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Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma

  • Authors:
    • Song Xu
    • Xiao-Ming Yi
    • Chao-Peng Tang
    • Jing-Ping Ge
    • Zheng-Yu Zhang
    • Wen-Quan Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 10-22
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    Published online on: May 9, 2016
       https://doi.org/10.3892/or.2016.4791
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Abstract

Long non-coding RNAs (lncRNAs) have been identified to be critical mediators in various tumors associated with cancer progression. Long non-coding RNA activated by TGF-β (lncRNA-ATB) is a stimulator of epithelial-mesenchymal transition (EMT) and serves as a novel prognostic biomarker for hepatocellular carcinoma. However, the biological role and clinical significance of lncRNA-ATB in human prostate cancer have yet to be fully elucidated. The present study was designed to explore the expression of lncRNA-ATB in human prostate cancer patients and the role of lncRNA-ATB in prostate cancer cells. We showed that lncRNA-ATB expression was significantly upregulated in tumor tissues in patients with prostate cancer in comparison with adjacent non-tumor tissues. Further analysis indicted that high lncRNA-ATB expression may be an independent prognostic factor for biochemical recurrence (BCR)-free survival in prostate cancer patients. Overexpression of lncRNA-ATB promoted, and knockdown of lncRNA-ATB inhibited the growth of prostate cancer cells via regulations of cell cycle regulatory protein expression levels. In addition, lncRNA-ATB stimulated epithelial-mesenchymal transition (EMT) associated with ZEB1 and ZNF217 expression levels via ERK and PI3K/AKT signaling pathways. These results indicated that lncRNA-ATB may be considered as a new predictor in the clinical prognosis of patients with prostate cancer. Overexpression of lncRNA-ATB exerts mitogenic and EMT effects of prostate cancer via activation of ERK and PI3K/AKT signaling pathways.
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Copy and paste a formatted citation
Spandidos Publications style
Xu S, Yi X, Tang C, Ge J, Zhang Z and Zhou W: Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma. Oncol Rep 36: 10-22, 2016.
APA
Xu, S., Yi, X., Tang, C., Ge, J., Zhang, Z., & Zhou, W. (2016). Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma. Oncology Reports, 36, 10-22. https://doi.org/10.3892/or.2016.4791
MLA
Xu, S., Yi, X., Tang, C., Ge, J., Zhang, Z., Zhou, W."Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma". Oncology Reports 36.1 (2016): 10-22.
Chicago
Xu, S., Yi, X., Tang, C., Ge, J., Zhang, Z., Zhou, W."Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma". Oncology Reports 36, no. 1 (2016): 10-22. https://doi.org/10.3892/or.2016.4791
Copy and paste a formatted citation
x
Spandidos Publications style
Xu S, Yi X, Tang C, Ge J, Zhang Z and Zhou W: Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma. Oncol Rep 36: 10-22, 2016.
APA
Xu, S., Yi, X., Tang, C., Ge, J., Zhang, Z., & Zhou, W. (2016). Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma. Oncology Reports, 36, 10-22. https://doi.org/10.3892/or.2016.4791
MLA
Xu, S., Yi, X., Tang, C., Ge, J., Zhang, Z., Zhou, W."Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma". Oncology Reports 36.1 (2016): 10-22.
Chicago
Xu, S., Yi, X., Tang, C., Ge, J., Zhang, Z., Zhou, W."Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma". Oncology Reports 36, no. 1 (2016): 10-22. https://doi.org/10.3892/or.2016.4791
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