|
1
|
Xu D, Tan J, Zhou M, Jiang B, Xie H, Nie
X, Xia K and Zhou J: Let-7b and microRNA-199a inhibit the
proliferation of B16F10 melanoma cells. Oncol Lett. 4:941–946.
2012.PubMed/NCBI
|
|
2
|
Thompson JF, Scolyer RA and Kefford RF:
Cutaneous melanoma. Lancet. 365:687–701. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Hanahan D and Weinberg RA: Hallmarks of
cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Stathem M, Marimuthu S, O'Neal J, Rathmell
JC, Chesney JA, Beverly LJ and Siskind LJ: Glucose availability and
glycolytic metabolism dictate glycosphingolipid levels. J Cell
Biochem. 116:67–80. 2015. View Article : Google Scholar
|
|
5
|
Vander Heiden MG, Cantley LC and Thompson
CB: Understanding the Warburg effect: The metabolic requirements of
cell proliferation. Science. 324:1029–1033. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Warburg O: On the origin of cancer cells.
Science. 123:309–314. 1956. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Hannun YA and Obeid LM: Principles of
bioactive lipid signalling: Lessons from sphingolipids. Nat Rev Mol
Cell Biol. 9:139–150. 2008. View
Article : Google Scholar : PubMed/NCBI
|
|
8
|
Ogretmen B: Sphingolipids in cancer:
Regulation of pathogenesis and therapy. FEBS Lett. 580:5467–5476.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Ogretmen B and Hannun YA: Biologically
active sphingolipids in cancer pathogenesis and treatment. Nat Rev
Cancer. 4:604–616. 2004. View
Article : Google Scholar : PubMed/NCBI
|
|
10
|
Mathias S, Peña LA and Kolesnick RN:
Signal transduction of stress via ceramide. Biochem J. 335:465–480.
1998. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Knapp P, Baranowski M, Knapp M, Zabielski
P, Błachnio-Zabielska AU and Górski J: Altered sphingolipid
metabolism in human endometrial cancer. Prostaglandins Other Lipid
Mediat. 92:62–66. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Wu J, Cheng Y, Nilsson A and Duan RD:
Identification of one exon deletion of intestinal alkaline
sphingomyelinase in colon cancer HT-29 cells and a
differentiation-related expression of the wild-type enzyme in
Caco-2 cells. Carcinogenesis. 25:1327–1333. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Bektas M, Jolly PS, Müller C, Eberle J,
Spiegel S and Geilen CC: Sphingosine kinase activity counteracts
ceramide-mediated cell death in human melanoma cells: Role of Bcl-2
expression. Oncogene. 24:178–187. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Samsel L, Zaidel G, Drumgoole HM, Jelovac
D, Drachenberg C, Rhee JG, Brodie AM, Bielawska A and Smyth MJ: The
ceramide analog, B13, induces apoptosis in prostate cancer cell
lines and inhibits tumor growth in prostate cancer xenografts.
Prostate. 58:382–393. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Gouazé V, Liu YY, Prickett CS, Yu JY,
Giuliano AE and Cabot MC: Glucosylceramide synthase blockade
down-regulates P-glycoprotein and resensitizes multidrug-resistant
breast cancer cells to anticancer drugs. Cancer Res. 65:3861–3867.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Levy M and Futerman AH: Mammalian ceramide
synthases. IUBMB Life. 62:347–356. 2010.PubMed/NCBI
|
|
17
|
Pewzner-Jung Y, Ben-Dor S and Futerman AH:
When do Lasses (longevity assurance genes) become CerS (ceramide
synthases)?: Insights into the regulation of ceramide synthesis. J
Biol Chem. 281:25001–25005. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Teufel A, Maass T, Galle PR and Malik N:
The longevity assurance homologue of yeast lag1 (Lass) gene family
(Review). Int J Mol Med. 23:135–140. 2009.PubMed/NCBI
|
|
19
|
Harel R and Futerman AH: Inhibition of
sphingolipid synthesis affects axonal outgrowth in cultured
hippocampal neurons. J Biol Chem. 268:14476–14481. 1993.PubMed/NCBI
|
|
20
|
Bose R, Verheij M, Haimovitz-Friedman A,
Scotto K, Fuks Z and Kolesnick R: Ceramide synthase mediates
daunorubicin-induced apoptosis: An alternative mechanism for
generating death signals. Cell. 82:405–414. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Spassieva SD, Mullen TD, Townsend DM and
Obeid LM: Disruption of ceramide synthesis by CerS2 down-regulation
leads to autophagy and the unfolded protein response. Biochem J.
424:273–283. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
White-Gilbertson S, Mullen T, Senkal C, Lu
P, Ogretmen B, Obeid L and Voelkel-Johnson C: Ceramide synthase 6
modulates TRAIL sensitivity and nuclear translocation of active
caspase-3 in colon cancer cells. Oncogene. 28:1132–1141. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Senkal CE, Ponnusamy S, Rossi MJ,
Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA and
Ogretmen B: Role of human longevity assurance gene 1 and
C18-ceramide in chemotherapy-induced cell death in human
head and neck squamous cell carcinomas. Mol Cancer Ther. 6:712–722.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Senkal CE, Ponnusamy S, Bielawski J,
Hannun YA and Ogretmen B: Antiapoptotic roles of
ceramide-synthase-6-generated C16-ceramide via selective
regulation of the ATF6/CHOP arm of ER-stress-response pathways.
FASEB J. 24:296–308. 2010. View Article : Google Scholar :
|
|
25
|
Zhou J, Liu R, Wang Y, Tang J, Tang S,
Chen X, Xia K, Xiong W, Xu D, Wang S, et al: miR-199a-5p regulates
the expression of metastasis-associated genes in B16F10 melanoma
cells. Int J Clin Exp Pathol. 7:7182–7190. 2014.PubMed/NCBI
|
|
26
|
Zhou J, Xu D, Xie H, Tang J, Liu R, Li J,
Wang S, Chen X, Su J, Zhou X, Xia K, He Q, Chen J, Xiong W, Cao P
and Cao K: miR-33a functions as a tumor suppressor in melanoma by
targeting HIF-1α. Cancer Biol Ther. 16:846–855. 2015. View Article : Google Scholar
|
|
27
|
Zhang Y, Liu H, Jin J, Zhu X, Lu L and
Jiang H: The role of endogenous reactive oxygen species in
oxymatrine-induced caspase-3-dependent apoptosis in human melanoma
A375 cells. Anticancer Drugs. 21:494–501. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Sun J, Han J, Zhu Q, Li Z and Hu J:
Camptothecin fails to induce apoptosis in tumor necrosis
factor-alpha-treated HaCaT cells. Pharmacology. 89:58–63. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Koybasi S, Senkal CE, Sundararaj K,
Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM,
Hannun YA, et al: Defects in cell growth regulation by
C18:0-ceramide and longevity assurance gene 1 in human
head and neck squamous cell carcinomas. J Biol Chem.
279:44311–44319. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Karahatay S, Thomas K, Koybasi S, Senkal
CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D,
et al: Clinical relevance of ceramide metabolism in the
pathogenesis of human head and neck squamous cell carcinoma
(HNSCC): Attenuation of C18-ceramide in HNSCC tumors
correlates with lymphovascular invasion and nodal metastasis.
Cancer Lett. 256:101–111. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Weinmann A, Galle PR and Teufel A: LASS6,
an additional member of the longevity assurance gene family. Int J
Mol Med. 16:905–910. 2005.PubMed/NCBI
|
|
32
|
Novgorodov SA, Chudakova DA, Wheeler BW,
Bielawski J, Kindy MS, Obeid LM and Gudz TI: Developmentally
regulated ceramide synthase 6 increases mitochondrial
Ca2+ loading capacity and promotes apoptosis. J Biol
Chem. 286:4644–4658. 2011. View Article : Google Scholar :
|
|
33
|
Sherwood V, Chaurasiya SK, Ekström EJ,
Guilmain W, Liu Q, Koeck T, Brown K, Hansson K, Agnarsdóttir M,
Bergqvist M, et al: WNT5A-mediated β-catenin-independent signalling
is a novel regulator of cancer cell metabolism. Carcinogenesis.
35:784–794. 2014. View Article : Google Scholar :
|
|
34
|
Grossmann AH, Yoo JH, Clancy J, Sorensen
LK, Sedgwick A, Tong Z, Ostanin K, Rogers A, Grossmann KF, Tripp
SR, et al: The small GTPase ARF6 stimulates β-catenin
transcriptional activity during WNT5A-mediated melanoma invasion
and metastasis. Sci Signal. 6:ra142013. View Article : Google Scholar
|
|
35
|
Mullen TD, Spassieva S, Jenkins RW,
Kitatani K, Bielawski J, Hannun YA and Obeid LM: Selective
knockdown of ceramide synthases reveals complex interregulation of
sphingolipid metabolism. J Lipid Res. 52:68–77. 2011. View Article : Google Scholar :
|
