Imperatorin exhibits anticancer activities in human colon cancer cells via the caspase cascade

Zheng,Yi  Mei; Lu,Amy  Xiaoxu; Shen,James  Zheng; Kwok,Amy  Ho Yan; Ho,Wing  Shing

doi:10.3892/or.2016.4586

April-2016 Volume 35 Issue 4

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April-2016 Volume 35 Issue 4

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Article

Imperatorin exhibits anticancer activities in human colon cancer cells via the caspase cascade

Authors:
- Yi Mei Zheng
- Amy Xiaoxu Lu
- James Zheng Shen
- Amy Ho Yan Kwok
- Wing Shing Ho
View Affiliations / Copyright

Affiliations: College of Biological Science and Technology, Minnan Normal University, Zhangzhou, Fujian 363000, P.R. China, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, P.R. China
Pages: 1995-2002
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Published online on: January 21, 2016

https://doi.org/10.3892/or.2016.4586
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Abstract

Despite advances in medical treatments for colon cancer, it remains one of the leading causes of cancer-related mortality among men. Thus, more efficacious treatment strategies for colon cancer are needed. Imperatorin is one of the major ingredients present in the root of Angelica dahurica, and has been used in herbal formulations for the treatment of hypertension and cardiovascular diseases. However, the medical properties of imperatorin remain unclear. In the present study, the anti‑proliferative activities of imperatorin were investigated in the HT‑29 colon cancer cell line. The results showed that imperatorin significantly inhibited HT‑29 colon cancer cell growth with an IC50 value of 78 µM. Imperatorin induced the apoptosis of colon cancer cells through upregulation of p53 and the caspase cascade. Our findings revealed that imperatorin induced cell cycle arrest in the G1 phase. The apoptotic index showed a steady increment when the imperatorin concentration was increased. The results suggest that imperatorin exerts considerable anti‑proliferative activities in HT‑29 colon cancer cells and highlight the potential of imperatorin as an anticancer agent for colon cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Imperatorin exhibits anticancer activities in human colon cancer cells via the caspase cascade

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