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Review Open Access

The role of JAM-B in cancer and cancer metastasis (Review)

  • Authors:
    • Huishan Zhao
    • Hefen Yu
    • Tracey A. Martin
    • Xu Teng
    • Wen G. Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, School of Basic Medicine, Capital Medical University, Beijing 100069, P.R. China, Cardiff-China Medical Research Collaborative, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK, Cancer Institute of Capital Medical University, Beijing 100069, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3-9
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    Published online on: April 27, 2016
       https://doi.org/10.3892/or.2016.4773
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Abstract

The junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein, which belongs to the immunoglobulin superfamily (IgSF). JAM-B is localized to cell-cell contacts and enriched at cell junctions in epithelial and endothelial cells, as well as on the surface of erythrocytes, leukocytes, and platelets. Recent research in this field has shown that JAM-B plays an important role in numerous cellular processes, such as tight junction assembly, spermatogenesis, regulation of paracellular permeability, leukocytic transmigration, angiogenesis, tumor metastasis and cell proliferation. This study provides a new research direction for the diagnosis and treatment of relevant diseases. In this review, we briefly focus on what is currently known about the structure, function, and mechanism of JAM-B, with particular emphasis on cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao H, Yu H, Martin TA, Teng X and Jiang WG: The role of JAM-B in cancer and cancer metastasis (Review). Oncol Rep 36: 3-9, 2016.
APA
Zhao, H., Yu, H., Martin, T.A., Teng, X., & Jiang, W.G. (2016). The role of JAM-B in cancer and cancer metastasis (Review). Oncology Reports, 36, 3-9. https://doi.org/10.3892/or.2016.4773
MLA
Zhao, H., Yu, H., Martin, T. A., Teng, X., Jiang, W. G."The role of JAM-B in cancer and cancer metastasis (Review)". Oncology Reports 36.1 (2016): 3-9.
Chicago
Zhao, H., Yu, H., Martin, T. A., Teng, X., Jiang, W. G."The role of JAM-B in cancer and cancer metastasis (Review)". Oncology Reports 36, no. 1 (2016): 3-9. https://doi.org/10.3892/or.2016.4773
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao H, Yu H, Martin TA, Teng X and Jiang WG: The role of JAM-B in cancer and cancer metastasis (Review). Oncol Rep 36: 3-9, 2016.
APA
Zhao, H., Yu, H., Martin, T.A., Teng, X., & Jiang, W.G. (2016). The role of JAM-B in cancer and cancer metastasis (Review). Oncology Reports, 36, 3-9. https://doi.org/10.3892/or.2016.4773
MLA
Zhao, H., Yu, H., Martin, T. A., Teng, X., Jiang, W. G."The role of JAM-B in cancer and cancer metastasis (Review)". Oncology Reports 36.1 (2016): 3-9.
Chicago
Zhao, H., Yu, H., Martin, T. A., Teng, X., Jiang, W. G."The role of JAM-B in cancer and cancer metastasis (Review)". Oncology Reports 36, no. 1 (2016): 3-9. https://doi.org/10.3892/or.2016.4773
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