The tumor suppressor role of miR-4782-3p in hepatocellular carcinoma

  • Authors:
    • Wentao Bo
    • Yong Hu
    • Xielin Feng
    • Hui Zhang
    • Lang Tian
    • Aixiang Liu
  • View Affiliations

  • Published online on: January 18, 2016     https://doi.org/10.3892/or.2016.4568
  • Pages: 2107-2112
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Abstract

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortalities in China. Although advances have been made in treatments, the prognosis of HCC patients has not improved significantly. MicroRNAs (miRNA) play important roles in all stage of the progress of HCC. miR-4782-3p takes part in the pathogenesis of non-small cell lung cancer (NSCLC). However, the role of miR-4782-3p in HCC remains unknown. In the present study, we found that miR-4782-3p had low expression in HCC tissues. The low expression of miR-4782-3p indicated shorter survival of HCC patients. Moreover, the low expression of miR-4782-3p promoted HCC cells growth and inhibited cell apoptosis. We confirmed that USP14 was targeted by miR-4782-3p in HCC cells.
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April-2016
Volume 35 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Bo W, Hu Y, Feng X, Zhang H, Tian L and Liu A: The tumor suppressor role of miR-4782-3p in hepatocellular carcinoma. Oncol Rep 35: 2107-2112, 2016
APA
Bo, W., Hu, Y., Feng, X., Zhang, H., Tian, L., & Liu, A. (2016). The tumor suppressor role of miR-4782-3p in hepatocellular carcinoma. Oncology Reports, 35, 2107-2112. https://doi.org/10.3892/or.2016.4568
MLA
Bo, W., Hu, Y., Feng, X., Zhang, H., Tian, L., Liu, A."The tumor suppressor role of miR-4782-3p in hepatocellular carcinoma". Oncology Reports 35.4 (2016): 2107-2112.
Chicago
Bo, W., Hu, Y., Feng, X., Zhang, H., Tian, L., Liu, A."The tumor suppressor role of miR-4782-3p in hepatocellular carcinoma". Oncology Reports 35, no. 4 (2016): 2107-2112. https://doi.org/10.3892/or.2016.4568