y., Li, H., & Zhang, Y. (2016). Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A Retraction in /10.3892/or.2024.8717. Oncology Reports, 35, 1778-1786. https://doi.org/10.3892/or.2015.4538
MLA
Cai, Y., Li, H., Zhang, Y."Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A Retraction in /10.3892/or.2024.8717". Oncology Reports 35.3 (2016): 1778-1786.
Chicago
Cai, Y., Li, H., Zhang, Y."Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A Retraction in /10.3892/or.2024.8717". Oncology Reports 35, no. 3 (2016): 1778-1786. https://doi.org/10.3892/or.2015.4538
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