|
1
|
Mathew R, Karp CM, Beaudoin B, Vuong N,
Chen G, Chen HY, Bray K, Reddy A, Bhanot G, Gelinas C, et al:
Autophagy suppresses tumorigenesis through elimination of p62.
Cell. 137:1062–1075. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Tang YC, Williams BR, Siegel JJ and Amon
A: Identification of aneuploidy-selective antiproliferation
compounds. Cell. 144:499–512. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Courtois-Cox S, Genther Williams SM,
Reczek EE, Johnson BW, McGillicuddy LT, Johannessen CM, Hollstein
PE, MacCollin M and Cichowski K: A negative feedback signaling
network underlies oncogene-induced senescence. Cancer Cell.
10:459–472. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Young AR, Narita M, Ferreira M, Kirschner
K, Sadaie M, Darot JF, Tavaré S, Arakawa S, Shimizu S, Watt FM, et
al: Autophagy mediates the mitotic senescence transition. Genes
Dev. 23:798–803. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Rong Y, McPhee CK, Deng S, Huang L, Chen
L, Liu M, Tracy K, Baehrecke EH, Yu L and Lenardo MJ: Spinster is
required for autophagic lysosome reformation and mTOR reactivation
following starvation. Proc Natl Acad Sci USA. 108:7826–7831. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Narita M, Young AR, Arakawa S, Samarajiwa
SA, Nakashima T, Yoshida S, Hong S, Berry LS, Reichelt S, Ferreira
M, et al: Spatial coupling of mTOR and autophagy augments secretory
phenotypes. Science. 332:966–970. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Guo JY, Chen HY, Mathew R, Fan J,
Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM,
Karantza V, et al: Activated Ras requires autophagy to maintain
oxidative metabolism and tumorigenesis. Genes Dev. 25:460–470.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Flier JS, Mueckler MM, Usher P and Lodish
HF: Elevated levels of glucose transport and transporter messenger
RNA are induced by ras or src oncogenes. Science. 235:1492–1495.
1987. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Greer EL, Oskoui PR, Banko MR, Maniar JM,
Gygi MP, Gygi SP and Brunet A: The energy sensor AMP-activated
protein kinase directly regulates the mammalian FOXO3 transcription
factor. J Biol Chem. 282:30107–30119. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
García-Escudero V and Gargini R: Autophagy
induction as an efficient strategy to eradicate tumors. Autophagy.
4:923–925. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Gargini R, García-Escudero V and Izquierdo
M: Therapy mediated by mitophagy abrogates tumor progression.
Autophagy. 7:466–476. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Nikiforov MA, Riblett M, Tang WH,
Gratchouck V, Zhuang D, Fernandez Y, Verhaegen M, Varambally S,
Chinnaiyan AM, Jakubowiak AJ, et al: Tumor cell-selective
regulation of NOXA by c-MYC in response to proteasome inhibition.
Proc Natl Acad Sci USA. 104:19488–19493. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Beauséjour CM, Krtolica A, Galimi F,
Narita M, Lowe SW, Yaswen P and Campisi J: Reversal of human
cellular senescence: Roles of the p53 and p16 pathways. EMBO J.
22:4212–4222. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Amaravadi RK, Yu D, Lum JJ, Bui T,
Christophorou MA, Evan GI, Thomas-Tikhonenko A and Thompson CB:
Autophagy inhibition enhances therapy-induced apoptosis in a
Myc-induced model of lymphoma. J Clin Invest. 117:326–336. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Thibodeaux CA, Liu X, Disbrow GL, Zhang Y,
Rone JD, Haddad BR and Schlegel R: Immortalization and
transformation of human mammary epithelial cells by a tumor-derived
Myc mutant. Breast Cancer Res Treat. 116:281–294. 2009. View Article : Google Scholar
|
|
16
|
Datta S, Hoenerhoff MJ, Bommi P, Sainger
R, Guo WJ, Dimri M, Band H, Band V, Green JE and Dimri GP: Bmi-1
cooperates with H-Ras to transform human mammary epithelial cells
via dysregulation of multiple growth-regulatory pathways. Cancer
Res. 67:10286–10295. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Pankiv S, Clausen TH, Lamark T, Brech A,
Bruun JA, Outzen H, Øvervatn A, Bjørkøy G and Johansen T:
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of
ubiquitinated protein aggregates by autophagy. J Biol Chem.
282:24131–24145. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Duran A, Linares JF, Galvez AS,
Wikenheiser K, Flores JM, Diaz-Meco MT and Moscat J: The signaling
adaptor p62 is an important NF-kappaB mediator in tumorigenesis.
Cancer Cell. 13:343–354. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Mammucari C, Milan G, Romanello V, Masiero
E, Rudolf R, Del Piccolo P, Burden SJ, Di Lisi R, Sandri C, Zhao J,
et al: FoxO3 controls autophagy in skeletal muscle in vivo. Cell
Metab. 6:458–471. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Zhao J, Brault JJ, Schild A, Cao P, Sandri
M, Schiaffino S, Lecker SH and Goldberg AL: FoxO3 coordinately
activates protein degradation by the autophagic/lysosomal and
proteasomal pathways in atrophying muscle cells. Cell Metab.
6:472–483. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Maclean KH, Dorsey FC, Cleveland JL and
Kastan MB: Targeting lysosomal degradation induces p53-dependent
cell death and prevents cancer in mouse models of lymphomagenesis.
J Clin Invest. 118:79–88. 2008. View
Article : Google Scholar
|
|
22
|
Kanzawa T, Zhang L, Xiao L, Germano IM,
Kondo Y and Kondo S: Arsenic trioxide induces autophagic cell death
in malignant glioma cells by upregulation of mitochondrial cell
death protein BNIP3. Oncogene. 24:980–991. 2005. View Article : Google Scholar
|
|
23
|
Chang CP, Yang MC, Liu HS, Lin YS and Lei
HY: Concanavalin A induces autophagy in hepatoma cells and has a
therapeutic effect in a murine in situ hepatoma model. Hepatology.
45:286–296. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
García-Escudero V, Gargini R and Izquierdo
M: Glioma regression in vitro and in vivo by a suicide combined
treatment. Mol Cancer Res. 6:407–417. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Kim H, Farris J, Christman SA, Kong BW,
Foster LK, O'Grady SM and Foster DN: Events in the immortalizing
process of primary human mammary epithelial cells by the catalytic
subunit of human telomerase. Biochem J. 365:765–772. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Levine AJ and Puzio-Kuter AM: The control
of the metabolic switch in cancers by oncogenes and tumor
suppressor genes. Science. 330:1340–1344. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Jeon SM, Chandel NS and Hay N: AMPK
regulates NADPH homeostasis to promote tumour cell survival during
energy stress. Nature. 485:661–665. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Dang CV: Links between metabolism and
cancer. Genes Dev. 26:877–890. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Lin A, Yao J, Zhuang L, Wang D, Han J, Lam
EW and Gan B: The FoxO-BNIP3 axis exerts a unique regulation of
mTORC1 and cell survival under energy stress. Oncogene.
33:3183–3194. 2014. View Article : Google Scholar
|
|
30
|
Yogalingam G and Pendergast AM: Abl
kinases regulate autophagy by promoting the trafficking and
function of lysosomal components. J Biol Chem. 283:35941–35953.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Turcotte S, Chan DA, Sutphin PD, Hay MP,
Denny WA and Giaccia AJ: A molecule targeting VHL-deficient renal
cell carcinoma that induces autophagy. Cancer Cell. 14:90–102.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Weihua Z, Tsan R, Huang WC, Wu Q, Chiu CH,
Fidler IJ and Hung MC: Survival of cancer cells is maintained by
EGFR independent of its kinase activity. Cancer Cell. 13:385–393.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Lu Z, Luo RZ, Lu Y, Zhang X, Yu Q, Khare
S, Kondo S, Kondo Y, Yu Y, Mills GB, et al: The tumor suppressor
gene ARHI regulates autophagy and tumor dormancy in human ovarian
cancer cells. J Clin Invest. 118:3917–3929. 2008.PubMed/NCBI
|
