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Article

Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways

  • Authors:
    • Qianqian Jiang
    • Yu Pan
    • Yupeng Cheng
    • Huiling Li
    • Dandan Liu
    • Hui Li
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Basic Medical Science College, Harbin Medical University, Harbin 150081, P.R. China, School of Environment and Chemical Engineering, Heilongjiang University of Science and Technology, Harbin 150022, P.R. China, Pharmaceutical College, Heilongjiang University of Chinese Medicine, Harbin 150040, P.R. China
  • Pages: 253-262
    |
    Published online on: May 9, 2016
       https://doi.org/10.3892/or.2016.4798
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Abstract

Lunasin is a naturally existing bioactive peptide with an Arg-Gly-Asp (RGD) motif, which competes with integrins to bind with the extracellular matrix (ECM) consequently suppressing the integrin-mediated signaling pathway. Owing to the RGD motif, lunasin has been proven as an effective anti-inflammatory, antitumor and antimetastatic agent in many types of cancer. However, knowledge of its inhibitory effect on metastasis and the related mechanism of action in breast cancer cells is limited. In this study, the inhibitory effect of lunasin on the proliferation, migration and invasion of two typical breast cancer cell lines, ER-negative MDA-MB-231 with αVβ3 expression and ER-positive MCF-7 with αVβ5/α5β1 expression, were examined in vitro as well the related mechanisms. The results demonstrated that lunasin (10-20 µM) effectively inhibited the migration and invasion activity and expression of matrix metalloproteinase (MMP)‑2/-9 in both breast cancer cell lines. Meanwhile, we also found that lunasin inhibited the phosphorylation of focal adhesion kinase (FAK), Src, Akt, ERK and nucleus translocation of NF-κB, which indicates that, possibly via competing with αVβ3 or αVβ5/α5β1 integrin, lunasin suppresses the metastasis of breast cancer cells through integrin-mediated FAK/Akt/ERK and NF-κB signaling pathways followed by downregulation of the activity and expression of MMP-2/-9.
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View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Weigelt B, Peterse JL and van't Veer LJ: Breast cancer metastasis: Markers and models. Nat Rev Cancer. 5:591–602. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Danen EH: Integrins: regulators of tissue function and cancer progression. Curr Pharm Des. 11:881–891. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Eliceiri BP and Cheresh DA: Adhesion events in angiogenesis. Curr Opin Cell Biol. 13:563–568. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Ruoslahti E: Specialization of tumour vasculature. Nat Rev Cancer. 2:83–90. 2002. View Article : Google Scholar

6 

Temming K, Schiffelers RM, Molema G and Kok RJ: RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature. Drug Resist Updat. 8:381–402. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Galvez AF and de Lumen BO: A soybean cDNA encoding a chromatin-binding peptide inhibits mitosis of mammalian cells. Nat Biotechnol. 17:495–500. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Jeong HJ, Lam Y and de Lumen BO: Barley lunasin suppresses ras-induced colony formation and inhibits core histone acetylation in mammalian cells. J Agric Food Chem. 50:5903–5908. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Jeong HJ, Jeong JB, Kim DS, Park JH, Lee JB, Kweon DH, Chung GY, Seo EW and de Lumen BO: The cancer preventive peptide lunasin from wheat inhibits core histone acetylation. Cancer Lett. 255:42–48. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Silva-Sánchez C, de la Rosa AP, León-Galván MF, de Lumen BO, de León-Rodríguez A and de Mejía EG: Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed. J Agric Food Chem. 56:1233–1240. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Jeong JB, Jeong HJ, Park JH, Lee SH, Lee JR, Lee HK, Chung GY, Choi JD and de Lumen BO: Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histones H3 and H4 and phosphorylation of retinoblastoma protein (Rb). J Agric Food Chem. 55:10707–10713. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Hernández-Ledesma B, Hsieh CC and de Lumen BO: Relationship between lunasin's sequence and its inhibitory activity of histones H3 and H4 acetylation. Mol Nutr Food Res. 55:989–998. 2011. View Article : Google Scholar : PubMed/NCBI

13 

de Lumen BO: Lunasin: a cancer-preventive soy peptide. Nutr Rev. 63:16–21. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Dia VP and Gonzalez de Mejia E: Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to α5β1 integrin and suppresses FAK/ERK/NF-κB signaling. Cancer Lett. 313:167–180. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Cam A and de Mejia EG: RGD-peptide lunasin inhibits Akt-mediated NF-κB activation in human macrophages through interaction with the αVβ3 integrin. Mol Nutr Food Res. 56:1569–1581. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Hsieh CC, Hernandez-Ledesma B and de Lumen B: Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells. Food Chem. 125:630–636. 2011. View Article : Google Scholar

17 

Liang CC, Park AY and Guan JL: In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc. 2:329–333. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Xu L and Deng X: Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains. J Biol Chem. 281:4457–4466. 2006. View Article : Google Scholar

19 

Li C, Zhao Y, Yang D, Yu Y, Guo H, Zhao Z, Zhang B and Yin X: Inhibitory effects of kaempferol on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. Biochem Cell Biol. 93:16–27. 2015. View Article : Google Scholar

20 

Zhou R, Xu L, Ye M, Liao M, Du H and Chen H: Formononetin inhibits migration and invasion of MDA-MB-231 and 4T1 breast cancer cells by suppressing MMP-2 and MMP-9 through PI3K/AKT signaling pathways. Horm Metab Res. 46:753–760. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Hernández-Ledesma B, Hsieh CC and de Lumen BO: Lunasin, a novel seed peptide for cancer prevention. Peptides. 30:426–430. 2009. View Article : Google Scholar

22 

McCawley LJ and Matrisian LM: Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol Med Today. 6:149–156. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Hanemaaijer R, Verheijen JH, Maguire TM, Visser H, Toet K, McDermott E, O'Higgins N and Duffy MJ: Increased gelatinase-A and gelatinase-B activities in malignant vs. benign breast tumors. Int J Cancer. 86:204–207. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Zhang J and Hochwald SN: The role of FAK in tumor metabolism and therapy. Pharmacol Ther. 142:154–163. 2014. View Article : Google Scholar

25 

Toutant M, Costa A, Studler JM, Kadaré G, Carnaud M and Girault JA: Alternative splicing controls the mechanisms of FAK autophosphorylation. Mol Cell Biol. 22:7731–7743. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Schlaepfer DD, Mitra SK and Ilic D: Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta. 1692:77–102. 2004. View Article : Google Scholar : PubMed/NCBI

27 

van Nimwegen MJ and van de Water B: Focal adhesion kinase: a potential target in cancer therapy. Biochem Pharmacol. 73:597–609. 2007. View Article : Google Scholar

28 

Wu JT and Kral JG: The NF-kappaB/IkappaB signaling system: a molecular target in breast cancer therapy. J Surg Res. 123:158–169. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Hsieh CC, Hernández-Ledesma B and de Lumen BO: Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 186:127–134. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Deryugina EI and Quigley JP: Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev. 25:9–34. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Pellikainen JM, Ropponen KM, Kataja VV, Kellokoski JK, Eskelinen MJ and Kosma VM: Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis. Clin Cancer Res. 10:7621–7628. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Jezierska A and Motyl T: Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review. Med Sci Monit. 15:RA32–40. 2009.PubMed/NCBI

33 

Takada Y, Ye X and Simon S: The integrins. Genome Biol. 8:2152007. View Article : Google Scholar : PubMed/NCBI

34 

Cabodi S, Di Stefano P, Leal MP, Tinnirello A, Bisaro B, Morello V, Damiano L, Aramu S, Repetto D, Tornillo G, et al: Integrins and signal transduction. Adv Exp Med Biol. 674:43–54. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Meyer A, Auernheimer J, Modlinger A and Kessler H: Targeting RGD recognizing integrins: drug development, biomaterial research, tumor imaging and targeting. Curr Pharm Des. 12:2723–2747. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Dia VP and Gonzalez de Mejia E: Lunasin induces apoptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells. Mol Nutr Food Res. 55:623–634. 2011. View Article : Google Scholar : PubMed/NCBI

37 

de Mejia EG, Wang W and Dia VP: Lunasin, with an arginine-glycine-aspartic acid motif, causes apoptosis to L1210 leukemia cells by activation of caspase-3. Mol Nutr Food Res. 54:406–414. 2010. View Article : Google Scholar

38 

Inaba J, McConnell EJ and Davis KR: Lunasin sensitivity in non-small cell lung cancer cells is linked to suppression of integrin signaling and changes in histone acetylation. Int J Mol Sci. 15:23705–23724. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Meyer T, Marshall JF and Hart IR: Expression of alpha-V integrins and vitronectin receptor identity in breast cancer cells. Br J Cancer. 77:530–536. 1998. View Article : Google Scholar : PubMed/NCBI

40 

Rashidi LH, Homayoni H, Zou X, Liu L and Chen W: Investigation of the strategies for targeting of the afterglow nanoparticles to tumor cells. Photodiagnosis Photodyn Ther. 13:244–254. 2016. View Article : Google Scholar

41 

Shan D, Li J, Cai P, Prasad P, Liu F, Rauth AM and Wu XY: RGD-conjugated solid lipid nanoparticles inhibit adhesion and invasion of αVβ3 integrin-overexpressing breast cancer cells. Drug Deliv Transl Res. 5:15–26. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Zeng F, Luo F, Lv S, Zhang H, Cao C, Chen X, Wang S, Li Z, Wang X, Dou X, et al: A monoclonal antibody targeting neuropilin-1 inhibits adhesion of MCF7 breast cancer cells to fibronectin by suppressing the FAK/p130cas signaling pathway. Anticancer Drugs. 25:663–672. 2014.PubMed/NCBI

43 

Pal S, Moulik S, Dutta A and Chatterjee A: Extracellular matrix protein laminin induces matrix metalloproteinase-9 in human breast cancer cell line MCF-7. Cancer Microenviron. 7:71–78. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Cao W, Zheng W and Chen T: Ruthenium polypyridyl complex inhibits growth and metastasis of breast cancer cells by suppressing FAK signaling with enhancement of TRAIL-induced apoptosis. Sci Rep. 5:91572015. View Article : Google Scholar : PubMed/NCBI

45 

Tian T, Nan KJ, Guo H, Wang WJ, Ruan ZP, Wang SH, Liang X and Lu CX: PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway. Oncol Rep. 23:1593–1600. 2010.PubMed/NCBI

46 

Jung CH, Kim EM, Park JK, Hwang SG, Moon SK, Kim WJ and Um HD: Bmal1 suppresses cancer cell invasion by blocking the phosphoinositide 3-kinase-Akt-MMP-2 signaling pathway. Oncol Rep. 9:2109–2113. 2013.

47 

O-charoenrat P, Wongkajornsilp A, Rhys-Evans PH and Eccles SA: Signaling pathways required for matrix metalloproteinase-9 induction by betacellulin in head-and-neck squamous carcinoma cells. Int J Cancer. 111:174–183. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Kane LP, Shapiro VS, Stokoe D and Weiss A: Induction of NF-kappaB by the Akt/PKB kinase. Curr Biol. 9:601–604. 1999. View Article : Google Scholar : PubMed/NCBI

49 

de Mejia EG and Dia VP: Lunasin and lunasin-like peptides inhibit inflammation through suppression of NF-kappaB pathway in the macrophage. Peptides. 30:2388–2398. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang Q, Pan Y, Cheng Y, Li H, Liu D and Li H: Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways. Oncol Rep 36: 253-262, 2016.
APA
Jiang, Q., Pan, Y., Cheng, Y., Li, H., Liu, D., & Li, H. (2016). Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways. Oncology Reports, 36, 253-262. https://doi.org/10.3892/or.2016.4798
MLA
Jiang, Q., Pan, Y., Cheng, Y., Li, H., Liu, D., Li, H."Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways". Oncology Reports 36.1 (2016): 253-262.
Chicago
Jiang, Q., Pan, Y., Cheng, Y., Li, H., Liu, D., Li, H."Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways". Oncology Reports 36, no. 1 (2016): 253-262. https://doi.org/10.3892/or.2016.4798
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Q, Pan Y, Cheng Y, Li H, Liu D and Li H: Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways. Oncol Rep 36: 253-262, 2016.
APA
Jiang, Q., Pan, Y., Cheng, Y., Li, H., Liu, D., & Li, H. (2016). Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways. Oncology Reports, 36, 253-262. https://doi.org/10.3892/or.2016.4798
MLA
Jiang, Q., Pan, Y., Cheng, Y., Li, H., Liu, D., Li, H."Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways". Oncology Reports 36.1 (2016): 253-262.
Chicago
Jiang, Q., Pan, Y., Cheng, Y., Li, H., Liu, D., Li, H."Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways". Oncology Reports 36, no. 1 (2016): 253-262. https://doi.org/10.3892/or.2016.4798
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