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Article

Depletion of G9a gene induces cell apoptosis in human gastric carcinoma

  • Authors:
    • Xiaolei Lin
    • Yiqun Huang
    • Yong Zou
    • Xingsheng Chen
    • Xudong Ma
  • View Affiliations / Copyright

    Affiliations: Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, P.R. China, United Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. China
  • Pages: 3041-3049
    |
    Published online on: March 17, 2016
       https://doi.org/10.3892/or.2016.4692
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Abstract

G9a is a mammalian histone methyltransferase that contributes to the epigenetic silencing of tumor suppressor genes. Evidence suggests that G9a is required to maintain the malignant phenotype, but little documentation show the role of G9a function in mediating tumor growth. We retrospectively analyzed the protein of G9a and monomethylated histone H3 lysine 9 (H3K9 me1), and dimethylated histone H3 lysine 9 (H3K9 me2) in 175 cases of gastric carcinoma by immunohistochemistry. RNAi-based inhibition of G9a in MGC803 cancer cell line was studied. G9a depletion was done by transient transfection using Lipofectamine 2000. Depletion efficiency of G9a was tested using real-time PCR and western blot analysis. Cell apoptosis and proliferation were detected by TUNEL assay and MTT, respectively. The proteins of H3K9 me1, me2, trimethylation of H3K9 (H3K9 me3), monomethylated histone H3 lysine 27 (H3K27 me1), dimethylated histone H3 lysine 27 (H3K27 me2) and histone acetylated H3, apoptotic proteins were studied by western blot analysis. G9a and H3K9 me2 expression was higher in gastric cancer cells compared to the control (p<0.05). Both G9a and H3K9 me2 were positively correlated with the degree of differentiation, depth of infiltration, lymphatic invasions and tumor-node-metastasis stage in gastric carcinoma, (p<0.05). RNAi-mediated knockdown of G9a induced cell apoptosis and inhibited cell proliferation. Depletion of G9a reduced the levels of H3K9 me1 and me2, H3K27 me1 and me2. Nonetheless, it did not activate acetylation of H3 and H3K9 me3. These data suggest that G9a is required in tumorigenesis, and correlated with prognosis. Furthermore, G9a plays a critical role in regulating epigenetics. Depletion of G9a inhibits cell growth and induces cells apoptosis in gastric cancer. It might be of therapeutic benefit in gastric cancers.
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1 

Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC and Kouzarides T: Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature. 410:120–124. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Jacobs SA, Taverna SD, Zhang Y, Briggs SD, Li J, Eissenberg JC, Allis CD and Khorasanizadeh S: Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3. EMBO J. 20:5232–5241. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Lachner M, O'Carroll D, Rea S, Mechtler K and Jenuwein T: Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature. 410:116–120. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Kouzarides T: Chromatin modifications and their function. Cell. 128:693–705. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Schneider R, Bannister AJ and Kouzarides T: Unsafe SETs: Histone lysine methyltransferases and cancer. Trends Biochem Sci. 27:396–402. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Aagaard L, Schmid M, Warburton P and Jenuwein T: Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres. J Cell Sci. 113:817–829. 2000.PubMed/NCBI

7 

Aagaard L, Laible G, Selenko P, Schmid M, Dorn R, Schotta G, Kuhfittig S, Wolf A, Lebersorger A, Singh PB, et al: Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 18:1923–1938. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Melcher M, Schmid M, Aagaard L, Selenko P, Laible G and Jenuwein T: Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression. Mol Cell Biol. 20:3728–3741. 2000. View Article : Google Scholar : PubMed/NCBI

9 

O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, et al: Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. Mol Cell Biol. 20:9423–9433. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Tachibana M, Sugimoto K, Fukushima T and Shinkai Y: Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J Biol Chem. 276:25309–25317. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, et al: G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 16:1779–1791. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Estève PO, Patnaik D, Chin HG, Benner J, Teitell MA and Pradhan S: Functional analysis of the N- and C-terminus of mammalian G9a histone H3 methyltransferase. Nucleic Acids Res. 33:3211–3223. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Dong KB, Maksakova IA, Mohn F, Leung D, Appanah R, Lee S, Yang HW, Lam LL, Mager DL, Schübeler D, et al: DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J. 27:2691–2701. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Ikegami K, Iwatani M, Suzuki M, Tachibana M, Shinkai Y, Tanaka S, Greally JM, Yagi S, Hattori N and Shiota K: Genome-wide and locus-specific DNA hypomethylation in G9a deficient mouse embryonic stem cells. Genes Cells. 12:1–11. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Ma X, Fang Y, Beklemisheva A, Dai W, Feng J, Ahmed T, Liu D and Chiao JW: Phenylhexyl isothiocyanate inhibits histone deacetylases and remodels chromatins to induce growth arrest in human leukemia cells. Int J Oncol. 28:1287–1293. 2006.PubMed/NCBI

16 

Lachner M, Sengupta R, Schotta G and Jenuwein T: Trilogies of histone lysine methylation as epigenetic landmarks of the eukaryotic genome. Cold Spring Harb Symp Quant Biol. 69:209–218. 2004. View Article : Google Scholar

17 

Jenuwein T: The epigenetic magic of histone lysine methylation. FEBS J. 273:3121–3135. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Santos-Rosa H, Schneider R, Bannister AJ, Sherriff J, Bernstein BE, Emre NC, Schreiber SL, Mellor J and Kouzarides T: Active genes are tri-methylated at K4 of histone H3. Nature. 419:407–411. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Chen MW, Hua KT, Kao HJ, Chi CC, Wei LH, Johansson G, Shiah SG, Chen PS, Jeng YM, Cheng TY, et al: H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res. 70:7830–7840. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Yuan Y, Tang AJ, Castoreno AB, Kuo SY, Wang Q, Kuballa P, Xavier R, Shamji AF, Schreiber SL and Wagner BK: Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death Dis. 4:e6902013. View Article : Google Scholar : PubMed/NCBI

21 

Kondo Y, Shen L, Suzuki S, Kurokawa T, Masuko K, Tanaka Y, Kato H, Mizuno Y, Yokoe M, Sugauchi F, et al: Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas. Hepatol Res. 37:974–983. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Cai L, Ma X, Huang Y, Zou Y and Chen X: Aberrant histone methylation and the effect of Suv39H1 siRNA on gastric carcinoma. Oncol Rep. 31:2593–2600. 2014.PubMed/NCBI

23 

Steeg PS: Metastasis suppressors alter the signal transduction of cancer cells. Nat Rev Cancer. 3:55–63. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Seligson DB, Horvath S, Shi T, Yu H, Tze S, Grunstein M and Kurdistani SK: Global histone modification patterns predict risk of prostate cancer recurrence. Nature. 435:1262–1266. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Park YS, Jin MY, Kim YJ, Yook JH, Kim BS and Jang SJ: The global histone modification pattern correlates with cancer recurrence and overall survival in gastric adenocarcinoma. Ann Surg Oncol. 15:1968–1976. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Wei Y, Xia W, Zhang Z, Liu J, Wang H, Adsay NV, Albarracin C, Yu D, Abbruzzese JL, Mills GB, et al: Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. Mol Carcinog. 47:701–706. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Ding L, Erdmann C, Chinnaiyan AM, Merajver SD and Kleer CG: Identification of EZH2 as a molecular marker for a precancerous state in morphologically normal breast tissues. Cancer Res. 66:4095–4099. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Bryant RJ, Cross NA, Eaton CL, Hamdy FC and Cunliffe VT: EZH2 promotes proliferation and invasiveness of prostate cancer cells. Prostate. 67:547–556. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Choi JH, Song YS, Yoon JS, Song KW and Lee YY: Enhancer of zeste homolog 2 expression is associated with tumor cell proliferation and metastasis in gastric cancer. APMIS. 118:196–202. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, Macconaill LE, Beroukhim R, et al: An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat Med. 16:286–294. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Watanabe H, Soejima K, Yasuda H, Kawada I, Nakachi I, Yoda S, Naoki K and Ishizaka A: Deregulation of histone lysine methyl-transferases contributes to oncogenic transformation of human bronchoepithelial cells. Cancer Cell Int. 8:152008. View Article : Google Scholar

32 

Wozniak RJ, Klimecki WT, Lau SS, Feinstein Y and Futscher BW: 5-Aza-2′-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation. Oncogene. 26:77–90. 2007. View Article : Google Scholar

33 

Xin ZH, Ma HL, Wu SY and Dai CH: Determination of the inhibitory activity of angiotensin-converting enzyme inhibitor captopril by high performance capillary electrophoresis. Yao Xue Xue Bao. 38:843–845. 2003.In Chinese.

34 

Bachman KE, Park BH, Rhee I, Rajagopalan H, Herman JG, Baylin SB, Kinzler KW and Vogelstein B: Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell. 3:89–95. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Collins R and Cheng X: A case study in cross-talk: The histone lysine methyltransferases G9a and GLP. Nucleic Acids Res. 38:3503–3511. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Lee SH, Kim J, Kim WH and Lee YM: Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. Oncogene. 28:184–194. 2009. View Article : Google Scholar

37 

Estève PO, Chin HG, Smallwood A, Feehery GR, Gangisetty O, Karpf AR, Carey MF and Pradhan S: Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication. Genes Dev. 20:3089–3103. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Martin C and Zhang Y: The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol. 6:838–849. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Kondo Y, Shen L, Ahmed S, Boumber Y, Sekido Y, Haddad BR and Issa JP: Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells. PLoS One. 3:e20372008. View Article : Google Scholar : PubMed/NCBI

40 

Czermin B, Schotta G, Hülsmann BB, Brehm A, Becker PB, Reuter G and Imhof A: Physical and functional association of SU(VAR)3–9 and HDAC1 in Drosophila. EMBO Rep. 2:915–919. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lin X, Huang Y, Zou Y, Chen X and Ma X: Depletion of G9a gene induces cell apoptosis in human gastric carcinoma. Oncol Rep 35: 3041-3049, 2016.
APA
Lin, X., Huang, Y., Zou, Y., Chen, X., & Ma, X. (2016). Depletion of G9a gene induces cell apoptosis in human gastric carcinoma. Oncology Reports, 35, 3041-3049. https://doi.org/10.3892/or.2016.4692
MLA
Lin, X., Huang, Y., Zou, Y., Chen, X., Ma, X."Depletion of G9a gene induces cell apoptosis in human gastric carcinoma". Oncology Reports 35.5 (2016): 3041-3049.
Chicago
Lin, X., Huang, Y., Zou, Y., Chen, X., Ma, X."Depletion of G9a gene induces cell apoptosis in human gastric carcinoma". Oncology Reports 35, no. 5 (2016): 3041-3049. https://doi.org/10.3892/or.2016.4692
Copy and paste a formatted citation
x
Spandidos Publications style
Lin X, Huang Y, Zou Y, Chen X and Ma X: Depletion of G9a gene induces cell apoptosis in human gastric carcinoma. Oncol Rep 35: 3041-3049, 2016.
APA
Lin, X., Huang, Y., Zou, Y., Chen, X., & Ma, X. (2016). Depletion of G9a gene induces cell apoptosis in human gastric carcinoma. Oncology Reports, 35, 3041-3049. https://doi.org/10.3892/or.2016.4692
MLA
Lin, X., Huang, Y., Zou, Y., Chen, X., Ma, X."Depletion of G9a gene induces cell apoptosis in human gastric carcinoma". Oncology Reports 35.5 (2016): 3041-3049.
Chicago
Lin, X., Huang, Y., Zou, Y., Chen, X., Ma, X."Depletion of G9a gene induces cell apoptosis in human gastric carcinoma". Oncology Reports 35, no. 5 (2016): 3041-3049. https://doi.org/10.3892/or.2016.4692
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