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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March-2016 Volume 35 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer

  • Authors:
    • Zengjun Li
    • Haipeng Wang
    • Zhongfa Xu
    • Yanlai Sun
    • Jianjun Han
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Science, Jinan, Shandong 250117, P.R. China
  • Pages: 1403-1408
    |
    Published online on: January 5, 2016
       https://doi.org/10.3892/or.2016.4546
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Abstract

The emerging role of microRNA-181A (miR-181A) in CRC patients with late liver metastases was studied. In the present study we investigated the association between expression and mechanism of miRNA-181A, liver metastasis and prognosis of colorectal cancer (CRC). The expression of miR-181A and PTEN in CRC patients with late liver metastases was higher than that of the normal (control) group, whereas the expression of miR-181A and PTEN was lower in all pathological groups (TNM I-TNM IV). Overall survival (OS) of lower expression miR-181A CRC patients with late liver metastases was higher than that of higher expression miR-181A CRC patients with late liver metastases. The expression of miR-181A and PTEN in the colon cell line NCM460 was lower than that of the colon cancer SW620 cell line. Upregulation of miR-181A promoted cell viability and inhibited apoptosis of SW620 cells, suppressed PTEN expression and activated phosphorylation of AKT (p-AKT) in SW620 cells. Additionally, downregulation of miR-181A inhibited cell viability of SW620 cells through promotion of PTEN and inhibition of p-AKT. Together, our results indicate that miR-181A expression is associated with CRC patients with late liver metastases through PTEN/AKT signaling.
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Copy and paste a formatted citation
Spandidos Publications style
Li Z, Wang H, Xu Z, Sun Y and Han J: Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer. Oncol Rep 35: 1403-1408, 2016.
APA
Li, Z., Wang, H., Xu, Z., Sun, Y., & Han, J. (2016). Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer. Oncology Reports, 35, 1403-1408. https://doi.org/10.3892/or.2016.4546
MLA
Li, Z., Wang, H., Xu, Z., Sun, Y., Han, J."Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer". Oncology Reports 35.3 (2016): 1403-1408.
Chicago
Li, Z., Wang, H., Xu, Z., Sun, Y., Han, J."Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer". Oncology Reports 35, no. 3 (2016): 1403-1408. https://doi.org/10.3892/or.2016.4546
Copy and paste a formatted citation
x
Spandidos Publications style
Li Z, Wang H, Xu Z, Sun Y and Han J: Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer. Oncol Rep 35: 1403-1408, 2016.
APA
Li, Z., Wang, H., Xu, Z., Sun, Y., & Han, J. (2016). Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer. Oncology Reports, 35, 1403-1408. https://doi.org/10.3892/or.2016.4546
MLA
Li, Z., Wang, H., Xu, Z., Sun, Y., Han, J."Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer". Oncology Reports 35.3 (2016): 1403-1408.
Chicago
Li, Z., Wang, H., Xu, Z., Sun, Y., Han, J."Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer". Oncology Reports 35, no. 3 (2016): 1403-1408. https://doi.org/10.3892/or.2016.4546
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