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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2016 Volume 35 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Inhibition of β2-adrenergic receptor reduces triple-negative breast cancer brain metastases: The potential benefit of perioperative β-blockade

Cecilia Choy, John L. Raytis, David D. Smith, Matthew Duenas, Josh Neman, Rahul Jandial, Michael W. Lew
Pages: 3135-3142
Published online on: 28 March 2016

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Article Open Access

Expression of tropomyosin 2 gene isoforms in human breast cancer cell lines

Syamalima Dube, Anish Thomas, Lynn Abbott, Patricia Benz, Charles Mitschow, Dipak K. Dube, Bernard J. Poiesz
Pages: 3143-3150
Published online on: 04 April 2016

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Article Open Access

Low dose of GRP78-targeting subtilase cytotoxin improves the efficacy of photodynamic therapy in vivo

Magdalena Gabrysiak, Malgorzata Wachowska, Joanna Barankiewicz, Zofia Pilch, Anna Ratajska, Ewa Skrzypek, Magdalena Winiarska, Antoni Domagala, Tomasz P. Rygiel, Alicja Jozkowicz, Louis Boon, Jakub Golab, Malgorzata Firczuk
Pages: 3151-3158
Published online on: 01 April 2016

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Article Open Access

Enhanced tumor retention of radioiodinated anti-epidermal growth factor receptor antibody using novel bifunctional iodination linker for radioimmunotherapy

Eun Jung Kim, Byoung Soo Kim, Dan Bee Choi, Sung-Gil Chi, Tae Hyun Choi
Pages: 3159-3168
Published online on: 24 March 2016

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Article Open Access

Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium

Fumi Utsumi, Hiroaki Kajiyama, Kae Nakamura, Hiromasa Tanaka, Masaaki Mizuno, Shinnya Toyokuni, Masaru Hori, Fumitaka Kikkawa
Pages: 3169-3177
Published online on: 01 April 2016

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Article Open Access

Tumor-suppressing roles of miR-214 and miR-218 in breast cancer

Bo Liu, Yanfeng Tian, Fang Li, Zengren Zhao, Xia Jiang, Congjie Zhai, Xiaodong Han, Like Zhang
Pages: 3178-3184
Published online on: 15 April 2016

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Article Open Access

Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer

Chunliang Shang, Wenhui Zhu, Tianyu Liu, Wei Wang, Guangxin Huang, Jiaming Huang, Peizhen Zhao, Yunhe Zhao, Shuzhong Yao
Pages: 3185-3197
Published online on: 29 March 2016

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Article Open Access

Dual oxidase 1: A predictive tool for the prognosis of hepatocellular carcinoma patients

Shengsen Chen, Qingxia Ling, Kangkang Yu, Chong Huang, Ning Li, Jianming Zheng, Suxia Bao, Qi Cheng, Mengqi Zhu, Mingquan Chen
Pages: 3198-3208
Published online on: 14 April 2016

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Article Open Access

Aloe-emodin-mediated photodynamic therapy induces autophagy and apoptosis in human osteosarcoma cell line MG‑63 through the ROS/JNK signaling pathway

Pinghua Tu, Qiu Huang, Yunsheng Ou, Xing Du, Kaiting Li, Yong Tao, Hang Yin
Pages: 3209-3215
Published online on: 24 March 2016

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Article Open Access

Suppression of STAT5b in pancreatic cancer cells leads to attenuated gemcitabine chemoresistance, adhesion and invasion

Hiroki Sumiyoshi, Akira Matsushita, Yoshiharu Nakamura, Yoko Matsuda, Toshiyuki Ishiwata, Zenya Naito, Eiji Uchida
Pages: 3216-3226
Published online on: 01 April 2016

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Article Open Access

Coupling Gd‑DTPA with a bispecific, recombinant protein anti‑EGFR‑iRGD complex improves tumor targeting in MRI

Xiaoyan Xin, Huizi Sha, Jingtao Shen, Bing Zhang, Bin Zhu, Baorui Liu
Pages: 3227-3235
Published online on: 29 March 2016

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Article

Malignant, but not benign, intraductal papillary mucinous neoplasm preferentially associates with prior extrapancreatic malignancies

Takaharu Kato, Sergio Alonso, Hiroshi Noda, Yasuyuki Miyakura, Shingo Tsujinaka, Masaaki Saito, Yuta Muto, Taro Fukui, Kosuke Ichida, Yuji Takayama, Fumiaki Watanabe, Nao Kakizawa, Manuel Perucho, Toshiki Rikiyama
Pages: 3236-3240
Published online on: 19 April 2016

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Article

Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice

Takashi Ohno, Masahiro Ohtani, Hiroyuki Suto, Makoto Ohta, Yoshiaki Imamura, Hidetaka Matsuda, Katsushi Hiramatsu, Tomoyuki Nemoto, Yasunari Nakamoto
Pages: 3241-3247
Published online on: 29 March 2016

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Article

Gold-conjugated resveratrol nanoparticles attenuate the invasion and MMP-9 and COX-2 expression in breast cancer cells

Sun Young Park, Seon Yeong Chae, Jin Oh Park, Kyu Jin Lee, Geuntae Park
Pages: 3248-3256
Published online on: 29 March 2016

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Article

MicroRNA-603 functions as an oncogene by suppressing BRCC2 protein translation in osteosarcoma

Chengbin Ma, Chuan Zhan, Hongmou Yuan, Yan Cui, Zhiyu Zhang
Pages: 3257-3264
Published online on: 30 March 2016

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Article Open Access

Increased interleukin-6 expression is associated with poor prognosis and acquired cisplatin resistance in head and neck squamous cell carcinoma

Jian Gao, Sen Zhao, Trond S. Halstensen
Pages: 3265-3274
Published online on: 20 April 2016

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Article

MicroRNA-205 acts as a tumor suppressor in osteosarcoma via targeting RUNX2 Retraction in /10.3892/or.2021.8106

Can Zhang, Feng Long, Jun Wan, Yihe Hu, Hongbo He
Pages: 3275-3284
Published online on: 23 March 2016

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Article

MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN

Jiansong Chen, Dingding Yan, Weiliang Wu, Jian Zhu, Wensong Ye, Qiang Shu
Pages: 3285-3292
Published online on: 31 March 2016

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Article

CD44hiCD24lo mammosphere-forming cells from primary breast cancer display resistance to multiple chemotherapeutic drugs

Ping Ji, Yong Zhang, Shu-Jun Wang, Hai-Liang Ge, Guo-Ping Zhao, Ying-Chun Xu, Ying Wang
Pages: 3293-3302
Published online on: 11 April 2016

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Article

Silencing of ataxia-telangiectasia mutated by siRNA enhances the in vitro and in vivo radiosensitivity of glioma

Yan Li, Luchun Li, Bo Li, Zhijuan Wu, Yongzhong Wu, Ying Wang, Fu Jin, Dairong Li, Huiwen Ma, Donglin Wang
Pages: 3303-3312
Published online on: 19 April 2016

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Article

NOB1 silencing inhibits the growth and metastasis of laryngeal cancer cells through the regulation of JNK signaling pathway

Xin Gao, Jin Wang, Weiliang Bai, Wenyue Ji, Liping Wang
Pages: 3313-3320
Published online on: 24 March 2016

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Article

Identification of prognostic microRNA candidates for head and neck squamous cell carcinoma

Lian Hui, Hua Wu, Ning Yang, Xing Guo, Xuejun Jang
Pages: 3321-3330
Published online on: 23 March 2016

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Article

Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer

Nuri Kim, Sung-Bum Cho, Young-Lan Park, Sun-Young Park, Eun Myung, Seung-Hun Kim, Hyung-Min Yu, Young-Ae Son, Dae-Seong Myung, Wan-Sik Lee, Young-Eun Joo
Pages: 3331-3340
Published online on: 31 March 2016

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Article

Oridonin upregulates PTEN through activating p38 MAPK and inhibits proliferation in human colon cancer cells

Qiu-Xiang Wu, Shuang-Xue Yuan, Chun-Mei Ren, Yu Yu, Wen-Juan Sun, Bai-Cheng He, Ke Wu
Pages: 3341-3348
Published online on: 07 April 2016

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Article

Whole-exome sequencing identifies a somatic missense mutation of NBN in clear cell sarcoma of the salivary gland

Lei Zhang, Zhen Jia, Fengbiao Mao, Yueyi Shi, Rong Fa Bu, Baorong Zhang
Pages: 3349-3356
Published online on: 08 April 2016

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Article

Karyopherin α2 induces apoptosis in tongue squamous cell carcinoma CAL-27 cells through the p53 pathway

Li Gao, Lei Yu, Chun-Ming Li, Ying Li, Bao-Lin Jia, Bin Zhang
Pages: 3357-3362
Published online on: 15 April 2016

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Article

Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways

Jiming Liu, Qiang Li, Zhilong Liu, Liuming Lin, Xiangqiang Zhang, Mingrong Cao, Jianwei Jiang
Pages: 3363-3370
Published online on: 21 March 2016

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Article

Genome-wide profiling of long non-coding RNA expression patterns in the EGFR-TKI resistance of lung adenocarcinoma by microarray

Ying Wu, Dan-Dan Yu, Yong Hu, Dali Yan, Xiu Chen, Hai‑Xia Cao, Shao-Rong Yu, Zhuo Wang, Ji-Feng Feng
Pages: 3371-3386
Published online on: 20 April 2016

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Article

Circadian clock gene Per2 plays an important role in cell proliferation, apoptosis and cell cycle progression in human oral squamous cell carcinoma

Qingqing Wang, Yiran Ao, Kai Yang, Hong Tang, Dan Chen
Pages: 3387-3394
Published online on: 01 April 2016

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Article

Nogo-A inhibits the migration and invasion of human malignant glioma U87MG cells

Shu-Guang Jin, Hyang-Hwa Ryu, Song-Yuan Li, Chun-Hao Li, Sa-Hoe Lim, Woo-Youl Jang, Shin Jung
Pages: 3395-3402
Published online on: 08 April 2016

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Article

Tumstatin induces apoptosis and stimulates phosphorylation of p65NF-κB in human osteoblastic osteosarcoma Saos-2 cells

Yang Wang, Ruo-Feng Yin, Jia-Song Teng
Pages: 3403-3408
Published online on: 20 April 2016

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Article

Lentivirus-mediated knockdown of TSP50 suppresses the growth of non-small cell lung cancer cells via G0/G1 phase arrest

Wen-Liang Qiao, Hai-Yang Hu, Bo-Wen Shi, Li-Juan Zang, Wei Jin, Qiang Lin
Pages: 3409-3418
Published online on: 20 April 2016

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Article

S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation

Teng Hua, Shuangge Liu, Xiaoyan Xin, Liqiong Cai, Rui Shi, Shuqi Chi, Dilu Feng, Hongbo Wang
Pages: 3419-3426
Published online on: 20 April 2016

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Article

Mild oxidative stress induced by a low dose of cisplatin contributes to the escape of TRAIL-mediated apoptosis in the ovarian cancer SKOV3 cell line

Jinzhi Lu, Lei Zhang, Fang Xie, Liya Zhu, Xiaolan Li, Jingping Ouyang, Xiaohua He, Song Han, Cunjian Yi
Pages: 3427-3434
Published online on: 23 March 2016

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Article

MicroRNA-194 restrains the cell progression of non-small cell lung cancer by targeting human nuclear distribution protein C

Lirong Zhou, Qingguo Di, Baohua Sun, Xiaosheng Wang, Min Li, Jian Shi
Pages: 3435-3444
Published online on: 28 March 2016

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Article

h-prune affects anaplastic thyroid cancer invasion and metastasis

Junko Nambu, Tsuyoshi Kobayashi, Masakazu Hashimoto, Hirotaka Tashiro, Keizo Sugino, Fumio Shimamoto, Akira Kikuchi, Hideki Ohdan
Pages: 3445-3452
Published online on: 20 April 2016

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Article

miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7

Shao-Mei Zhou, Fang Zhang, Xue-Bin Chen, Cao-Ming Jun, Xin Jing, Deng-Xiong Wei, Yang Xia, Yu-Bai Zhou, Xiang-Qian Xiao, Run-Qing Jia, Jing-Tao Li, Wang Sheng, Yi Zeng
Pages: 3453-3459
Published online on: 23 March 2016

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Article

Zoledronic acid increases the antitumor effect of gefitinib treatment for non-small cell lung cancer with EGFR mutations

Chengjun Feng, Xiaoke Liu, Xiaoyu Li, Fuchun Guo, Chuying Huang, Qing Qin, Yongsheng Wang
Pages: 3460-3470
Published online on: 13 April 2016

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Article

Inhibition of autophagic flux by ROS promotes apoptosis during DTT-induced ER/oxidative stress in HeLa cells

Xi-Yan Xiang, Xiao-Chun Yang, Jin Su, Jing-Song Kang, Yao Wu, Ya-Nan Xue, Yu-Tong Dong, Lian-Kun Sun
Pages: 3471-3479
Published online on: 01 April 2016

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Article

A novel cell cycle blocker extracted from Stellera chamaejasme L. inhibits the proliferation of hepatocarcinoma cells

Xiao-Xi Kan, Qi Li, Xi Chen, Ya-Jie Wang, Yu-Jie Li, Qing Yang, Hong-Bin Xiao, Zhi-Xin Wang, Ying Chen, Xiao-Gang Weng, Wei-Yan Cai, Xiao-Xin Zhu
Pages: 3480-3488
Published online on: 13 April 2016

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Article

EFEMP1 inhibits migration of hepatocellular carcinoma by regulating MMP2 and MMP9 via ERK1/2 activity

Cheng-Yun Dou, Chuang-Jie Cao, Zhuo Wang, Ru-Hua Zhang, Lei‑Lei Huang, Jia-Yan Lian, Wen-Lin Xie, Lian-Tang Wang
Pages: 3489-3495
Published online on: 05 April 2016

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Article

Stromal interaction molecule 1 plays an important role in gastric cancer progression

Jin-Mei Xu, Yan Zhou, Long Gao, Shu-Xian Zhou, Wei-Hua Liu, Xiao-An Li
Pages: 3496-3504
Published online on: 24 March 2016

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Article

Recombinant adeno-associated virus-delivered anginex inhibits angiogenesis and growth of HUVECs by regulating the Akt, JNK and NF-κB signaling pathways

Ke Ma, Chuying Wang, Qianqian Geng, Yangwei Fan, Jing Ning, Haixia Yang, Xuyuan Dong, Danfeng Dong, Yuyan Guo, Xin Wei, Enxiao Li, Yinying Wu
Pages: 3505-3513
Published online on: 28 March 2016

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Article

n-3 polyunsaturated fatty acids abrogate mTORC1/2 signaling and inhibit adrenocortical carcinoma growth in vitro and in vivo

Jun Liu, Meinian Xu, Yongbin Zhao, Chunping Ao, Yukun Wu, Zhenguo Chen, Bangqi Wang, Xiaochun Bai, Ming Li, Weilie Hu
Pages: 3514-3522
Published online on: 31 March 2016

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Article

mir-1-mediated paracrine effect of cancer-associated fibroblasts on lung cancer cell proliferation and chemoresistance

Jianmin Li, Jing Guan, Xiaoping Long, Yang Wang, Xudong Xiang
Pages: 3523-3531
Published online on: 29 March 2016

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Article

Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1

Jun Luo, Cheng Zhang, Congyi Wang, Linjun Li, Chunhong Li, Qiang Li, Min Zhang, Qingchen Wu
Pages: 3532-3540
Published online on: 04 April 2016

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Article

miR-491-5p suppresses cell growth and invasion by targeting Notch3 in nasopharyngeal carcinoma

Qi Zhang, Qiang Li, Tao Xu, Hui Jiang, Lin-Gen Xu
Pages: 3541-3547
Published online on: 29 March 2016

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Article

Prediction of key genes in ovarian cancer treated with decitabine based on network strategy

Yu-Zhen Wang, Sheng-Chun Qiu
Pages: 3548-3558
Published online on: 23 March 2016

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Article

Radiation-induced autophagy promotes esophageal squamous cell carcinoma cell survival via the LKB1 pathway

Chi Lu, Conghua Xie
Pages: 3559-3565
Published online on: 19 April 2016

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Article

SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways

Jinghui Yang, Qiwei Yang, Jing Yu, Ximeng Li, Shan Yu, Xuewen Zhang
Pages: 3566-3576
Published online on: 20 April 2016

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Article

HOTTIP and HOXA13 are oncogenes associated with gastric cancer progression

Shuai Chang, Junsong Liu, Shaochun Guo, Shicai He, Guanglin Qiu, Jing Lu, Jin Wang, Lin Fan, Wei Zhao, Xiangming Che
Pages: 3577-3585
Published online on: 13 April 2016

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Article

LSD1-mediated epigenetic modification contributes to ovarian cancer cell migration and invasion

Yuanxia Li, Xiaolei Wan, Ye Wei, Xiuwen Liu, Wensheng Lai, Liuping Zhang, Jie Jin, Chaoyang Wu, Qixiang Shao, Genbao Shao, Qiong Lin
Pages: 3586-3592
Published online on: 04 April 2016

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Article

Inhibition of the Ras-ERK pathway in mitotic COS7 cells is due to the inability of EGFR/Raf to transduce EGF signaling to downstream proteins

Huaiping Shi, Tianying Zhang, Yongqing Yi, Yue Ma
Pages: 3593-3599
Published online on: 21 March 2016

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Article

Improved antitumor activity and reduced myocardial toxicity of doxorubicin encapsulated in MPEG-PCL nanoparticles

Chuntang Sun, Le Zhou, Maling Gou, Shuai Shi, Tao Li, Jinyi Lang
Pages: 3600-3606
Published online on: 15 April 2016

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Article

FOXQ1 promotes gastric cancer metastasis through upregulation of Snail

Jing Zhang, Yimin Liu, Jia Zhang, Xiaohai Cui, Gang Li, Jiansheng Wang, Hong Ren, Yunfeng Zhang
Pages: 3607-3613
Published online on: 08 April 2016

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Article

Meloxicam suppresses hepatocellular carcinoma cell proliferation and migration by targeting COX-2/PGE2-regulated activation of the β-catenin signaling pathway

Tao Li, Jingtao Zhong, Xiaofeng Dong, Peng Xiu, Fuhai Wang, Honglong Wei, Xin Wang, Zongzhen Xu, Feng Liu, Xueying Sun, Jie Li
Pages: 3614-3622
Published online on: 20 April 2016

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Article

Tumor metastatic promoter ABCE1 interacts with the cytoskeleton protein actin and increases cell motility

Xu Han, Ye Tian, Dali Tian
Pages: 3623-3629
Published online on: 19 April 2016

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Article

NF-YA promotes invasion and angiogenesis by upregulating EZH2-STAT3 signaling in human melanoma cells

Zihan Xu, Yaowen Sun, Yadong Guo, Gaoping Qin, Shengzhi Mu, Ronghui Fan, Benfeng Wang, Wenjie Gao, Hangli Wu, Guodong Wang, Zhenxin Zhang
Pages: 3630-3638
Published online on: 20 April 2016

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Article

Radiation induces autophagic cell death via the p53/DRAM signaling pathway in breast cancer cells

Li Cui, Zhiheng Song, Bing Liang, Lili Jia, Shumei Ma, Xiaodong Liu
Pages: 3639-3647
Published online on: 19 April 2016

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Article

Diallyl trisulfide induces osteosarcoma cell apoptosis through reactive oxygen species-mediated downregulation of the PI3K/Akt pathway

Hongliang Wang, Na Sun, Xin Li, Ka Li, Jiguang Tian, Jianmin Li
Pages: 3648-3658
Published online on: 01 April 2016

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Osthole shows the potential to overcome P-glycoprotein‑mediated multidrug resistance in human myelogenous leukemia K562/ADM cells by inhibiting the PI3K/Akt signaling pathway

Hong Wang, Xiu-Hong Jia, Jie-Ru Chen, Jian-Yong Wang, You-Jie Li
Pages: 3659-3668
Published online on: 04 April 2016

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Article

Radiosensitization of esophageal carcinoma cells by the silencing of BMI-1

Xing-Xiao Yang, Mei-Xiang Sang, Shu-Chai Zhu, Zhi-Kun Liu, Ming Ma
Pages: 3669-3678
Published online on: 13 April 2016

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Article

ETS transcription factor ERG cooperates with histone demethylase KDM4A

Tae-Dong Kim, Sook Shin, Ralf Janknecht
Pages: 3679-3688
Published online on: 15 April 2016

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Article

Oncogene-mediated tumor transformation sensitizes cells to autophagy induction

Ricardo Gargini, Vega García-Escudero, Marta Izquierdo, Francisco Wandosell
Pages: 3689-3695
Published online on: 23 March 2016

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Article

Resveratrol inhibits cell cycle progression by targeting Aurora kinase A and Polo-like kinase 1 in breast cancer cells

Rubiceli Medina-Aguilar, Laurence A. Marchat, Elena Arechaga Ocampo, Patricio Gariglio, Jaime García Mena, Nicolás Villegas Sepúlveda, Macario Martínez Castillo, César López-Camarillo
Pages: 3696-3704
Published online on: 04 April 2016

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Article

MAP30 inhibits autophagy through enhancing acetyltransferase p300 and induces apoptosis in acute myeloid leukemia cells

Shanhu Qian, Lan Sun, Jiaqi Li, Junqing Wu, Gang Hu, Yixiang Han, Kang Yu, Shenghui Zhang
Pages: 3705-3713
Published online on: 24 March 2016

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Article

Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, angiopoiesis and migration effects via activating HSP90 pathway in EC109 cells

Yiyan Lei, Yulan Zhen, Wei Zhang, Xiuting Sun, Xiaoxiong Lin, Jianqiang Feng, Honghe Luo, Zhenguang Chen, Chunhua Su, Bo Zeng, Jingfu Chen
Pages: 3714-3720
Published online on: 05 April 2016

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Article

Suppression of SOX18 by siRNA inhibits cell growth and invasion of breast cancer cells

Jianxiang Zhang, Yanmei Ma, Shoujun Wang, Fu Chen, Yuanting Gu
Pages: 3721-3727
Published online on: 15 April 2016

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Article

Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway

Lei Cao, Xue Xiao, Jianjun Lei, Wanxing Duan, Qingyong Ma, Wei Li
Pages: 3728-3734
Published online on: 28 March 2016

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Article

Combined metformin and resveratrol confers protection against UVC-induced DNA damage in A549 lung cancer cells via modulation of cell cycle checkpoints and DNA repair

Yong-Syu Lee, Barbara B. Doonan, Joseph M. Wu, Tze-Chen Hsieh
Pages: 3735-3741
Published online on: 11 April 2016

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Article

Knockdown of p54nrb inhibits migration, invasion and TNF-α release of human acute monocytic leukemia THP1 cells

Xiujuan Zhang, Changli Wu, Wei Xiong, Chunling Chen, Rong Li, Guangji Zhou
Pages: 3742-3748
Published online on: 20 April 2016

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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