|
1
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Sarkar FH, Banerjee S and Li Y: Pancreatic
cancer: Pathogenesis, prevention and treatment. Toxicol Appl
Pharmacol. 224:326–336. 2007. View Article : Google Scholar
|
|
3
|
Castellanos EH, Cardin DB and Berlin JD:
Treatment of early-stage pancreatic cancer. Oncology (Williston
Park). 25:182–189. 2011.
|
|
4
|
Chang J and Erler J: Hypoxia-mediated
metastasis. Adv Exp Med Biol. 772:55–81. 2014. View Article : Google Scholar
|
|
5
|
Lei J, Ma J, Ma Q, Li X, Liu H, Xu Q, Duan
W, Sun Q, Xu J, Wu Z, et al: Hedgehog signaling regulates hypoxia
induced epithelial to mesenchymal transition and invasion in
pancreatic cancer cells via a ligand-independent manner. Mol
Cancer. 12:662013. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Duan W, Chang Y, Li R, Xu Q, Lei J, Yin C,
Li T, Wu Y, Ma Q and Li X: Curcumin inhibits hypoxia inducible
factor-1α-induced epithelial-mesenchymal transition in HepG2
hepatocellular carcinoma cells. Mol Med Rep. 10:2505–2510.
2014.PubMed/NCBI
|
|
7
|
Li W, Ma Q, Liu J, Han L, Ma G, Liu H,
Shan T, Xie K and Wu E: Hyperglycemia as a mechanism of pancreatic
cancer metastasis. Front Biosci (Landmark Ed). 17:1761–1774. 2012.
View Article : Google Scholar
|
|
8
|
Thiery JP, Acloque H, Huang RY and Nieto
MA: Epithelial-mesenchymal transitions in development and disease.
Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Pirozzi G, Tirino V, Camerlingo R, Franco
R, La Rocca A, Liguori E, Martucci N, Paino F, Normanno N and Rocco
G: Epithelial to mesenchymal transition by TGFβ-1 induction
increases stemness characteristics in primary non small cell lung
cancer cell line. PLoS One. 6:e215482011. View Article : Google Scholar
|
|
10
|
Shanmugam MK, Rane G, Kanchi MM, Arfuso F,
Chinnathambi A, Zayed ME, Alharbi SA, Tan BK, Kumar AP and Sethi G:
The multifaceted role of curcumin in cancer prevention and
treatment. Molecules. 20:2728–2769. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Kocaadam B and Sanlier N: Curcumin, an
active component of turmeric (Curcuma longa), and its effects on
health. Crit Rev Food Sci Nutr. 0:Nov 3–2015.Epub ahead of
print.
|
|
12
|
Sun XD, Liu XE and Huang DS: Curcumin
reverses the epithelial-mesenchymal transition of pancreatic cancer
cells by inhibiting the Hedgehog signaling pathway. Oncol Rep.
29:2401–2407. 2013.PubMed/NCBI
|
|
13
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
14
|
Nieto MA: Epithelial-mesenchymal
transitions in development and disease: Old views and new
perspectives. Int J Dev Biol. 53:1541–1547. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Spivak-Kroizman TR, Hostetter G, Posner R,
Aziz M, Hu C, Demeure MJ, Von Hoff D, Hingorani SR, Palculict TB,
Izzo J, et al: Hypoxia triggers hedgehog-mediated tumor-stromal
interactions in pancreatic cancer. Cancer Res. 73:3235–3247. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Vincent A, Herman J, Schulick R, Hruban RH
and Goggins M: Pancreatic cancer. Lancet. 378:607–620. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Liu H, Ma Q, Xu Q, Lei J, Li X, Wang Z and
Wu E: Therapeutic potential of perineural invasion, hypoxia and
desmoplasia in pancreatic cancer. Curr Pharm Des. 18:2395–2403.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Vasseur S, Tomasini R, Tournaire R and
Iovanna JL: Hypoxia induced tumor metabolic switch contributes to
pancreatic cancer aggressiveness. Cancers (Basel). 2:2138–2152.
2010. View Article : Google Scholar
|
|
19
|
Ghattass K, Assah R, El-Sabban M and
Gali-Muhtasib H: Targeting hypoxia for sensitization of tumors to
radio- and chemotherapy. Curr Cancer Drug Targets. 13:670–685.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Liao D and Johnson RS: Hypoxia: A key
regulator of angiogenesis in cancer. Cancer Metastasis Rev.
26:281–290. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Nagaraju GP, Bramhachari PV, Raghu G and
El-Rayes BF: Hypoxia inducible factor-1α: Its role in colorectal
carcinogenesis and metastasis. Cancer Lett. 366:11–18. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Lei J, Huo X, Duan W, Xu Q, Li R, Ma J, Li
X, Han L, Li W, Sun H, et al: α-Mangostin inhibits hypoxia-driven
ROS-induced PSC activation and pancreatic cancer cell invasion.
Cancer Lett. 347:129–138. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Li W, Ma J, Ma Q, Li B, Han L, Liu J, Xu
Q, Duan W, Yu S, Wang F, et al: Resveratrol inhibits the
epithelial-mesenchymal transition of pancreatic cancer cells via
suppression of the PI-3K/Akt/NF-κB pathway. Curr Med Chem.
20:4185–4194. 2013. View Article : Google Scholar
|
|
24
|
Youns M and Fathy GM: Upregulation of
extrinsic apoptotic pathway in curcumin-mediated antiproliferative
effect on human pancreatic carcinogenesis. J Cell Biochem.
114:2654–2665. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Nagaraju GP, Zhu S, Ko JE, Ashritha N,
Kandimalla R, Snyder JP, Shoji M and El-Rayes BF: Antiangiogenic
effects of a novel synthetic curcumin analogue in pancreatic
cancer. Cancer Lett. 357:557–565. 2015. View Article : Google Scholar
|
|
26
|
Kunnumakkara AB, Guha S, Krishnan S,
Diagaradjane P, Gelovani J and Aggarwal BB: Curcumin potentiates
antitumor activity of gemcitabine in an orthotopic model of
pancreatic cancer through suppression of proliferation,
angiogenesis, and inhibition of nuclear factor-kappaB-regulated
gene products. Cancer Res. 67:3853–3861. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Bao B, Ali S, Ahmad A, Azmi AS, Li Y,
Banerjee S, Kong D, Sethi S, Aboukameel A, Padhye SB, et al:
Hypoxia-induced aggressiveness of pancreatic cancer cells is due to
increased expression of VEGF, IL-6 and miR-21, which can be
attenuated by CDF treatment. PLoS One. 7:e501652012. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Elamin MH, Shinwari Z, Hendrayani SF,
Al-Hindi H, Al-Shail E, Khafaga Y, Al-Kofide A and Aboussekhra A:
Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers
apoptosis in medulloblastoma cells. Mol Carcinog. 49:302–314.
2010.
|
|
29
|
Slusarz A, Shenouda NS, Sakla MS,
Drenkhahn SK, Narula AS, MacDonald RS, Besch-Williford CL and
Lubahn DB: Common botanical compounds inhibit the hedgehog
signaling pathway in prostate cancer. Cancer Res. 70:3382–3390.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Mohapatra P, Satapathy SR, Siddharth S,
Das D, Nayak A and Kundu CN: Resveratrol and curcumin
synergistically induces apoptosis in cigarette smoke condensate
transformed breast epithelial cells through a
p21Waf1/Cip1 mediated inhibition of Hh-Gli signaling.
Int J Biochem Cell Biol. 66:75–84. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Guan X: Cancer metastases: Challenges and
opportunities. Acta Pharm Sin B. 5:402–418. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Liu ZJ, Semenza GL and Zhang HF:
Hypoxia-inducible factor 1 and breast cancer metastasis. J Zhejiang
Univ Sci B. 16:32–43. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Li W, Cao L, Han L, Xu Q and Ma Q:
Superoxide dismutase promotes the epithelial-mesenchymal transition
of pancreatic cancer cells via activation of the
H2O2/ERK/NF-κB axis. Int J Oncol.
46:2613–2620. 2015.
|
