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Article

Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer

  • Authors:
    • Nuri Kim
    • Sung-Bum Cho
    • Young-Lan Park
    • Sun-Young Park
    • Eun Myung
    • Seung-Hun Kim
    • Hyung-Min Yu
    • Young-Ae Son
    • Dae-Seong Myung
    • Wan-Sik Lee
    • Young-Eun Joo
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Chonnam National University Medical School, Dong-ku, Gwangju 501-757, Republic of Korea
  • Pages: 3331-3340
    |
    Published online on: March 31, 2016
       https://doi.org/10.3892/or.2016.4721
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Abstract

Recepteur d'Origine Nantais (RON) expression is known to induce oncogenic properties including tumor cell growth, survival, motility, angiogenesis and chemoresistance. In the present study, we evaluated whether RON affects chemosensitivity and oncogenic behavior of colorectal cancer cells and investigated its prognostic value in colorectal cancer. To evaluate the impact of RON on chemosensitivity and tumor cell behavior, we treated colorectal cancer cells with small interfering RNAs specific to RON. This was followed by flow cytometric analyses and migration, Matrigel invasion and endothelial tube formation assays. The expression of RON was investigated by immunohistochemistry in colorectal cancer tissues. TUNEL assay and immunohistochemical staining for CD34 and D2-40 were deployed to determine apoptosis, angiogenesis and lymphangiogenesis. RON knockdown enhanced 5-fluorouracil (FU)-induced apoptosis by upregulating the activities of caspases and expression of proapoptotic genes. Moreover, it enhanced 5-FU-induced cell cycle arrest by decreasing the expression of cyclins and cyclin‑dependent kinases and inducing that of p21. Furthermore, RON knockdown augmented the 5-FU-induced inhibition of invasion and migration of colorectal cancer cells. The β-catenin signaling cascade was blocked by RON knockdown upon 5-FU treatment. RON knockdown also decreased endothelial tube formation and expression of VEGF-A and HIF-1α and increased angiostatin expression. Furthermore, it inhibited lymphatic endothelial cell tube formation and the expression of VEGF-C and COX-2. RON expression was observed to be associated with age, tumor size, lymphovascular and perineural invasion, tumor stage, lymph node and distant metastasis, and poor survival rate. The mean microvessel density value of RON-positive tumors was significantly higher than that of RON-negative ones. These results indicate that RON is associated with tumor progression by inhibiting chemosensitivity and enhancing angiogenesis in colorectal cancer.
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View References

1 

Brenner H, Kloor M and Pox CP: Colorectal cancer. Lancet. 383:1490–1502. 2014. View Article : Google Scholar

2 

Park SH, Song CW, Kim YB, Kim YS, Chun HR, Lee JH, Seol WJ, Yoon HS, Lee MK, Lee JH, et al: Clinicopathological characteristics of colon cancer diagnosed at primary health care institutions. Intest Res. 12:131–138. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Lee CK: Clinicopathological characteristics of newly diagnosed colorectal cancers in community gastroenterology practice. Intest Res. 12:87–89. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Kim ER and Kim YH: Clinical application of genetics in management of colorectal cancer. Intest Res. 12:184–193. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Riethdorf S, Wikman H and Pantel K: Review: Biological relevance of disseminated tumor cells in cancer patients. Int J Cancer. 123:1991–2006. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Chambers AF, Groom AC and MacDonald IC: Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer. 2:563–572. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Mittal K, Ebos J and Rini B: Angiogenesis and the tumor microenvironment: Vascular endothelial growth factor and beyond. Semin Oncol. 41:235–251. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Zhao Y and Adjei AA: Targeting angiogenesis in cancer therapy: Moving beyond vascular endothelial growth factor. Oncologist. 20:660–673. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Gomes FG, Nedel F, Alves AM, Nör JE and Tarquinio SB: Tumor angiogenesis and lymphangiogenesis: Tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms. Life Sci. 92:101–107. 2013. View Article : Google Scholar :

10 

Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB and Achen MG: Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat Rev Cancer. 14:159–172. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Duong T, Koopman P and Francois M: Tumor lymphangiogenesis as a potential therapeutic target. J Oncol. 2012:2049462012. View Article : Google Scholar : PubMed/NCBI

12 

Marques I, Araújo A and de Mello RA: Anti-angiogenic therapies for metastatic colorectal cancer: Current and future perspectives. World J Gastroenterol. 19:7955–7971. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Royston D and Jackson DG: Mechanisms of lymphatic metastasis in human colorectal adenocarcinoma. J Pathol. 217:608–619. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Sun XF and Zhang H: Clinicopathological significance of stromal variables: Angiogenesis, lymphangiogenesis, inflammatory infiltration, MMP and PINCH in colorectal carcinomas. Mol Cancer. 5:432006. View Article : Google Scholar : PubMed/NCBI

15 

Zhang W, Meng Y, Liu N, Wen XF and Yang T: Insights into chemoresistance of prostate cancer. Int J Biol Sci. 11:1160–1170. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Ojha R, Bhattacharyya S and Singh SK: Autophagy in cancer stem cells: A potential link between chemoresistance, recurrence, and metastasis. Biores Open Access. 4:97–108. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Wang X, Li X, Fu X, Bai M, Li X, Mei Q, Nie J, Wu Z and Han W: Eliminating ovarian cancer stem cells: A potential therapeutic target for ovarian cancer chemoresistance. Curr Protein Pept Sci. 16:270–278. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Carta A, Chetcuti R and Ayers D: An introspective update on the influence of miRNAs in breast carcinoma and neuroblastoma chemoresistance. Genet Res Int. 2014:7430502014.PubMed/NCBI

19 

Hoshiba T and Tanaka M: Optimization of the tissue source, malignancy, and initial substrate of tumor cell-derived matrices to increase cancer cell chemoresistance against 5-fluorouracil. Biochem Biophys Res Commun. 457:353–357. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Garza-Treviño EN, Said-Fernández SL and Martínez-Rodríguez HG: Understanding the colon cancer stem cells and perspectives on treatment. Cancer Cell Int. 15:22015. View Article : Google Scholar : PubMed/NCBI

21 

Paldino E, Tesori V, Casalbore P, Gasbarrini A and Puglisi MA: Tumor initiating cells and chemoresistance: Which is the best strategy to target colon cancer stem cells? Biomed Res Int. 2014:8598712014. View Article : Google Scholar : PubMed/NCBI

22 

Grossi V, Peserico A, Tezil T and Simone C: p38α MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance. World J Gastroenterol. 20:9744–9758. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Lu Y, Yao HP and Wang MH: Multiple variants of the RON receptor tyrosine kinase: Biochemical properties, tumorigenic activities, and potential drug targets. Cancer Lett. 257:157–164. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Leonis MA, Thobe MN and Waltz SE: Ron-receptor tyrosine kinase in tumorigenesis and metastasis. Future Oncol. 3:441–448. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Camp ER, Liu W, Fan F, Yang A, Somcio R and Ellis LM: RON, a tyrosine kinase receptor involved in tumor progression and metastasis. Ann Surg Oncol. 12:273–281. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Wang MH, Yao HP and Zhou YQ: Oncogenesis of RON receptor tyrosine kinase: A molecular target for malignant epithelial cancers. Acta Pharmacol Sin. 27:641–650. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Wang MH, Wang D and Chen YQ: Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase. Carcinogenesis. 24:1291–1300. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Wagh PK, Peace BE and Waltz SE: Met-related receptor tyrosine kinase Ron in tumor growth and metastasis. Adv Cancer Res. 100:1–33. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Danilkovitch-Miagkova A: Oncogenic signaling pathways activated by RON receptor tyrosine kinase. Curr Cancer Drug Targets. 3:31–40. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Lee CT, Chow NH, Su PF, Lin SC, Lin PC and Lee JC: The prognostic significance of RON and MET receptor coexpression in patients with colorectal cancer. Dis Colon Rectum. 51:1268–1274. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Park YL, Lee GH, Kim KY, Myung E, Kim JS, Myung DS, Park KJ, Cho SB, Lee WS, Jung YD, et al: Expression of RON in colorectal cancer and its relationships with tumor cell behavior and prognosis. Tumori. 98:652–662. 2012.PubMed/NCBI

32 

Song YA, Park YL, Kim KY, Myung E, Chung CY, Cho SB, Lee WS, Jung YD, Kweon SS and Joo YE: RON is associated with tumor progression via the inhibition of apoptosis and cell cycle arrest in human gastric cancer. Pathol Int. 62:127–136. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Maggiora P, Marchio S, Stella MC, Giai M, Belfiore A, De Bortoli M, Di Renzo MF, Costantino A, Sismondi P and Comoglio PM: Overexpression of the RON gene in human breast carcinoma. Oncogene. 16:2927–2933. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Kim SA, Yoon TM, Lee DH, Park YL, Lee KH, Lim SC, Joo YE and Lee JK: RON (recepteur d'origine Nantais) expression and its association with tumor progression in laryngeal squamous cell carcinoma. Auris Nasus Larynx. 41:201–206. 2014. View Article : Google Scholar

35 

Yoon TM, Kim SA, Park YL, Lee KH, Sung MW, Lee JK, Lim SC, Chung IJ and Joo YE: Expression of the receptor tyrosine kinase recepteur d'origine Nantais and its association with tumor progression in hypopharyngeal cancer. Head Neck. 35:1106–1113. 2013. View Article : Google Scholar

36 

Chung CY, Park YL, Song YA, Myung E, Kim KY, Lee GH, Ki HS, Park KJ, Cho SB, Lee WS, et al: Knockdown of RON inhibits AP-1 activity and induces apoptosis and cell cycle arrest through the modulation of Akt/FoxO signaling in human colorectal cancer cells. Dig Dis Sci. 57:371–380. 2012. View Article : Google Scholar

37 

Cho SB, Park YL, Song YA, Kim KY, Lee GH, Cho DH, Myung DS, Park KJ, Lee WS, Chung IJ, et al: Small interfering RNA-directed targeting of RON alters invasive and oncogenic phenotypes of human hepatocellular carcinoma cells. Oncol Rep. 26:1581–1586. 2011.PubMed/NCBI

38 

American Joint Committee on Cancer Classification (AJCC): Cancer Staging Manual. 6th edition. revised. Lippincott-Raven; Philadelphia: pp. 113–123. 2002

39 

Paschall AV and Liu K: Epigenetic regulation of apoptosis and cell cycle regulatory genes in human colon carcinoma cells. Genom Data. 5:189–191. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Mason EF and Rathmell JC: Cell metabolism: An essential link between cell growth and apoptosis. Biochim Biophys Acta. 1813:645–654. 2011. View Article : Google Scholar

41 

Schultz DR and Harrington WJ Jr: Apoptosis: Programmed cell death at a molecular level. Semin Arthritis Rheum. 32:345–369. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Morgan DO: Principles of CDK regulation. Nature. 374:131–134. 1995. View Article : Google Scholar : PubMed/NCBI

43 

Graña X and Reddy EP: Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene. 11:211–219. 1995.PubMed/NCBI

44 

Johnson N and Shapiro GI: Cyclin-dependent kinases (cdks) and the DNA damage response: Rationale for cdk inhibitor-chemotherapy combinations as an anticancer strategy for solid tumors. Expert Opin Ther Targets. 14:1199–1212. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Wang D, Shen Q, Xu XM, Chen YQ and Wang MH: Activation of the RON receptor tyrosine kinase attenuates transforming growth factor-beta1-induced apoptotic death and promotes phenotypic changes in mouse intestinal epithelial cells. Carcinogenesis. 26:27–36. 2005. View Article : Google Scholar

46 

Danilkovitch-Miagkova A, Miagkov A, Skeel A, Nakaigawa N, Zbar B and Leonard EJ: Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway. Mol Cell Biol. 21:5857–5868. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Thobe MN, Gurusamy D, Pathrose P and Waltz SE: The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells. Oncogene. 29:214–226. 2010. View Article : Google Scholar :

48 

Karnezis T, Shayan R, Fox S, Achen MG and Stacker SA: The connection between lymphangiogenic signalling and prostaglandin biology: A missing link in the metastatic pathway. Oncotarget. 3:893–906. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Maggiora P, Lorenzato A, Fracchioli S, Costa B, Castagnaro M, Arisio R, Katsaros D, Massobrio M, Comoglio PM and Flavia Di Renzo M: The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness. Exp Cell Res. 288:382–389. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Cheng HL, Liu HS, Lin YJ, Chen HH, Hsu PY, Chang TY, Ho CL, Tzai TS and Chow NH: Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder. Br J Cancer. 92:1906–1914. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim N, Cho S, Park Y, Park S, Myung E, Kim S, Yu H, Son Y, Myung D, Lee W, Lee W, et al: Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer. Oncol Rep 35: 3331-3340, 2016.
APA
Kim, N., Cho, S., Park, Y., Park, S., Myung, E., Kim, S. ... Joo, Y. (2016). Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer. Oncology Reports, 35, 3331-3340. https://doi.org/10.3892/or.2016.4721
MLA
Kim, N., Cho, S., Park, Y., Park, S., Myung, E., Kim, S., Yu, H., Son, Y., Myung, D., Lee, W., Joo, Y."Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer". Oncology Reports 35.6 (2016): 3331-3340.
Chicago
Kim, N., Cho, S., Park, Y., Park, S., Myung, E., Kim, S., Yu, H., Son, Y., Myung, D., Lee, W., Joo, Y."Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer". Oncology Reports 35, no. 6 (2016): 3331-3340. https://doi.org/10.3892/or.2016.4721
Copy and paste a formatted citation
x
Spandidos Publications style
Kim N, Cho S, Park Y, Park S, Myung E, Kim S, Yu H, Son Y, Myung D, Lee W, Lee W, et al: Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer. Oncol Rep 35: 3331-3340, 2016.
APA
Kim, N., Cho, S., Park, Y., Park, S., Myung, E., Kim, S. ... Joo, Y. (2016). Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer. Oncology Reports, 35, 3331-3340. https://doi.org/10.3892/or.2016.4721
MLA
Kim, N., Cho, S., Park, Y., Park, S., Myung, E., Kim, S., Yu, H., Son, Y., Myung, D., Lee, W., Joo, Y."Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer". Oncology Reports 35.6 (2016): 3331-3340.
Chicago
Kim, N., Cho, S., Park, Y., Park, S., Myung, E., Kim, S., Yu, H., Son, Y., Myung, D., Lee, W., Joo, Y."Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer". Oncology Reports 35, no. 6 (2016): 3331-3340. https://doi.org/10.3892/or.2016.4721
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