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Article

miR-183 functions as an oncogene by targeting ABCA1 in colon cancer

  • Authors:
    • Da-Peng Bi
    • Cheng-Hua Yin
    • Xiao-Yue Zhang
    • Na-Na Yang
    • Jia-You Xu
  • View Affiliations / Copyright

    Affiliations: The Second Department of Internal Medicine, Jinan Second People's Hospital, Jinan, Shandong 250001, P.R. China, Department of General Surgery, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
  • Pages: 2873-2879
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    Published online on: February 23, 2016
       https://doi.org/10.3892/or.2016.4631
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Abstract

Colon cancer remains the second most common cause of cancer-related death, indicating that a proportion of cancer cells are not eradicated by current therapies. Investigation of the molecular mechanisms involved in the development and progression of the disease will aid in the further understanding of the pathogenesis and progression and offer new targets for effective therapies. In the present study, we initially confirmed that ABCA1 was aberrantly expressed in colon cancer tissues and colon cancer cells. Its overexpression inhibited the proliferation of colon cancer HCT116 cells while silencing of ABCA1 promoted the proliferation and inhibited the apoptosis of colon cancer LDL1 cells. Upregulation of specific miRNAs can contribute to the downregulation of tumor-suppressive genes. Thus, we aimed to ascertain whether ABCA1 is downregulated by overexpression of a specific miRNA in colon cancer. We screened microRNAs that may target ABCA1 by miRanda which is a commonly used prediction algorithm. We found that miR-183 targets the 3'UTR of ABCA1 mRNA. Subsequent experiments confirmed that miR-183 degraded ABCA1 mRNA in the colon cancer cells. Finally, we demonstrated that miR-183 promoted the proliferation and inhibited the apoptosis of colon cancer cells. Thus, we conclude that miR-183 promotes proliferation and inhibits apoptosis by degrading ABCA1 in colon cancer.
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1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar

2 

Dessí S, Batetta B, Anchisi C, Pani P, Costelli P, Tessitore L and Baccino FM: Cholesterol metabolism during the growth of a rat ascites hepatoma (Yoshida AH-130). Br J Cancer. 66:787–793. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Dessì S, Batetta B, Pulisci D, Spano O, Anchisi C, Tessitore L, Costelli P, Baccino FM, Aroasio E and Pani P: Cholesterol content in tumor tissues is inversely associated with high-density lipoprotein cholesterol in serum in patients with gastrointestinal cancer. Cancer. 73:253–258. 1994. View Article : Google Scholar : PubMed/NCBI

4 

Kolanjiappan K, Ramachandran CR and Manoharan S: Biochemical changes in tumor tissues of oral cancer patients. Clin Biochem. 36:61–65. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Rudling M and Collins VP: Low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels are coordinately reduced in human renal cell carcinoma. Biochim Biophys Acta. 1299:75–79. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Schaffner CP: Prostatic cholesterol metabolism: Regulation and alteration. Prog Clin Biol Res. 75A:279–324. 1981.PubMed/NCBI

7 

Yoshioka Y, Sasaki J, Yamamoto M, Saitoh K, Nakaya S and Kubokawa M: Quantitation by (1)H-NMR of dolichol, cholesterol and choline-containing lipids in extracts of normal and phathological thyroid tissue. NMR Biomed. 13:377–383. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Järvinen R, Knekt P, Hakulinen T, Rissanen H and Heliövaara M: Dietary fat, cholesterol and colorectal cancer in a prospective study. Br J Cancer. 85:357–361. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Caruso MG, Notarnicola M, Santillo M, Cavallini A and Di Leo A: Enhanced 3-hydroxy-3-methyl-glutaryl coenzyme A reductase activity in human colorectal cancer not expressing low density lipoprotein receptor. Anticancer Res. 19:451–454. 1999.PubMed/NCBI

10 

Caruso MG, Notarnicola M, Cavallini A and Di Leo A: 3-Hydroxy-3-methylglutaryl coenzyme A reductase activity and low-density lipoprotein receptor expression in diffuse-type and intestinal-type human gastric cancer. J Gastroenterol. 37:504–508. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Notarnicola M, Messa C, Pricci M, Guerra V, Altomare DF, Montemurro S and Caruso MG: Up-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in left-sided human colon cancer. Anticancer Res. 24:3837–3842. 2004.

12 

Gregg RG, Davidson M and Wilce PA: Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats. Int J Biochem. 18:389–393. 1986. View Article : Google Scholar : PubMed/NCBI

13 

Hentosh P, Yuh SH, Elson CE and Peffley DM: Sterol-independent regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in tumor cells. Mol Carcinog. 32:154–166. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Siperstein MD: Cholesterol, cholesterogenesis and cancer. Adv Exp Med Biol. 369:155–166. 1995. View Article : Google Scholar : PubMed/NCBI

15 

Graziani SR, Igreja FA, Hegg R, Meneghetti C, Brandizzi LI, Barboza R, Amâncio RF, Pinotti JA and Maranhão RC: Uptake of a cholesterol-rich emulsion by breast cancer. Gynecol Oncol. 85:493–497. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Schimanski S, Wild PJ, Treeck O, Horn F, Sigruener A, Rudolph C, Blaszyk H, Klinkhammer-Schalke M, Ortmann O, Hartmann A, et al: Expression of the lipid transporters ABCA3 and ABCA1 is diminished in human breast cancer tissue. Horm Metab Res. 42:102–109. 2010. View Article : Google Scholar

17 

Tatidis L, Masquelier M and Vitols S: Elevated uptake of low density lipoprotein by drug resistant human leukemic cell lines. Biochem Pharmacol. 63:2169–2180. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Basso K, Margolin AA, Stolovitzky G, Klein U, Dalla-Favera R and Califano A: Reverse engineering of regulatory networks in human B cells. Nat Genet. 37:382–390. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Ki DH, Jeung HC, Park CH, Kang SH, Lee GY, Lee WS, Kim NK, Chung HC and Rha SY: Whole genome analysis for liver metastasis gene signatures in colorectal cancer. Int J Cancer. 121:2005–2012. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Moustafa MA, Ogino D, Nishimura M, Ueda N, Naito S, Furukawa M, Uchida T, Ikai I, Sawada H and Fukumoto M: Comparative analysis of ATP-binding cassette (ABC) transporter gene expression levels in peripheral blood leukocytes and in liver with hepatocellular carcinoma. Cancer Sci. 95:530–536. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Attie AD: ABCA1: At the nexus of cholesterol, HDL and atherosclerosis. Trends Biochem Sci. 32:172–179. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Kim VN: Small RNAs: Classification, biogenesis, and function. Mol Cells. 19:1–15. 2005.PubMed/NCBI

24 

Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE and Näär AM: MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science. 328:1566–1569. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Ramirez CM, Dávalos A, Goedeke L, Salerno AG, Warrier N, Cirera-Salinas D, Suárez Y and Fernández-Hernando C: MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol. 31:2707–2714. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Ramírez CM, Rotllan N, Vlassov AV, Dávalos A, Li M, Goedeke L, Aranda JF, Cirera-Salinas D, Araldi E, Salerno A, et al: Control of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144. Circ Res. 112:1592–1601. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Mendell JT: miRiad roles for the miR-17-92 cluster in development and disease. Cell. 133:217–222. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, et al: MicroRNA expression profiles classify human cancers. Nature. 435:834–838. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Subramanian S, Lui WO, Lee CH, Espinosa I, Nielsen TO, Heinrich MC, Corless CL, Fire AZ and van de Rijn M: MicroRNA expression signature of human sarcomas. Oncogene. 27:2015–2026. 2008. View Article : Google Scholar

30 

Sarver AL, Phalak R, Thayanithy V and Subramanian S: S-MED: Sarcoma microRNA expression database. Lab Invest. 90:753–761. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, Shimizu M, Taccioli C, Zanesi N, Garzon R, Aqeilan RI, et al: miR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci USA. 105:5166–5171. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Sarver AL, Li L and Subramanian S: MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration. Cancer Res. 70:9570–9580. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST and Patel T: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology. 133:647–658. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Zhu S, Wu H, Wu F, Nie D, Sheng S and Mo YY: MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res. 18:350–359. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Zhu S, Si ML, Wu H and Mo YY: MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem. 282:14328–14336. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Wang XW, Xi XQ, Wu J, Wan YY, Hui HX and Cao XF: Micro-RNA-206 attenuates tumor proliferation and migration involving the downregulation of NOTCH3 in colorectal cancer. Oncol Rep. 33:1402–1410. 2015.PubMed/NCBI

37 

Bekker-Méndez C, Guzmán-Aguilar RM, Hernández-Cueto MA, Huerta-Yepez S, Jarillo-Luna RA, González-Veyrand E and González-Bonilla CR: TUNEL-positive cells in the surgical border of an amputation due to infected diabetic foot. Mol Med Rep. 5:363–372. 2012.

38 

Ji F, Zhang H, Wang Y, Li M, Xu W, Kang Y, Wang Z, Wang Z, Cheng P, Tong D, et al: MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1. Bone. 56:220–226. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Zhang H, Cai X, Wang Y, Tang H, Tong D and Ji F: microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2. Oncol Rep. 24:1363–1369. 2010.PubMed/NCBI

40 

Lee RC, Feinbaum RL and Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:843–854. 1993. View Article : Google Scholar : PubMed/NCBI

41 

Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, et al: Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 408:86–89. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR and Ruvkun G: The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 403:901–906. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Farh KK, Grimson A, Jan C, Lewis BP, Johnston WK, Lim LP, Burge CB and Bartel DP: The widespread impact of mammalian microRNAs on mRNA repression and evolution. Science. 310:1817–1821. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, et al: miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol. 12:247–256. 2010.PubMed/NCBI

46 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Center MM, Jemal A, Smith RA and Ward E: Worldwide variations in colorectal cancer. CA Cancer J Clin. 59:366–378. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Heresbach D, Manfredi S, D'halluin PN, Bretagne JF and Branger B: Review in depth and meta-analysis of controlled trials on colorectal cancer screening by faecal occult blood test. Eur J Gastroenterol Hepatol. 18:427–433. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Oram JF and Lawn RM: ABCA1. The gatekeeper for eliminating excess tissue cholesterol. J Lipid Res. 42:1173–1179. 2001.PubMed/NCBI

50 

Kennedy MA, Barrera GC, Nakamura K, Baldán A, Tarr P, Fishbein MC, Frank J, Francone OL and Edwards PA: ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metab. 1:121–131. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Solomon KR, Allott EH, Freeman MR and Freedland SJ: Words of wisdom. Re: Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1. Eur Urol. 63:1128–1129. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Liang Z, Gao Y, Shi W, Zhai D, Li S, Jing L, Guo H, Liu T, Wang Y and Du Z: Expression and significance of microRNA-183 in hepatocellular carcinoma. Scientific World Journal. 2013:3818742013. View Article : Google Scholar : PubMed/NCBI

53 

Ueno K, Hirata H, Shahryari V, Deng G, Tanaka Y, Tabatabai ZL, Hinoda Y and Dahiya R: microRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer. Br J Cancer. 108:1659–1667. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Li J, Fu H, Xu C, Tie Y, Xing R, Zhu J, Qin Y, Sun Z and Zheng X: miR-183 inhibits TGF-beta1-induced apoptosis by downregulation of PDCD4 expression in human hepatocellular carcinoma cells. BMC Cancer. 10:3542010. View Article : Google Scholar : PubMed/NCBI

55 

Zhou T, Zhang GJ, Zhou H, Xiao HX and Li Y: Overexpression of microRNA-183 in human colorectal cancer and its clinical significance. Eur J Gastroenterol Hepatol. 26:229–233. 2014. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Bi D, Yin C, Zhang X, Yang N and Xu J: miR-183 functions as an oncogene by targeting ABCA1 in colon cancer. Oncol Rep 35: 2873-2879, 2016.
APA
Bi, D., Yin, C., Zhang, X., Yang, N., & Xu, J. (2016). miR-183 functions as an oncogene by targeting ABCA1 in colon cancer. Oncology Reports, 35, 2873-2879. https://doi.org/10.3892/or.2016.4631
MLA
Bi, D., Yin, C., Zhang, X., Yang, N., Xu, J."miR-183 functions as an oncogene by targeting ABCA1 in colon cancer". Oncology Reports 35.5 (2016): 2873-2879.
Chicago
Bi, D., Yin, C., Zhang, X., Yang, N., Xu, J."miR-183 functions as an oncogene by targeting ABCA1 in colon cancer". Oncology Reports 35, no. 5 (2016): 2873-2879. https://doi.org/10.3892/or.2016.4631
Copy and paste a formatted citation
x
Spandidos Publications style
Bi D, Yin C, Zhang X, Yang N and Xu J: miR-183 functions as an oncogene by targeting ABCA1 in colon cancer. Oncol Rep 35: 2873-2879, 2016.
APA
Bi, D., Yin, C., Zhang, X., Yang, N., & Xu, J. (2016). miR-183 functions as an oncogene by targeting ABCA1 in colon cancer. Oncology Reports, 35, 2873-2879. https://doi.org/10.3892/or.2016.4631
MLA
Bi, D., Yin, C., Zhang, X., Yang, N., Xu, J."miR-183 functions as an oncogene by targeting ABCA1 in colon cancer". Oncology Reports 35.5 (2016): 2873-2879.
Chicago
Bi, D., Yin, C., Zhang, X., Yang, N., Xu, J."miR-183 functions as an oncogene by targeting ABCA1 in colon cancer". Oncology Reports 35, no. 5 (2016): 2873-2879. https://doi.org/10.3892/or.2016.4631
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