Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer

  • Authors:
    • Zengjun Li
    • Haipeng Wang
    • Zhongfa Xu
    • Yanlai Sun
    • Jianjun Han
  • View Affiliations

  • Published online on: January 5, 2016     https://doi.org/10.3892/or.2016.4546
  • Pages: 1403-1408
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Abstract

The emerging role of microRNA-181A (miR-181A) in CRC patients with late liver metastases was studied. In the present study we investigated the association between expression and mechanism of miRNA-181A, liver metastasis and prognosis of colorectal cancer (CRC). The expression of miR-181A and PTEN in CRC patients with late liver metastases was higher than that of the normal (control) group, whereas the expression of miR-181A and PTEN was lower in all pathological groups (TNM I-TNM IV). Overall survival (OS) of lower expression miR-181A CRC patients with late liver metastases was higher than that of higher expression miR-181A CRC patients with late liver metastases. The expression of miR-181A and PTEN in the colon cell line NCM460 was lower than that of the colon cancer SW620 cell line. Upregulation of miR-181A promoted cell viability and inhibited apoptosis of SW620 cells, suppressed PTEN expression and activated phosphorylation of AKT (p-AKT) in SW620 cells. Additionally, downregulation of miR-181A inhibited cell viability of SW620 cells through promotion of PTEN and inhibition of p-AKT. Together, our results indicate that miR-181A expression is associated with CRC patients with late liver metastases through PTEN/AKT signaling.
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March-2016
Volume 35 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Li Z, Wang H, Xu Z, Sun Y and Han J: Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer. Oncol Rep 35: 1403-1408, 2016
APA
Li, Z., Wang, H., Xu, Z., Sun, Y., & Han, J. (2016). Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer. Oncology Reports, 35, 1403-1408. https://doi.org/10.3892/or.2016.4546
MLA
Li, Z., Wang, H., Xu, Z., Sun, Y., Han, J."Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer". Oncology Reports 35.3 (2016): 1403-1408.
Chicago
Li, Z., Wang, H., Xu, Z., Sun, Y., Han, J."Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer". Oncology Reports 35, no. 3 (2016): 1403-1408. https://doi.org/10.3892/or.2016.4546