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Article

miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12

Retraction in: /10.3892/or.2021.8157
  • Authors:
    • Su Dong
    • Meishan Jin
    • Ye Li
    • Peiyou Ren
    • Jia Liu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesia, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China, Department of Pathology, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China, Department of Radiology, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China, Department of Thyroid Surgery, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China
  • Pages: 2151-2158
    |
    Published online on: February 1, 2016
       https://doi.org/10.3892/or.2016.4604
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Abstract

Accumulating evidence has shown that aberrantly expressed microRNAs (miRs) are extensively involved in tumorigenesis. microRNA-137 (miR-137) has been reported as a tumor suppressor in various types of cancer. However, the biological function and underlying molecular mechanism of miR-137 in papillary thyroid carcinoma (PTC) remain largely unknown. Therefore, the present study aimed to investigate the expression pattern of miR-137 and its functional significance in PTC. Quantitative RT-PCR (qRT-PCR) assay showed that miR-137 expression was significantly downregulated in human PTC tissues, and its expression was significantly negatively correlated with tumor-node-metastasis (TNM) stage and lymph node metastasis. Functional assays showed that forced expression of miR-137 in PTC cells significantly inhibited proliferation, colony formation, migration and invasion in vitro. Importantly, on the basis of bioinformatic analysis and luciferase reporter assay, we found that miR-137 directly targeted the 3'-untranslated region (3'-UTR) of C-X-C motif chemokine 12 (also known as SDF-1) (CXCL12). qRT-PCR and western blot analysis further verified the results and demonstrated that miR-137 could downregulate CXCL12 expression in PTC cells. We also confirmed that CXCL12 expression was increased in PTC tissues and was inversely correlated with miR-137. In addition, our results also showed that downregulation of CXCL12 mimicked the effects of miR-137 overexpression, and upregulation of CXCL12 partially reversed the inhibitory effects of miR-137 in PTC cells. These results showed that miR-137 may function as a tumor suppressor in PTC by targeting CXCL12, suggesting that miR-137 may act as a potential target for PTC treatment.
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1 

Brown RL, de Souza JA and Cohen EE: Thyroid cancer: Burden of illness and management of disease. J Cancer. 2:193–199. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Pitoia F, Bueno F, Urciuoli C, Abelleira E, Cross G and Tuttle RM: Outcomes of patients with differentiated thyroid cancer risk-stratified according to the American Thyroid Association and Latin American Thyroid Society Risk of Recurrence Classification Systems. Thyroid. 23:1401–1407. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Nikiforova MN and Nikiforov YE: Molecular genetics of thyroid cancer: Implications for diagnosis, treatment and prognosis. Expert Rev Mol Diagn. 8:83–95. 2008. View Article : Google Scholar

4 

Lang BH, Wong KP, Wan KY and Lo CY: Significance of metastatic lymph node ratio on stimulated thyroglobulin levels in papillary thyroid carcinoma after prophylactic unilateral central neck dissection. Ann Surg Oncol. 19:1257–1263. 2012. View Article : Google Scholar :

5 

Brennecke J and Cohen SM: Towards a complete description of the microRNA complement of animal genomes. Genome Biol. 4:2282003. View Article : Google Scholar : PubMed/NCBI

6 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Carthew RW and Sontheimer EJ: Origins and mechanisms of miRNAs and siRNAs. Cell. 136:642–655. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, et al: MicroRNA expression profiles classify human cancers. Nature. 435:834–838. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, et al: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA. 103:2257–2261. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Aragon Han P, Weng CH, Khawaja HT, Nagarajan N, Schneider EB, Umbricht CB, Witwer KW and Zeiger MA: MicroRNA expression and association with clinicopathologic features in papillary thyroid cancer: A systematic review. Thyroid. 25:1322–1329. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Chen Q, Chen X, Zhang M, Fan Q, Luo S and Cao X: miR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42. Dig Dis Sci. 56:2009–2016. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Liu M, Lang N, Qiu M, Xu F, Li Q, Tang Q, Chen J, Chen X, Zhang S, Liu Z, et al: miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells. Int J Cancer. 128:1269–1279. 2011. View Article : Google Scholar

15 

Bi Y, Han Y, Bi H, Gao F and Wang X: miR-137 impairs the proliferative and migratory capacity of human non-small cell lung cancer cells by targeting paxillin. Hum Cell. 27:95–102. 2014. View Article : Google Scholar

16 

Guo J, Xia B, Meng F and Lou G: miR-137 suppresses cell growth in ovarian cancer by targeting AEG-1. Biochem Biophys Res Commun. 441:357–363. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Althoff K, Beckers A, Odersky A, Mestdagh P, Köster J, Bray IM, Bryan K, Vandesompele J, Speleman F, Stallings RL, et al: MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A. Int J Cancer. 133:1064–1073. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Zhao Y, Li Y, Lou G, Zhao L, Xu Z, Zhang Y and He F: MiR-137 targets estrogen-related receptor alpha and impairs the proliferative and migratory capacity of breast cancer cells. PLoS One. 7:e391022012. View Article : Google Scholar : PubMed/NCBI

19 

Zhang L, Li Z, Gai F and Wang Y: MicroRNA-137 suppresses tumor growth in epithelial ovarian cancer in vitro and in vivo. Mol Med Rep. 12:3107–3114. 2015.PubMed/NCBI

20 

He Y, Meng C, Shao Z, Wang H and Yang S: MiR-23a functions as a tumor suppressor in osteosarcoma. Cell Physiol Biochem. 34:1485–1496. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Minna E, Romeo P, De Cecco L, Dugo M, Cassinelli G, Pilotti S, Degl'Innocenti D, Lanzi C, Casalini P, Pierotti MA, et al: miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma. Oncotarget. 5:2513–2528. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Chou CK, Yang KD, Chou FF, Huang CC, Lan YW, Lee YF, Kang HY and Liu RT: Prognostic implications of miR-146b expression and its functional role in papillary thyroid carcinoma. J Clin Endocrinol Metab. 98:E196–E205. 2013. View Article : Google Scholar

23 

Liu L, Wang J, Li X, Ma J, Shi C, Zhu H, Xi Q, Zhang J, Zhao X and Gu M: MiR-204-5p suppresses cell proliferation by inhibiting IGFBP5 in papillary thyroid carcinoma. Biochem Biophys Res Commun. 457:621–626. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Ma Y, Qin H and Cui Y: MiR-34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway. Biochem Biophys Res Commun. 441:958–963. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Xiu Y, Liu Z, Xia S, Jin C, Yin H, Zhao W and Wu Q: MicroRNA-137 upregulation increases bladder cancer cell proliferation and invasion by targeting PAQR3. PLoS One. 9:e1097342014. View Article : Google Scholar : PubMed/NCBI

26 

Liu LL, Lu SX, Li M, Li LZ, Fu J, Hu W, Yang YZ, Luo RZ, Zhang CZ and Yun JP: FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2. Oncotarget. 5:5113–5124. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Secchiero P, Celeghini C, Cutroneo G, Di Baldassarre A, Rana R and Zauli G: Differential effects of stromal derived factor-1 alpha (SDF-1 alpha) on early and late stages of human megakaryocytic development. Anat Rec. 260:141–147. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Nagasawa T: CXCL12/SDF-1 and CXCR4. Front Immunol. 6:3012015. View Article : Google Scholar : PubMed/NCBI

29 

Jung YY, Park IA, Kim MA, Min HS, Won JK and Ryu HS: Application of chemokine CXC motif ligand 12 as a novel diagnostic marker in preoperative fine-needle aspiration biopsy for papillary thyroid carcinoma. Acta Cytol. 57:447–454. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Mochizuki H, Matsubara A, Teishima J, Mutaguchi K, Yasumoto H, Dahiya R, Usui T and Kamiya K: Interaction of ligand-receptor system between stromal-cell-derived factor-1 and CXC chemokine receptor 4 in human prostate cancer: A possible predictor of metastasis. Biochem Biophys Res Commun. 320:656–663. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Kinouchi M, Uchida D, Kuribayashi N, Tamatani T, Nagai H and Miyamoto Y: Involvement of miR-518c-5p to growth and metastasis in oral cancer. PLoS One. 9:e1159362014. View Article : Google Scholar : PubMed/NCBI

32 

Zhang J, Liu J, Liu Y, Wu W, Li X, Wu Y, Chen H, Zhang K and Gu L: miR-101 represses lung cancer by inhibiting interaction of fibroblasts and cancer cells by down-regulating CXCL12. Biomed Pharmacother. 74:215–221. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Lv Y, Lei Y, Hu Y, Ding W, Zhang C and Fang C: miR-448 negatively regulates ovarian cancer cell growth and metastasis by targeting CXCL12. Clin Transl Oncol. 17:903–909. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dong S, Jin M, Li Y, Ren P and Liu J: miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12 Retraction in /10.3892/or.2021.8157. Oncol Rep 35: 2151-2158, 2016.
APA
Dong, S., Jin, M., Li, Y., Ren, P., & Liu, J. (2016). miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12 Retraction in /10.3892/or.2021.8157. Oncology Reports, 35, 2151-2158. https://doi.org/10.3892/or.2016.4604
MLA
Dong, S., Jin, M., Li, Y., Ren, P., Liu, J."miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12 Retraction in /10.3892/or.2021.8157". Oncology Reports 35.4 (2016): 2151-2158.
Chicago
Dong, S., Jin, M., Li, Y., Ren, P., Liu, J."miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12 Retraction in /10.3892/or.2021.8157". Oncology Reports 35, no. 4 (2016): 2151-2158. https://doi.org/10.3892/or.2016.4604
Copy and paste a formatted citation
x
Spandidos Publications style
Dong S, Jin M, Li Y, Ren P and Liu J: miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12 Retraction in /10.3892/or.2021.8157. Oncol Rep 35: 2151-2158, 2016.
APA
Dong, S., Jin, M., Li, Y., Ren, P., & Liu, J. (2016). miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12 Retraction in /10.3892/or.2021.8157. Oncology Reports, 35, 2151-2158. https://doi.org/10.3892/or.2016.4604
MLA
Dong, S., Jin, M., Li, Y., Ren, P., Liu, J."miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12 Retraction in /10.3892/or.2021.8157". Oncology Reports 35.4 (2016): 2151-2158.
Chicago
Dong, S., Jin, M., Li, Y., Ren, P., Liu, J."miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12 Retraction in /10.3892/or.2021.8157". Oncology Reports 35, no. 4 (2016): 2151-2158. https://doi.org/10.3892/or.2016.4604
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