Potential diagnostic value of lncRNA SPRY4-IT1 in hepatocellular carcinoma

  • Authors:
    • Wei Jing
    • Shanshan Gao
    • Man Zhu
    • Ping Luo
    • Xuan Jing
    • Hongyan Chai
    • Jiancheng Tu
  • View Affiliations

  • Published online on: June 7, 2016     https://doi.org/10.3892/or.2016.4859
  • Pages: 1085-1092
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Abstract

The manifestation of hepatocellular carcinoma (HCC) involves a multi-factor, multi-step and complex process. Due to the lack of early prediction indices, numerous patients are diagnosed in their late stage. Recently, research in the field of non-coding RNAs (ncRNAs) has changed the original idea that ncRNA genes are just ̔noise̓. Cumulative evidence shows that long non-coding RNAs (lncRNAs) among ncRNAs play an increasingly important role in epigenetics, pre-transcription and post-transcription. In the present study, we focused on the expression pattern of lncRNA SPRY4 intronic transcript 1 (SPRY4-IT1) and its clinical significance in HCC diagnostics. We analyzed the expression, its association with clinical characteristics and the diagnostic value of SPRY4-IT1 using HCC tissues, cell lines and plasma. The levels of SPRY4-IT1 were upregulated in HCC and were associated with tumor differentiation (r=0.249, p=0.039), tumor size (r=0.258, p=0.024) and tumor-node-metastasis (TNM) stage (r=0.287, p=0.015). Meanwhile, the sensitive of SPRY4-IT1 was 87.3% in differentiating HCC patients from controls. Our data suggest that SPRY4-IT1 plays a critical role in HCC tumorigenesis and may be considered as a potential diagnostic indicator in HCC.
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August-2016
Volume 36 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jing W, Gao S, Zhu M, Luo P, Jing X, Chai H and Tu J: Potential diagnostic value of lncRNA SPRY4-IT1 in hepatocellular carcinoma. Oncol Rep 36: 1085-1092, 2016
APA
Jing, W., Gao, S., Zhu, M., Luo, P., Jing, X., Chai, H., & Tu, J. (2016). Potential diagnostic value of lncRNA SPRY4-IT1 in hepatocellular carcinoma. Oncology Reports, 36, 1085-1092. https://doi.org/10.3892/or.2016.4859
MLA
Jing, W., Gao, S., Zhu, M., Luo, P., Jing, X., Chai, H., Tu, J."Potential diagnostic value of lncRNA SPRY4-IT1 in hepatocellular carcinoma". Oncology Reports 36.2 (2016): 1085-1092.
Chicago
Jing, W., Gao, S., Zhu, M., Luo, P., Jing, X., Chai, H., Tu, J."Potential diagnostic value of lncRNA SPRY4-IT1 in hepatocellular carcinoma". Oncology Reports 36, no. 2 (2016): 1085-1092. https://doi.org/10.3892/or.2016.4859