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Article

Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer

  • Authors:
    • Guangming Jin
    • Mingji Jin
    • Zhehu Jin
    • Zhonggao Gao
    • Xuezhe Yin
  • View Affiliations / Copyright

    Affiliations: Yanbian University Hospital, Yanji, Jilin 133000, P.R. China, State Key Laboratory of Bioactive Substance and Functions of Natural Medicines, Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China
  • Pages: 871-876
    |
    Published online on: June 8, 2016
       https://doi.org/10.3892/or.2016.4863
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Abstract

The aim of the present study was mainly to assess the advantage of docetaxel-loaded PEG-albumin nanoparticles (PEG-DANPs) against non-small cell lung cancer (NSCLC) compared with the commercial product of docetaxel (Aisu®) and docetaxel-albumin nanoparticles (DANPs). We made systematic assessments on these three drugs against NSCLC both in vitro and in vivo. Based on our experiments, PEG-DANPs showed a dose- and time-dependent efficacy in the in vitro cytotoxicity studies; the tumors growth and the metastases in the livers of NSCLC-bearing nude mice in vivo were reduced dmarkedly by PEG-DANPs, and the PEG-DANP-treated mice had a minimum of weight loss; furthermore, the mice which were treated with PEG-DANPs can survive longer than the other groups. In conclusion, the PEG-DANPs have the lowest side-effects, and the highest antitumor and metastases activity of the three drugs, and it may provide an alternative to patients with NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Jin G, Jin M, Jin Z, Gao Z and Yin X: Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer. Oncol Rep 36: 871-876, 2016.
APA
Jin, G., Jin, M., Jin, Z., Gao, Z., & Yin, X. (2016). Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer. Oncology Reports, 36, 871-876. https://doi.org/10.3892/or.2016.4863
MLA
Jin, G., Jin, M., Jin, Z., Gao, Z., Yin, X."Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer". Oncology Reports 36.2 (2016): 871-876.
Chicago
Jin, G., Jin, M., Jin, Z., Gao, Z., Yin, X."Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer". Oncology Reports 36, no. 2 (2016): 871-876. https://doi.org/10.3892/or.2016.4863
Copy and paste a formatted citation
x
Spandidos Publications style
Jin G, Jin M, Jin Z, Gao Z and Yin X: Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer. Oncol Rep 36: 871-876, 2016.
APA
Jin, G., Jin, M., Jin, Z., Gao, Z., & Yin, X. (2016). Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer. Oncology Reports, 36, 871-876. https://doi.org/10.3892/or.2016.4863
MLA
Jin, G., Jin, M., Jin, Z., Gao, Z., Yin, X."Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer". Oncology Reports 36.2 (2016): 871-876.
Chicago
Jin, G., Jin, M., Jin, Z., Gao, Z., Yin, X."Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer". Oncology Reports 36, no. 2 (2016): 871-876. https://doi.org/10.3892/or.2016.4863
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