Journal Articles
Review
Role of the tumor microenvironment in tumor progression and the clinical applications (Review)
Yao Yuan, Yu-Chen Jiang, Chong-Kui Sun, Qian-Ming Chen
Pages: 2499-2515 Published online on: 07 March 2016
Review
Chemically induced skin carcinogenesis: Updates in experimental models (Review)
Monica Neagu, Constantin Caruntu, Carolina Constantin, Daniel Boda, Sabina Zurac, Demetrios A. Spandidos, Aristidis M. Tsatsakis
Pages: 2516-2528 Published online on: 17 March 2016
Article
Inhibition of rhotekin exhibits antitumor effects in lung cancer cells
Weizhen Zhang, Zhenyu Liang, Jing Li
Pages: 2529-2534 Published online on: 24 February 2016
Article
Histone deacetylase inhibitor screening identifies HC toxin as the most effective in intrahepatic cholangiocarcinoma cells
Wenjie Zhou, Xiaoxun Chen, Ke He, Jinfeng Xiao, Xiaopeng Duan, Rui Huang, Zhenglin Xia, Jingliang He, Jinqian Zhang, Guoan Xiang
Pages: 2535-2542 Published online on: 25 February 2016
Article
PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells
Nobuhisa Yoshikawa, Hiroaki Kajiyama, Kae Nakamura, Fumi Utsumi, Kaoru Niimi, Hiroko Mitsui, Ryuichiro Sekiya, Shiro Suzuki, Kiyosumi Shibata, David Callen, Fumitaka Kikkawa
Pages: 2543-2552 Published online on: 03 March 2016
Article
Anticancer effect of metformin on estrogen receptor-positive and tamoxifen-resistant breast cancer cell lines
Jinkyoung Kim, Jiyun Lee, Soon Young Jang, Chungyeul Kim, Yoojin Choi, Aeree Kim
Pages: 2553-2560 Published online on: 11 March 2016
Article
SKA1 regulates the metastasis and cisplatin resistance of non-small cell lung cancer
Lihua Shen, Min Yang, Qionghua Lin, Zhongwei Zhang, Changhong Miao, Biao Zhu
Pages: 2561-2568 Published online on: 10 March 2016
Article
Radiofrequency thermal treatment with chemoradiotherapy for advanced rectal cancer
Hisanori Shoji, Masahiko Motegi, Kiyotaka Osawa, Noriyuki Okonogi, Atsushi Okazaki, Yoshitaka Andou, Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi, Kyoji Ogoshi
Pages: 2569-2575 Published online on: 07 March 2016
Article
Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma
Junro Kataoka, Hidenori Shiraha, Shigeru Horiguchi, Hiroaki Sawahara, Daisuke Uchida, Teruya Nagahara, Masaya Iwamuro, Hiroki Morimoto, Yasuto Takeuchi, Kenji Kuwaki, Hideki Onishi, Shinichiro Nakamura, Akinobu Takaki, Kazuhiro Nouso, Takahito Yagi, Kazuhide Yamamoto, Hiroyuki Okada
Pages: 2576-2582 Published online on: 16 March 2016
Article
miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1
Wenlong Cao, Weiyuan Wei, Zexu Zhan, Yubo Xie, Qiang Xiao
Pages: 2583-2591 Published online on: 29 February 2016
Article
A new histological therapeutic classification system to predict eradicated and residual lymph nodes in breast cancer after neoadjuvant chemotherapy
Satoko Morohashi, Tadashi Yoshizawa, Hiroko Seino, Hideaki Hirai, Toshihiro Haga, Rie Ota, Yunyan Wu, Eri Yoshida, Kenichi Hakamada, Hiroshi Kijima
Pages: 2592-2598 Published online on: 25 February 2016
Article
Cancer testis antigen SPAG9 is a promising marker for the diagnosis and treatment of lung cancer
Biqiong Ren, Xiaobin Wei, Guoying Zou, Junyu He, Guofeng Xu, Fei Xu, Yiran Huang, Haowen Zhu, Yong Li, Guoan Ma, Ping Yu
Pages: 2599-2605 Published online on: 01 March 2016
Article
ER stress and autophagy are involved in the apoptosis induced by cisplatin in human lung cancer cells
Shaomin Shi, Ping Tan, Bingdi Yan, Rong Gao, Jianjun Zhao, Jing Wang, Jia Guo, Ning Li, Zhongsen Ma
Pages: 2606-2614 Published online on: 16 March 2016
Article
Curcumin inhibits tumor epithelial‑mesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells
Zewei Zhang, Haitao Chen, Chao Xu, Lu Song, Lulu Huang, Yuebiao Lai, Yuqi Wang, Hanlu Chen, Danlin Gu, Lili Ren, Qinghua Yao
Pages: 2615-2623 Published online on: 10 March 2016
Article
Inhibition of peritoneal metastasis of human gastric cancer cells by dextran sulphate through the reduction in HIF-1α and ITGβ1 expression
Yuanyi Xu, Xiu Jin, Yunning Huang, Jianda Dong, Honghong Wang, Xiaofei Wang, Xiangmei Cao
Pages: 2624-2634 Published online on: 18 March 2016
Article
Activation of ERK/IER3/PP2A-B56γ-positive feedback loop in lung adenocarcinoma by allelic deletion of B56γ gene
Tomoko Ito, Satoru Ozaki, Rachanee Chanasong, Yuki Mizutani, Takeru Oyama, Hiroshi Sakurai, Isao Matsumoto, Hirofumi Takemura, Ei Kawahara
Pages: 2635-2642 Published online on: 16 March 2016
Article
Forced expression of Nanog with mRNA synthesized in vitro to evaluate the malignancy of HeLa cells through acquiring cancer stem cell phenotypes
Yan Ding, Ai Qing Yu, Xiao Li Wang, Xing Rong Guo, Ya Hong Yuan, Dong Sheng Li
Pages: 2643-2650 Published online on: 26 February 2016
Article
Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells
Huijin Fan, Yan Liang, Bing Jiang, Xiabing Li, Hang Xun, Jia Sun, Wei He, Hay Tong Lau, Xiaofeng Ma
Pages: 2651-2656 Published online on: 17 March 2016
Article
Phenethyl isothiocyanate induces apoptosis and inhibits cell proliferation and invasion in Hep-2 laryngeal cancer cells
Meng-Yuan Dai, Yan Wang, Chen Chen, Fen Li, Bo-Kui Xiao, Shi-Ming Chen, Ze-Zhang Tao
Pages: 2657-2664 Published online on: 17 March 2016
Article
Cigarette smoke extract induces the proliferation of normal human urothelial cells through the NF-κB pathway
Qi-Fei Deng, Xin Sun, Zhao-Feng Liang, Zhi-Qiang Zhang, De-Xin Yu, Cai-Yun Zhong
Pages: 2665-2672 Published online on: 16 February 2016
Article
Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas
Lenka Zlamalikova, Mojmir Moulis, David Salek, Jiri Jarkovsky, Jan Smarda, Jana Smardova
Pages: 2673-2680 Published online on: 07 March 2016
Article
Secreted recombinant human IL-24 protein inhibits the proliferation of esophageal squamous cell carcinoma Eca-109 cells in vitro and in vivo
Qunfeng Ma, Bangming Jin, Yao Zhang, Yinan Shi, Chi Zhang, Dan Luo, Pengkun Wang, Cuimi Duan, Heyu Song, Xue Li, Xuefeng Deng, Zhinan Chen, Ziling Wang, Hong Jiang, Yan Liu
Pages: 2681-2690 Published online on: 24 February 2016
Article
Oridonin inhibits the proliferation of human colon cancer cells by upregulating BMP7 to activate p38 MAPK
Chun-Mei Ren, Yang Li, Qian-Zhao Chen, Yu-Hua Zeng, Ying Shao, Qiu-Xiang Wu, Shuang-Xue Yuan, Jun-Qin Yang, Yu Yu, Ke Wu, Bai-Cheng He, Wen-Juan Sun
Pages: 2691-2698 Published online on: 07 March 2016
Article
Strong inflammatory response and Th1-polarization profile in children with acute lymphoblastic leukemia without apparent infection
E. Pérez-Figueroa, M. Sánchez-Cuaxospa, K. A. Martínez-Soto, N. Sánchez-Zauco, A. Medina-Sansón, E. Jiménez-Hernández, J. R. Torres-Nava, J. M. Félix-Castro, A. Gómez, E. Ortega, C. Maldonado-Bernal
Pages: 2699-2706 Published online on: 07 March 2016
Article
PTEN enhances G2/M arrest in etoposide-treated MCF‑7 cells through activation of the ATM pathway
Ruopeng Zhang, Li Zhu, Lirong Zhang, Anli Xu, Zhengwei Li, Yijuan Xu, Pei He, Maoqing Wu, Fengxiang Wei, Chenhong Wang
Pages: 2707-2714 Published online on: 11 March 2016
Article
FASN, ErbB2-mediated glycolysis is required for breast cancer cell migration
Lan Zhou, Sufang Jiang, Qiang Fu, Kelly Smith, Kailing Tu, Hua Li, Yuhua Zhao
Pages: 2715-2722 Published online on: 19 February 2016
Article
Carnosic acid induces apoptosis through inactivation of Src/STAT3 signaling pathway in human renal carcinoma Caki cells
Ji Eun Park, Byoungduck Park, In Gyeong Chae, Do-Hee Kim, Juthika Kundu, Joydeb Kumar Kundu, Kyung-Soo Chun
Pages: 2723-2732 Published online on: 29 February 2016
Article
miR-608 inhibits the migration and invasion of glioma stem cells by targeting macrophage migration inhibitory factor
Zhenhua Wang, Yixue Xue, Ping Wang, Jiaqi Zhu, Jun Ma
Pages: 2733-2742 Published online on: 03 March 2016
Article
The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy
Qiong Wu, Ying Jiang, Shoubin Cui, Yanshi Wang, Xin Wu
Pages: 2743-2754 Published online on: 17 February 2016
Article
miR-99a regulates ROS-mediated invasion and migration of lung adenocarcinoma cells by targeting NOX4
Mei Sun, Shunming Hong, Wenhan Li, Pengfei Wang, Jinqiang You, Xuebin Zhang, Fan Tang, Ping Wang, Chunzhi Zhang
Pages: 2755-2766 Published online on: 11 March 2016
Article
Nobiletin inhibits epithelial-mesenchymal transition of human non-small cell lung cancer cells by antagonizing the TGF-β1/Smad3 signaling pathway
Chunli Da, Yuting Liu, Yiyi Zhan, Kai Liu, Ruozheng Wang
Pages: 2767-2774 Published online on: 07 March 2016
Article
Sedum sarmentosum Bunge extract induces apoptosis and inhibits proliferation in pancreatic cancer cells via the hedgehog signaling pathway
Yongheng Bai, Bicheng Chen, Weilong Hong, Yong Liang, Mengtao Zhou, Lan Zhou
Pages: 2775-2784 Published online on: 16 March 2016
Article
ADAM10 mediates the cell invasion and metastasis of human esophageal squamous cell carcinoma via regulation of E-cadherin activity
Bo Ma, Hong-Yan Zhang, Xue Bai, Feng Wang, Xiu-Hua Ren, Lei Zhang, Ming-Zhi Zhang
Pages: 2785-2794 Published online on: 09 March 2016
Article
Selective suppression of Notch1 inhibits proliferation of renal cell carcinoma cells through JNK/p38 pathway
Kerong Wu, Linkun Hu, Jianquan Hou
Pages: 2795-2800 Published online on: 17 March 2016
Article
Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer
Guoyu Huang, Jun Cheng, Fudong Yu, Xisheng Liu, Chenwei Yuan, Chenchen Liu, Xiaolei Chen, Zhihai Peng
Pages: 2801-2810 Published online on: 17 March 2016
Article
Epigenetic targeting of glioma stem cells: Short-term and long-term treatments with valproic acid modulate DNA methylation and differentiation behavior, but not temozolomide sensitivity
Gabriele Riva, Valentina Butta, Chiara Cilibrasi, Simona Baronchelli, Serena Redaelli, Leda Dalprà, Marialuisa Lavitrano, Angela Bentivegna
Pages: 2811-2824 Published online on: 09 March 2016
Article
Hydrogen sulfide promotes cell proliferation of oral cancer through activation of the COX2/AKT/ERK1/2 axis
Shuai Zhang, Huan Bian, Xiaoxu Li, Huanhuan Wu, Qingwei Bi, Yingbin Yan, Yixiang Wang
Pages: 2825-2832 Published online on: 17 March 2016
Article
FTY720-induced enhancement of autophagy protects cells from FTY720 cytotoxicity in colorectal cancer
Juan Li, Shu-Wei Wang, Dong-Sheng Zhang, Ye Sun, Chun-Yan Zhu, Qiang Fei, Jun Hu, Chuan Zhang, Yue-Ming Sun
Pages: 2833-2842 Published online on: 09 March 2016
Article
Radiosensitization effect of Huaier on breast cancer cells
Xia Ding, Qifeng Yang, Xiangnan Kong, Bruce G. Haffty, Sumei Gao, Meena S. Moran
Pages: 2843-2850 Published online on: 23 February 2016
Article
Goniothalamin induces apoptosis associated with autophagy activation through MAPK signaling in SK-BR-3 cells
Sukanda Innajak, Wilawan Mahabusrakum, Ramida Watanapokasin
Pages: 2851-2858 Published online on: 07 March 2016
Article
miR-218 impedes IL-6-induced prostate cancer cell proliferation and invasion via suppression of LGR4 expression
Fujun Li, Chaohui Gu, Fengyan Tian, Zhankui Jia, Zhenglei Meng, Yinghui Ding, Jinjian Yang
Pages: 2859-2865 Published online on: 08 March 2016
Article
MicroRNA miR-93-5p regulates expression of IL-8 and VEGF in neuroblastoma SK-N-AS cells
Enrica Fabbri, Giulia Montagner, Nicoletta Bianchi, Alessia Finotti, Monica Borgatti, Ilaria Lampronti, Giulio Cabrini, Roberto Gambari
Pages: 2866-2872 Published online on: 15 March 2016
Article
miR-183 functions as an oncogene by targeting ABCA1 in colon cancer
Da-Peng Bi, Cheng-Hua Yin, Xiao-Yue Zhang, Na-Na Yang, Jia-You Xu
Pages: 2873-2879 Published online on: 23 February 2016
Article
Tetrandrine suppresses metastatic phenotype of prostate cancer cells by regulating Akt/mTOR/MMP-9 signaling pathway
Bo Kou, Wei Liu, Wenbo He, Yuanyuan Zhang, Jianjie Zheng, Yang Yan, Yongjian Zhang, Suochun Xu, Haichen Wang
Pages: 2880-2886 Published online on: 03 March 2016
Article
Rhapontigenin inhibits TGF-β-mediated epithelial‑mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1α degradation
Yen-Hsiu Yeh, Shih-Wei Wang, Yen-Cheng Yeh, Ho-Fu Hsiao, Tsai-Kun Li
Pages: 2887-2895 Published online on: 09 March 2016
Article
Effect of brefeldin A and castanospermine on resistant cell lines as supplements in anticancer therapy
Karolina Wojtowicz, Radosław Januchowski, Patrycja Sosińska, Michał Nowicki, Maciej Zabel
Pages: 2896-2906 Published online on: 07 March 2016
Article
Silencing of CerS6 increases the invasion and glycolysis of melanoma WM35, WM451 and SK28 cell lines via increased GLUT1-induced downregulation of WNT5A
Yuanyuan Tang, Ke Cao, Qi Wang, Jia Chen, Rui Liu, Shaohua Wang, Jianda Zhou, Huiqing Xie
Pages: 2907-2915 Published online on: 02 March 2016
Article
Protein phosphatase 1γ regulates the proliferation of human glioma via the NF-κB pathway
Zhen Bao, Chengwei Duan, Cheng Gong, Liang Wang, Chaoyan Shen, Cheng Wang, Gang Cui
Pages: 2916-2926 Published online on: 01 March 2016
Article
Inhibitor of growth 4 suppresses colorectal cancer growth and invasion by inducing G1 arrest, inhibiting tumor angiogenesis and reversing epithelial-mesenchymal transition
Hui Qu, Hong Yin, Su Yan, Min Tao, Yufeng Xie, Weichang Chen
Pages: 2927-2935 Published online on: 18 February 2016
Article
Development of a high-resolution melting method for the screening of TNFAIP3 gene mutations
Yuli Christine Chang, Ya-Sian Chang, Chun-Chi Chang, Ta-Chih Liu, Ying-Chin Ko, Chien-Chin Lee, Shun-Jen Chang, Jan-Gowth Chang
Pages: 2936-2942 Published online on: 08 March 2016
Article
MicroRNA-141 and its associated gene FUS modulate proliferation, migration and cisplatin chemosensitivity in neuroblastoma cell lines
Ziran Wang, Hongyan Lei, Quanyu Sun
Pages: 2943-2951 Published online on: 26 February 2016
Article
Reversal of liver cancer-associated stellate cell-induced stem-like characteristics in SMMC-7721 cells by 8-bromo-7-methoxychrysin via inhibiting STAT3 activation
Yinghong Cui, Shuwen Sun, Kaiqun Ren, Meifang Quan, Zhenwei Song, Hui Zou, Duo Li, Jianguo Cao
Pages: 2952-2962 Published online on: 26 February 2016
Article
Downregulation of miR-129-2 by promoter hypermethylation regulates breast cancer cell proliferation and apoptosis
Xiaofeng Tang, Jianjun Tang, Xia Liu, Lei Zeng, Chun Cheng, Yanqin Luo, Liping Li, Shu-Lan Qin, Yi Sang, Liang-Ming Deng, Xiao-Bin Lv
Pages: 2963-2969 Published online on: 02 March 2016
Article
Cantharidin inhibits cell proliferation and induces apoptosis through G2/M phase cell cycle arrest in hepatocellular carcinoma stem cells
Ai-Ping Le, Lun-Li Zhang, Wei Liu, Yu-Fei Shi
Pages: 2970-2976 Published online on: 17 March 2016
Article
Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway
Jinsheng Wu, Jingli Han, Benxin Hou, Chengwei Deng, Huanliang Wu, Liangfang Shen
Pages: 2977-2983 Published online on: 26 February 2016
Article
Expression of α-fetoprotein in gastric cancer AGS cells contributes to invasion and metastasis by influencing anoikis sensitivity
Sumei Lu, Yongmei Ma, Tao Sun, Rui Ren, Xiaoning Zhang, Wanshan Ma
Pages: 2984-2990 Published online on: 16 March 2016
Article
Assessment of sFRP4 as a bio-marker for predicting aggressiveness and recurrence of growth hormone-secreting pituitary adenomas
Youtu Wu, Chunhui Liu, Shengyuan Yu, Hua Gao, Zhenye Li, Chuzhong Li, Yazhuo Zhang
Pages: 2991-2999 Published online on: 03 March 2016
Article
miR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression
Feng Xiong, Keyun Liu, Fumei Zhang, Kaihui Sha, Xinyuan Wang, Xiaojuan Guo, Ning Huang
Pages: 3000-3008 Published online on: 16 February 2016
Article
Paclitaxel enhances tumoricidal potential of TRAIL via inhibition of MAPK in resistant gastric cancer cells
Lin Li, Xian-Zi Wen, Zhao-De Bu, Xiao-Jing Cheng, Xiao-Fang Xing, Xiao-Hong Wang, Lian-Hai Zhang, Ting Guo, Hong Du, Ying Hu, Biao Fan, Jia-Fu Ji
Pages: 3009-3017 Published online on: 09 March 2016
Article
Insulin resistance contributes to multidrug resistance in HepG2 cells via activation of the PERK signaling pathway and upregulation of Bcl-2 and P-gp
Xinyue Liu, Linjing Li, Jing Li, Yan Cheng, Jing Chen, Minghui Shen, Shangdi Zhang, Hulai Wei
Pages: 3018-3024 Published online on: 24 February 2016
Article
Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia
Yuxuan Che, Xing Ren, Liye Xu, Xiaolei Ding, Xuan Zhang, Xiuhua Sun
Pages: 3025-3033 Published online on: 11 March 2016
Article
Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo
Xian Yu, Tingting Li, Yifan Xia, Jun Lei, Yan Wang, Lijuan Zhang
Pages: 3034-3040 Published online on: 18 March 2016
Article
Depletion of G9a gene induces cell apoptosis in human gastric carcinoma
Xiaolei Lin, Yiqun Huang, Yong Zou, Xingsheng Chen, Xudong Ma
Pages: 3041-3049 Published online on: 17 March 2016
Article
BLCAP arrests G1/S checkpoint and induces apoptosis through downregulation of pRb1 in HeLa cells
Min Zhao, Li Zhang, Xiaoping Qiu, Fanyu Zeng, Wen Chen, Yuehui An, Bicheng Hu, Xufeng Wu, Xinxing Wu
Pages: 3050-3058 Published online on: 17 March 2016
Article
In vitro and in vivo magnetic resonance imaging with chlorotoxin-conjugated superparamagnetic nanoprobes for targeting hepatocarcinoma
Zhu Chen, En-Hua Xiao, Zhen Kang, Wen-Bin Zeng, Hui-Long Tan, Hua-Bing Li, Du-Jun Bian, Quan-Liang Shang
Pages: 3059-3067 Published online on: 23 February 2016
Article
GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1
Yang Ma, Chen-Chen Han, Qiong Huang, Wu-Yi Sun, Wei Wei
Pages: 3068-3074 Published online on: 26 February 2016
Article
Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway
Ruixuan Wang, Lijie Ma, Dan Weng, Jiahui Yao, Xueying Liu, Faguang Jin
Pages: 3075-3083 Published online on: 17 March 2016
Article
Downregulation of importin-9 protects MCF-7 cells against apoptosis induced by the combination of garlic-derived alliin and paclitaxel
Magdalena Izdebska, Dariusz Grzanka, Maciej Gagat, Marta Hałas-Wiśniewska, Alina Grzanka
Pages: 3084-3093 Published online on: 22 February 2016
Article
Abnormal expression of leiomyoma cytoskeletal proteins involved in cell migration
Blendi Ura, Federica Scrimin, Giorgio Arrigoni, Emmanouil Athanasakis, Michelangelo Aloisio, Lorenzo Monasta, Giuseppe Ricci
Pages: 3094-3100 Published online on: 17 March 2016
Article
UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis
Emilie Laure Dubois, Scott Gerber, Alexei Kisselev, Annick Harel-Bellan, Regina Groisman
Pages: 3101-3105 Published online on: 11 March 2016
Article
Suppression of forkhead box Q1 by microRNA-506 represses the proliferation and epithelial-mesenchymal transition of cervical cancer cells
Mingting Zhang, Qingli Xu, Shufen Yan, Zhigang Li, Wei Yan, Xiaojing Jia
Pages: 3106-3114 Published online on: 03 March 2016
Article
miR-124 inhibits cell proliferation, migration and invasion by directly targeting SOX9 in lung adenocarcinoma
Xiaoying Wang, Yanli Liu, Xiaoli Liu, Jingyan Yang, Guoxin Teng, Lulu Zhang, Chengjun Zhou
Pages: 3115-3121 Published online on: 03 March 2016
Article
