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Article

Malignant, but not benign, intraductal papillary mucinous neoplasm preferentially associates with prior extrapancreatic malignancies

  • Authors:
    • Takaharu Kato
    • Sergio Alonso
    • Hiroshi Noda
    • Yasuyuki Miyakura
    • Shingo Tsujinaka
    • Masaaki Saito
    • Yuta Muto
    • Taro Fukui
    • Kosuke Ichida
    • Yuji Takayama
    • Fumiaki Watanabe
    • Nao Kakizawa
    • Manuel Perucho
    • Toshiki Rikiyama
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Saitama Medical Center, Jichi Medical University, Omiya-ku, Saitama 330-8503, Japan, Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Institut d'Investigació en Ciéncies de la Salut Germans Trias I Pujol, (IGTP), Campus Can Ruti, 08916 Badalona, Barcelona, Spain
  • Pages: 3236-3240
    |
    Published online on: April 19, 2016
       https://doi.org/10.3892/or.2016.4755
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Abstract

Intraductal papillary mucinous neoplasm (IPMN) has been associated with a high incidence of extrapancreatic malignancies (EPMs). However, it is controversial whether IPMN is prognostic for EPM. We aimed to help clarify the issue studying this association in patients with histologically proven IPMN. We reviewed 51 surgically resected IPMNs in Saitama Medical Center, Jichi Medical University between January 1991 and June 2012. Mean follow-up was 63.7±47.8 months. The observed EPM incidence was compared with the expected incidence of cancer in Japan. Of the 51 IPMNs, 14 were malignant and the rest benign. Seventeen EPMs developed in 15 patients (29.4%), nine of which occurred prior to IPMN diagnosis. For all IPMNs, the standardized incidence ratio (SIR) was significantly increased for the six types of reported EPMs (SIR=2.18, CI=1.31-3.42, P=0.004). Benign IPMNs showed no association with EPMs (SIR=0.92, CI=0.43-1,76, P=0.87). In contrast, malignant IPMNs showed a higher association (SIR=3.83, CI=1.87-7.03, P=0.0009). However, the association was mostly due to the prior EPMs, as removal of metachronous EPMs had no significant effect (SIR=3.63, CI=1.59-7.17, P=0.005). Thus, only malignant IPMNs drive the significant association with prior EPMs, showing a near 4-fold increased incidence compared to the general Japanese population. Histological characterization of IPMNs may offer clinical value for EPM patient management. We hypothesize that these observations may be explained if some patients with EPMs present a higher risk to develop IPMNs (and vice versa), possibly resulting from an uncharacterized multiple cancer predisposition condition.
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Copy and paste a formatted citation
Spandidos Publications style
Kato T, Alonso S, Noda H, Miyakura Y, Tsujinaka S, Saito M, Muto Y, Fukui T, Ichida K, Takayama Y, Takayama Y, et al: Malignant, but not benign, intraductal papillary mucinous neoplasm preferentially associates with prior extrapancreatic malignancies. Oncol Rep 35: 3236-3240, 2016.
APA
Kato, T., Alonso, S., Noda, H., Miyakura, Y., Tsujinaka, S., Saito, M. ... Rikiyama, T. (2016). Malignant, but not benign, intraductal papillary mucinous neoplasm preferentially associates with prior extrapancreatic malignancies. Oncology Reports, 35, 3236-3240. https://doi.org/10.3892/or.2016.4755
MLA
Kato, T., Alonso, S., Noda, H., Miyakura, Y., Tsujinaka, S., Saito, M., Muto, Y., Fukui, T., Ichida, K., Takayama, Y., Watanabe, F., Kakizawa, N., Perucho, M., Rikiyama, T."Malignant, but not benign, intraductal papillary mucinous neoplasm preferentially associates with prior extrapancreatic malignancies". Oncology Reports 35.6 (2016): 3236-3240.
Chicago
Kato, T., Alonso, S., Noda, H., Miyakura, Y., Tsujinaka, S., Saito, M., Muto, Y., Fukui, T., Ichida, K., Takayama, Y., Watanabe, F., Kakizawa, N., Perucho, M., Rikiyama, T."Malignant, but not benign, intraductal papillary mucinous neoplasm preferentially associates with prior extrapancreatic malignancies". Oncology Reports 35, no. 6 (2016): 3236-3240. https://doi.org/10.3892/or.2016.4755
Copy and paste a formatted citation
x
Spandidos Publications style
Kato T, Alonso S, Noda H, Miyakura Y, Tsujinaka S, Saito M, Muto Y, Fukui T, Ichida K, Takayama Y, Takayama Y, et al: Malignant, but not benign, intraductal papillary mucinous neoplasm preferentially associates with prior extrapancreatic malignancies. Oncol Rep 35: 3236-3240, 2016.
APA
Kato, T., Alonso, S., Noda, H., Miyakura, Y., Tsujinaka, S., Saito, M. ... Rikiyama, T. (2016). Malignant, but not benign, intraductal papillary mucinous neoplasm preferentially associates with prior extrapancreatic malignancies. Oncology Reports, 35, 3236-3240. https://doi.org/10.3892/or.2016.4755
MLA
Kato, T., Alonso, S., Noda, H., Miyakura, Y., Tsujinaka, S., Saito, M., Muto, Y., Fukui, T., Ichida, K., Takayama, Y., Watanabe, F., Kakizawa, N., Perucho, M., Rikiyama, T."Malignant, but not benign, intraductal papillary mucinous neoplasm preferentially associates with prior extrapancreatic malignancies". Oncology Reports 35.6 (2016): 3236-3240.
Chicago
Kato, T., Alonso, S., Noda, H., Miyakura, Y., Tsujinaka, S., Saito, M., Muto, Y., Fukui, T., Ichida, K., Takayama, Y., Watanabe, F., Kakizawa, N., Perucho, M., Rikiyama, T."Malignant, but not benign, intraductal papillary mucinous neoplasm preferentially associates with prior extrapancreatic malignancies". Oncology Reports 35, no. 6 (2016): 3236-3240. https://doi.org/10.3892/or.2016.4755
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