|
1
|
Saif MW: Pancreatic neoplasm in 2011: An
update. JOP. 12:316–321. 2011.PubMed/NCBI
|
|
2
|
Miranda TB and Jones PA: DNA methylation:
The nuts and bolts of repression. J Cell Physiol. 213:384–390.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Cheng X and Blumenthal RM: Mammalian DNA
methyltransferases: A structural perspective. Structure.
16:341–350. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Bird A: DNA methylation patterns and
epigenetic memory. Genes Dev. 16:6–21. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Ueki T, Toyota M, Skinner H, Walter KM,
Yeo CJ, Issa JP, Hruban RH and Goggins M: Identification and
characterization of differentially methylated CpG islands in
pancreatic carcinoma. Cancer Res. 61:8540–8546. 2001.PubMed/NCBI
|
|
6
|
Fukushima N, Sato N, Ueki T, Rosty C,
Walter KM, Wilentz RE, Yeo CJ, Hruban RH and Goggins M: Aberrant
methylation of preproenkephalin and p16 genes in pancreatic
intraepithelial neoplasia and pancreatic ductal adenocarcinoma. Am
J Pathol. 160:1573–1581. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Schutte M, Hruban RH, Geradts J, Maynard
R, Hilgers W, Rabindran SK, Moskaluk CA, Hahn SA, Schwarte-Waldhoff
I, Schmiegel W, et al: Abrogation of the Rb/p16 tumor-suppressive
pathway in virtually all pancreatic carcinomas. Cancer Res.
57:3126–3130. 1997.PubMed/NCBI
|
|
8
|
Moore PS, Sipos B, Orlandini S, Sorio C,
Real FX, Lemoine NR, Gress T, Bassi C, Klöppel G, Kalthoff H, et
al: Genetic profile of 22 pancreatic carcinoma cell lines. Analysis
of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch. 439:798–802.
2001. View Article : Google Scholar
|
|
9
|
Dammann R, Schagdarsurengin U, Liu L, Otto
N, Gimm O, Dralle H, Boehm BO, Pfeifer GP and Hoang-Vu C: Frequent
RASSF1A promoter hypermethylation and K-ras mutations in pancreatic
carcinoma. Oncogene. 22:3806–3812. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Brueckner B, Kuck D and Lyko F: DNA
methyltransferase inhibitors for cancer therapy. Cancer J.
13:17–22. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Zhang H, Chen L, Bu HQ, Yu QJ, Jiang DD,
Pan FP, Wang Y, Liu DL and Lin SZ: Effects of emodin on the
demethylation of tumor-suppressor genes in pancreatic cancer PANC-1
cells. Oncol Rep. 33:3015–3023. 2015.PubMed/NCBI
|
|
12
|
Li-Weber M: Targeting apoptosis pathways
in cancer by Chinese medicine. Cancer Lett. 332:304–312. 2013.
View Article : Google Scholar
|
|
13
|
Liu A, Chen H, Tong H, Ye S, Qiu M, Wang
Z, Tan W, Liu J and Lin S: Emodin potentiates the antitumor effects
of gemcitabine in pancreatic cancer cells via inhibition of nuclear
factor-κB. Mol Med Rep. 4:221–227. 2011.PubMed/NCBI
|
|
14
|
Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim
SH, Ito S, Yang C, Wang P, Xiao MT, et al: Oncometabolite
2-hydroxyglutarate is a competitive inhibitor of
α-ketoglutarate-dependent dioxygenases. Cancer Cell. 19:17–30.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Bestor TH: The DNA methyltransferases of
mammals. Hum Mol Genet. 9:2395–2402. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Baylin SB and Herman JG: DNA
hypermethylation in tumorigenesis: Epigenetics joins genetics.
Trends Genet. 16:168–174. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Hanaoka M, Shimizu K, Shigemura M, Kato A,
Fujii H, Honoki K and Tsujiuchi T: Cloning of the hamster p16 gene
5′ upstream region and its aberrant methylation patterns in
pancreatic cancer. Biochem Biophys Res Commun. 333:1249–1253. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Peng DF, Kanai Y, Sawada M, Ushijima S,
Hiraoka N, Kitazawa S and Hirohashi S: DNA methylation of multiple
tumor-related genes in association with overexpression of DNA
methyltransferase 1 (DNMT1) during multistage carcinogenesis of the
pancreas. Carcinogenesis. 27:1160–1168. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Yang WH, Wang CY, Zhu QS, et al: Gene
methylation changes and protein expression analysis of Pl6 in
pancreatic cancer. Chinese J of General Surgery. 16:46–450. 2007.In
Chinese.
|
|
20
|
Attri J, Srinivasan R, Majumdar S, Radotra
BD and Wig J: Alterations of tumor suppressor gene
pl6INK4a in pancreatic duetal carcinoma. BMC
Gastroenterol. 5:222005. View Article : Google Scholar
|
|
21
|
Shimizu K, Itsuzaki Y, Fujii H, Honoki K
and Tsujiuchi T: Reduced expression of the Rassf1a gene and its
aberrant DNA methylation in pancreatic duct adenocarcinomas induced
by N-nitrosobis(2-oxopropyl)amine in hamsters. Mol Carcinog.
47:80–87. 2008. View
Article : Google Scholar
|
|
22
|
Lin SZ, Wei WT, Chen H, Chen KJ, Tong HF,
Wang ZH, Ni ZL, Liu HB, Guo HC and Liu DL: Antitumor activity of
emodin against pancreatic cancer depends on its dual role:
Promotion of apoptosis and suppression of angiogenesis. PLoS One.
7:e421462012. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Tahiliani M, Koh KP, Shen Y, Pastor WA,
Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, et
al: Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in
mammalian DNA by MLL partner TET1. Science. 324:930–935. 2009.
View Article : Google Scholar : PubMed/NCBI
|