Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice

  • Authors:
    • Takashi Ohno
    • Masahiro Ohtani
    • Hiroyuki Suto
    • Makoto Ohta
    • Yoshiaki Imamura
    • Hidetaka Matsuda
    • Katsushi Hiramatsu
    • Tomoyuki Nemoto
    • Yasunari Nakamoto
  • View Affiliations

  • Published online on: March 29, 2016     https://doi.org/10.3892/or.2016.4717
  • Pages: 3241-3247
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Abstract

Green tea catechins (GTCs) have been implicated in various physiological effects, including anti-carcinogenic activities. In the present study, we evaluated the effects of GTCs specifically on the development of gastritis and pre-malignant lesions in insulin-gastrin mice. Nine-week-old male INS-GAS mice (n=38) were supplemented with GTCs for 4 and 28 weeks, and their body weights, serum gastrin levels, histopathology and pro-inflammatory cytokine levels in gastric tissue and mucosal cell proliferation were monitored. Body weights of the GTC-treated mice were significantly lower than those of the untreated controls (P≤0.05). Serum gastrin levels were suppressed at the age of 37-weeks (P≤0.05). The histopathological scores indicated that the extent of dysplasia was significantly diminished (P≤0.05), although GTC supplementation did not affect the inflammation scores. The messenger RNA levels of interferon (IFN)-γ were significantly reduced at the age of 13 weeks (P≤0.05), although the changes did not reach statistical significance at the age of 37 weeks (P=0.056). The labeling index of Ki-67 immunohistochemistry was significantly decreased (P≤0.05). These results demonstrated that GTCs may play a protective role in the development of gastritis and pre-malignant lesions via an IFN-γ, gastrin, and mucosal cell proliferation-dependent mechanism in this rodent model and potentially in humans.
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June-2016
Volume 35 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ohno T, Ohtani M, Suto H, Ohta M, Imamura Y, Matsuda H, Hiramatsu K, Nemoto T and Nakamoto Y: Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice. Oncol Rep 35: 3241-3247, 2016
APA
Ohno, T., Ohtani, M., Suto, H., Ohta, M., Imamura, Y., Matsuda, H. ... Nakamoto, Y. (2016). Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice. Oncology Reports, 35, 3241-3247. https://doi.org/10.3892/or.2016.4717
MLA
Ohno, T., Ohtani, M., Suto, H., Ohta, M., Imamura, Y., Matsuda, H., Hiramatsu, K., Nemoto, T., Nakamoto, Y."Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice". Oncology Reports 35.6 (2016): 3241-3247.
Chicago
Ohno, T., Ohtani, M., Suto, H., Ohta, M., Imamura, Y., Matsuda, H., Hiramatsu, K., Nemoto, T., Nakamoto, Y."Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice". Oncology Reports 35, no. 6 (2016): 3241-3247. https://doi.org/10.3892/or.2016.4717