Journal Articles

Role of the tumor microenvironment in tumor progression and the clinical applications (Review)

Yao Yuan, Yu-Chen Jiang, Chong-Kui Sun, Qian-Ming Chen

Pages: 2499-2515 Published online on: 07 March 2016
Open Access

Chemically induced skin carcinogenesis: Updates in experimental models (Review)

Monica Neagu, Constantin Caruntu, Carolina Constantin, Daniel Boda, Sabina Zurac, Demetrios A. Spandidos, Aristidis M. Tsatsakis

Pages: 2516-2528 Published online on: 17 March 2016
Open Access

Inhibition of rhotekin exhibits antitumor effects in lung cancer cells

Weizhen Zhang, Zhenyu Liang, Jing Li

Pages: 2529-2534 Published online on: 24 February 2016
Open Access

Histone deacetylase inhibitor screening identifies HC toxin as the most effective in intrahepatic cholangiocarcinoma cells

Wenjie Zhou, Xiaoxun Chen, Ke He, Jinfeng Xiao, Xiaopeng Duan, Rui Huang, Zhenglin Xia, Jingliang He, Jinqian Zhang, Guoan Xiang

Pages: 2535-2542 Published online on: 25 February 2016
Open Access

PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells

Nobuhisa Yoshikawa, Hiroaki Kajiyama, Kae Nakamura, Fumi Utsumi, Kaoru Niimi, Hiroko Mitsui, Ryuichiro Sekiya, Shiro Suzuki, Kiyosumi Shibata, David Callen, Fumitaka Kikkawa

Pages: 2543-2552 Published online on: 03 March 2016
Open Access

Anticancer effect of metformin on estrogen receptor-positive and tamoxifen-resistant breast cancer cell lines

Jinkyoung Kim, Jiyun Lee, Soon Young Jang, Chungyeul Kim, Yoojin Choi, Aeree Kim

Pages: 2553-2560 Published online on: 11 March 2016
Open Access

SKA1 regulates the metastasis and cisplatin resistance of non-small cell lung cancer

Lihua Shen, Min Yang, Qionghua Lin, Zhongwei Zhang, Changhong Miao, Biao Zhu

Pages: 2561-2568 Published online on: 10 March 2016
Open Access

Radiofrequency thermal treatment with chemoradiotherapy for advanced rectal cancer

Hisanori Shoji, Masahiko Motegi, Kiyotaka Osawa, Noriyuki Okonogi, Atsushi Okazaki, Yoshitaka Andou, Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi, Kyoji Ogoshi

Pages: 2569-2575 Published online on: 07 March 2016
Open Access

Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma

Junro Kataoka, Hidenori Shiraha, Shigeru Horiguchi, Hiroaki Sawahara, Daisuke Uchida, Teruya Nagahara, Masaya Iwamuro, Hiroki Morimoto, Yasuto Takeuchi, Kenji Kuwaki, Hideki Onishi, Shinichiro Nakamura, Akinobu Takaki, Kazuhiro Nouso, Takahito Yagi, Kazuhide Yamamoto, Hiroyuki Okada

Pages: 2576-2582 Published online on: 16 March 2016

miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1

Wenlong Cao, Weiyuan Wei, Zexu Zhan, Yubo Xie, Qiang Xiao

Pages: 2583-2591 Published online on: 29 February 2016
Open Access

A new histological therapeutic classification system to predict eradicated and residual lymph nodes in breast cancer after neoadjuvant chemotherapy

Satoko Morohashi, Tadashi Yoshizawa, Hiroko Seino, Hideaki Hirai, Toshihiro Haga, Rie Ota, Yunyan Wu, Eri Yoshida, Kenichi Hakamada, Hiroshi Kijima

Pages: 2592-2598 Published online on: 25 February 2016
Open Access

Cancer testis antigen SPAG9 is a promising marker for the diagnosis and treatment of lung cancer

Biqiong Ren, Xiaobin Wei, Guoying Zou, Junyu He, Guofeng Xu, Fei Xu, Yiran Huang, Haowen Zhu, Yong Li, Guoan Ma, Ping Yu

Pages: 2599-2605 Published online on: 01 March 2016
Open Access

ER stress and autophagy are involved in the apoptosis induced by cisplatin in human lung cancer cells

Shaomin Shi, Ping Tan, Bingdi Yan, Rong Gao, Jianjun Zhao, Jing Wang, Jia Guo, Ning Li, Zhongsen Ma

Pages: 2606-2614 Published online on: 16 March 2016
Open Access

Curcumin inhibits tumor epithelial‑mesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells

Zewei Zhang, Haitao Chen, Chao Xu, Lu Song, Lulu Huang, Yuebiao Lai, Yuqi Wang, Hanlu Chen, Danlin Gu, Lili Ren, Qinghua Yao

Pages: 2615-2623 Published online on: 10 March 2016
Open Access

Inhibition of peritoneal metastasis of human gastric cancer cells by dextran sulphate through the reduction in HIF-1α and ITGβ1 expression

Yuanyi Xu, Xiu Jin, Yunning Huang, Jianda Dong, Honghong Wang, Xiaofei Wang, Xiangmei Cao

Pages: 2624-2634 Published online on: 18 March 2016

Activation of ERK/IER3/PP2A-B56γ-positive feedback loop in lung adenocarcinoma by allelic deletion of B56γ gene

Tomoko Ito, Satoru Ozaki, Rachanee Chanasong, Yuki Mizutani, Takeru Oyama, Hiroshi Sakurai, Isao Matsumoto, Hirofumi Takemura, Ei Kawahara

Pages: 2635-2642 Published online on: 16 March 2016

Forced expression of Nanog with mRNA synthesized in vitro to evaluate the malignancy of HeLa cells through acquiring cancer stem cell phenotypes

Yan Ding, Ai Qing Yu, Xiao Li Wang, Xing Rong Guo, Ya Hong Yuan, Dong Sheng Li

Pages: 2643-2650 Published online on: 26 February 2016

Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells

Huijin Fan, Yan Liang, Bing Jiang, Xiabing Li, Hang Xun, Jia Sun, Wei He, Hay Tong Lau, Xiaofeng Ma

Pages: 2651-2656 Published online on: 17 March 2016

Phenethyl isothiocyanate induces apoptosis and inhibits cell proliferation and invasion in Hep-2 laryngeal cancer cells

Meng-Yuan Dai, Yan Wang, Chen Chen, Fen Li, Bo-Kui Xiao, Shi-Ming Chen, Ze-Zhang Tao

Pages: 2657-2664 Published online on: 17 March 2016

Cigarette smoke extract induces the proliferation of normal human urothelial cells through the NF-κB pathway

Qi-Fei Deng, Xin Sun, Zhao-Feng Liang, Zhi-Qiang Zhang, De-Xin Yu, Cai-Yun Zhong

Pages: 2665-2672 Published online on: 16 February 2016

Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas

Lenka Zlamalikova, Mojmir Moulis, David Salek, Jiri Jarkovsky, Jan Smarda, Jana Smardova

Pages: 2673-2680 Published online on: 07 March 2016

Secreted recombinant human IL-24 protein inhibits the proliferation of esophageal squamous cell carcinoma Eca-109 cells in vitro and in vivo

Qunfeng Ma, Bangming Jin, Yao Zhang, Yinan Shi, Chi Zhang, Dan Luo, Pengkun Wang, Cuimi Duan, Heyu Song, Xue Li, Xuefeng Deng, Zhinan Chen, Ziling Wang, Hong Jiang, Yan Liu

Pages: 2681-2690 Published online on: 24 February 2016

Oridonin inhibits the proliferation of human colon cancer cells by upregulating BMP7 to activate p38 MAPK

Chun-Mei Ren, Yang Li, Qian-Zhao Chen, Yu-Hua Zeng, Ying Shao, Qiu-Xiang Wu, Shuang-Xue Yuan, Jun-Qin Yang, Yu Yu, Ke Wu, Bai-Cheng He, Wen-Juan Sun

Pages: 2691-2698 Published online on: 07 March 2016

Strong inflammatory response and Th1-polarization profile in children with acute lymphoblastic leukemia without apparent infection

E. Pérez-Figueroa, M. Sánchez-Cuaxospa, K. A. Martínez-Soto, N. Sánchez-Zauco, A. Medina-Sansón, E. Jiménez-Hernández, J. R. Torres-Nava, J. M. Félix-Castro, A. Gómez, E. Ortega, C. Maldonado-Bernal

Pages: 2699-2706 Published online on: 07 March 2016

PTEN enhances G2/M arrest in etoposide-treated MCF‑7 cells through activation of the ATM pathway

Ruopeng Zhang, Li Zhu, Lirong Zhang, Anli Xu, Zhengwei Li, Yijuan Xu, Pei He, Maoqing Wu, Fengxiang Wei, Chenhong Wang

Pages: 2707-2714 Published online on: 11 March 2016

FASN, ErbB2-mediated glycolysis is required for breast cancer cell migration

Lan Zhou, Sufang Jiang, Qiang Fu, Kelly Smith, Kailing Tu, Hua Li, Yuhua Zhao

Pages: 2715-2722 Published online on: 19 February 2016

Carnosic acid induces apoptosis through inactivation of Src/STAT3 signaling pathway in human renal carcinoma Caki cells

Ji Eun Park, Byoungduck Park, In Gyeong Chae, Do-Hee Kim, Juthika Kundu, Joydeb Kumar Kundu, Kyung-Soo Chun

Pages: 2723-2732 Published online on: 29 February 2016

miR-608 inhibits the migration and invasion of glioma stem cells by targeting macrophage migration inhibitory factor

Zhenhua Wang, Yixue Xue, Ping Wang, Jiaqi Zhu, Jun Ma

Pages: 2733-2742 Published online on: 03 March 2016

The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy

Qiong Wu, Ying Jiang, Shoubin Cui, Yanshi Wang, Xin Wu

Pages: 2743-2754 Published online on: 17 February 2016

miR-99a regulates ROS-mediated invasion and migration of lung adenocarcinoma cells by targeting NOX4

Mei Sun, Shunming Hong, Wenhan Li, Pengfei Wang, Jinqiang You, Xuebin Zhang, Fan Tang, Ping Wang, Chunzhi Zhang

Pages: 2755-2766 Published online on: 11 March 2016

Nobiletin inhibits epithelial-mesenchymal transition of human non-small cell lung cancer cells by antagonizing the TGF-β1/Smad3 signaling pathway

Chunli Da, Yuting Liu, Yiyi Zhan, Kai Liu, Ruozheng Wang

Pages: 2767-2774 Published online on: 07 March 2016

Sedum sarmentosum Bunge extract induces apoptosis and inhibits proliferation in pancreatic cancer cells via the hedgehog signaling pathway

Yongheng Bai, Bicheng Chen, Weilong Hong, Yong Liang, Mengtao Zhou, Lan Zhou

Pages: 2775-2784 Published online on: 16 March 2016

ADAM10 mediates the cell invasion and metastasis of human esophageal squamous cell carcinoma via regulation of E-cadherin activity

Bo Ma, Hong-Yan Zhang, Xue Bai, Feng Wang, Xiu-Hua Ren, Lei Zhang, Ming-Zhi Zhang

Pages: 2785-2794 Published online on: 09 March 2016

Selective suppression of Notch1 inhibits proliferation of renal cell carcinoma cells through JNK/p38 pathway

Kerong Wu, Linkun Hu, Jianquan Hou

Pages: 2795-2800 Published online on: 17 March 2016

Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer

Guoyu Huang, Jun Cheng, Fudong Yu, Xisheng Liu, Chenwei Yuan, Chenchen Liu, Xiaolei Chen, Zhihai Peng

Pages: 2801-2810 Published online on: 17 March 2016

Epigenetic targeting of glioma stem cells: Short-term and long-term treatments with valproic acid modulate DNA methylation and differentiation behavior, but not temozolomide sensitivity

Gabriele Riva, Valentina Butta, Chiara Cilibrasi, Simona Baronchelli, Serena Redaelli, Leda Dalprà, Marialuisa Lavitrano, Angela Bentivegna

Pages: 2811-2824 Published online on: 09 March 2016

Hydrogen sulfide promotes cell proliferation of oral cancer through activation of the COX2/AKT/ERK1/2 axis

Shuai Zhang, Huan Bian, Xiaoxu Li, Huanhuan Wu, Qingwei Bi, Yingbin Yan, Yixiang Wang

Pages: 2825-2832 Published online on: 17 March 2016

FTY720-induced enhancement of autophagy protects cells from FTY720 cytotoxicity in colorectal cancer

Juan Li, Shu-Wei Wang, Dong-Sheng Zhang, Ye Sun, Chun-Yan Zhu, Qiang Fei, Jun Hu, Chuan Zhang, Yue-Ming Sun

Pages: 2833-2842 Published online on: 09 March 2016

Radiosensitization effect of Huaier on breast cancer cells

Xia Ding, Qifeng Yang, Xiangnan Kong, Bruce G. Haffty, Sumei Gao, Meena S. Moran

Pages: 2843-2850 Published online on: 23 February 2016

Goniothalamin induces apoptosis associated with autophagy activation through MAPK signaling in SK-BR-3 cells

Sukanda Innajak, Wilawan Mahabusrakum, Ramida Watanapokasin

Pages: 2851-2858 Published online on: 07 March 2016

miR-218 impedes IL-6-induced prostate cancer cell proliferation and invasion via suppression of LGR4 expression

Fujun Li, Chaohui Gu, Fengyan Tian, Zhankui Jia, Zhenglei Meng, Yinghui Ding, Jinjian Yang

Pages: 2859-2865 Published online on: 08 March 2016

MicroRNA miR-93-5p regulates expression of IL-8 and VEGF in neuroblastoma SK-N-AS cells

Enrica Fabbri, Giulia Montagner, Nicoletta Bianchi, Alessia Finotti, Monica Borgatti, Ilaria Lampronti, Giulio Cabrini, Roberto Gambari

Pages: 2866-2872 Published online on: 15 March 2016

miR-183 functions as an oncogene by targeting ABCA1 in colon cancer

Da-Peng Bi, Cheng-Hua Yin, Xiao-Yue Zhang, Na-Na Yang, Jia-You Xu

Pages: 2873-2879 Published online on: 23 February 2016

Tetrandrine suppresses metastatic phenotype of prostate cancer cells by regulating Akt/mTOR/MMP-9 signaling pathway

Bo Kou, Wei Liu, Wenbo He, Yuanyuan Zhang, Jianjie Zheng, Yang Yan, Yongjian Zhang, Suochun Xu, Haichen Wang

Pages: 2880-2886 Published online on: 03 March 2016

Rhapontigenin inhibits TGF-β-mediated epithelial‑mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1α degradation

Yen-Hsiu Yeh, Shih-Wei Wang, Yen-Cheng Yeh, Ho-Fu Hsiao, Tsai-Kun Li

Pages: 2887-2895 Published online on: 09 March 2016

Effect of brefeldin A and castanospermine on resistant cell lines as supplements in anticancer therapy

Karolina Wojtowicz, Radosław Januchowski, Patrycja Sosińska, Michał Nowicki, Maciej Zabel

Pages: 2896-2906 Published online on: 07 March 2016

Silencing of CerS6 increases the invasion and glycolysis of melanoma WM35, WM451 and SK28 cell lines via increased GLUT1-induced downregulation of WNT5A

Yuanyuan Tang, Ke Cao, Qi Wang, Jia Chen, Rui Liu, Shaohua Wang, Jianda Zhou, Huiqing Xie

Pages: 2907-2915 Published online on: 02 March 2016

Protein phosphatase 1γ regulates the proliferation of human glioma via the NF-κB pathway

Zhen Bao, Chengwei Duan, Cheng Gong, Liang Wang, Chaoyan Shen, Cheng Wang, Gang Cui

Pages: 2916-2926 Published online on: 01 March 2016

Inhibitor of growth 4 suppresses colorectal cancer growth and invasion by inducing G1 arrest, inhibiting tumor angiogenesis and reversing epithelial-mesenchymal transition

Hui Qu, Hong Yin, Su Yan, Min Tao, Yufeng Xie, Weichang Chen

Pages: 2927-2935 Published online on: 18 February 2016

Development of a high-resolution melting method for the screening of TNFAIP3 gene mutations

Yuli Christine Chang, Ya-Sian Chang, Chun-Chi Chang, Ta-Chih Liu, Ying-Chin Ko, Chien-Chin Lee, Shun-Jen Chang, Jan-Gowth Chang

Pages: 2936-2942 Published online on: 08 March 2016
Open Access

MicroRNA-141 and its associated gene FUS modulate proliferation, migration and cisplatin chemosensitivity in neuroblastoma cell lines

Ziran Wang, Hongyan Lei, Quanyu Sun

Pages: 2943-2951 Published online on: 26 February 2016

Reversal of liver cancer-associated stellate cell-induced stem-like characteristics in SMMC-7721 cells by 8-bromo-7-methoxychrysin via inhibiting STAT3 activation

Yinghong Cui, Shuwen Sun, Kaiqun Ren, Meifang Quan, Zhenwei Song, Hui Zou, Duo Li, Jianguo Cao

Pages: 2952-2962 Published online on: 26 February 2016

Downregulation of miR-129-2 by promoter hypermethylation regulates breast cancer cell proliferation and apoptosis

Xiaofeng Tang, Jianjun Tang, Xia Liu, Lei Zeng, Chun Cheng, Yanqin Luo, Liping Li, Shu-Lan Qin, Yi Sang, Liang-Ming Deng, Xiao-Bin Lv

Pages: 2963-2969 Published online on: 02 March 2016

Cantharidin inhibits cell proliferation and induces apoptosis through G2/M phase cell cycle arrest in hepatocellular carcinoma stem cells

Ai-Ping Le, Lun-Li Zhang, Wei Liu, Yu-Fei Shi

Pages: 2970-2976 Published online on: 17 March 2016

Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway

Jinsheng Wu, Jingli Han, Benxin Hou, Chengwei Deng, Huanliang Wu, Liangfang Shen

Pages: 2977-2983 Published online on: 26 February 2016

Expression of α-fetoprotein in gastric cancer AGS cells contributes to invasion and metastasis by influencing anoikis sensitivity

Sumei Lu, Yongmei Ma, Tao Sun, Rui Ren, Xiaoning Zhang, Wanshan Ma

Pages: 2984-2990 Published online on: 16 March 2016

Assessment of sFRP4 as a bio-marker for predicting aggressiveness and recurrence of growth hormone-secreting pituitary adenomas

Youtu Wu, Chunhui Liu, Shengyuan Yu, Hua Gao, Zhenye Li, Chuzhong Li, Yazhuo Zhang

Pages: 2991-2999 Published online on: 03 March 2016

miR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression

Feng Xiong, Keyun Liu, Fumei Zhang, Kaihui Sha, Xinyuan Wang, Xiaojuan Guo, Ning Huang

Pages: 3000-3008 Published online on: 16 February 2016

Paclitaxel enhances tumoricidal potential of TRAIL via inhibition of MAPK in resistant gastric cancer cells

Lin Li, Xian-Zi Wen, Zhao-De Bu, Xiao-Jing Cheng, Xiao-Fang Xing, Xiao-Hong Wang, Lian-Hai Zhang, Ting Guo, Hong Du, Ying Hu, Biao Fan, Jia-Fu Ji

Pages: 3009-3017 Published online on: 09 March 2016

Insulin resistance contributes to multidrug resistance in HepG2 cells via activation of the PERK signaling pathway and upregulation of Bcl-2 and P-gp

Xinyue Liu, Linjing Li, Jing Li, Yan Cheng, Jing Chen, Minghui Shen, Shangdi Zhang, Hulai Wei

Pages: 3018-3024 Published online on: 24 February 2016

Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia

Yuxuan Che, Xing Ren, Liye Xu, Xiaolei Ding, Xuan Zhang, Xiuhua Sun

Pages: 3025-3033 Published online on: 11 March 2016

Depletion of G9a gene induces cell apoptosis in human gastric carcinoma

Xiaolei Lin, Yiqun Huang, Yong Zou, Xingsheng Chen, Xudong Ma

Pages: 3041-3049 Published online on: 17 March 2016

BLCAP arrests G1/S checkpoint and induces apoptosis through downregulation of pRb1 in HeLa cells

Min Zhao, Li Zhang, Xiaoping Qiu, Fanyu Zeng, Wen Chen, Yuehui An, Bicheng Hu, Xufeng Wu, Xinxing Wu

Pages: 3050-3058 Published online on: 17 March 2016

In vitro and in vivo magnetic resonance imaging with chlorotoxin-conjugated superparamagnetic nanoprobes for targeting hepatocarcinoma

Zhu Chen, En-Hua Xiao, Zhen Kang, Wen-Bin Zeng, Hui-Long Tan, Hua-Bing Li, Du-Jun Bian, Quan-Liang Shang

Pages: 3059-3067 Published online on: 23 February 2016

GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1

Yang Ma, Chen-Chen Han, Qiong Huang, Wu-Yi Sun, Wei Wei

Pages: 3068-3074 Published online on: 26 February 2016

Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway

Ruixuan Wang, Lijie Ma, Dan Weng, Jiahui Yao, Xueying Liu, Faguang Jin

Pages: 3075-3083 Published online on: 17 March 2016

Downregulation of importin-9 protects MCF-7 cells against apoptosis induced by the combination of garlic-derived alliin and paclitaxel

Magdalena Izdebska, Dariusz Grzanka, Maciej Gagat, Marta Hałas-Wiśniewska, Alina Grzanka

Pages: 3084-3093 Published online on: 22 February 2016

Abnormal expression of leiomyoma cytoskeletal proteins involved in cell migration

Blendi Ura, Federica Scrimin, Giorgio Arrigoni, Emmanouil Athanasakis, Michelangelo Aloisio, Lorenzo Monasta, Giuseppe Ricci

Pages: 3094-3100 Published online on: 17 March 2016

UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis

Emilie Laure Dubois, Scott Gerber, Alexei Kisselev, Annick Harel-Bellan, Regina Groisman

Pages: 3101-3105 Published online on: 11 March 2016

Suppression of forkhead box Q1 by microRNA-506 represses the proliferation and epithelial-mesenchymal transition of cervical cancer cells

Mingting Zhang, Qingli Xu, Shufen Yan, Zhigang Li, Wei Yan, Xiaojing Jia

Pages: 3106-3114 Published online on: 03 March 2016

miR-124 inhibits cell proliferation, migration and invasion by directly targeting SOX9 in lung adenocarcinoma

Xiaoying Wang, Yanli Liu, Xiaoli Liu, Jingyan Yang, Guoxin Teng, Lulu Zhang, Chengjun Zhou

Pages: 3115-3121 Published online on: 03 March 2016

Mda-7/IL-24 enhances sensitivity of B cell lymphoma to chemotherapy drugs

Ming Ma, Lianmei Zhao, Guogui Sun, Chao Zhang, Lihua Liu, Yanyan Du, Xingxiao Yang, Baoen Shan

Pages: 3122-3130 Published online on: 15 February 2016
Journal Cover

May-2016
Volume 35 Issue 5

Print ISSN: 1021-335X
Online ISSN: 1791-2431

Sign up for eToc alerts

Recommend to Library

Full Size Image