Journal Articles

Open Access

The role of JAM-B in cancer and cancer metastasis (Review)

Huishan Zhao, Hefen Yu, Tracey A. Martin, Xu Teng, Wen G. Jiang

Pages: 3-9 Published online on: 27 April 2016
Open Access

Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma

Song Xu, Xiao-Ming Yi, Chao-Peng Tang, Jing-Ping Ge, Zheng-Yu Zhang, Wen-Quan Zhou

Pages: 10-22 Published online on: 09 May 2016

Overexpression of WNT5B promotes COLO 205 cell migration and invasion through the JNK signaling pathway

Ying Zhang, Lianjie Lin, Yu Jin, Yan Lin, Yong Cao, Changqing Zheng

Pages: 23-30 Published online on: 27 April 2016
Open Access

Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells

Hye-Sook Seo, Jin Mo Ku, Han-Seok Choi, Youn Kyung Choi, Jong-Kyu Woo, Minsoo Kim, Ilhwan Kim, Chang Hyeok Na, Hansol Hur, Bo‑Hyoung Jang, Yong Cheol Shin, Seong-Gyu Ko

Pages: 31-42 Published online on: 05 May 2016
Open Access

Low expression of leptin and its association with breast cancer: A transcriptomic study

Sajjad Karim, Adnan Merdad, Hans-Juergen Schulten, Manikandan Jayapal, Ashraf Dallol, Abdelbaset Buhmeida, Fatima Al-Thubaity, Zeenat Mirza, Mamdooh A. Gari, Adeel G. Chaudhary, Adel M. Abuzenadah, Mohammed H. Al-Qahtani

Pages: 43-48 Published online on: 13 May 2016
Open Access

Regulation of cell apoptosis and proliferation in pancreatic cancer through PI3K/Akt pathway via Polo-like kinase 1

Yonghuan Mao, Ling Xi, Quan Li, Zeling Cai, Yimei Lai, Xinhua Zhang, Chunzhao Yu

Pages: 49-56 Published online on: 18 May 2016
Open Access

Methylation-induced silencing of maspin contributes to the proliferation of human glioma cells

Liang Xu, Hongyuan Liu, Ju Yu, Zhongyong Wang, Qing Zhu, Zongping Li, Qi Zhong, Shuyu Zhang, Mingqi Qu, Qing Lan

Pages: 57-64 Published online on: 04 May 2016
Open Access

miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer

Meisi Yan, Xiaobo Li, Dandan Tong, Changsong Han, Ran Zhao, Yan He, Xiaoming Jin

Pages: 65-71 Published online on: 25 April 2016
Open Access

Ionizing radiation promotes advanced malignant traits in nasopharyngeal carcinoma via activation of epithelial-mesenchymal transition and the cancer stem cell phenotype

Zhongwu Su, Guo Li, Chao Liu, Shuling Ren, Yongquan Tian, Yong Liu, Yuanzheng Qiu

Pages: 72-78 Published online on: 25 April 2016
Open Access

A new non-muscle-invasive bladder tumor-homing peptide identified by phage display in vivo

Xiaofeng Yang, Fan Zhang, Junqian Luo, Jianzhi Pang, Sanhua Yan, Fang Luo, Jiehao Liu, Wei Wang, Yongping Cui, Xixi Su

Pages: 79-89 Published online on: 23 May 2016
Open Access

Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway

Kun Ma, Chuan Zhang, Man-Yu Huang, Wu-Yin Li, Guo-Qiang Hu

Pages: 90-98 Published online on: 28 April 2016
Open Access

Polyphenols from Korean prostrate spurge Euphorbia supina induce apoptosis through the Fas-associated extrinsic pathway and activation of ERK in human leukemic U937 cells

Min-Ho Han, Won Sup Lee, Arulkumar Nagappan, Hye Jung Kim, Cheol Park, Gi-Young Kim, Sang Hoon Hong, Nam Deuk Kim, Gonsup Kim, Chung Ho Ryu, Sung Chul Shin, Yung Hyun Choi

Pages: 99-107 Published online on: 28 April 2016
Open Access

STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer

Yao Cui, Yun-Yun Li, Jian Li, Hong-Yan Zhang, Feng Wang, Xue Bai, Shan-Shan Li

Pages: 108-116 Published online on: 19 May 2016

Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway

Ka Hwi Kim, Jung-Il Chae, Hana Oh, Jin Hyoung Cho, Ra-Ham Lee, Goo Yoon, Seung-Sik Cho, Young-Sik Cho, Mee-Hyun Lee, Kangdong Liu, Hyun-Jeong Lee, Jung-Hyun Shim

Pages: 117-124 Published online on: 10 May 2016

Increased expression and activity of p75NTR are crucial events in azacitidine-induced cell death in prostate cancer

Giovanni Luca Gravina, Francesco Marampon, Patrizia Sanità, Andrea Mancini, Alessandro Colapietro, Luca Scarsella, Ana Jitariuc, Leda Biordi, Corrado Ficorella, Claudio Festuccia

Pages: 125-130 Published online on: 23 May 2016

Development of a novel microbubble-liposome complex conjugated with peptide ligands targeting IL4R on brain tumor cells

See-Hyoung Park, Young II Yoon, Hyoungwon Moon, Ga-Hyun Lee, Byung-Heon Lee, Tae-Jong Yoon, Hak Jong Lee

Pages: 131-136 Published online on: 24 May 2016

20(S)-ginsenoside Rh2 inhibits the proliferation and induces the apoptosis of KG-1a cells through the Wnt/β-catenin signaling pathway

Yi Chen, Ze-Hong Liu, Jing Xia, Xiao-Peng Li, Ke‑Qiong Li, Wei Xiong, Jing Li, Di-Long Chen

Pages: 137-146 Published online on: 27 April 2016

Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway

Jian-Ying Li, Jun Yu, Xu-Sheng Du, Hui-Min Zhang, Bo Wang, Hua Guo, Jie Bai, Juan-Hong Wang, An Liu, Yi-Li Wang

Pages: 147-154 Published online on: 04 May 2016

Genome-wide analysis of the effect of esophageal squamous cell carcinoma on human umbilical vein endothelial cells

Guoguo Jin, Yi Yang, Hangfan Liu, Kangdong Liu, Jimin Zhao, Xinhuan Chen, Xiaoyan Zhang, Yanyan Zhang, Jing Lu, Ziming Dong

Pages: 155-164 Published online on: 18 May 2016

Isoquercitrin inhibits bladder cancer progression in vivo and in vitro by regulating the PI3K/Akt and PKC signaling pathways

Feng Chen, Xiaochi Chen, Deyong Yang, Xiangyu Che, Jianbo Wang, Xiancheng Li, Zhiwei Zhang, Qifei Wang, Wei Zheng, Lina Wang, Xuejian Wang, Xishuang Song

Pages: 165-172 Published online on: 09 May 2016

RNaseH2A is involved in human gliomagenesis through the regulation of cell proliferation and apoptosis

Bin Dai, Peng Zhang, Yisong Zhang, Changcun Pan, Guolu Meng, Xinru Xiao, Zhen Wu, Wang Jia, Junting Zhang, Liwei Zhang

Pages: 173-180 Published online on: 10 May 2016

Notch2 is a crucial regulator of self-renewal and tumorigenicity in human hepatocellular carcinoma cells

Wen-Rui Wu, Rui Zhang, Xiang-De Shi, Cao Yi, Lei-Bo Xu, Chao Liu

Pages: 181-188 Published online on: 23 May 2016

MicroRNA-146a inhibits cell migration and invasion by targeting RhoA in breast cancer

Qin Liu, Wei Wang, Xiongfa Yang, Dongxiao Zhao, Fangqiong Li, Hai Wang

Pages: 189-196 Published online on: 06 May 2016

Nuclear EpICD expression and its role in hepatocellular carcinoma

Shin Young Park, Jun Sang Bae, Eun Jung Cha, Hyun Hee Chu, Jang Sihn Sohn, Woo Sung Moon

Pages: 197-204 Published online on: 06 May 2016

Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway

Moon Hee Lee, Su-Hyun Hong, Cheol Park, Gi-Young Kim, Sun-Hee Leem, Sung Hyun Choi, Young-Sam Keum, Jin Won Hyun, Taeg Kyu Kwon, Sang Hoon Hong, Yung Hyun Choi

Pages: 205-214 Published online on: 17 May 2016

An eight-long non-coding RNA signature as a candidate prognostic biomarker for lung cancer

Zhenbo Tu, Du He, Xinzhou Deng, Meng Xiong, Xiaoxing Huang, Xinran Li, Ling Hao, Qianshan Ding, Qiuping Zhang

Pages: 215-222 Published online on: 18 May 2016

Knockdown of DDX46 inhibits proliferation and induces apoptosis in esophageal squamous cell carcinoma cells

Bin Li, Yu-Min Li, Wen-Ting He, Hao Chen, Hong-Wen Zhu, Tao Liu, Jian-Hua Zhang, Tie-Niu Song, Ya-Li Zhou

Pages: 223-230 Published online on: 11 May 2016

B7-H3 upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu

Zhang Zhang Sun, Ting Zhang, Kuan Ning, Ruan Zhu, Fen Liu, Shou-Ching Tang, Bo Jiang, Dong Hua

Pages: 231-238 Published online on: 13 May 2016

Zidovudine, abacavir and lamivudine increase the radiosensitivity of human esophageal squamous cancer cell lines

Xuan Chen, Cong Wang, Shanghui Guan, Yuan Liu, Lihui Han, Yufeng Cheng

Pages: 239-246 Published online on: 18 May 2016

Downregulation of miR-377 contributes to IRX3 deregulation in hepatocellular carcinoma

Pei Wang, Chunbo Zhuang, Da Huang, Keshu Xu

Pages: 247-252 Published online on: 18 May 2016

Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways

Qianqian Jiang, Yu Pan, Yupeng Cheng, Huiling Li, Dandan Liu, Hui Li

Pages: 253-262 Published online on: 09 May 2016

Silencing of long non-coding RNA ANRIL inhibits the development of multidrug resistance in gastric cancer cells

Wei-Guang Lan, Dian-Hong Xu, Chen Xu, Chang-Ling Ding, Fang-Ling Ning, Yan-Li Zhou, Long-Bo Ma, Chang-Min Liu, Xia Han

Pages: 263-270 Published online on: 26 April 2016

Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition

Xiang Zhang, Dan Lin, Rong Jiang, Hongzhong Li, Jingyuan Wan, Hongyuan Li

Pages: 271-278 Published online on: 12 May 2016

S100A8 facilitates the migration of colorectal cancer cells through regulating macrophages in the inflammatory microenvironment

He Zha, Hui Sun, Xueru Li, Liang Duan, Aifang Li, Yue Gu, Zongyue Zeng, Jiali Zhao, Jiaqing Xie, Shimei Yuan, Huan Li, Lan Zhou

Pages: 279-290 Published online on: 06 May 2016

Oxymatrine inhibits the proliferation of CaSki cells via downregulating HPV16E7 expression

Zhijun Pei, Jing Zeng, Yan Gao, Fuyan Li, Wei Li, Hong Zhou, Yi Yang, Ruimin Wu, Yijia Chen, Jie Liu

Pages: 291-298 Published online on: 10 May 2016

Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference

Yi Zhang, Yan Ran, Yan Xiong, Zi-Biao Zhong, Zheng‑Hua Wang, Xiao-Li Fan, Qi-Fa Ye

Pages: 299-305 Published online on: 19 May 2016

T-box transcription factor brachyury promotes tumor cell invasion and metastasis in non-small cell lung cancer via upregulation of matrix metalloproteinase 12

Zongmiao Wan, Dongjie Jiang, Su Chen, Jian Jiao, Lei Ji, Abdus Saboor Shah, Haifeng Wei, Xinghai Yang, Xiaotao Li, Ying Wang, Jianru Xiao

Pages: 306-314 Published online on: 09 May 2016

Lentinan mitigates therarubicin-induced myelosuppression by activating bone marrow-derived macrophages in an MAPK/NF-κB-dependent manner

Qiang Liu, Lei Dong, Hong Li, Jia Yuan, Yuping Peng, Shejiao Dai

Pages: 315-323 Published online on: 26 April 2016

Induction of KIFC1 expression in gastric cancer spheroids

Naohide Oue, Shoichiro Mukai, Takeharu Imai, Trang T.B. Pham, Takashi Oshima, Kazuhiro Sentani, Naoya Sakamoto, Kazuhiro Yoshida, Wataru Yasui

Pages: 349-355 Published online on: 28 April 2016

The combination of NVP-BKM120 with trastuzumab or RAD001 synergistically inhibits the growth of breast cancer stem cells in vivo

Feng Yu, Jing Zhao, Yunhui Hu, Yang Zhou, Rong Guo, Jingchao Bai, Sheng Zhang, Huilai Zhang, Jin Zhang

Pages: 356-364 Published online on: 10 May 2016

Combined use of PI3K and MEK inhibitors synergistically inhibits lung cancer with EGFR and KRAS mutations

Ze-Bo Jiang, Jun Huang, Chun Xie, Xia Li, Liping Liu, Jiaxi He, Hui Pan, Liyan Huang, Xing-Xing Fan, Xiao-Jun Yao, Ying Xie, Na Li, Liang Liu, Jian-Xing He, Elaine Lai-Han Leung

Pages: 365-375 Published online on: 26 April 2016

Downregulation of miR-195 promotes prostate cancer progression by targeting HMGA1

Xiaowen Zhang, Tao Tao, Chunhui Liu, Han Guan, Yeqing Huang, Bin Xu, Ming Chen

Pages: 376-382 Published online on: 09 May 2016

Downregulation of miR-34a contributes to the proliferation and migration of laryngeal carcinoma cells by targeting cyclin D1

Jin Ye, Laisheng Li, Pinning Feng, Jianxin Wan, Jingjia Li

Pages: 390-398 Published online on: 19 May 2016

Improved safety and efficacy of a lipid emulsion loaded with a paclitaxel-cholesterol complex for the treatment of breast tumors

Jun Ye, Yuling Liu, Xuejun Xia, Luhua Meng, Wujun Dong, Renyun Wang, Zhaodi Fu, Hongyan Liu, Rui Han

Pages: 399-409 Published online on: 06 May 2016

BMP9 inhibits the growth and migration of lung adenocarcinoma A549 cells in a bone marrow stromal cell‑derived microenvironment through the MAPK/ERK and NF-κB pathways

Jing Wang, Yaguang Weng, Minghao Zhang, Ya Li, Mengtian Fan, Yangliu Guo, Yanting Sun, Wang Li, Qiong Shi

Pages: 410-418 Published online on: 09 May 2016

Aberrant expression of B7-H4 correlates with poor prognosis and suppresses tumor-infiltration of CD8+ T lymphocytes in human cholangiocarcinoma

Xin Zhao, Fei Guo, Zhonghu Li, Peng Jiang, Xiang Deng, Feng Tian, Xiaowu Li, Shuguang Wang

Pages: 419-427 Published online on: 13 May 2016

Ursolic acid inhibits proliferation and reverses drug resistance of ovarian cancer stem cells by downregulating ABCG2 through suppressing the expression of hypoxia-inducible factor-1α in vitro

Wen-Jing Wang, Hua Sui, Cong Qi, Qi Li, Jie Zhang, Shao-Fei Wu, Ming-Zhu Mei, Ying-Yu Lu, Yi-Ting Wan, Hannah Chang, Piao-Ting Guo

Pages: 428-440 Published online on: 18 May 2016

Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells

Jia Wang, Xianyao Wan, Yifan Gao, Mintao Zhong, Li Sha, Ben Liu, Wei Zhang, Li Tian, Wenjing Ruan, Shuyun Cao, Min Huang

Pages: 441-447 Published online on: 23 May 2016

Tspan9 inhibits the proliferation, migration and invasion of human gastric cancer SGC7901 cells via the ERK1/2 pathway

Pai-Yun Li, Jing Lv, Wei-Wei Qi, Shu-Fen Zhao, Li-Bin Sun, Ning Liu, Jie Sheng, Wen-Sheng Qiu

Pages: 448-454 Published online on: 13 May 2016

Upregulation of ABCG2 via the PI3K-Akt pathway contributes to acidic microenvironment-induced cisplatin resistance in A549 and LTEP-a-2 lung cancer cells

Chun Fang Hu, Yi Ying Huang, Yong Jie Wang, Feng Guang Gao

Pages: 455-461 Published online on: 23 May 2016

Transcriptional network in ovarian cancer cell line SKOV3 treated with Pinellia pedatisecta Schott extract

Li Zhou, Teng Xu, Ying Zhang, Mei Zhu, Wen Zhu, Ziqiang Wang, Hangzhi Gu, Hanchu Wang, Peizhen Li, Jun Ying, Lei Yang, Ping Ren, Jinsong Li, Zuyuan Xu, Liyan Ni, Qiyu Bao, Jindong Chen

Pages: 462-470 Published online on: 28 April 2016

MicroRNA-18b inhibits the growth of malignant melanoma via inhibition of HIF-1α-mediated glycolysis

Yao Chen, Ziqing Zhang, Chengqun Luo, Zizi Chen, Jianda Zhou

Pages: 471-479 Published online on: 20 May 2016

miR-410-3p suppresses breast cancer progression by targeting Snail

Ya-Feng Zhang, Yue Yu, Wang-Zhao Song, Rui-Ming Zhang, Shan Jin, Jun-Wen Bai, Hong-Bin Kang, Xin Wang, Xu-Chen Cao

Pages: 480-486 Published online on: 23 May 2016

miR-375 inhibits the invasion and metastasis of colorectal cancer via targeting SP1 and regulating EMT-associated genes

Fengyun Cui, Shuyang Wang, Iweng Lao, Chunxian Zhou, Hui Kong, Nayima Bayaxi, Jiali Li, Qi Chen, Tengfang Zhu, Hongguang Zhu

Pages: 487-493 Published online on: 24 May 2016

Expression and inhibitory role of TIMP-3 in hepatocellular carcinoma

Bo Shen, Yingjie Jiang, Yuan-Ran Chen, Hui-Cong Zheng, Wei Zeng, Yu-Yuan Li, Aoxian Yin, Yuqiang Nie

Pages: 494-502 Published online on: 18 May 2016

Usefulness of a fluorescence visualization system for the detection of oral precancerous and early cancerous lesions

Yuichi Ohnishi, Tomoko Fujii, Yoshihide Ugaki, Hiroki Yasui, Masahiro Watanabe, Suguru Dateoka, Kenji Kakudo

Pages: 514-520 Published online on: 28 April 2016

Hypoxia inducible factor-1α-dependent epithelial to mesenchymal transition under hypoxic conditions in prostate cancer cells

Mingchuan Li, Yong Xing Wang, Yong Luo, Jiahui Zhao, Qing Li, Jiao Zhang, Yongguang Jiang

Pages: 521-527 Published online on: 25 April 2016

Anticancer activity of 7,8-dihydroxyflavone in melanoma cells via downregulation of α-MSH/cAMP/MITF pathway

Deok Yong Sim, Jae Kyung Sohng, Hye Jin Jung

Pages: 528-534 Published online on: 20 May 2016

Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer

Hye Youn Sung, Jihye Han, Woong Ju, Jung-Hyuck Ahn

Pages: 535-541 Published online on: 24 May 2016

Overexpression of PAD4 suppresses drug resistance of NSCLC cell lines to gefitinib through inhibiting Elk1-mediated epithelial-mesenchymal transition

Qiong Duan, Cui Pang, Ning Chang, Ju Zhang, Wenchao Liu

Pages: 551-558 Published online on: 28 April 2016

Skp2 is associated with paclitaxel resistance in prostate cancer cells

Yeguo Yang, Yi Lu, Lihui Wang, Atsushi Mizokami, Evan T. Keller, Jian Zhang, Jiejun Fu

Pages: 559-566 Published online on: 13 May 2016

Clinicopathological implications of vascular endothelial growth factor 165b expression in oral squamous cell carcinoma stroma

Masahiro Nagasaki, Seiji Kondo, Yoshiki Mukudai, Takaaki Kamatani, Ayako Akizuki, Atsushi Yaso, Toshikazu Shimane, Tatsuo Shirota

Pages: 573-581 Published online on: 20 May 2016

Hepatitis C virus core protein regulates OCT4 expression and promotes cell cycle progression in hepatocellular carcinoma

Jia-Jia Zhou, Zhe Meng, Yu Zhou, Di Cheng, Hui-Lin Ye, Quan-Bo Zhou, Xiao-Geng Deng, Ru-Fu Chen

Pages: 582-588 Published online on: 27 April 2016

HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma

Zhihao Wang, Fang Tang, Pengchao Hu, Ying Wang, Jun Gong, Shaoxing Sun, Conghua Xie

Pages: 589-597 Published online on: 16 May 2016
Journal Cover

July-2016
Volume 36 Issue 1

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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