Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium

Utsumi,Fumi; Kajiyama,Hiroaki; Nakamura,Kae; Tanaka,Hiromasa; Mizuno,Masaaki; Toyokuni,Shinnya; Hori,Masaru; Kikkawa,Fumitaka

doi:10.3892/or.2016.4726

June-2016 Volume 35 Issue 6

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June-2016 Volume 35 Issue 6

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Article Open Access

Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium

Authors:
- Fumi Utsumi
- Hiroaki Kajiyama
- Kae Nakamura
- Hiromasa Tanaka
- Masaaki Mizuno
- Shinnya Toyokuni
- Masaru Hori
- Fumitaka Kikkawa
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan, Department of Electrical Engineering and Computer Science, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan, Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan, Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan

Copyright: © Utsumi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 3169-3177
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Published online on: April 1, 2016

https://doi.org/10.3892/or.2016.4726
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Abstract

Non-thermal atmospheric pressure plasma has been widely studied in recent years in many fields, including cancer treatment. However, its efficiency for inducing apoptosis sometimes varies depending on the cell species and experimental conditions. The aim of this study was to elucidate what causes these differences in responses to plasma treatment. Using four ovarian cancer cell lines, the cell density had a markedly negative impact on the proliferation inhibition rate (PIR) and it was more obvious in OVCAR-3 and NOS2 cells. Furthermore, TOV21G and ES-2 cells were drastically sensitive to plasma‑activated medium (PAM) compared with the other two cell lines. We demonstrated that the proportion of reactive oxygen species and cell number had a marked impact on the effect of PAM against ovarian cancer cells. Additionally it was suggested that the morphological features of cells were also closely related to the sensitivity of cancer cells to the plasma treatment.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium

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Abstract

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