Journal Articles

Enabling personalized cancer medicine decisions: The challenging pharmacological approach of PBPK models for nanomedicine and pharmacogenomics (Review)

Ioannis S. Vizirianakis, George A. Mystridis, Konstantinos Avgoustakis, Dimitrios G. Fatouros, Marios Spanakis

Pages: 1891-1904 Published online on: 18 January 2016

Real-time RT-PCR systems for CTC detection from blood samples of breast cancer and gynaecological tumour patients (Review)

Ulrich Andergassen, Alexandra C. Kölbl, Sven Mahner, Udo Jeschke

Pages: 1905-1915 Published online on: 02 February 2016

Long non-coding RNA BACE1-AS is a novel target for anisomycin-mediated suppression of ovarian cancer stem cell proliferation and invasion

Qing Chen, Xinghui Liu, Limin Xu, Ying Wang, Suwei Wang, Qiong Li, Yongyi Huang, Te Liu

Pages: 1916-1924 Published online on: 18 January 2016
Open Access

Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase

Manal Mehibel, Simendra Singh, Rachel L. Cowen, Kaye J. Williams, Ian J. Stratford

Pages: 1925-1932 Published online on: 13 January 2016
Open Access

siRNA-induced TRAF6 knockdown promotes the apoptosis and inhibits the invasion of human lung cancer SPC-A1 cells

Zhiyong He, Chuanzhong Huang, Gen Lin, Yunbin Ye

Pages: 1933-1940 Published online on: 01 February 2016
Open Access

Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK

Feng-Ping Pan, Hong-Kun Zhou, He-Qi Bu, Zi-Qiang Chen, Hao Zhang, Lu-Ping Xu, Jian Tang, Qing-Jiang Yu, Yong-Quan Chu, Jie Pan, Yong Fei, Sheng-Zhang Lin, Dian-Lei Liu, Liang Chen

Pages: 1941-1949 Published online on: 13 January 2016
Open Access

miRNA-10b sponge: An anti-breast cancer study in vitro

Ai-Ling Liang, Ting-Ting Zhang, Ning Zhou, Cui Yun Wu, Man-Hua Lin, Yong-Jun Liu

Pages: 1950-1958 Published online on: 26 January 2016

Induction of eEF2-specific antitumor CTL responses in vivo by vaccination with eEF2-derived 9mer-peptides

Hiroko Nakajima, Yui Murakami, Eiichi Morii, Toshiki Akao, Naoya Tatsumi, Satoko Odajima, Mari Fukuda, Takao Machitani, Miki Iwai, Sayo Kawata, Nozomi Hojo, Yoshihiro Oka, Haruo Sugiyama, Yusuke Oji

Pages: 1959-1966 Published online on: 22 January 2016

Oncogenic cAMP responsive element binding protein 1 is overexpressed upon loss of tumor suppressive miR-10b-5p and miR-363-3p in renal cancer

Yifan Li, Duqun Chen, Yuchi Li, Lu Jin, Jiaju Liu, Zhengming Su, Zhengyu Qi, Min Shi, Zhimao Jiang, Liangchao Ni, Shangqi Yang, Yaoting Gui, Xiangming Mao, Yun Chen, Yongqing Lai

Pages: 1967-1978 Published online on: 20 January 2016

Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma

M. Brisam, S. Rauthe, S. Hartmann, C. Linz, R. C. Brands, A. C. Kübler, A. Rosenwald, U. D. Müller-Richter

Pages: 1979-1986 Published online on: 28 January 2016

Constitutive expression and anticancer potency of a novel immunotoxin onconase-DV3

Miaonan Sun, Huichun Tang, Yan Gao, Xinxuan Dai, Yue Yuan, Chunmei Zhang, Dejun Sun

Pages: 1987-1994 Published online on: 18 January 2016

Imperatorin exhibits anticancer activities in human colon cancer cells via the caspase cascade

Yi Mei Zheng, Amy Xiaoxu Lu, James Zheng Shen, Amy Ho Yan Kwok, Wing Shing Ho

Pages: 1995-2002 Published online on: 21 January 2016

SEPT7 overexpression inhibits glioma cell migration by targeting the actin cytoskeleton pathway

Mingshan Hou, Xiaobing Liu, Jie Cao, Bo Chen

Pages: 2003-2010 Published online on: 03 February 2016

HOXB13-mediated suppression of p21WAF1/CIP1 regulates JNK/c-Jun signaling in prostate cancer cells

Young-Rang Kim, Taek Won Kang, Phuong Kim To, Nguyen Thi Xuan Nguyen, Young Seok Cho, Chaeyong Jung, Min Soo Kim

Pages: 2011-2016 Published online on: 15 January 2016

MicroRNA-365a-3p promotes tumor growth and metastasis in laryngeal squamous cell carcinoma

Jiangqiao Geng, Yuanhu Liu, Yaqiong Jin, Jun Tai, Jie Zhang, Xiao Xiao, Ping Chu, Yongbo Yu, Sheng Cai Wang, Jie Lu, Shujing Han, Jin Shi, Yongli Guo, Xin Ni

Pages: 2017-2026 Published online on: 11 February 2016

Emodin inhibits epithelial to mesenchymal transition in epithelial ovarian cancer cells by regulation of GSK-3β/β-catenin/ZEB1 signaling pathway

Chen Hu, Taotao Dong, Rui Li, Jingjing Lu, Xuan Wei, Peishu Liu

Pages: 2027-2034 Published online on: 25 January 2016

Expression profile of long non-coding RNAs in colorectal cancer: A microarray analysis

Jia Luo, Luning Xu, Yigui Jiang, Dexiang Zhuo, Shengjun Zhang, Lianhui Wu, Huadong Xu, Yue Huang

Pages: 2035-2044 Published online on: 01 February 2016

Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity

Ke Si Wang, Juan Ma, Chunliu Mi, Jing Li, Jung Joon Lee, Xuejun Jin

Pages: 2045-2052 Published online on: 19 January 2016

Activation of NLRP3 inflammasome enhances the proliferation and migration of A549 lung cancer cells

Yanli Wang, Hui Kong, Xiaoning Zeng, Wenrui Liu, Zailiang Wang, Xiaopei Yan, Hong Wang, Weiping Xie

Pages: 2053-2064 Published online on: 18 January 2016

Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells

Hasaya Dokduang, Puangrat Yongvanit, Nisana Namwat, Chawalit Pairojkul, Sakkarn Sangkhamanon, Mika Sakurai Yageta, Yoshinori Murakami, Watcharin Loilome

Pages: 2065-2072 Published online on: 21 January 2016

Clinical and biological significance of transcription termination factor, RNA polymerase I in human liver hepatocellular carcinoma

Hisateru Komatsu, Tomohiro Iguchi, Masami Ueda, Sho Nambara, Tomoko Saito, Hidenari Hirata, Shotaro Sakimura, Yuki Takano, Ryutaro Uchi, Yoshiaki Shinden, Hidetoshi Eguchi, Takaaki Masuda, Keishi Sugimachi, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori, Koshi Mimori

Pages: 2073-2080 Published online on: 25 January 2016

YL4073 is a potent autophagy-stimulating antitumor agent in an in vivo model of Lewis lung carcinoma

You-Zhi Xu, Yong-Huai Li, Wen-Jie Lu, Kun Lu, Chun-Ting Wang, Yan Li, Hong-Jun Lin, Li-Xin Kan, Sheng-Yong Yang, Si-Ying Wang, Ying-Lan Zhao

Pages: 2081-2088 Published online on: 01 February 2016

Benzyl isothiocyanate alters the gene expression with cell cycle regulation and cell death in human brain glioblastoma GBM 8401 cells

Nou-Ying Tang, Fu-Shin Chueh, Chien-Chih Yu, Ching-Lung Liao, Jen-Jyh Lin, Te-Chun Hsia, King-Chuen Wu, Hsin-Chung Liu, Kung-Wen Lu, Jing-Gung Chung

Pages: 2089-2096 Published online on: 19 January 2016

Novel, isoform-selective, cholecystokinin A receptor antagonist inhibits colon and pancreatic cancers in preclinical models through novel mechanism of action

Suriyan Ponnusamy, Eric Lattmann, Pornthip Lattmann, Thirumagal Thiyagarajan, Balaram N. Padinjarethalakal, Ramesh Narayanan

Pages: 2097-2106 Published online on: 22 January 2016

The tumor suppressor role of miR-4782-3p in hepatocellular carcinoma

Wentao Bo, Yong Hu, Xielin Feng, Hui Zhang, Lang Tian, Aixiang Liu

Pages: 2107-2112 Published online on: 18 January 2016

Inhibition of mitogen-activated protein kinase signaling pathway sensitizes breast cancer cells to endoplasmic reticulum stress-induced apoptosis

Fen Yang, Xiao Yan Tang, Hao Liu, Zhi Wen Jiang

Pages: 2113-2120 Published online on: 20 January 2016

Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells

Xiaoqing Wang, Zhihong Niu, Yang Jia, Meng Cui, Liping Han, Yongfei Zhang, Zheng Liu, Dongbin Bi, Shuai Liu

Pages: 2121-2130 Published online on: 03 February 2016

ST6GalNAcII mediates tumor invasion through PI3K/Akt/NF-κB signaling pathway in follicular thyroid carcinoma

Xiaolong Miao, Yongfu Zhao

Pages: 2131-2140 Published online on: 22 January 2016

Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma

Kai Jiang, Wei Li, Shuxin Shang, Lu Sun, Kun Guo, Shu Zhang, Yinkun Liu

Pages: 2141-2150 Published online on: 28 January 2016

miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12

Su Dong, Meishan Jin, Ye Li, Peiyou Ren, Jia Liu

Pages: 2151-2158 Published online on: 01 February 2016

Gene expression of membrane transporters: Importance for prognosis and progression of ovarian carcinoma

Katerina Elsnerova, Beatrice Mohelnikova-Duchonova, Ela Cerovska, Marie Ehrlichova, Ivan Gut, Lukas Rob, Petr Skapa, Martin Hruda, Alena Bartakova, Jiri Bouda, Pavel Vodicka, Pavel Soucek, Radka Vaclavikova

Pages: 2159-2170 Published online on: 28 January 2016

Identification of miRNAs and differentially expressed genes in early phase non-small cell lung cancer

Wen Tian, Jie Liu, Baojing Pei, Xiaobo Wang, Yu Guo, Lin Yuan

Pages: 2171-2176 Published online on: 14 January 2016

Genomic profiling of a combined large cell neuroendocrine carcinoma of the submandibular gland

Simon Andreasen, Marta Persson, Katalin Kiss, Preben Homøe, Steffen Heegaard, Göran Stenman

Pages: 2177-2182 Published online on: 12 February 2016

B7-H3, B7-H4, Foxp3 and IL-2 expression in cervical cancer: Associations with patient outcome and clinical significance

Chenglin Huang, Lei Zhou, Xiaohan Chang, Xiaoao Pang, Huijie Zhang, Shulan Zhang

Pages: 2183-2190 Published online on: 02 February 2016

Norcantharidin blocks Wnt/β-catenin signaling via promoter demethylation of WIF-1 in glioma

Dajiang Xie, Jixi Xie, Yingfeng Wan, Li Ma, Xuchen Qi, Kun Wang, Shuxu Yang

Pages: 2191-2197 Published online on: 14 January 2016

Co-expression of FOXL1 and PP2A inhibits proliferation inducing apoptosis in pancreatic cancer cells via promoting TRAIL and reducing phosphorylated MYC

Yunwei Li, Dongyang Yu, Weiwei Sheng, He Song, Yuji Li, Ming Dong

Pages: 2198-2206 Published online on: 25 January 2016

Chromosomal aberrations and prognosis in patients with concomitant chemoradiotherapy for resected head and neck cancer

Sung‑Won Park, Young‑Hoon Joo, Seung‑Hyun Jung, Seon‑Hee Yim, In‑Chul Nam, Kwang‑Jae Cho, Min‑Sik Kim, Yeun‑Jun Chung

Pages: 2207-2215 Published online on: 26 January 2016

MicroRNA-199a-5p inhibits VEGF-induced tumorigenesis through targeting oxidored-nitro domain-containing protein 1 in human HepG2 cells

Rong Gui, Rong Huang, Jun-Hua Zhang, Xian-Hui Wen, Xin-Min Nie

Pages: 2216-2222 Published online on: 12 January 2016

MDM2 gene amplification in esophageal carcinoma

Maike Michalk, Jeannine Meinrath, Helen Künstlinger, Ulrike Koitzsch, Uta Drebber, Sabine Merkelbach‑Bruse, Elfriede Bollschweiler, Michael Kloth, Wolfgang Hartmann, Arnulf Hölscher, Alexander Quaas, Peter P. Grimminger, Margarete Odenthal

Pages: 2223-2227 Published online on: 20 January 2016

Genome-wide DNA methylation analysis in hepatocellular carcinoma

Nobuhisa Yamada, Kohichiroh Yasui, Osamu Dohi, Yasuyuki Gen, Akira Tomie, Tomoko Kitaichi, Naoto Iwai, Hironori Mitsuyoshi, Yoshio Sumida, Michihisa Moriguchi, Kanji Yamaguchi, Taichiro Nishikawa, Atsushi Umemura, Yuji Naito, Shinji Tanaka, Shigeki Arii, Yoshito Itoh

Pages: 2228-2236 Published online on: 11 February 2016

Effects of HSP27 downregulation on PDT resistance through PDT-induced autophagy in head and neck cancer cells

Jisun Kim, Haesoon Lim, Sangwoo Kim, Hyejung Cho, Yong Kim, Xiaojie Li, Hongran Choi, Okjoon Kim

Pages: 2237-2245 Published online on: 26 January 2016

(-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity

Bingyu Guo, Xiaodong Li, Shuai Song, Meng Chen, Maosheng Cheng, Dongmei Zhao, Feng Li

Pages: 2246-2256 Published online on: 25 January 2016

A transcriptional miRNA-gene network associated with lung adenocarcinoma metastasis based on the TCGA database

Yubo Wang, Rui Han, Zhaojun Chen, Ming Fu, Jun Kang, Kunlin Li, Li Li, Hengyi Chen, Yong He

Pages: 2257-2269 Published online on: 14 January 2016

Evaluation of HO-1 expression, cellular ROS production, cellular proliferation and cellular apoptosis in human esophageal squamous cell carcinoma tumors and cell lines

Quan-Guang Ren, Sheng-Li Yang, Jian-Li Hu, Pin-Dong Li, Ye-Shan Chen, Qiu-Shuang Wang

Pages: 2270-2276 Published online on: 13 January 2016

Downregulation of IDH2 exacerbates the malignant progression of osteosarcoma cells via increased NF-κB and MMP-9 activation

Wan-Rong Yi, Zong-Huan Li, Bai-Wen Qi, Mendame Ehya Regis Ernest, Xiang Hu, Ai-Xi Yu

Pages: 2277-2285 Published online on: 13 January 2016

Unveiling a novel biomarker panel for diagnosis and classification of well-differentiated thyroid carcinomas

N. Monique Paricharttanakul, Kittirat Saharat, Daranee Chokchaichamnankit, Phaibul Punyarit, Chantragan Srisomsap, Jisnuson Svasti

Pages: 2286-2296 Published online on: 15 January 2016

Methylation and expression of miRNAs in precancerous lesions and cervical cancer with HPV16 infection

Hilda Jiménez-Wences, Dinorah Nashely Martínez-Carrillo, Oscar Peralta-Zaragoza, Gabriela Elizabeth Campos-Viguri, Daniel Hernández-Sotelo, Marco Antonio Jiménez-López, José Guadalupe Muñoz-Camacho, Víctor Hugo Garzón-Barrientos, Berenice Illades-Aguiar, Gloria Fernández-Tilapa

Pages: 2297-2305 Published online on: 21 January 2016

Silencing NACK by siRNA inhibits tumorigenesis in non-small cell lung cancer via targeting Notch1 signaling pathway

Ranran Kong, Jie Feng, Yuefeng Ma, Bin Zhou, Shaomin Li, Wei Zhang, Jiantao Jiang, Jin Zhang, Zhe Qiao, Ting Zhang, Quanjin Zang, Xijing He

Pages: 2306-2314 Published online on: 13 January 2016

RNA-binding motif protein 5 inhibits the proliferation of cigarette smoke-transformed BEAS-2B cells through cell cycle arrest and apoptosis

Xue-Jiao Lv, Yan-Wei Du, Yu-Qiu Hao, Zhen-Zhong Su, Lin Zhang, Li-Jing Zhao, Jie Zhang

Pages: 2315-2327 Published online on: 12 January 2016

EGCG induces lung cancer A549 cell apoptosis by regulating Ku70 acetylation

Min Li, Jing-Jing Li, Qi-Hua Gu, Jian An, Li-Ming Cao, Hua-Ping Yang, Cheng-Ping Hu

Pages: 2339-2347 Published online on: 21 January 2016

GSK-3 inhibitor inhibits cell proliferation and induces apoptosis in human osteosarcoma cells

Hideki Nishimura, Osamu Nakamura, Yoshiki Yamagami, Masaki Mori, Ryosuke Horie, Natsuko Fukuoka, Tetsuji Yamamoto

Pages: 2348-2354 Published online on: 15 January 2016

Distinct characterization of two vinorelbine-resistant breast cancer cell lines developed by different strategies

Mingjie Xu, Donghai Jiang, Jiaying Shen, Huilin Zheng, Weimin Fan

Pages: 2355-2363 Published online on: 15 January 2016

Dracorhodin perchlorate induces the apoptosis of glioma cells

Xin Chen, Junjie Luo, Linghu Meng, Taifeng Pan, Binjie Zhao, Zhen-Gang Tang, Yongjian Dai

Pages: 2364-2372 Published online on: 04 February 2016

Decreased expression of the type III TGF-β receptor enhances metastasis and invasion in hepatocellullar carcinoma progression

Sen Zhang, Wu-Yi Sun, Jing-Jing Wu, Yuan-Jing Gu, Wei Wei

Pages: 2373-2381 Published online on: 08 February 2016

BCL-3 promotes the tumor growth of hepatocellular carcinoma by regulating cell proliferation and the cell cycle through cyclin D1

Kangsheng Tu, Zhikui Liu, Bowen Yao, Yumo Xue, Meng Xu, Changwei Dou, Guozhi Yin, Jun Wang

Pages: 2382-2390 Published online on: 11 February 2016

MEK activity controls IL-8 expression in tamoxifen-resistant MCF-7 breast cancer cells

Sangmin Kim, Myeongjin Jeon, Jeong Eon Lee, Seok Jin Nam

Pages: 2398-2404 Published online on: 13 January 2016

SMC1 promotes epithelial-mesenchymal transition in triple-negative breast cancer through upregulating Brachyury

Kaichun Li, Mingzhen Ying, Dan Feng, Yan Chen, Jingwen Wang, Yajie Wang

Pages: 2405-2412 Published online on: 15 January 2016

Effects of BP-14, a novel cyclin-dependent kinase inhibitor, on anaplastic thyroid cancer cells

Lorenzo Allegri, Federica Baldan, Catia Mio, Cinzia Puppin, Diego Russo, Vladimir Kryštof, Giuseppe Damante

Pages: 2413-2418 Published online on: 05 February 2016

Knockdown of chemokine receptor CXCR4 gene by RNA interference: Effects on the B16-F10 melanoma growth

Nayara Delgado André, Viviane Aline Oliveira Silva, Maria Angelica Ehara Watanabe, Fernando Luiz De Lucca

Pages: 2419-2424 Published online on: 12 February 2016

Spheroid-based 3-dimensional culture models: Gene expression and functionality in head and neck cancer

Marianne Schmidt, Claus-Juergen Scholz, Christine Polednik, Jeanette Roller

Pages: 2431-2440 Published online on: 21 January 2016

MicroRNA-27b suppresses Helicobacter pylori-induced gastric tumorigenesis through negatively regulating Frizzled7

Yan Geng, Xiaolan Lu, Xiaokang Wu, Li Xue, Xiangling Wang, Jiru Xu

Pages: 2441-2450 Published online on: 18 January 2016

DNA methylation-induced E-cadherin silencing is correlated with the clinicopathological features of melanoma

Mario Venza, Maria Visalli, Teresa Catalano, Carmelo Biondo, Concetta Beninati, Diana Teti, Isabella Venza

Pages: 2451-2460 Published online on: 11 February 2016

Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182

Eric J. Devor, Brandon M. Schickling, Henry D. Reyes, Akshaya Warrier, Brittany Lindsay, Michael J. Goodheart, Donna A. Santillan, Kimberly K. Leslie

Pages: 2461-2465 Published online on: 01 February 2016

Knockdown of MACC1 expression increases cisplatin sensitivity in cisplatin-resistant epithelial ovarian cancer cells

Ruitao Zhang, Huirong Shi, Fang Ren, Xia Li, Minghui Zhang, Wei Feng, Yanyan Jia

Pages: 2466-2472 Published online on: 21 January 2016

Quercetin-3-O-glucoside suppresses pancreatic cancer cell migration induced by tumor-deteriorated growth factors in vitro

Jungwhoi Lee, Jungsul Lee, Seung Jun Kim, Jae Hoon Kim

Pages: 2473-2479 Published online on: 28 January 2016

TIPE2, a negative regulator of TLR signaling, regulates p27 through IRF4-induced signaling

Yanping Peng, Qian Zhao, Hanyu Zhang, Bo Han, Suxia Liu, Mingyong Han, Shili Liu

Pages: 2480-2486 Published online on: 14 January 2016

Upregulation of PAWR by small activating RNAs induces cell apoptosis in human prostate cancer cells

Kai Yang, Jie Shen, Shan-Wen Chen, Jie Qin, Xiang-Yi Zheng, Li-Ping Xie

Pages: 2487-2493 Published online on: 21 January 2016
Open Access

[Corrigendum] Antitumor effects of IDN5109 on head and neck squamous cell carcinoma

Daisuke Sano, Hideki Matsuda, Yukari Ishiguro, Goshi Nishimura, Mariko Kawakami, Mamoru Tsukuda

Pages: 2494-2494 Published online on: 18 January 2016
Open Access

[Corrigendum] Antitumor effects of ZD6474 on head and neck squamous cell carcinoma

Daisuke Sano, Mariko Kawakami, Kyoko Fujita, Machiko Kimura, Yukiko Yamashita, Yukari Ishiguro, Goshi Nishimura, Hideki Matsuda, Mamoru Tsukuda

Pages: 2495-2495 Published online on: 18 January 2016
Journal Cover

April-2016
Volume 35 Issue 4

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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