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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2016 Volume 36 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

The role of JAM-B in cancer and cancer metastasis (Review)

Huishan Zhao, Hefen Yu, Tracey A. Martin, Xu Teng, Wen G. Jiang
Pages: 3-9
Published online on: 27 April 2016

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Article Open Access

Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma

Song Xu, Xiao-Ming Yi, Chao-Peng Tang, Jing-Ping Ge, Zheng-Yu Zhang, Wen-Quan Zhou
Pages: 10-22
Published online on: 09 May 2016

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Article

Overexpression of WNT5B promotes COLO 205 cell migration and invasion through the JNK signaling pathway

Ying Zhang, Lianjie Lin, Yu Jin, Yan Lin, Yong Cao, Changqing Zheng
Pages: 23-30
Published online on: 27 April 2016

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Article Open Access

Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells

Hye-Sook Seo, Jin Mo Ku, Han-Seok Choi, Youn Kyung Choi, Jong-Kyu Woo, Minsoo Kim, Ilhwan Kim, Chang Hyeok Na, Hansol Hur, Bo‑Hyoung Jang, Yong Cheol Shin, Seong-Gyu Ko
Pages: 31-42
Published online on: 05 May 2016

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Article Open Access

Low expression of leptin and its association with breast cancer: A transcriptomic study

Sajjad Karim, Adnan Merdad, Hans-Juergen Schulten, Manikandan Jayapal, Ashraf Dallol, Abdelbaset Buhmeida, Fatima Al-Thubaity, Zeenat Mirza, Mamdooh A. Gari, Adeel G. Chaudhary, Adel M. Abuzenadah, Mohammed H. Al-Qahtani
Pages: 43-48
Published online on: 13 May 2016

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Article Open Access

Regulation of cell apoptosis and proliferation in pancreatic cancer through PI3K/Akt pathway via Polo-like kinase 1

Yonghuan Mao, Ling Xi, Quan Li, Zeling Cai, Yimei Lai, Xinhua Zhang, Chunzhao Yu
Pages: 49-56
Published online on: 18 May 2016

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Article Open Access

Methylation-induced silencing of maspin contributes to the proliferation of human glioma cells

Liang Xu, Hongyuan Liu, Ju Yu, Zhongyong Wang, Qing Zhu, Zongping Li, Qi Zhong, Shuyu Zhang, Mingqi Qu, Qing Lan
Pages: 57-64
Published online on: 04 May 2016

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Article Open Access

miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer

Meisi Yan, Xiaobo Li, Dandan Tong, Changsong Han, Ran Zhao, Yan He, Xiaoming Jin
Pages: 65-71
Published online on: 25 April 2016

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Article Open Access

Ionizing radiation promotes advanced malignant traits in nasopharyngeal carcinoma via activation of epithelial-mesenchymal transition and the cancer stem cell phenotype

Zhongwu Su, Guo Li, Chao Liu, Shuling Ren, Yongquan Tian, Yong Liu, Yuanzheng Qiu
Pages: 72-78
Published online on: 25 April 2016

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Article Open Access

A new non-muscle-invasive bladder tumor-homing peptide identified by phage display in vivo

Xiaofeng Yang, Fan Zhang, Junqian Luo, Jianzhi Pang, Sanhua Yan, Fang Luo, Jiehao Liu, Wei Wang, Yongping Cui, Xixi Su
Pages: 79-89
Published online on: 23 May 2016

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Article Open Access

Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway Retraction in /10.3892/or.2025.8928

Kun Ma, Chuan Zhang, Man-Yu Huang, Wu-Yin Li, Guo-Qiang Hu
Pages: 90-98
Published online on: 28 April 2016

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Article Open Access

Polyphenols from Korean prostrate spurge Euphorbia supina induce apoptosis through the Fas-associated extrinsic pathway and activation of ERK in human leukemic U937 cells

Min-Ho Han, Won Sup Lee, Arulkumar Nagappan, Hye Jung Kim, Cheol Park, Gi-Young Kim, Sang Hoon Hong, Nam Deuk Kim, Gonsup Kim, Chung Ho Ryu, Sung Chul Shin, Yung Hyun Choi
Pages: 99-107
Published online on: 28 April 2016

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Article Open Access

STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer

Yao Cui, Yun-Yun Li, Jian Li, Hong-Yan Zhang, Feng Wang, Xue Bai, Shan-Shan Li
Pages: 108-116
Published online on: 19 May 2016

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Article

Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway

Ka Hwi Kim, Jung-Il Chae, Hana Oh, Jin Hyoung Cho, Ra-Ham Lee, Goo Yoon, Seung-Sik Cho, Young-Sik Cho, Mee-Hyun Lee, Kangdong Liu, Hyun-Jeong Lee, Jung-Hyun Shim
Pages: 117-124
Published online on: 10 May 2016

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Article

Increased expression and activity of p75NTR are crucial events in azacitidine-induced cell death in prostate cancer

Giovanni Luca Gravina, Francesco Marampon, Patrizia Sanità, Andrea Mancini, Alessandro Colapietro, Luca Scarsella, Ana Jitariuc, Leda Biordi, Corrado Ficorella, Claudio Festuccia
Pages: 125-130
Published online on: 23 May 2016

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Article

Development of a novel microbubble-liposome complex conjugated with peptide ligands targeting IL4R on brain tumor cells

See-Hyoung Park, Young II Yoon, Hyoungwon Moon, Ga-Hyun Lee, Byung-Heon Lee, Tae-Jong Yoon, Hak Jong Lee
Pages: 131-136
Published online on: 24 May 2016

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Article

20(S)-ginsenoside Rh2 inhibits the proliferation and induces the apoptosis of KG-1a cells through the Wnt/β-catenin signaling pathway

Yi Chen, Ze-Hong Liu, Jing Xia, Xiao-Peng Li, Ke‑Qiong Li, Wei Xiong, Jing Li, Di-Long Chen
Pages: 137-146
Published online on: 27 April 2016

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Article

Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway

Jian-Ying Li, Jun Yu, Xu-Sheng Du, Hui-Min Zhang, Bo Wang, Hua Guo, Jie Bai, Juan-Hong Wang, An Liu, Yi-Li Wang
Pages: 147-154
Published online on: 04 May 2016

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Article

Genome-wide analysis of the effect of esophageal squamous cell carcinoma on human umbilical vein endothelial cells

Guoguo Jin, Yi Yang, Hangfan Liu, Kangdong Liu, Jimin Zhao, Xinhuan Chen, Xiaoyan Zhang, Yanyan Zhang, Jing Lu, Ziming Dong
Pages: 155-164
Published online on: 18 May 2016

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Article

Isoquercitrin inhibits bladder cancer progression in vivo and in vitro by regulating the PI3K/Akt and PKC signaling pathways Retraction in /10.3892/or.2023.8684

Feng Chen, Xiaochi Chen, Deyong Yang, Xiangyu Che, Jianbo Wang, Xiancheng Li, Zhiwei Zhang, Qifei Wang, Wei Zheng, Lina Wang, Xuejian Wang, Xishuang Song
Pages: 165-172
Published online on: 09 May 2016

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Article

RNaseH2A is involved in human gliomagenesis through the regulation of cell proliferation and apoptosis

Bin Dai, Peng Zhang, Yisong Zhang, Changcun Pan, Guolu Meng, Xinru Xiao, Zhen Wu, Wang Jia, Junting Zhang, Liwei Zhang
Pages: 173-180
Published online on: 10 May 2016

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Article

Notch2 is a crucial regulator of self-renewal and tumorigenicity in human hepatocellular carcinoma cells

Wen-Rui Wu, Rui Zhang, Xiang-De Shi, Cao Yi, Lei-Bo Xu, Chao Liu
Pages: 181-188
Published online on: 23 May 2016

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Article

MicroRNA-146a inhibits cell migration and invasion by targeting RhoA in breast cancer

Qin Liu, Wei Wang, Xiongfa Yang, Dongxiao Zhao, Fangqiong Li, Hai Wang
Pages: 189-196
Published online on: 06 May 2016

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Article

Nuclear EpICD expression and its role in hepatocellular carcinoma

Shin Young Park, Jun Sang Bae, Eun Jung Cha, Hyun Hee Chu, Jang Sihn Sohn, Woo Sung Moon
Pages: 197-204
Published online on: 06 May 2016

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Article

Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway Corrigendum in /10.3892/or.2022.8301

Moon Hee Lee, Su-Hyun Hong, Cheol Park, Gi-Young Kim, Sun-Hee Leem, Sung Hyun Choi, Young-Sam Keum, Jin Won Hyun, Taeg Kyu Kwon, Sang Hoon Hong, Yung Hyun Choi
Pages: 205-214
Published online on: 17 May 2016

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Article

An eight-long non-coding RNA signature as a candidate prognostic biomarker for lung cancer

Zhenbo Tu, Du He, Xinzhou Deng, Meng Xiong, Xiaoxing Huang, Xinran Li, Ling Hao, Qianshan Ding, Qiuping Zhang
Pages: 215-222
Published online on: 18 May 2016

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Article

Knockdown of DDX46 inhibits proliferation and induces apoptosis in esophageal squamous cell carcinoma cells

Bin Li, Yu-Min Li, Wen-Ting He, Hao Chen, Hong-Wen Zhu, Tao Liu, Jian-Hua Zhang, Tie-Niu Song, Ya-Li Zhou
Pages: 223-230
Published online on: 11 May 2016

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Article

B7-H3 upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu

Zhang Zhang Sun, Ting Zhang, Kuan Ning, Ruan Zhu, Fen Liu, Shou-Ching Tang, Bo Jiang, Dong Hua
Pages: 231-238
Published online on: 13 May 2016

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Article

Zidovudine, abacavir and lamivudine increase the radiosensitivity of human esophageal squamous cancer cell lines

Xuan Chen, Cong Wang, Shanghui Guan, Yuan Liu, Lihui Han, Yufeng Cheng
Pages: 239-246
Published online on: 18 May 2016

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Article

Downregulation of miR-377 contributes to IRX3 deregulation in hepatocellular carcinoma

Pei Wang, Chunbo Zhuang, Da Huang, Keshu Xu
Pages: 247-252
Published online on: 18 May 2016

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Article

Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways

Qianqian Jiang, Yu Pan, Yupeng Cheng, Huiling Li, Dandan Liu, Hui Li
Pages: 253-262
Published online on: 09 May 2016

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Article

Silencing of long non-coding RNA ANRIL inhibits the development of multidrug resistance in gastric cancer cells

Wei-Guang Lan, Dian-Hong Xu, Chen Xu, Chang-Ling Ding, Fang-Ling Ning, Yan-Li Zhou, Long-Bo Ma, Chang-Min Liu, Xia Han
Pages: 263-270
Published online on: 26 April 2016

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Article

Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition

Xiang Zhang, Dan Lin, Rong Jiang, Hongzhong Li, Jingyuan Wan, Hongyuan Li
Pages: 271-278
Published online on: 12 May 2016

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Article

S100A8 facilitates the migration of colorectal cancer cells through regulating macrophages in the inflammatory microenvironment

He Zha, Hui Sun, Xueru Li, Liang Duan, Aifang Li, Yue Gu, Zongyue Zeng, Jiali Zhao, Jiaqing Xie, Shimei Yuan, Huan Li, Lan Zhou
Pages: 279-290
Published online on: 06 May 2016

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Article

Oxymatrine inhibits the proliferation of CaSki cells via downregulating HPV16E7 expression

Zhijun Pei, Jing Zeng, Yan Gao, Fuyan Li, Wei Li, Hong Zhou, Yi Yang, Ruimin Wu, Yijia Chen, Jie Liu
Pages: 291-298
Published online on: 10 May 2016

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Article

Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference

Yi Zhang, Yan Ran, Yan Xiong, Zi-Biao Zhong, Zheng‑Hua Wang, Xiao-Li Fan, Qi-Fa Ye
Pages: 299-305
Published online on: 19 May 2016

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Article

T-box transcription factor brachyury promotes tumor cell invasion and metastasis in non-small cell lung cancer via upregulation of matrix metalloproteinase 12

Zongmiao Wan, Dongjie Jiang, Su Chen, Jian Jiao, Lei Ji, Abdus Saboor Shah, Haifeng Wei, Xinghai Yang, Xiaotao Li, Ying Wang, Jianru Xiao
Pages: 306-314
Published online on: 09 May 2016

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Article

Lentinan mitigates therarubicin-induced myelosuppression by activating bone marrow-derived macrophages in an MAPK/NF-κB-dependent manner

Qiang Liu, Lei Dong, Hong Li, Jia Yuan, Yuping Peng, Shejiao Dai
Pages: 315-323
Published online on: 26 April 2016

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Article

Bergamottin isolated from Citrus bergamia exerts in vitro and in vivo antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and invasion Retraction in /10.3892/or.2021.8058

Hui-Juan Wu, Hong-Bo Wu, Yan-Qiu Zhao, Li-Juan Chen, Hong-Zhi Zou
Pages: 324-332
Published online on: 23 May 2016

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Article

A novel all-trans retinoic acid derivative 4-amino‑2‑trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP

Hui Liu, Feihu Chen, Ling Zhang, Qing Zhou, Shuyu Gui, Yuan Wang
Pages: 333-341
Published online on: 09 May 2016

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Article

Myricetin suppresses p21-activated kinase 1 in human breast cancer MCF-7 cells through downstream signaling of the β-catenin pathway

De Jiao, Xue Dong Zhang
Pages: 342-348
Published online on: 28 April 2016

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Article

Induction of KIFC1 expression in gastric cancer spheroids

Naohide Oue, Shoichiro Mukai, Takeharu Imai, Trang T.B. Pham, Takashi Oshima, Kazuhiro Sentani, Naoya Sakamoto, Kazuhiro Yoshida, Wataru Yasui
Pages: 349-355
Published online on: 28 April 2016

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Article

The combination of NVP-BKM120 with trastuzumab or RAD001 synergistically inhibits the growth of breast cancer stem cells in vivo

Feng Yu, Jing Zhao, Yunhui Hu, Yang Zhou, Rong Guo, Jingchao Bai, Sheng Zhang, Huilai Zhang, Jin Zhang
Pages: 356-364
Published online on: 10 May 2016

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Article

Combined use of PI3K and MEK inhibitors synergistically inhibits lung cancer with EGFR and KRAS mutations

Ze-Bo Jiang, Jun Huang, Chun Xie, Xia Li, Liping Liu, Jiaxi He, Hui Pan, Liyan Huang, Xing-Xing Fan, Xiao-Jun Yao, Ying Xie, Na Li, Liang Liu, Jian-Xing He, Elaine Lai-Han Leung
Pages: 365-375
Published online on: 26 April 2016

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Article

Downregulation of miR-195 promotes prostate cancer progression by targeting HMGA1

Xiaowen Zhang, Tao Tao, Chunhui Liu, Han Guan, Yeqing Huang, Bin Xu, Ming Chen
Pages: 376-382
Published online on: 09 May 2016

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Article

Protocadherin-10 acts as a tumor suppressor gene, and is frequently downregulated by promoter methylation in pancreatic cancer cells

Chan Qiu, Xiaona Bu, Zheng Jiang
Pages: 383-389
Published online on: 09 May 2016

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Article

Downregulation of miR-34a contributes to the proliferation and migration of laryngeal carcinoma cells by targeting cyclin D1

Jin Ye, Laisheng Li, Pinning Feng, Jianxin Wan, Jingjia Li
Pages: 390-398
Published online on: 19 May 2016

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Article

Improved safety and efficacy of a lipid emulsion loaded with a paclitaxel-cholesterol complex for the treatment of breast tumors

Jun Ye, Yuling Liu, Xuejun Xia, Luhua Meng, Wujun Dong, Renyun Wang, Zhaodi Fu, Hongyan Liu, Rui Han
Pages: 399-409
Published online on: 06 May 2016

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Article

BMP9 inhibits the growth and migration of lung adenocarcinoma A549 cells in a bone marrow stromal cell‑derived microenvironment through the MAPK/ERK and NF-κB pathways

Jing Wang, Yaguang Weng, Minghao Zhang, Ya Li, Mengtian Fan, Yangliu Guo, Yanting Sun, Wang Li, Qiong Shi
Pages: 410-418
Published online on: 09 May 2016

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Article

Aberrant expression of B7-H4 correlates with poor prognosis and suppresses tumor-infiltration of CD8+ T lymphocytes in human cholangiocarcinoma

Xin Zhao, Fei Guo, Zhonghu Li, Peng Jiang, Xiang Deng, Feng Tian, Xiaowu Li, Shuguang Wang
Pages: 419-427
Published online on: 13 May 2016

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Article

Ursolic acid inhibits proliferation and reverses drug resistance of ovarian cancer stem cells by downregulating ABCG2 through suppressing the expression of hypoxia-inducible factor-1α in vitro

Wen-Jing Wang, Hua Sui, Cong Qi, Qi Li, Jie Zhang, Shao-Fei Wu, Ming-Zhu Mei, Ying-Yu Lu, Yi-Ting Wan, Hannah Chang, Piao-Ting Guo
Pages: 428-440
Published online on: 18 May 2016

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Article

Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells

Jia Wang, Xianyao Wan, Yifan Gao, Mintao Zhong, Li Sha, Ben Liu, Wei Zhang, Li Tian, Wenjing Ruan, Shuyun Cao, Min Huang
Pages: 441-447
Published online on: 23 May 2016

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Article

Tspan9 inhibits the proliferation, migration and invasion of human gastric cancer SGC7901 cells via the ERK1/2 pathway

Pai-Yun Li, Jing Lv, Wei-Wei Qi, Shu-Fen Zhao, Li-Bin Sun, Ning Liu, Jie Sheng, Wen-Sheng Qiu
Pages: 448-454
Published online on: 13 May 2016

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Article

Upregulation of ABCG2 via the PI3K-Akt pathway contributes to acidic microenvironment-induced cisplatin resistance in A549 and LTEP-a-2 lung cancer cells

Chun Fang Hu, Yi Ying Huang, Yong Jie Wang, Feng Guang Gao
Pages: 455-461
Published online on: 23 May 2016

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Article

Transcriptional network in ovarian cancer cell line SKOV3 treated with Pinellia pedatisecta Schott extract

Li Zhou, Teng Xu, Ying Zhang, Mei Zhu, Wen Zhu, Ziqiang Wang, Hangzhi Gu, Hanchu Wang, Peizhen Li, Jun Ying, Lei Yang, Ping Ren, Jinsong Li, Zuyuan Xu, Liyan Ni, Qiyu Bao, Jindong Chen
Pages: 462-470
Published online on: 28 April 2016

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Article

MicroRNA-18b inhibits the growth of malignant melanoma via inhibition of HIF-1α-mediated glycolysis Retraction in /10.3892/or.2021.8161

Yao Chen, Ziqing Zhang, Chengqun Luo, Zizi Chen, Jianda Zhou
Pages: 471-479
Published online on: 20 May 2016

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miR-410-3p suppresses breast cancer progression by targeting Snail

Ya-Feng Zhang, Yue Yu, Wang-Zhao Song, Rui-Ming Zhang, Shan Jin, Jun-Wen Bai, Hong-Bin Kang, Xin Wang, Xu-Chen Cao
Pages: 480-486
Published online on: 23 May 2016

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miR-375 inhibits the invasion and metastasis of colorectal cancer via targeting SP1 and regulating EMT-associated genes

Fengyun Cui, Shuyang Wang, Iweng Lao, Chunxian Zhou, Hui Kong, Nayima Bayaxi, Jiali Li, Qi Chen, Tengfang Zhu, Hongguang Zhu
Pages: 487-493
Published online on: 24 May 2016

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Expression and inhibitory role of TIMP-3 in hepatocellular carcinoma

Bo Shen, Yingjie Jiang, Yuan-Ran Chen, Hui-Cong Zheng, Wei Zeng, Yu-Yuan Li, Aoxian Yin, Yuqiang Nie
Pages: 494-502
Published online on: 18 May 2016

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Comparative analysis of macrophage transcriptomes reveals a key mechanism of the immunomodulatory activity of Tricholoma matsutake polysaccharide

Xiang Ding, Jian Li, Yiling Hou, Wanru Hou
Pages: 503-513
Published online on: 18 May 2016

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Usefulness of a fluorescence visualization system for the detection of oral precancerous and early cancerous lesions

Yuichi Ohnishi, Tomoko Fujii, Yoshihide Ugaki, Hiroki Yasui, Masahiro Watanabe, Suguru Dateoka, Kenji Kakudo
Pages: 514-520
Published online on: 28 April 2016

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Hypoxia inducible factor-1α-dependent epithelial to mesenchymal transition under hypoxic conditions in prostate cancer cells

Mingchuan Li, Yong Xing Wang, Yong Luo, Jiahui Zhao, Qing Li, Jiao Zhang, Yongguang Jiang
Pages: 521-527
Published online on: 25 April 2016

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Anticancer activity of 7,8-dihydroxyflavone in melanoma cells via downregulation of α-MSH/cAMP/MITF pathway

Deok Yong Sim, Jae Kyung Sohng, Hye Jin Jung
Pages: 528-534
Published online on: 20 May 2016

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Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer

Hye Youn Sung, Jihye Han, Woong Ju, Jung-Hyuck Ahn
Pages: 535-541
Published online on: 24 May 2016

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MicroRNA-874 inhibits growth, induces apoptosis and reverses chemoresistance in colorectal cancer by targeting X-linked inhibitor of apoptosis protein Retraction in /10.3892/or.2022.8280

Jinfeng Han, Zhongmin Liu, Nanya Wang, Weiyun Pan
Pages: 542-550
Published online on: 16 May 2016

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Overexpression of PAD4 suppresses drug resistance of NSCLC cell lines to gefitinib through inhibiting Elk1-mediated epithelial-mesenchymal transition

Qiong Duan, Cui Pang, Ning Chang, Ju Zhang, Wenchao Liu
Pages: 551-558
Published online on: 28 April 2016

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Skp2 is associated with paclitaxel resistance in prostate cancer cells

Yeguo Yang, Yi Lu, Lihui Wang, Atsushi Mizokami, Evan T. Keller, Jian Zhang, Jiejun Fu
Pages: 559-566
Published online on: 13 May 2016

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Berberine in combination with cisplatin suppresses breast cancer cell growth through induction of DNA breaks and caspase-3-dependent apoptosis

Yuwan Zhao, Zuolei Jing, Yan Li, Weifeng Mao
Pages: 567-572
Published online on: 05 May 2016

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Article

Clinicopathological implications of vascular endothelial growth factor 165b expression in oral squamous cell carcinoma stroma

Masahiro Nagasaki, Seiji Kondo, Yoshiki Mukudai, Takaaki Kamatani, Ayako Akizuki, Atsushi Yaso, Toshikazu Shimane, Tatsuo Shirota
Pages: 573-581
Published online on: 20 May 2016

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Article

Hepatitis C virus core protein regulates OCT4 expression and promotes cell cycle progression in hepatocellular carcinoma

Jia-Jia Zhou, Zhe Meng, Yu Zhou, Di Cheng, Hui-Lin Ye, Quan-Bo Zhou, Xiao-Geng Deng, Ru-Fu Chen
Pages: 582-588
Published online on: 27 April 2016

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Article

HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma

Zhihao Wang, Fang Tang, Pengchao Hu, Ying Wang, Jun Gong, Shaoxing Sun, Conghua Xie
Pages: 589-597
Published online on: 16 May 2016

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Journal Cover
January-2026 Volume 55 Issue 1

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Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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