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Article

(-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity

Retraction in: /10.3892/or.2025.8892
  • Authors:
    • Bingyu Guo
    • Xiaodong Li
    • Shuai Song
    • Meng Chen
    • Maosheng Cheng
    • Dongmei Zhao
    • Feng Li
  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, Key Laboratory of Cell Biology, Chinese Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Chinese Ministry of Education, China Medical University, Shenyang North New Area, Shenyang, Liaoning 110122, P.R. China, Key Laboratory of Structure-Based Drug Design and Discovery of the Chinese Ministry of Education, Shenyang Pharmaceutical University, Shenhe, Shenyang, Liaoning 110016, P.R. China
  • Pages: 2246-2256
    |
    Published online on: January 25, 2016
       https://doi.org/10.3892/or.2016.4594
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Abstract

(-)-β-hydrastine is one of the main active components of the medicinal plant, Hydrastis canadensis, which is used in many dietary supplements intended to enhance the immune system. However, whether (-)-β-hydrastine affects the tumor signaling pathway remains unexplored. In the present study, we found that (-)-β-hydrastine inhibited the kinase activity of p21-activated kinase 4 (PAK4), which is involved in the regulation of cytoskeletal reorganization, cell proliferation, gene transcription, oncogenic transformation and cell invasion. In the present study, (-)-β-hydrastine suppressed lung adenocarcinoma cell proliferation by inhibiting expression of cyclin D1/D3 and CDK2/4/6, leading to cell cycle arrest at the G1 phase, in a PAK4 kinase-dependent manner. Moreover, inhibition of PAK4 kinase activity by (-)-β-hydrastine also promoted the early apoptosis of lung adenocarcinoma cells through the mitochondrial apoptosis pathway. In addition, (-)-β-hydrastine significantly suppressed the migration and invasion of human lung adenocarcinoma cells in conjunction with concomitant blockage of the PAK4/LIMK1/cofilin, PAK4/SCG10 and PAK4/MMP2 pathways. All of these data indicate that (-)-β-hydrastine, as a novel PAK4 inhibitor, suppresses the proliferation and invasion of lung adenocarcinoma cells. Taken together, these results provide novel insight into the development of a PAK4 kinase inhibitor and a potential therapeutic strategy for lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Guo B, Li X, Song S, Chen M, Cheng M, Zhao D and Li F: (-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity Retraction in /10.3892/or.2025.8892. Oncol Rep 35: 2246-2256, 2016.
APA
Guo, B., Li, X., Song, S., Chen, M., Cheng, M., Zhao, D., & Li, F. (2016). (-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity Retraction in /10.3892/or.2025.8892. Oncology Reports, 35, 2246-2256. https://doi.org/10.3892/or.2016.4594
MLA
Guo, B., Li, X., Song, S., Chen, M., Cheng, M., Zhao, D., Li, F."(-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity Retraction in /10.3892/or.2025.8892". Oncology Reports 35.4 (2016): 2246-2256.
Chicago
Guo, B., Li, X., Song, S., Chen, M., Cheng, M., Zhao, D., Li, F."(-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity Retraction in /10.3892/or.2025.8892". Oncology Reports 35, no. 4 (2016): 2246-2256. https://doi.org/10.3892/or.2016.4594
Copy and paste a formatted citation
x
Spandidos Publications style
Guo B, Li X, Song S, Chen M, Cheng M, Zhao D and Li F: (-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity Retraction in /10.3892/or.2025.8892. Oncol Rep 35: 2246-2256, 2016.
APA
Guo, B., Li, X., Song, S., Chen, M., Cheng, M., Zhao, D., & Li, F. (2016). (-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity Retraction in /10.3892/or.2025.8892. Oncology Reports, 35, 2246-2256. https://doi.org/10.3892/or.2016.4594
MLA
Guo, B., Li, X., Song, S., Chen, M., Cheng, M., Zhao, D., Li, F."(-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity Retraction in /10.3892/or.2025.8892". Oncology Reports 35.4 (2016): 2246-2256.
Chicago
Guo, B., Li, X., Song, S., Chen, M., Cheng, M., Zhao, D., Li, F."(-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity Retraction in /10.3892/or.2025.8892". Oncology Reports 35, no. 4 (2016): 2246-2256. https://doi.org/10.3892/or.2016.4594
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