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Article

Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas

  • Authors:
    • Lenka Zlamalikova
    • Mojmir Moulis
    • David Salek
    • Jiri Jarkovsky
    • Jan Smarda
    • Jana Smardova
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, University Hospital, 625 00 Brno, Czech Republic, Department of Hematooncology, University Hospital, 625 00 Brno, Czech Republic, Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic, Department of Experimental Biology, Faculty of Science, Masaryk University, 611 37 Brno, Czech Republic
  • Pages: 2673-2680
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    Published online on: March 7, 2016
       https://doi.org/10.3892/or.2016.4658
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Abstract

D-type cyclins are involved in cell cycle regulation and play an important role in the pathogenesis of lymphomas. Aberrant expression of cyclin D1 is associated with mantle cell lymphoma (MCL) and serves as a diagnostic marker of MCL. Analysis of cyclin D expression in tumor tissues of patients with diffuse large B-cell lymphoma (DLBCL) which comprises a heterogeneous group of tumors may contribute to their stratification. We analyzed expression of cyclin D1, D2, and D3 mRNAs in 30 MCL and 104 DLBCL patients using qRT-PCR and addressed their significance for disease outcome. We confirmed a high level of cyclin D1 mRNA in 29 MCL cases (97%). One case (3%) was identified as positive for cyclin D2. Expression of cyclin D1 was limited to MCL and did not occur in DLBCL. Overexpression of cyclin D2, which is rare in MCL, occurred more frequently in DLBCL (11 cases, 10.6%). We showed that high expression of cyclin D2 in DLBCL cases de novo decreased the overall survival rate (P=0.016) and progression-free survival (P=0.009). The expression pattern of cyclin D3 was similar in both types of studied lymphomas and it did not affect the disease outcome.
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Copy and paste a formatted citation
Spandidos Publications style
Zlamalikova L, Moulis M, Salek D, Jarkovsky J, Smarda J and Smardova J: Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas. Oncol Rep 35: 2673-2680, 2016.
APA
Zlamalikova, L., Moulis, M., Salek, D., Jarkovsky, J., Smarda, J., & Smardova, J. (2016). Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas. Oncology Reports, 35, 2673-2680. https://doi.org/10.3892/or.2016.4658
MLA
Zlamalikova, L., Moulis, M., Salek, D., Jarkovsky, J., Smarda, J., Smardova, J."Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas". Oncology Reports 35.5 (2016): 2673-2680.
Chicago
Zlamalikova, L., Moulis, M., Salek, D., Jarkovsky, J., Smarda, J., Smardova, J."Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas". Oncology Reports 35, no. 5 (2016): 2673-2680. https://doi.org/10.3892/or.2016.4658
Copy and paste a formatted citation
x
Spandidos Publications style
Zlamalikova L, Moulis M, Salek D, Jarkovsky J, Smarda J and Smardova J: Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas. Oncol Rep 35: 2673-2680, 2016.
APA
Zlamalikova, L., Moulis, M., Salek, D., Jarkovsky, J., Smarda, J., & Smardova, J. (2016). Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas. Oncology Reports, 35, 2673-2680. https://doi.org/10.3892/or.2016.4658
MLA
Zlamalikova, L., Moulis, M., Salek, D., Jarkovsky, J., Smarda, J., Smardova, J."Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas". Oncology Reports 35.5 (2016): 2673-2680.
Chicago
Zlamalikova, L., Moulis, M., Salek, D., Jarkovsky, J., Smarda, J., Smardova, J."Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas". Oncology Reports 35, no. 5 (2016): 2673-2680. https://doi.org/10.3892/or.2016.4658
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