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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2016 Volume 36 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

The role of JAM-B in cancer and cancer metastasis (Review)

Huishan Zhao, Hefen Yu, Tracey A. Martin, Xu Teng, Wen G. Jiang
Pages: 3-9
Published online on: 27 April 2016

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Article Open Access

Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma

Song Xu, Xiao-Ming Yi, Chao-Peng Tang, Jing-Ping Ge, Zheng-Yu Zhang, Wen-Quan Zhou
Pages: 10-22
Published online on: 09 May 2016

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Article

Overexpression of WNT5B promotes COLO 205 cell migration and invasion through the JNK signaling pathway

Ying Zhang, Lianjie Lin, Yu Jin, Yan Lin, Yong Cao, Changqing Zheng
Pages: 23-30
Published online on: 27 April 2016

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Article Open Access

Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells

Hye-Sook Seo, Jin Mo Ku, Han-Seok Choi, Youn Kyung Choi, Jong-Kyu Woo, Minsoo Kim, Ilhwan Kim, Chang Hyeok Na, Hansol Hur, Bo‑Hyoung Jang, Yong Cheol Shin, Seong-Gyu Ko
Pages: 31-42
Published online on: 05 May 2016

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Article Open Access

Low expression of leptin and its association with breast cancer: A transcriptomic study

Sajjad Karim, Adnan Merdad, Hans-Juergen Schulten, Manikandan Jayapal, Ashraf Dallol, Abdelbaset Buhmeida, Fatima Al-Thubaity, Zeenat Mirza, Mamdooh A. Gari, Adeel G. Chaudhary, Adel M. Abuzenadah, Mohammed H. Al-Qahtani
Pages: 43-48
Published online on: 13 May 2016

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Article Open Access

Regulation of cell apoptosis and proliferation in pancreatic cancer through PI3K/Akt pathway via Polo-like kinase 1

Yonghuan Mao, Ling Xi, Quan Li, Zeling Cai, Yimei Lai, Xinhua Zhang, Chunzhao Yu
Pages: 49-56
Published online on: 18 May 2016

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Article Open Access

Methylation-induced silencing of maspin contributes to the proliferation of human glioma cells

Liang Xu, Hongyuan Liu, Ju Yu, Zhongyong Wang, Qing Zhu, Zongping Li, Qi Zhong, Shuyu Zhang, Mingqi Qu, Qing Lan
Pages: 57-64
Published online on: 04 May 2016

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Article Open Access

miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer

Meisi Yan, Xiaobo Li, Dandan Tong, Changsong Han, Ran Zhao, Yan He, Xiaoming Jin
Pages: 65-71
Published online on: 25 April 2016

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Article Open Access

Ionizing radiation promotes advanced malignant traits in nasopharyngeal carcinoma via activation of epithelial-mesenchymal transition and the cancer stem cell phenotype

Zhongwu Su, Guo Li, Chao Liu, Shuling Ren, Yongquan Tian, Yong Liu, Yuanzheng Qiu
Pages: 72-78
Published online on: 25 April 2016

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Article Open Access

A new non-muscle-invasive bladder tumor-homing peptide identified by phage display in vivo

Xiaofeng Yang, Fan Zhang, Junqian Luo, Jianzhi Pang, Sanhua Yan, Fang Luo, Jiehao Liu, Wei Wang, Yongping Cui, Xixi Su
Pages: 79-89
Published online on: 23 May 2016

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Article Open Access

Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway Retraction in /10.3892/or.2025.8928

Kun Ma, Chuan Zhang, Man-Yu Huang, Wu-Yin Li, Guo-Qiang Hu
Pages: 90-98
Published online on: 28 April 2016

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Article Open Access

Polyphenols from Korean prostrate spurge Euphorbia supina induce apoptosis through the Fas-associated extrinsic pathway and activation of ERK in human leukemic U937 cells

Min-Ho Han, Won Sup Lee, Arulkumar Nagappan, Hye Jung Kim, Cheol Park, Gi-Young Kim, Sang Hoon Hong, Nam Deuk Kim, Gonsup Kim, Chung Ho Ryu, Sung Chul Shin, Yung Hyun Choi
Pages: 99-107
Published online on: 28 April 2016

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Article Open Access

STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer

Yao Cui, Yun-Yun Li, Jian Li, Hong-Yan Zhang, Feng Wang, Xue Bai, Shan-Shan Li
Pages: 108-116
Published online on: 19 May 2016

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Article

Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway

Ka Hwi Kim, Jung-Il Chae, Hana Oh, Jin Hyoung Cho, Ra-Ham Lee, Goo Yoon, Seung-Sik Cho, Young-Sik Cho, Mee-Hyun Lee, Kangdong Liu, Hyun-Jeong Lee, Jung-Hyun Shim
Pages: 117-124
Published online on: 10 May 2016

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Article

Increased expression and activity of p75NTR are crucial events in azacitidine-induced cell death in prostate cancer

Giovanni Luca Gravina, Francesco Marampon, Patrizia Sanità, Andrea Mancini, Alessandro Colapietro, Luca Scarsella, Ana Jitariuc, Leda Biordi, Corrado Ficorella, Claudio Festuccia
Pages: 125-130
Published online on: 23 May 2016

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Article

Development of a novel microbubble-liposome complex conjugated with peptide ligands targeting IL4R on brain tumor cells

See-Hyoung Park, Young II Yoon, Hyoungwon Moon, Ga-Hyun Lee, Byung-Heon Lee, Tae-Jong Yoon, Hak Jong Lee
Pages: 131-136
Published online on: 24 May 2016

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Article

20(S)-ginsenoside Rh2 inhibits the proliferation and induces the apoptosis of KG-1a cells through the Wnt/β-catenin signaling pathway

Yi Chen, Ze-Hong Liu, Jing Xia, Xiao-Peng Li, Ke‑Qiong Li, Wei Xiong, Jing Li, Di-Long Chen
Pages: 137-146
Published online on: 27 April 2016

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Article

Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway

Jian-Ying Li, Jun Yu, Xu-Sheng Du, Hui-Min Zhang, Bo Wang, Hua Guo, Jie Bai, Juan-Hong Wang, An Liu, Yi-Li Wang
Pages: 147-154
Published online on: 04 May 2016

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Article

Genome-wide analysis of the effect of esophageal squamous cell carcinoma on human umbilical vein endothelial cells

Guoguo Jin, Yi Yang, Hangfan Liu, Kangdong Liu, Jimin Zhao, Xinhuan Chen, Xiaoyan Zhang, Yanyan Zhang, Jing Lu, Ziming Dong
Pages: 155-164
Published online on: 18 May 2016

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Article

Isoquercitrin inhibits bladder cancer progression in vivo and in vitro by regulating the PI3K/Akt and PKC signaling pathways Retraction in /10.3892/or.2023.8684

Feng Chen, Xiaochi Chen, Deyong Yang, Xiangyu Che, Jianbo Wang, Xiancheng Li, Zhiwei Zhang, Qifei Wang, Wei Zheng, Lina Wang, Xuejian Wang, Xishuang Song
Pages: 165-172
Published online on: 09 May 2016

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Article

RNaseH2A is involved in human gliomagenesis through the regulation of cell proliferation and apoptosis

Bin Dai, Peng Zhang, Yisong Zhang, Changcun Pan, Guolu Meng, Xinru Xiao, Zhen Wu, Wang Jia, Junting Zhang, Liwei Zhang
Pages: 173-180
Published online on: 10 May 2016

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Article

Notch2 is a crucial regulator of self-renewal and tumorigenicity in human hepatocellular carcinoma cells

Wen-Rui Wu, Rui Zhang, Xiang-De Shi, Cao Yi, Lei-Bo Xu, Chao Liu
Pages: 181-188
Published online on: 23 May 2016

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Article

MicroRNA-146a inhibits cell migration and invasion by targeting RhoA in breast cancer

Qin Liu, Wei Wang, Xiongfa Yang, Dongxiao Zhao, Fangqiong Li, Hai Wang
Pages: 189-196
Published online on: 06 May 2016

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Article

Nuclear EpICD expression and its role in hepatocellular carcinoma

Shin Young Park, Jun Sang Bae, Eun Jung Cha, Hyun Hee Chu, Jang Sihn Sohn, Woo Sung Moon
Pages: 197-204
Published online on: 06 May 2016

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Article

Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway Corrigendum in /10.3892/or.2022.8301

Moon Hee Lee, Su-Hyun Hong, Cheol Park, Gi-Young Kim, Sun-Hee Leem, Sung Hyun Choi, Young-Sam Keum, Jin Won Hyun, Taeg Kyu Kwon, Sang Hoon Hong, Yung Hyun Choi
Pages: 205-214
Published online on: 17 May 2016

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Article

An eight-long non-coding RNA signature as a candidate prognostic biomarker for lung cancer

Zhenbo Tu, Du He, Xinzhou Deng, Meng Xiong, Xiaoxing Huang, Xinran Li, Ling Hao, Qianshan Ding, Qiuping Zhang
Pages: 215-222
Published online on: 18 May 2016

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Article

Knockdown of DDX46 inhibits proliferation and induces apoptosis in esophageal squamous cell carcinoma cells

Bin Li, Yu-Min Li, Wen-Ting He, Hao Chen, Hong-Wen Zhu, Tao Liu, Jian-Hua Zhang, Tie-Niu Song, Ya-Li Zhou
Pages: 223-230
Published online on: 11 May 2016

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Article

B7-H3 upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu

Zhang Zhang Sun, Ting Zhang, Kuan Ning, Ruan Zhu, Fen Liu, Shou-Ching Tang, Bo Jiang, Dong Hua
Pages: 231-238
Published online on: 13 May 2016

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Article

Zidovudine, abacavir and lamivudine increase the radiosensitivity of human esophageal squamous cancer cell lines

Xuan Chen, Cong Wang, Shanghui Guan, Yuan Liu, Lihui Han, Yufeng Cheng
Pages: 239-246
Published online on: 18 May 2016

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Article

Downregulation of miR-377 contributes to IRX3 deregulation in hepatocellular carcinoma

Pei Wang, Chunbo Zhuang, Da Huang, Keshu Xu
Pages: 247-252
Published online on: 18 May 2016

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Article

Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways

Qianqian Jiang, Yu Pan, Yupeng Cheng, Huiling Li, Dandan Liu, Hui Li
Pages: 253-262
Published online on: 09 May 2016

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Article

Silencing of long non-coding RNA ANRIL inhibits the development of multidrug resistance in gastric cancer cells

Wei-Guang Lan, Dian-Hong Xu, Chen Xu, Chang-Ling Ding, Fang-Ling Ning, Yan-Li Zhou, Long-Bo Ma, Chang-Min Liu, Xia Han
Pages: 263-270
Published online on: 26 April 2016

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Article

Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition

Xiang Zhang, Dan Lin, Rong Jiang, Hongzhong Li, Jingyuan Wan, Hongyuan Li
Pages: 271-278
Published online on: 12 May 2016

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Article

S100A8 facilitates the migration of colorectal cancer cells through regulating macrophages in the inflammatory microenvironment

He Zha, Hui Sun, Xueru Li, Liang Duan, Aifang Li, Yue Gu, Zongyue Zeng, Jiali Zhao, Jiaqing Xie, Shimei Yuan, Huan Li, Lan Zhou
Pages: 279-290
Published online on: 06 May 2016

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Article

Oxymatrine inhibits the proliferation of CaSki cells via downregulating HPV16E7 expression

Zhijun Pei, Jing Zeng, Yan Gao, Fuyan Li, Wei Li, Hong Zhou, Yi Yang, Ruimin Wu, Yijia Chen, Jie Liu
Pages: 291-298
Published online on: 10 May 2016

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Article

Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference

Yi Zhang, Yan Ran, Yan Xiong, Zi-Biao Zhong, Zheng‑Hua Wang, Xiao-Li Fan, Qi-Fa Ye
Pages: 299-305
Published online on: 19 May 2016

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Article

T-box transcription factor brachyury promotes tumor cell invasion and metastasis in non-small cell lung cancer via upregulation of matrix metalloproteinase 12

Zongmiao Wan, Dongjie Jiang, Su Chen, Jian Jiao, Lei Ji, Abdus Saboor Shah, Haifeng Wei, Xinghai Yang, Xiaotao Li, Ying Wang, Jianru Xiao
Pages: 306-314
Published online on: 09 May 2016

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Article

Lentinan mitigates therarubicin-induced myelosuppression by activating bone marrow-derived macrophages in an MAPK/NF-κB-dependent manner

Qiang Liu, Lei Dong, Hong Li, Jia Yuan, Yuping Peng, Shejiao Dai
Pages: 315-323
Published online on: 26 April 2016

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Article

Bergamottin isolated from Citrus bergamia exerts in vitro and in vivo antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and invasion Retraction in /10.3892/or.2021.8058

Hui-Juan Wu, Hong-Bo Wu, Yan-Qiu Zhao, Li-Juan Chen, Hong-Zhi Zou
Pages: 324-332
Published online on: 23 May 2016

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Article

A novel all-trans retinoic acid derivative 4-amino‑2‑trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP

Hui Liu, Feihu Chen, Ling Zhang, Qing Zhou, Shuyu Gui, Yuan Wang
Pages: 333-341
Published online on: 09 May 2016

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Article

Myricetin suppresses p21-activated kinase 1 in human breast cancer MCF-7 cells through downstream signaling of the β-catenin pathway

De Jiao, Xue Dong Zhang
Pages: 342-348
Published online on: 28 April 2016

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Article

Induction of KIFC1 expression in gastric cancer spheroids

Naohide Oue, Shoichiro Mukai, Takeharu Imai, Trang T.B. Pham, Takashi Oshima, Kazuhiro Sentani, Naoya Sakamoto, Kazuhiro Yoshida, Wataru Yasui
Pages: 349-355
Published online on: 28 April 2016

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Article

The combination of NVP-BKM120 with trastuzumab or RAD001 synergistically inhibits the growth of breast cancer stem cells in vivo

Feng Yu, Jing Zhao, Yunhui Hu, Yang Zhou, Rong Guo, Jingchao Bai, Sheng Zhang, Huilai Zhang, Jin Zhang
Pages: 356-364
Published online on: 10 May 2016

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Article

Combined use of PI3K and MEK inhibitors synergistically inhibits lung cancer with EGFR and KRAS mutations

Ze-Bo Jiang, Jun Huang, Chun Xie, Xia Li, Liping Liu, Jiaxi He, Hui Pan, Liyan Huang, Xing-Xing Fan, Xiao-Jun Yao, Ying Xie, Na Li, Liang Liu, Jian-Xing He, Elaine Lai-Han Leung
Pages: 365-375
Published online on: 26 April 2016

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Article

Downregulation of miR-195 promotes prostate cancer progression by targeting HMGA1

Xiaowen Zhang, Tao Tao, Chunhui Liu, Han Guan, Yeqing Huang, Bin Xu, Ming Chen
Pages: 376-382
Published online on: 09 May 2016

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Article

Protocadherin-10 acts as a tumor suppressor gene, and is frequently downregulated by promoter methylation in pancreatic cancer cells

Chan Qiu, Xiaona Bu, Zheng Jiang
Pages: 383-389
Published online on: 09 May 2016

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Article

Downregulation of miR-34a contributes to the proliferation and migration of laryngeal carcinoma cells by targeting cyclin D1

Jin Ye, Laisheng Li, Pinning Feng, Jianxin Wan, Jingjia Li
Pages: 390-398
Published online on: 19 May 2016

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Article

Improved safety and efficacy of a lipid emulsion loaded with a paclitaxel-cholesterol complex for the treatment of breast tumors

Jun Ye, Yuling Liu, Xuejun Xia, Luhua Meng, Wujun Dong, Renyun Wang, Zhaodi Fu, Hongyan Liu, Rui Han
Pages: 399-409
Published online on: 06 May 2016

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Article

BMP9 inhibits the growth and migration of lung adenocarcinoma A549 cells in a bone marrow stromal cell‑derived microenvironment through the MAPK/ERK and NF-κB pathways

Jing Wang, Yaguang Weng, Minghao Zhang, Ya Li, Mengtian Fan, Yangliu Guo, Yanting Sun, Wang Li, Qiong Shi
Pages: 410-418
Published online on: 09 May 2016

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Article

Aberrant expression of B7-H4 correlates with poor prognosis and suppresses tumor-infiltration of CD8+ T lymphocytes in human cholangiocarcinoma

Xin Zhao, Fei Guo, Zhonghu Li, Peng Jiang, Xiang Deng, Feng Tian, Xiaowu Li, Shuguang Wang
Pages: 419-427
Published online on: 13 May 2016

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Article

Ursolic acid inhibits proliferation and reverses drug resistance of ovarian cancer stem cells by downregulating ABCG2 through suppressing the expression of hypoxia-inducible factor-1α in vitro

Wen-Jing Wang, Hua Sui, Cong Qi, Qi Li, Jie Zhang, Shao-Fei Wu, Ming-Zhu Mei, Ying-Yu Lu, Yi-Ting Wan, Hannah Chang, Piao-Ting Guo
Pages: 428-440
Published online on: 18 May 2016

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Article

Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells

Jia Wang, Xianyao Wan, Yifan Gao, Mintao Zhong, Li Sha, Ben Liu, Wei Zhang, Li Tian, Wenjing Ruan, Shuyun Cao, Min Huang
Pages: 441-447
Published online on: 23 May 2016

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Article

Tspan9 inhibits the proliferation, migration and invasion of human gastric cancer SGC7901 cells via the ERK1/2 pathway

Pai-Yun Li, Jing Lv, Wei-Wei Qi, Shu-Fen Zhao, Li-Bin Sun, Ning Liu, Jie Sheng, Wen-Sheng Qiu
Pages: 448-454
Published online on: 13 May 2016

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Article

Upregulation of ABCG2 via the PI3K-Akt pathway contributes to acidic microenvironment-induced cisplatin resistance in A549 and LTEP-a-2 lung cancer cells

Chun Fang Hu, Yi Ying Huang, Yong Jie Wang, Feng Guang Gao
Pages: 455-461
Published online on: 23 May 2016

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Article

Transcriptional network in ovarian cancer cell line SKOV3 treated with Pinellia pedatisecta Schott extract

Li Zhou, Teng Xu, Ying Zhang, Mei Zhu, Wen Zhu, Ziqiang Wang, Hangzhi Gu, Hanchu Wang, Peizhen Li, Jun Ying, Lei Yang, Ping Ren, Jinsong Li, Zuyuan Xu, Liyan Ni, Qiyu Bao, Jindong Chen
Pages: 462-470
Published online on: 28 April 2016

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Article

MicroRNA-18b inhibits the growth of malignant melanoma via inhibition of HIF-1α-mediated glycolysis Retraction in /10.3892/or.2021.8161

Yao Chen, Ziqing Zhang, Chengqun Luo, Zizi Chen, Jianda Zhou
Pages: 471-479
Published online on: 20 May 2016

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miR-410-3p suppresses breast cancer progression by targeting Snail

Ya-Feng Zhang, Yue Yu, Wang-Zhao Song, Rui-Ming Zhang, Shan Jin, Jun-Wen Bai, Hong-Bin Kang, Xin Wang, Xu-Chen Cao
Pages: 480-486
Published online on: 23 May 2016

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miR-375 inhibits the invasion and metastasis of colorectal cancer via targeting SP1 and regulating EMT-associated genes

Fengyun Cui, Shuyang Wang, Iweng Lao, Chunxian Zhou, Hui Kong, Nayima Bayaxi, Jiali Li, Qi Chen, Tengfang Zhu, Hongguang Zhu
Pages: 487-493
Published online on: 24 May 2016

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Expression and inhibitory role of TIMP-3 in hepatocellular carcinoma

Bo Shen, Yingjie Jiang, Yuan-Ran Chen, Hui-Cong Zheng, Wei Zeng, Yu-Yuan Li, Aoxian Yin, Yuqiang Nie
Pages: 494-502
Published online on: 18 May 2016

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Comparative analysis of macrophage transcriptomes reveals a key mechanism of the immunomodulatory activity of Tricholoma matsutake polysaccharide

Xiang Ding, Jian Li, Yiling Hou, Wanru Hou
Pages: 503-513
Published online on: 18 May 2016

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Usefulness of a fluorescence visualization system for the detection of oral precancerous and early cancerous lesions

Yuichi Ohnishi, Tomoko Fujii, Yoshihide Ugaki, Hiroki Yasui, Masahiro Watanabe, Suguru Dateoka, Kenji Kakudo
Pages: 514-520
Published online on: 28 April 2016

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Hypoxia inducible factor-1α-dependent epithelial to mesenchymal transition under hypoxic conditions in prostate cancer cells

Mingchuan Li, Yong Xing Wang, Yong Luo, Jiahui Zhao, Qing Li, Jiao Zhang, Yongguang Jiang
Pages: 521-527
Published online on: 25 April 2016

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Anticancer activity of 7,8-dihydroxyflavone in melanoma cells via downregulation of α-MSH/cAMP/MITF pathway

Deok Yong Sim, Jae Kyung Sohng, Hye Jin Jung
Pages: 528-534
Published online on: 20 May 2016

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Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer

Hye Youn Sung, Jihye Han, Woong Ju, Jung-Hyuck Ahn
Pages: 535-541
Published online on: 24 May 2016

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MicroRNA-874 inhibits growth, induces apoptosis and reverses chemoresistance in colorectal cancer by targeting X-linked inhibitor of apoptosis protein Retraction in /10.3892/or.2022.8280

Jinfeng Han, Zhongmin Liu, Nanya Wang, Weiyun Pan
Pages: 542-550
Published online on: 16 May 2016

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Overexpression of PAD4 suppresses drug resistance of NSCLC cell lines to gefitinib through inhibiting Elk1-mediated epithelial-mesenchymal transition

Qiong Duan, Cui Pang, Ning Chang, Ju Zhang, Wenchao Liu
Pages: 551-558
Published online on: 28 April 2016

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Skp2 is associated with paclitaxel resistance in prostate cancer cells

Yeguo Yang, Yi Lu, Lihui Wang, Atsushi Mizokami, Evan T. Keller, Jian Zhang, Jiejun Fu
Pages: 559-566
Published online on: 13 May 2016

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Article

Berberine in combination with cisplatin suppresses breast cancer cell growth through induction of DNA breaks and caspase-3-dependent apoptosis

Yuwan Zhao, Zuolei Jing, Yan Li, Weifeng Mao
Pages: 567-572
Published online on: 05 May 2016

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Article

Clinicopathological implications of vascular endothelial growth factor 165b expression in oral squamous cell carcinoma stroma

Masahiro Nagasaki, Seiji Kondo, Yoshiki Mukudai, Takaaki Kamatani, Ayako Akizuki, Atsushi Yaso, Toshikazu Shimane, Tatsuo Shirota
Pages: 573-581
Published online on: 20 May 2016

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Hepatitis C virus core protein regulates OCT4 expression and promotes cell cycle progression in hepatocellular carcinoma

Jia-Jia Zhou, Zhe Meng, Yu Zhou, Di Cheng, Hui-Lin Ye, Quan-Bo Zhou, Xiao-Geng Deng, Ru-Fu Chen
Pages: 582-588
Published online on: 27 April 2016

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Article

HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma

Zhihao Wang, Fang Tang, Pengchao Hu, Ying Wang, Jun Gong, Shaoxing Sun, Conghua Xie
Pages: 589-597
Published online on: 16 May 2016

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Journal Cover
April-2026 Volume 55 Issue 4

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Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

KDM5D expression is lost in cisplatin‑resistant neuroblastoma cells

Natalia Podhorska, Jan Hrabeta, Marie Belhajova, Tomas Eckschlager
Article Number: 79
Published online on: 25 February 2026

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Role of iron and TfR1 in the application of high‑dose ascorbate against pancreatic cancer

Alban Piotrowsky, Christian Leischner, Hendrik Schmieder, Katja Detert, Kathrin Schneider, Johanna Schulte, Sabrina Hammerschmidt, Luigi Marongiu, Olga Renner, Markus Burkard, Sascha Venturelli
Article Number: 78
Published online on: 24 February 2026

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Advances in immunotherapy and targeted therapy for nasopharyngeal carcinoma: Current progress and combined approaches (Review)

Zhen Yang, Huajun Liu, Meilin Chen, Liming Zhang, Meiling Gong, Ruilian Yu
Article Number: 77
Published online on: 24 February 2026

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Retraction Open Access

[Retracted] Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma

Zhongqian Hu, Haoshu Fang, Xinyi Wang, Danlei Chen, Zhuo Chen, Siying Wang
Article Number: 76
Published online on: 24 February 2026

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NR4A1 mediates chemotherapy‑induced senescence via the PI3K/AKT pathway in gastric cancer cells

Tingyu Zhang, Yue Wang, Jiuna Zhang, Xueshuai Ye, Yanfeng Shen, Zhiwei Zhang
Article Number: 75
Published online on: 18 February 2026

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Hypoxia‑induced miR‑135b‑5p promotes neuroendocrine differentiation of prostate cancer cells through HIF1AN‑HIF1α axis

Pampana Sandhya Venkata Lakshmi, Jagrati Parashar, Biswajit Biswas, Ramesh Ummanni
Article Number: 74
Published online on: 16 February 2026

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Retraction Open Access

[Retracted] Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP‑9

Zhu Yuan, Andrew J. Sanders, Lin Ye, Yu Wang, Wen G. Jiang
Article Number: 73
Published online on: 16 February 2026

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Liquid biopsy in malignant primary bone tumors: Clinical applications of circulating tumor DNA and circulating tumor cells for diagnosis, prognosis and treatment monitoring (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 72
Published online on: 12 February 2026

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Tumor visualization and evaluation of glioblastoma in mice using small animal 9.4T MRI and PET‑CT with high resolution

Shuangyi Li, Wenjiao Gu, Ying Jiang, Ting Liu, Limei Shuai, Yujie Wei, Youming Shi, Havyarimana Juvenal, Zhimin Wang, Yucai Wei, Bofan Wu, Xiaochun Zhou, Yumin Li, Futian Tang
Article Number: 71
Published online on: 12 February 2026

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Expression of Concern Open Access

[Expression of Concern] Interference of STAT 5b expression enhances the chemo‑sensitivity of gastric cancer cells to gefitinib by promoting mitochondrial pathway‑mediated cell apoptosis

Tao Sun, Yanfei Jia, Dongjie Xiao
Article Number: 70
Published online on: 11 February 2026

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Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling

Kun Li, Jinwei Chen, Zhi Zheng, Yichun Gao, Jiayu Zhang, Wenya Ding, Tongguo Yang, Yuyang Gu, Xuhua Duan, Tiesuo Zhao, Huijie Jia, Pengfei Chen, Jianzhuang Ren
Article Number: 69
Published online on: 11 February 2026

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Suppressive role of SCN4B in the epithelial‑mesenchymal transition of lung adenocarcinoma

Mengnan Guo, He Li, Zhifang Zhao, Yuanyuan Wang, Jiaqi Tang, Binghan Zhong, Yunxia Zhao
Article Number: 68
Published online on: 10 February 2026

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Retraction Open Access

[Retracted] miR‑218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D

Quanxing Cao, Pingshuan Dong, Yanyu Wang, Junwei Zhang, Xinge Shi, Yongsheng Wang
Article Number: 67
Published online on: 09 February 2026

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Impact of the intratumoral resident microbiome on the immune microenvironment of malignant tumors (Review)

Han Na Oh, Hoon Hur
Article Number: 66
Published online on: 06 February 2026

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[Corrigendum] Hypoxia and macrophages promote glioblastoma invasion by the CCL4‑CCR5 axis

Ying Wang, Tao Liu, Ning Yang, Shuo Xu, Xingang Li, Donghai Wang
Article Number: 65
Published online on: 04 February 2026

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Origin dictates function: The dual roles of exosomes derived from diverse origins in the onset and progression of colorectal cancer (Review)

Zhao Guo, Haoyan Zhuang, Qingfeng Liu
Article Number: 64
Published online on: 03 February 2026

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Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells

Wentao Fu, Leying Lin, Jie Li, Fei Qin, Chuan Chen, Yinglian Cai, Yilun Cai, Yiling Huang, Wang Yang, Shanshan Zhu
Article Number: 63
Published online on: 02 February 2026

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POSTN+ fibroblast‑secreted small extracellular vesicles drive macrophage M2 polarization through BMP4/BMPR2/Smad signaling

Chenyang Zhang, Si Chen, Chenghui Qian, Wanqi Lv, Qian Zhang, Yanjin Wang, Yuqiong Wu, Xue Liu
Article Number: 62
Published online on: 02 February 2026

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Retraction Open Access

[Retracted] EGFR/HER2 inhibitors effectively reduce the malignant potential of MDR breast cancer evoked by P‑gp substrates in vitro and in vivo

Yiting Jin, Wei Zhang, Hongying Wang, Zijing Zhang, Chengyu Chu, Xiuping Liu, Qiang Zou
Article Number: 61
Published online on: 02 February 2026

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Article

Tumor‑associated glucocorticoid inhibition by mifepristone reduces polymorphonuclear myeloid‑derived suppressor cells and promotes antitumor immunity in triple‑negative breast cancer‑bearing mice

Masato Kobayashi, Chisana Konno, Ayato Shimizu, Masanori Kobayashi, Tatsuya Hori
Article Number: 60
Published online on: 30 January 2026

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Mitochondria in T‑cell tumor immunity and tumor therapies targeting mitochondria (Review)

Minjie Zhou, Yijie Xie, Zhipeng Liu, Yi He, Yibing Yin, Keyu Chen, Zhengyu Zhao, Chengshun Zhang, Dingjun Cai
Article Number: 59
Published online on: 29 January 2026

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TRIM46 deficiency‑induced DNA damage enhances the sensitivity of cisplatin in non‑small cell lung cancer by regulating the Akt signaling pathway

Song Jin, Dandan Zhang, Zhicheng Liao, Lingpei Yu, Yuanyuan Wang, Pengcheng Jia, Minmin Pan, Yifan Li, Jizhou Zhang
Article Number: 58
Published online on: 28 January 2026

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Advances in isolation and detection technologies and immunotherapy applications of circulating tumor cells (Review)

Ping Zhou, Qin Ye, Yiyun Huang, Yumei Feng, Li Zhou, Ke Xie
Article Number: 57
Published online on: 28 January 2026

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Correction Open Access

[Corrigendum] 3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5

Yuzhong Chen, Li Wei, Xiaojing Zhang, Xianfu Liu, Yansong Chen, Song Zhang, Lanzhu Zhou, Qixiang Li, Qiong Pan, Surong Zhao, Hao Liu
Article Number: 56
Published online on: 28 January 2026

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High RMI1 expression is associated with cancer cell progression and poor prognosis in prostate cancer

Pengliang Shen, Xiaosong Wang, Xiaoting Yan, Hongyang Du, Bo Wu, Xiaoming Cao
Article Number: 55
Published online on: 27 January 2026

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Retraction Open Access

[Retracted] MicroRNA‑615‑5p targets insulin‑like growth factor 2 and exerts tumor‑suppressing functions in human esophageal squamous cell carcinoma

Bingyin Yang, Rui Xie, Shang-Nong Wu, Cheng-Cheng Gao, Xiao-Zhong Yang, Jing-Fang Zhou
Article Number: 54
Published online on: 26 January 2026

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May-2026 Volume 55 Issue 5

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Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

ZBTB7A promotes malignant phenotypes in ovarian cancer through transcriptional activation of CRLF1

Xiaobai Hao, Yu Chen
Article Number: 102
Published online on: 24 March 2026

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MS4322 is a selective protein arginine methyltransferase 5 degrader with antitumor effects in cervical cancer cells

Rui Luo, Jingping Chen, Zhaojie Chen, Surong Wang, Tianfeng Liu, Yang Xu
Article Number: 101
Published online on: 24 March 2026

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[Retracted] Roles of the SNHG7/microRNA‑9‑5p/DPP4 ceRNA network in the growth and 131I resistance of thyroid carcinoma cells through PI3K/Akt activation

Wanzhi Chen, Jichun Yu, Rong Xie, Tao Zhou, Chengfeng Xiong, Shuyong Zhang, Meijun Zhong
Article Number: 100
Published online on: 23 March 2026

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Andrographis exerts antitumor effects and enhances 5‑FU efficacy via the alteration of ferroptosis‑related genes in esophageal squamous cell carcinoma

Kosuke Yoshimura, Tadanobu Shimura, Ruiya Ma, Yaxuan Huang, Takahito Kitajima, Shinji Yamashita, Yuki Sato, Koki Higashi, Mikio Kawamura, Hiromi Yasuda, Yuhki Koike, Yoshiki Okita, Shigeyuki Yoshiyama, Minako Kobayashi, Masaki Ohi, Hiroki Ohge, Shinya Takahashi, Ajay Goel, Yoshinaga Okugawa, Yuji Toiyama
Article Number: 99
Published online on: 20 March 2026

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Sphingosine‑1‑phosphate receptor 1 enhances olfactory receptor 51E1‑mediated inhibition of proliferation via Src/JNK signaling in prostate cancer cells

Kiheon Kim, Jinwoo Lee, Chulwon Choi, Jungnam Bae, Hee-Jung Choi, Won-Ki Huh
Article Number: 98
Published online on: 19 March 2026

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Mechanistic insights into the roles of astragalosides and Astragalus polysaccharides in gynecological and breast cancers (Review)

Ruixin Liu, Zhanyu Lin, Yuelin Li, Yuetong Ci, Zhengqi Guo, Zhenguo Xu
Article Number: 97
Published online on: 19 March 2026

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[Retracted] Inhibition of tankyrase 1 in human gastric cancer cells enhances telomere shortening by telomerase inhibitors 

Hao Zhang, Meng-Hua Yang, Jing-Jing Zhao, Ling Chen, Song-Tao Yu, Xu-Dong Tang, Dian-Chun Fang, Shi-Ming Yang
Article Number: 96
Published online on: 16 March 2026

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Silencing of SIVA‑1 promotes cisplatin resistance in gastric cancer via the Bcl‑2/BAX‑mediated mitochondria‑dependent apoptosis pathway

Zheng-Yi Shi, Zheng-Rong Ding, Yu-Liang Huang, Yuan-Rui Lei, Hai-Bin Huang, Yan Qing, Miao-Ren Deng, Xu-Man Lu, Xu-Dong Dong, Long-Jie Xia, Sheng Xu, Xiao-Gang Zhong, Lei Li, Fan-Biao Kong, Xiao-Tong Wang
Article Number: 95
Published online on: 13 March 2026

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Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways

Ayaka Kunishima, Takatsune Shimizu, Tetsuya Takimoto, Atsunobu Sagara, Hiroyuki Nobusue, Hidetoshi Hasuwa, Shinya Hasegawa, Yuka Tamaoki, Hitomi Miyake, Yumi Fukuchi, Hideyuki Saya, Akihiro Muto
Article Number: 94
Published online on: 12 March 2026

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Unveiling the role of ANGPT2 in esophageal cancer: A prognostic factor and potential oncogene

Zhigang Zhai, Zhenyu Xue, Yuan Fang, Yixu Fan, Shijiao Li, Yunpeng Yu, Chuansheng Chen, Kaijun Zhang, Deyu Chen, Xiang Tang, Rui Ling
Article Number: 93
Published online on: 12 March 2026

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POLQ promotes tumor progression and immunosuppression via ATM‑P53 signaling in endometrial cancer

Ningning Zhu, Juanjuan Wang, Xiaoli Zhang, Kai Tang, Lei Gong, Yi Hu
Article Number: 92
Published online on: 11 March 2026

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Correction Open Access

[Corrigendum] 3‑Bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial‑mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth

Ting-An Wang, Xiao-Dong Zhang, Xing-Yu Guo, Shu-Lin Xian, Yun-Fei Lu
Article Number: 91
Published online on: 11 March 2026

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Unveiling the molecular landscape: Long non-coding RNAs in neuroblastoma (Review)

Zidong Xia, Huishan Zhai, Lei Zheng, Cheng Wang
Article Number: 90
Published online on: 09 March 2026

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Retraction Open Access

[Retracted] Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine‑γ‑lyase function

Liangyu Chen, Xinxing Li, Libo Liu, Bo Yu, Yixue Xue, Yunhui Liu
Article Number: 89
Published online on: 09 March 2026

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Review Open Access

Advances in the application of frailty scoring in the diagnosis and management of elderly patients with multiple myeloma (Review)

Junlun Liu, Danyu Li, Chao Li, Zhuoren Chen
Article Number: 88
Published online on: 06 March 2026

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Expression of Concern Open Access

[Expression of Concern] c‑Fos/ERK promotes the progression from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma 

Lei You, Xiaoxia Ren, Yongxing Du, Wenjing Zhao, Ming Cui, Ge Chen, Yupei Zhao
Article Number: 87
Published online on: 05 March 2026

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CXCL1 in triple‑negative breast cancer: Mechanisms, challenges, and therapeutic opportunities (Review)

Hiba Al Sayegh, Zahraa Assi, Amjad Kanaan, Mirvat El Sibai
Article Number: 86
Published online on: 03 March 2026

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Cellular and inflammatory characteristics of patient‑derived glioblastoma organoids during in vitro cultivation

Jessica Nojszewski, Nils Oliver Schröder, Jacqueline Clüver, Jonna Holler, Hajrullah Ahmeti, Michael Synowitz, Janka Held-Feindt
Article Number: 85
Published online on: 02 March 2026

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Retraction Open Access

[Retracted] Growth and differentiation factor‑9 promotes adhesive and motile capacity of prostate cancer cells by up‑regulating FAK and Paxillin via Smad dependent pathway 

Sivan M. Bokobza, Lin Ye, Howard G. Kynaston, Wen G. Jiang
Article Number: 84
Published online on: 02 March 2026

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Platycodin D sensitizes head and neck squamous cell carcinoma to cisplatin by inducing autophagy arrest

Minji Bae, Min Kyeong Lee, Mi Gyeong Jeong, Yeonseo Lee, Harim Joo, Young Chan Lee, Jung Woo Lee, Su Il Kim, Seong-Gyu Ko, Young-Gyu Eun
Article Number: 83
Published online on: 27 February 2026

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ACSBG1‑driven lipid reprogramming unveiled: A fatty acid metabolism‑associated prognostic model for lung adenocarcinoma

Panxin Hu, Anan Li
Article Number: 82
Published online on: 27 February 2026

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Article Open Access

Knockdown of CCT2 inhibits the malignant progression of hepatocellular carcinoma cells by impairing STAT3 activation

Chao Li, Lei Yang, Yudong Zhang, Baocheng Zhao, Hao Qu
Article Number: 81
Published online on: 25 February 2026

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Retraction Open Access

[Retracted] Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl‑2/Bax and GSK3β/β‑catenin signaling pathways

Hongxia Zhang, Ruifeng Dong, Ping Zhang, Yankui Wang
Article Number: 80
Published online on: 25 February 2026

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