1
|
Torre LA, Bray F, Siegel RL, Ferlay J,
Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA
Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI
|
2
|
Weigelt B, Peterse JL and van't Veer LJ:
Breast cancer metastasis: Markers and models. Nat Rev Cancer.
5:591–602. 2005. View
Article : Google Scholar : PubMed/NCBI
|
3
|
Scully OJ, Bay BH, Yip G and Yu Y: Breast
cancer metastasis. Cancer Genomics Proteomics. 9:311–320.
2012.PubMed/NCBI
|
4
|
Hanahan D and Weinberg RA: Hallmarks of
cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI
|
5
|
Hsu PP and Sabatini DM: Cancer cell
metabolism: Warburg and beyond. Cell. 134:703–707. 2008. View Article : Google Scholar : PubMed/NCBI
|
6
|
Kim JW and Dang CV: Cancer's molecular
sweet tooth and the Warburg effect. Cancer Res. 66:8927–8930. 2006.
View Article : Google Scholar : PubMed/NCBI
|
7
|
Kroemer G and Pouyssegur J: Tumor cell
metabolism: Cancer's Achilles' heel. Cancer Cell. 13:472–482. 2008.
View Article : Google Scholar : PubMed/NCBI
|
8
|
Vander Heiden MG, Cantley LC and Thompson
CB: Understanding the Warburg effect: The metabolic requirements of
cell proliferation. Science. 324:1029–1033. 2009. View Article : Google Scholar : PubMed/NCBI
|
9
|
Warburg O: On respiratory impairment in
cancer cells. Science. 124:269–270. 1956.PubMed/NCBI
|
10
|
Kumar-Sinha C, Ignatoski KW, Lippman ME,
Ethier SP and Chinnaiyan AM: Transcriptome analysis of HER2 reveals
a molecular connection to fatty acid synthesis. Cancer Res.
63:132–139. 2003.PubMed/NCBI
|
11
|
Menendez JA, Mehmi I, Atlas E, Colomer R
and Lupu R: Novel signaling molecules implicated in
tumor-associated fatty acid synthase-dependent breast cancer cell
proliferation and survival: Role of exogenous dietary fatty acids,
p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB. Int J
Oncol. 24:591–608. 2004.PubMed/NCBI
|
12
|
Slamon DJ, Godolphin W, Jones LA, Holt JA,
Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A, et al:
Studies of the HER-2/neu proto-oncogene in human breast and ovarian
cancer. Science. 244:707–712. 1989. View Article : Google Scholar : PubMed/NCBI
|
13
|
Guy CT, Webster MA, Schaller M, Parsons
TJ, Cardiff RD and Muller WJ: Expression of the neu protooncogene
in the mammary epithelium of transgenic mice induces metastatic
disease. Proc Natl Acad Sci USA. 89:10578–10582. 1992. View Article : Google Scholar : PubMed/NCBI
|
14
|
Johnson E, Seachrist DD, DeLeon-Rodriguez
CM, Lozada KL, Miedler J, Abdul-Karim FW and Keri RA:
HER2/ErbB2-induced breast cancer cell migration and invasion
require p120 catenin activation of Rac1 and Cdc42. J Biol Chem.
285:29491–29501. 2010. View Article : Google Scholar : PubMed/NCBI
|
15
|
Li J, Dong L, Wei D, Wang X, Zhang S and
Li H: Fatty acid synthase mediates the epithelial-mesenchymal
transition of breast cancer cells. Int J Biol Sci. 10:171–180.
2014. View Article : Google Scholar : PubMed/NCBI
|
16
|
Tan M, Li P, Klos KS, Lu J, Lan KH, Nagata
Y, Fang D, Jing T and Yu D: ErbB2 promotes Src synthesis and
stability: Novel mechanisms of Src activation that confer breast
cancer metastasis. Cancer Res. 65:1858–1867. 2005. View Article : Google Scholar : PubMed/NCBI
|
17
|
Tan M, Yao J and Yu D: Overexpression of
the c-erbB-2 gene enhanced intrinsic metastasis potential in human
breast cancer cells without increasing their transformation
abilities. Cancer Res. 57:1199–1205. 1997.PubMed/NCBI
|
18
|
Vazquez-Martin A, Colomer R, Brunet J,
Lupu R and Menendez JA: Overexpression of fatty acid synthase gene
activates HER1/HER2 tyrosine kinase receptors in human breast
epithelial cells. Cell Prolif. 41:59–85. 2008. View Article : Google Scholar : PubMed/NCBI
|
19
|
Zhao YH, Zhou M, Liu H, Ding Y, Khong HT,
Yu D, Fodstad O and Tan M: Upregulation of lactate dehydrogenase A
by ErbB2 through heat shock factor 1 promotes breast cancer cell
glycolysis and growth. Oncogene. 28:3689–3701. 2009. View Article : Google Scholar : PubMed/NCBI
|
20
|
Montero JC, Rodríguez-Barrueco R, Ocaña A,
Díaz-Rodríguez E, Esparís-Ogando A and Pandiella A: Neuregulins and
cancer. Clin Cancer Res. 14:3237–3241. 2008. View Article : Google Scholar : PubMed/NCBI
|
21
|
Agus DB, Akita RW, Fox WD, Lewis GD,
Higgins B, Pisacane PI, Lofgren JA, Tindell C, Evans DP, Maiese K,
et al: Targeting ligand-activated ErbB2 signaling inhibits breast
and prostate tumor growth. Cancer Cell. 2:127–137. 2002. View Article : Google Scholar : PubMed/NCBI
|
22
|
Cheng L, Zha Z, Lang B, Liu J and Yao X:
Heregulin-beta1 promotes metastasis of breast cancer cell line
SKBR3 through upregulation of Snail and induction of
epithelial-mesenchymal transition. Cancer Lett. 280:50–60. 2009.
View Article : Google Scholar : PubMed/NCBI
|
23
|
Kim J, Jeong H, Lee Y, Kim C, Kim H and
Kim A: HRG-β1-driven ErbB3 signaling induces epithelial-mesenchymal
transition in breast cancer cells. BMC Cancer. 13:3832013.
View Article : Google Scholar
|
24
|
Ruan SQ, Wang ZH, Wang SW, Fu ZX, Xu KL,
Li DB and Zhang SZ: Heregulin-β1-induced GPR30 upregulation
promotes the migration and invasion potential of SkBr3 breast
cancer cells via ErbB2/ErbB3-MAPK/ERK pathway. Biochem Biophys Res
Commun. 420:385–390. 2012. View Article : Google Scholar : PubMed/NCBI
|
25
|
Asrani K, Keri RA, Galisteo R, Brown SA,
Morgan SJ, Ghosh A, Tran NL and Winkles JA: The HER2- and heregulin
β1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven
breast cancer cell migration, invasion, and MMP9 expression. Mol
Cancer Res. 11:393–404. 2013. View Article : Google Scholar : PubMed/NCBI
|
26
|
Bonuccelli G, Tsirigos A, Whitaker-Menezes
D, Pavlides S, Pestell RG, Chiavarina B, Frank PG, Flomenberg N,
Howell A, Martinez-Outschoorn UE, et al: Ketones and lactate 'fuel'
tumor growth and metastasis: Evidence that epithelial cancer cells
use oxidative mitochondrial metabolism. Cell Cycle. 9:3506–3514.
2010. View Article : Google Scholar : PubMed/NCBI
|
27
|
Goetze K, Walenta S, Ksiazkiewicz M,
Kunz-Schughart LA and Mueller-Klieser W: Lactate enhances motility
of tumor cells and inhibits monocyte migration and cytokine
release. Int J Oncol. 39:453–463. 2011.PubMed/NCBI
|
28
|
Hirschhaeuser F, Sattler UG and
Mueller-Klieser W: Lactate: A metabolic key player in cancer.
Cancer Res. 71:6921–6925. 2011. View Article : Google Scholar : PubMed/NCBI
|
29
|
Stern R, Shuster S, Neudecker BA and
Formby B: Lactate stimulates fibroblast expression of hyaluronan
and CD44: The Warburg effect revisited. Exp Cell Res. 276:24–31.
2002. View Article : Google Scholar : PubMed/NCBI
|
30
|
Yoon S, Lee MY, Park SW, Moon JS, Koh YK,
Ahn YH, Park BW and Kim KS: Up-regulation of acetyl-CoA carboxylase
alpha and fatty acid synthase by human epidermal growth factor
receptor 2 at the translational level in breast cancer cells. J
Biol Chem. 282:26122–26131. 2007. View Article : Google Scholar : PubMed/NCBI
|
31
|
Jin Q, Yuan LX, Boulbes D, Baek JM, Wang
YN, Gomez-Cabello D, Hawke DH, Yeung SC, Lee MH, Hortobagyi GN, et
al: Fatty acid synthase phosphorylation: A novel therapeutic target
in HER2-overexpressing breast cancer cells. Breast Cancer Res.
12:R962010. View
Article : Google Scholar : PubMed/NCBI
|
32
|
Menendez JA, Vellon L, Mehmi I, Oza BP,
Ropero S, Colomer R and Lupu R: Inhibition of fatty acid synthase
(FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in
cancer cells. Proc Natl Acad Sci USA. 101:10715–10720. 2004.
View Article : Google Scholar : PubMed/NCBI
|
33
|
Ruan SQ, Wang SW, Wang ZH and Zhang SZ:
Regulation of HRG-β1-induced proliferation, migration and invasion
of MCF-7 cells by upregulation of GPR30 expression. Mol Med Rep.
6:131–138. 2012.PubMed/NCBI
|
34
|
Vijapurkar U, Kim MS and Koland JG: Roles
of mitogen-activated protein kinase and phosphoinositide 3′-kinase
in ErbB2/ErbB3 coreceptor-mediated heregulin signaling. Exp Cell
Res. 284:291–302. 2003. View Article : Google Scholar : PubMed/NCBI
|
35
|
Elstrom RL, Bauer DE, Buzzai M, Karnauskas
R, Harris MH, Plas DR, Zhuang H, Cinalli RM, Alavi A, Rudin CM, et
al: Akt stimulates aerobic glycolysis in cancer cells. Cancer Res.
64:3892–3899. 2004. View Article : Google Scholar : PubMed/NCBI
|