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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
May-2016 Volume 35 Issue 5

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Role of the tumor microenvironment in tumor progression and the clinical applications (Review)

Yao Yuan, Yu-Chen Jiang, Chong-Kui Sun, Qian-Ming Chen
Pages: 2499-2515
Published online on: 07 March 2016

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Review Open Access

Chemically induced skin carcinogenesis: Updates in experimental models (Review)

Monica Neagu, Constantin Caruntu, Carolina Constantin, Daniel Boda, Sabina Zurac, Demetrios A. Spandidos, Aristidis M. Tsatsakis
Pages: 2516-2528
Published online on: 17 March 2016

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Article Open Access

Inhibition of rhotekin exhibits antitumor effects in lung cancer cells

Weizhen Zhang, Zhenyu Liang, Jing Li
Pages: 2529-2534
Published online on: 24 February 2016

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Article Open Access

Histone deacetylase inhibitor screening identifies HC toxin as the most effective in intrahepatic cholangiocarcinoma cells

Wenjie Zhou, Xiaoxun Chen, Ke He, Jinfeng Xiao, Xiaopeng Duan, Rui Huang, Zhenglin Xia, Jingliang He, Jinqian Zhang, Guoan Xiang
Pages: 2535-2542
Published online on: 25 February 2016

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Article Open Access

PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells

Nobuhisa Yoshikawa, Hiroaki Kajiyama, Kae Nakamura, Fumi Utsumi, Kaoru Niimi, Hiroko Mitsui, Ryuichiro Sekiya, Shiro Suzuki, Kiyosumi Shibata, David Callen, Fumitaka Kikkawa
Pages: 2543-2552
Published online on: 03 March 2016

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Article Open Access

Anticancer effect of metformin on estrogen receptor-positive and tamoxifen-resistant breast cancer cell lines

Jinkyoung Kim, Jiyun Lee, Soon Young Jang, Chungyeul Kim, Yoojin Choi, Aeree Kim
Pages: 2553-2560
Published online on: 11 March 2016

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Article Open Access

SKA1 regulates the metastasis and cisplatin resistance of non-small cell lung cancer

Lihua Shen, Min Yang, Qionghua Lin, Zhongwei Zhang, Changhong Miao, Biao Zhu
Pages: 2561-2568
Published online on: 10 March 2016

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Article Open Access

Radiofrequency thermal treatment with chemoradiotherapy for advanced rectal cancer

Hisanori Shoji, Masahiko Motegi, Kiyotaka Osawa, Noriyuki Okonogi, Atsushi Okazaki, Yoshitaka Andou, Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi, Kyoji Ogoshi
Pages: 2569-2575
Published online on: 07 March 2016

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Article Open Access

Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma Corrigendum in /10.3892/or.2017.5419

Junro Kataoka, Hidenori Shiraha, Shigeru Horiguchi, Hiroaki Sawahara, Daisuke Uchida, Teruya Nagahara, Masaya Iwamuro, Hiroki Morimoto, Yasuto Takeuchi, Kenji Kuwaki, Hideki Onishi, Shinichiro Nakamura, Akinobu Takaki, Kazuhiro Nouso, Takahito Yagi, Kazuhide Yamamoto, Hiroyuki Okada
Pages: 2576-2582
Published online on: 16 March 2016

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Article

miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1

Wenlong Cao, Weiyuan Wei, Zexu Zhan, Yubo Xie, Qiang Xiao
Pages: 2583-2591
Published online on: 29 February 2016

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Article Open Access

A new histological therapeutic classification system to predict eradicated and residual lymph nodes in breast cancer after neoadjuvant chemotherapy

Satoko Morohashi, Tadashi Yoshizawa, Hiroko Seino, Hideaki Hirai, Toshihiro Haga, Rie Ota, Yunyan Wu, Eri Yoshida, Kenichi Hakamada, Hiroshi Kijima
Pages: 2592-2598
Published online on: 25 February 2016

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Article Open Access

Cancer testis antigen SPAG9 is a promising marker for the diagnosis and treatment of lung cancer

Biqiong Ren, Xiaobin Wei, Guoying Zou, Junyu He, Guofeng Xu, Fei Xu, Yiran Huang, Haowen Zhu, Yong Li, Guoan Ma, Ping Yu
Pages: 2599-2605
Published online on: 01 March 2016

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Article Open Access

ER stress and autophagy are involved in the apoptosis induced by cisplatin in human lung cancer cells

Shaomin Shi, Ping Tan, Bingdi Yan, Rong Gao, Jianjun Zhao, Jing Wang, Jia Guo, Ning Li, Zhongsen Ma
Pages: 2606-2614
Published online on: 16 March 2016

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Article Open Access

Curcumin inhibits tumor epithelial‑mesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells

Zewei Zhang, Haitao Chen, Chao Xu, Lu Song, Lulu Huang, Yuebiao Lai, Yuqi Wang, Hanlu Chen, Danlin Gu, Lili Ren, Qinghua Yao
Pages: 2615-2623
Published online on: 10 March 2016

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Article Open Access

Inhibition of peritoneal metastasis of human gastric cancer cells by dextran sulphate through the reduction in HIF-1α and ITGβ1 expression

Yuanyi Xu, Xiu Jin, Yunning Huang, Jianda Dong, Honghong Wang, Xiaofei Wang, Xiangmei Cao
Pages: 2624-2634
Published online on: 18 March 2016

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Article

Activation of ERK/IER3/PP2A-B56γ-positive feedback loop in lung adenocarcinoma by allelic deletion of B56γ gene

Tomoko Ito, Satoru Ozaki, Rachanee Chanasong, Yuki Mizutani, Takeru Oyama, Hiroshi Sakurai, Isao Matsumoto, Hirofumi Takemura, Ei Kawahara
Pages: 2635-2642
Published online on: 16 March 2016

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Article

Forced expression of Nanog with mRNA synthesized in vitro to evaluate the malignancy of HeLa cells through acquiring cancer stem cell phenotypes

Yan Ding, Ai Qing Yu, Xiao Li Wang, Xing Rong Guo, Ya Hong Yuan, Dong Sheng Li
Pages: 2643-2650
Published online on: 26 February 2016

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Article

Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells

Huijin Fan, Yan Liang, Bing Jiang, Xiabing Li, Hang Xun, Jia Sun, Wei He, Hay Tong Lau, Xiaofeng Ma
Pages: 2651-2656
Published online on: 17 March 2016

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Article

Phenethyl isothiocyanate induces apoptosis and inhibits cell proliferation and invasion in Hep-2 laryngeal cancer cells

Meng-Yuan Dai, Yan Wang, Chen Chen, Fen Li, Bo-Kui Xiao, Shi-Ming Chen, Ze-Zhang Tao
Pages: 2657-2664
Published online on: 17 March 2016

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Article

Cigarette smoke extract induces the proliferation of normal human urothelial cells through the NF-κB pathway

Qi-Fei Deng, Xin Sun, Zhao-Feng Liang, Zhi-Qiang Zhang, De-Xin Yu, Cai-Yun Zhong
Pages: 2665-2672
Published online on: 16 February 2016

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Article

Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas

Lenka Zlamalikova, Mojmir Moulis, David Salek, Jiri Jarkovsky, Jan Smarda, Jana Smardova
Pages: 2673-2680
Published online on: 07 March 2016

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Article

Secreted recombinant human IL-24 protein inhibits the proliferation of esophageal squamous cell carcinoma Eca-109 cells in vitro and in vivo

Qunfeng Ma, Bangming Jin, Yao Zhang, Yinan Shi, Chi Zhang, Dan Luo, Pengkun Wang, Cuimi Duan, Heyu Song, Xue Li, Xuefeng Deng, Zhinan Chen, Ziling Wang, Hong Jiang, Yan Liu
Pages: 2681-2690
Published online on: 24 February 2016

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Article

Oridonin inhibits the proliferation of human colon cancer cells by upregulating BMP7 to activate p38 MAPK

Chun-Mei Ren, Yang Li, Qian-Zhao Chen, Yu-Hua Zeng, Ying Shao, Qiu-Xiang Wu, Shuang-Xue Yuan, Jun-Qin Yang, Yu Yu, Ke Wu, Bai-Cheng He, Wen-Juan Sun
Pages: 2691-2698
Published online on: 07 March 2016

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Article

Strong inflammatory response and Th1-polarization profile in children with acute lymphoblastic leukemia without apparent infection

E. Pérez-Figueroa, M. Sánchez-Cuaxospa, K. A. Martínez-Soto, N. Sánchez-Zauco, A. Medina-Sansón, E. Jiménez-Hernández, J. R. Torres-Nava, J. M. Félix-Castro, A. Gómez, E. Ortega, C. Maldonado-Bernal
Pages: 2699-2706
Published online on: 07 March 2016

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Article

PTEN enhances G2/M arrest in etoposide-treated MCF‑7 cells through activation of the ATM pathway

Ruopeng Zhang, Li Zhu, Lirong Zhang, Anli Xu, Zhengwei Li, Yijuan Xu, Pei He, Maoqing Wu, Fengxiang Wei, Chenhong Wang
Pages: 2707-2714
Published online on: 11 March 2016

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Article

FASN, ErbB2-mediated glycolysis is required for breast cancer cell migration

Lan Zhou, Sufang Jiang, Qiang Fu, Kelly Smith, Kailing Tu, Hua Li, Yuhua Zhao
Pages: 2715-2722
Published online on: 19 February 2016

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Article

Carnosic acid induces apoptosis through inactivation of Src/STAT3 signaling pathway in human renal carcinoma Caki cells Corrigendum in /10.3892/or.2016.5137

Ji Eun Park, Byoungduck Park, In Gyeong Chae, Do-Hee Kim, Juthika Kundu, Joydeb Kumar Kundu, Kyung-Soo Chun
Pages: 2723-2732
Published online on: 29 February 2016

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Article

miR-608 inhibits the migration and invasion of glioma stem cells by targeting macrophage migration inhibitory factor

Zhenhua Wang, Yixue Xue, Ping Wang, Jiaqi Zhu, Jun Ma
Pages: 2733-2742
Published online on: 03 March 2016

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Article

The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy

Qiong Wu, Ying Jiang, Shoubin Cui, Yanshi Wang, Xin Wu
Pages: 2743-2754
Published online on: 17 February 2016

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Article

miR-99a regulates ROS-mediated invasion and migration of lung adenocarcinoma cells by targeting NOX4

Mei Sun, Shunming Hong, Wenhan Li, Pengfei Wang, Jinqiang You, Xuebin Zhang, Fan Tang, Ping Wang, Chunzhi Zhang
Pages: 2755-2766
Published online on: 11 March 2016

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Article

Nobiletin inhibits epithelial-mesenchymal transition of human non-small cell lung cancer cells by antagonizing the TGF-β1/Smad3 signaling pathway

Chunli Da, Yuting Liu, Yiyi Zhan, Kai Liu, Ruozheng Wang
Pages: 2767-2774
Published online on: 07 March 2016

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Article

Sedum sarmentosum Bunge extract induces apoptosis and inhibits proliferation in pancreatic cancer cells via the hedgehog signaling pathway

Yongheng Bai, Bicheng Chen, Weilong Hong, Yong Liang, Mengtao Zhou, Lan Zhou
Pages: 2775-2784
Published online on: 16 March 2016

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Article

ADAM10 mediates the cell invasion and metastasis of human esophageal squamous cell carcinoma via regulation of E-cadherin activity

Bo Ma, Hong-Yan Zhang, Xue Bai, Feng Wang, Xiu-Hua Ren, Lei Zhang, Ming-Zhi Zhang
Pages: 2785-2794
Published online on: 09 March 2016

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Article

Selective suppression of Notch1 inhibits proliferation of renal cell carcinoma cells through JNK/p38 pathway

Kerong Wu, Linkun Hu, Jianquan Hou
Pages: 2795-2800
Published online on: 17 March 2016

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Article

Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer

Guoyu Huang, Jun Cheng, Fudong Yu, Xisheng Liu, Chenwei Yuan, Chenchen Liu, Xiaolei Chen, Zhihai Peng
Pages: 2801-2810
Published online on: 17 March 2016

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Article

Epigenetic targeting of glioma stem cells: Short-term and long-term treatments with valproic acid modulate DNA methylation and differentiation behavior, but not temozolomide sensitivity

Gabriele Riva, Valentina Butta, Chiara Cilibrasi, Simona Baronchelli, Serena Redaelli, Leda Dalprà, Marialuisa Lavitrano, Angela Bentivegna
Pages: 2811-2824
Published online on: 09 March 2016

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Article

Hydrogen sulfide promotes cell proliferation of oral cancer through activation of the COX2/AKT/ERK1/2 axis

Shuai Zhang, Huan Bian, Xiaoxu Li, Huanhuan Wu, Qingwei Bi, Yingbin Yan, Yixiang Wang
Pages: 2825-2832
Published online on: 17 March 2016

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Article

FTY720-induced enhancement of autophagy protects cells from FTY720 cytotoxicity in colorectal cancer

Juan Li, Shu-Wei Wang, Dong-Sheng Zhang, Ye Sun, Chun-Yan Zhu, Qiang Fei, Jun Hu, Chuan Zhang, Yue-Ming Sun
Pages: 2833-2842
Published online on: 09 March 2016

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Article

Radiosensitization effect of Huaier on breast cancer cells

Xia Ding, Qifeng Yang, Xiangnan Kong, Bruce G. Haffty, Sumei Gao, Meena S. Moran
Pages: 2843-2850
Published online on: 23 February 2016

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Article

Goniothalamin induces apoptosis associated with autophagy activation through MAPK signaling in SK-BR-3 cells

Sukanda Innajak, Wilawan Mahabusrakum, Ramida Watanapokasin
Pages: 2851-2858
Published online on: 07 March 2016

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Article

miR-218 impedes IL-6-induced prostate cancer cell proliferation and invasion via suppression of LGR4 expression

Fujun Li, Chaohui Gu, Fengyan Tian, Zhankui Jia, Zhenglei Meng, Yinghui Ding, Jinjian Yang
Pages: 2859-2865
Published online on: 08 March 2016

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Article

MicroRNA miR-93-5p regulates expression of IL-8 and VEGF in neuroblastoma SK-N-AS cells

Enrica Fabbri, Giulia Montagner, Nicoletta Bianchi, Alessia Finotti, Monica Borgatti, Ilaria Lampronti, Giulio Cabrini, Roberto Gambari
Pages: 2866-2872
Published online on: 15 March 2016

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Article

miR-183 functions as an oncogene by targeting ABCA1 in colon cancer

Da-Peng Bi, Cheng-Hua Yin, Xiao-Yue Zhang, Na-Na Yang, Jia-You Xu
Pages: 2873-2879
Published online on: 23 February 2016

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Article

Tetrandrine suppresses metastatic phenotype of prostate cancer cells by regulating Akt/mTOR/MMP-9 signaling pathway

Bo Kou, Wei Liu, Wenbo He, Yuanyuan Zhang, Jianjie Zheng, Yang Yan, Yongjian Zhang, Suochun Xu, Haichen Wang
Pages: 2880-2886
Published online on: 03 March 2016

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Article

Rhapontigenin inhibits TGF-β-mediated epithelial‑mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1α degradation

Yen-Hsiu Yeh, Shih-Wei Wang, Yen-Cheng Yeh, Ho-Fu Hsiao, Tsai-Kun Li
Pages: 2887-2895
Published online on: 09 March 2016

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Article

Effect of brefeldin A and castanospermine on resistant cell lines as supplements in anticancer therapy

Karolina Wojtowicz, Radosław Januchowski, Patrycja Sosińska, Michał Nowicki, Maciej Zabel
Pages: 2896-2906
Published online on: 07 March 2016

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Article

Silencing of CerS6 increases the invasion and glycolysis of melanoma WM35, WM451 and SK28 cell lines via increased GLUT1-induced downregulation of WNT5A

Yuanyuan Tang, Ke Cao, Qi Wang, Jia Chen, Rui Liu, Shaohua Wang, Jianda Zhou, Huiqing Xie
Pages: 2907-2915
Published online on: 02 March 2016

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Article

Protein phosphatase 1γ regulates the proliferation of human glioma via the NF-κB pathway

Zhen Bao, Chengwei Duan, Cheng Gong, Liang Wang, Chaoyan Shen, Cheng Wang, Gang Cui
Pages: 2916-2926
Published online on: 01 March 2016

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Article

Inhibitor of growth 4 suppresses colorectal cancer growth and invasion by inducing G1 arrest, inhibiting tumor angiogenesis and reversing epithelial-mesenchymal transition

Hui Qu, Hong Yin, Su Yan, Min Tao, Yufeng Xie, Weichang Chen
Pages: 2927-2935
Published online on: 18 February 2016

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Article

Development of a high-resolution melting method for the screening of TNFAIP3 gene mutations

Yuli Christine Chang, Ya-Sian Chang, Chun-Chi Chang, Ta-Chih Liu, Ying-Chin Ko, Chien-Chin Lee, Shun-Jen Chang, Jan-Gowth Chang
Pages: 2936-2942
Published online on: 08 March 2016

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Article Open Access

MicroRNA-141 and its associated gene FUS modulate proliferation, migration and cisplatin chemosensitivity in neuroblastoma cell lines

Ziran Wang, Hongyan Lei, Quanyu Sun
Pages: 2943-2951
Published online on: 26 February 2016

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Article

Reversal of liver cancer-associated stellate cell-induced stem-like characteristics in SMMC-7721 cells by 8-bromo-7-methoxychrysin via inhibiting STAT3 activation

Yinghong Cui, Shuwen Sun, Kaiqun Ren, Meifang Quan, Zhenwei Song, Hui Zou, Duo Li, Jianguo Cao
Pages: 2952-2962
Published online on: 26 February 2016

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Article

Downregulation of miR-129-2 by promoter hypermethylation regulates breast cancer cell proliferation and apoptosis

Xiaofeng Tang, Jianjun Tang, Xia Liu, Lei Zeng, Chun Cheng, Yanqin Luo, Liping Li, Shu-Lan Qin, Yi Sang, Liang-Ming Deng, Xiao-Bin Lv
Pages: 2963-2969
Published online on: 02 March 2016

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Article

Cantharidin inhibits cell proliferation and induces apoptosis through G2/M phase cell cycle arrest in hepatocellular carcinoma stem cells

Ai-Ping Le, Lun-Li Zhang, Wei Liu, Yu-Fei Shi
Pages: 2970-2976
Published online on: 17 March 2016

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Article

Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway

Jinsheng Wu, Jingli Han, Benxin Hou, Chengwei Deng, Huanliang Wu, Liangfang Shen
Pages: 2977-2983
Published online on: 26 February 2016

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Article

Expression of α-fetoprotein in gastric cancer AGS cells contributes to invasion and metastasis by influencing anoikis sensitivity Retraction in /10.3892/or.2025.8945

Sumei Lu, Yongmei Ma, Tao Sun, Rui Ren, Xiaoning Zhang, Wanshan Ma
Pages: 2984-2990
Published online on: 16 March 2016

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Article

Assessment of sFRP4 as a bio-marker for predicting aggressiveness and recurrence of growth hormone-secreting pituitary adenomas

Youtu Wu, Chunhui Liu, Shengyuan Yu, Hua Gao, Zhenye Li, Chuzhong Li, Yazhuo Zhang
Pages: 2991-2999
Published online on: 03 March 2016

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Article

miR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression

Feng Xiong, Keyun Liu, Fumei Zhang, Kaihui Sha, Xinyuan Wang, Xiaojuan Guo, Ning Huang
Pages: 3000-3008
Published online on: 16 February 2016

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Article

Paclitaxel enhances tumoricidal potential of TRAIL via inhibition of MAPK in resistant gastric cancer cells

Lin Li, Xian-Zi Wen, Zhao-De Bu, Xiao-Jing Cheng, Xiao-Fang Xing, Xiao-Hong Wang, Lian-Hai Zhang, Ting Guo, Hong Du, Ying Hu, Biao Fan, Jia-Fu Ji
Pages: 3009-3017
Published online on: 09 March 2016

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Article

Insulin resistance contributes to multidrug resistance in HepG2 cells via activation of the PERK signaling pathway and upregulation of Bcl-2 and P-gp

Xinyue Liu, Linjing Li, Jing Li, Yan Cheng, Jing Chen, Minghui Shen, Shangdi Zhang, Hulai Wei
Pages: 3018-3024
Published online on: 24 February 2016

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Article

Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia

Yuxuan Che, Xing Ren, Liye Xu, Xiaolei Ding, Xuan Zhang, Xiuhua Sun
Pages: 3025-3033
Published online on: 11 March 2016

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Article

Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo

Xian Yu, Tingting Li, Yifan Xia, Jun Lei, Yan Wang, Lijuan Zhang
Pages: 3034-3040
Published online on: 18 March 2016

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Article

Depletion of G9a gene induces cell apoptosis in human gastric carcinoma

Xiaolei Lin, Yiqun Huang, Yong Zou, Xingsheng Chen, Xudong Ma
Pages: 3041-3049
Published online on: 17 March 2016

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Article

BLCAP arrests G1/S checkpoint and induces apoptosis through downregulation of pRb1 in HeLa cells

Min Zhao, Li Zhang, Xiaoping Qiu, Fanyu Zeng, Wen Chen, Yuehui An, Bicheng Hu, Xufeng Wu, Xinxing Wu
Pages: 3050-3058
Published online on: 17 March 2016

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Article

In vitro and in vivo magnetic resonance imaging with chlorotoxin-conjugated superparamagnetic nanoprobes for targeting hepatocarcinoma

Zhu Chen, En-Hua Xiao, Zhen Kang, Wen-Bin Zeng, Hui-Long Tan, Hua-Bing Li, Du-Jun Bian, Quan-Liang Shang
Pages: 3059-3067
Published online on: 23 February 2016

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Article

GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1

Yang Ma, Chen-Chen Han, Qiong Huang, Wu-Yi Sun, Wei Wei
Pages: 3068-3074
Published online on: 26 February 2016

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Article

Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway

Ruixuan Wang, Lijie Ma, Dan Weng, Jiahui Yao, Xueying Liu, Faguang Jin
Pages: 3075-3083
Published online on: 17 March 2016

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Article

Downregulation of importin-9 protects MCF-7 cells against apoptosis induced by the combination of garlic-derived alliin and paclitaxel

Magdalena Izdebska, Dariusz Grzanka, Maciej Gagat, Marta Hałas-Wiśniewska, Alina Grzanka
Pages: 3084-3093
Published online on: 22 February 2016

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Article

Abnormal expression of leiomyoma cytoskeletal proteins involved in cell migration

Blendi Ura, Federica Scrimin, Giorgio Arrigoni, Emmanouil Athanasakis, Michelangelo Aloisio, Lorenzo Monasta, Giuseppe Ricci
Pages: 3094-3100
Published online on: 17 March 2016

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Article

UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis

Emilie Laure Dubois, Scott Gerber, Alexei Kisselev, Annick Harel-Bellan, Regina Groisman
Pages: 3101-3105
Published online on: 11 March 2016

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Article

Suppression of forkhead box Q1 by microRNA-506 represses the proliferation and epithelial-mesenchymal transition of cervical cancer cells

Mingting Zhang, Qingli Xu, Shufen Yan, Zhigang Li, Wei Yan, Xiaojing Jia
Pages: 3106-3114
Published online on: 03 March 2016

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Article

miR-124 inhibits cell proliferation, migration and invasion by directly targeting SOX9 in lung adenocarcinoma

Xiaoying Wang, Yanli Liu, Xiaoli Liu, Jingyan Yang, Guoxin Teng, Lulu Zhang, Chengjun Zhou
Pages: 3115-3121
Published online on: 03 March 2016

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Article

Mda-7/IL-24 enhances sensitivity of B cell lymphoma to chemotherapy drugs

Ming Ma, Lianmei Zhao, Guogui Sun, Chao Zhang, Lihua Liu, Yanyan Du, Xingxiao Yang, Baoen Shan
Pages: 3122-3130
Published online on: 15 February 2016

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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