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Article

Activation of the FAK/PI3K pathway is crucial for AURKA-induced epithelial-mesenchymal transition in laryngeal cancer

  • Authors:
    • Liyun Yang
    • Quan Zhou
    • Xuehua Chen
    • Liping Su
    • Bingya Liu
    • Hao Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, P.R. China, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, P.R. China
  • Pages: 819-826
    |
    Published online on: June 13, 2016
       https://doi.org/10.3892/or.2016.4872
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Abstract

Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumors, and the main cause of death is metastasis. Overexpression of aurora kinase A (AURKA) plays an important role in the metastasis of LSCC. However, the mechanism by which AURKA promotes the metastasis of LSCC is poorly understood. Recent accumulating evidence indicates that epithelial-mesenchymal transition (EMT) may be one of the mechanisms of tumor metastasis. In the present study, we studied whether AURKA may induce EMT to promote the metastasis of LSCC. CCK-8 and plate colony-formation assays were carried out to show that AURKA significantly promoted the proliferation of Hep2 cells. Immunofluorescence staining and western blotting showed that EMT-related proteins changed in a time-dependent manner along with the alteration of AURKA, with decreased expression of N-cadherin, vimentin and slug and increased expression of E-cadherin. Additionally, downregulation of the expression of AURKA inhibited FAK/PI3K pathway activity. Inhibition of the FAK/PI3K pathway caused less mesenchymal-like characteristics and reduced the mobility, migration and invasion of Hep2 cells. In conclusion, AURKA may induce EMT to promote metastasis via activation of the FAK/PI3K pathway in LSCC. Those regulatory factors may present new diagnostic biomarkers and potential therapeutic targets for LSCC.
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1 

Li D, Feng J, Wu T, Wang Y, Sun Y, Ren J and Liu M: Long inter-genic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma. Am J Pathol. 182:64–70. 2013. View Article : Google Scholar

2 

Bingol F, Yoruk O, Bingol BO, Erdemci B, Ozkan O and Mazlumoglu MR: Estimation of the efficacy of chemo-radiotherapy on tumor regression in the patients with laryngeal cancer via computerized tomography using the Cavalieri method. Acta Otolaryngol. 136:164–167. 2016. View Article : Google Scholar

3 

Halec G, Holzinger D, Schmitt M, Flechtenmacher C, Dyckhoff G, Lloveras B, Höfler D, Bosch FX and Pawlita M: Biological evidence for a causal role of HPV16 in a small fraction of laryngeal squamous cell carcinoma. Br J Cancer. 109:172–183. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Yu GP, Mehta V, Branovan D, Huang Q, Hashibe M, Zhang ZF and Schantz SP: Improved survival among patients with base of tongue and tonsil cancer in the United States. Cancer Causes Control. 23:153–164. 2012. View Article : Google Scholar

5 

Shen Z, Li Q, Deng H, Lu D, Song H and Guo J: Long non-coding RNA profiling in laryngeal squamous cell carcinoma and its clinical significance: Potential biomarkers for LSCC. PLoS One. 9:e1082372014. View Article : Google Scholar : PubMed/NCBI

6 

Mitra A, Mishra L and Li S: EMT, CTCs and CSCs in tumor relapse and drug-resistance. Oncotarget. 6:10697–10711. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Amend SR and Pienta KJ: Ecology meets cancer biology: The cancer swamp promotes the lethal cancer phenotype. Oncotarget. 6:9669–9678. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Marumoto T, Zhang D and Saya H: Aurora-A - a guardian of poles. Nat Rev Cancer. 5:42–50. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Rojanala S, Han H, Muñoz RM, Browne W, Nagle R, Von Hoff DD and Bearss DJ: The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer. Mol Cancer Ther. 3:451–457. 2004.PubMed/NCBI

10 

Watanabe T, Imoto I, Katahira T, Hirasawa A, Ishiwata I, Emi M, Takayama M, Sato A and Inazawa J: Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers. Jpn J Cancer Res. 93:1114–1122. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Bischoff JR, Anderson L, Zhu Y, Mossie K, Ng L, Souza B, Schryver B, Flanagan P, Clairvoyant F, Ginther C, et al: A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17:3052–3065. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Xing Z, Gao S, Duan Y, Han H, Li L, Yang Y and Li Q: Delivery of DNAzyme targeting aurora kinase A to inhibit the proliferation and migration of human prostate cancer. Int J Nanomedicine. 10:5715–5727. 2015.PubMed/NCBI

13 

Zhang H, Chen X, Jin Y, Liu B and Zhou L: Overexpression of Aurora-A promotes laryngeal cancer progression by enhancing invasive ability and chromosomal instability. Eur Arch Otorhinolaryngol. 269:607–614. 2012. View Article : Google Scholar :

14 

Zhang H, Chen X, Liu B and Zhou L: Effects of stable knockdown of Aurora kinase A on proliferation, migration, chromosomal instability, and expression of focal adhesion kinase and matrix metalloproteinase-2 in HEp-2 cells. Mol Cell Biochem. 357:95–106. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Rao Q, Chen Y, Yeh CR, Ding J, Li L, Chang C and Yeh S: Recruited mast cells in the tumor microenvironment enhance bladder cancer metastasis via modulation of ERβ/CCL2/CCR2 EMT/MMP9 signals. Oncotarget. 7:7842–7855. 2016.

16 

Qin Y, Tang B, Hu CJ, Xiao YF, Xie R, Yong X, Wu YY, Dong H and Yang SM: An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer. Oncotarget. 7:351–631. 2016.

17 

Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, Wu CC, LeBleu VS and Kalluri R: Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. 527:525–530. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Burnett JP, Korkaya H, Ouzounova MD, Jiang H, Conley SJ, Newman BW, Sun L, Connarn JN, Chen CS, Zhang N, et al: Trastuzumab resistance induces EMT to transform HER2+ PTEN− to a triple negative breast cancer that requires unique treatment options. Sci Rep. 5:158212015. View Article : Google Scholar

19 

Attramadal CG, Kumar S, Boysen ME, Dhakal HP, Nesland JM and Bryne M: Tumor budding, EMT and cancer stem cells in T1-2/N0 oral squamous cell carcinomas. Anticancer Res. 35:6111–6120. 2015.PubMed/NCBI

20 

Wang SC, Chai DS, Chen CB, Wang ZY and Wang L: HPIP promotes thyroid cancer cell growth, migration and EMT through activating PI3K/AKT signaling pathway. Biomed Pharmacother. 75:33–39. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Buczek ME, Miles AK, Green W, Johnson C, Boocock DJ, Pockley AG, Rees RC, Hulman G, van Schalkwyk G, Parkinson R, et al: Cytoplasmic PML promotes TGF-β-associated epithelial-mesenchymal transition and invasion in prostate cancer. Oncogene. 43:124–127. 2015.

22 

Ota I, Masui T, Kurihara M, Yook JI, Mikami S, Kimura T, Shimada K, Konishi N, Yane K, Yamanaka T, et al: Snail-induced EMT promotes cancer stem cell-like properties in head and neck cancer cells. Oncol Rep. 35:261–266. 2016.

23 

Broster SA and Kyprianou N: Epithelial-mesenchymal transition in prostatic disease. Future Oncol. 11:3197–3206. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Lee SC, Kim OH, Lee SK and Kim SJ: IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression. Oncotarget. 6:27146–27159. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2:442–454. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI

27 

D'Assoro AB, Liu T, Quatraro C, Amato A, Opyrchal M, Leontovich A, Ikeda Y, Ohmine S, Lingle W, Suman V, et al: The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells. Oncogene. 33:599–610. 2014. View Article : Google Scholar

28 

Guan Z, Wang XR, Zhu XF, Huang XF, Xu J, Wang LH, Wan XB, Long ZJ, Liu JN, Feng GK, et al: Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Cancer Res. 67:10436–10444. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Thiyagarajan V, Tsai MJ and Weng CF: Antroquinonol targets FAK-signaling pathway suppressed cell migration, invasion, and tumor growth of C6 glioma. PLoS One. 10:e01412852015. View Article : Google Scholar : PubMed/NCBI

30 

Sun L, Liu L, Liu X, Wang Y, Li M, Yao L, Yang J, Ji G, Guo C, Pan Y, et al: MGr1-Ag/37LRP induces cell adhesion-mediated drug resistance through FAK/PI3K and MAPK pathway in gastric cancer. Cancer Sci. 105:651–659. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Lin Y, Rao J, Zha XL and Xu H: Angiopoietin-like 3 induces podocyte F-actin rearrangement through integrin αV/β3/FAK/PI3K pathway-mediated Rac1 activation. Biomed Res Int. 2013:1356082013.

32 

Fu QF, Liu Y, Fan Y, Hua SN, Qu HY, Dong SW, Li RL, Zhao MY, Zhen Y, Yu XL, et al: Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathway. J Hematol Oncol. 8:222015. View Article : Google Scholar : PubMed/NCBI

33 

Hochwald SN, Nyberg C, Zheng M, Zheng D, Wood C, Massoll NA, Magis A, Ostrov D, Cance WG and Golubovskaya VM: A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle. 8:2435–2443. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Greger JG, Eastman SD, Zhang V, Bleam MR, Hughes AM, Smitheman KN, Dickerson SH, Laquerre SG, Liu L and Gilmer TM: Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther. 11:909–920. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Evans EB and Lin SY: New insights into tumor dormancy: Targeting DNA repair pathways. World J Clin Oncol. 6:80–88. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Niu NK, Wang ZL, Pan ST, Ding HQ, Au GH, He ZX, Zhou ZW, Xiao G, Yang YX, Zhang X, et al: Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway. Drug Des Devel Ther. 9:1555–1584. 2015.PubMed/NCBI

37 

Dar AA, Goff LW, Majid S, Berlin J and El-Rifai W: Aurora kinase inhibitors - rising stars in cancer therapeutics? Mol Cancer Ther. 9:268–278. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Gu K, Li MM, Shen J, Liu F, Cao JY, Jin S and Yu Y: Interleukin-17-induced EMT promotes lung cancer cell migration and invasion via NF-κB/ZEB1 signal pathway. Am J Cancer Res. 5:1169–1179. 2015.

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Copy and paste a formatted citation
Spandidos Publications style
Yang L, Zhou Q, Chen X, Su L, Liu B and Zhang H: Activation of the FAK/PI3K pathway is crucial for AURKA-induced epithelial-mesenchymal transition in laryngeal cancer. Oncol Rep 36: 819-826, 2016.
APA
Yang, L., Zhou, Q., Chen, X., Su, L., Liu, B., & Zhang, H. (2016). Activation of the FAK/PI3K pathway is crucial for AURKA-induced epithelial-mesenchymal transition in laryngeal cancer. Oncology Reports, 36, 819-826. https://doi.org/10.3892/or.2016.4872
MLA
Yang, L., Zhou, Q., Chen, X., Su, L., Liu, B., Zhang, H."Activation of the FAK/PI3K pathway is crucial for AURKA-induced epithelial-mesenchymal transition in laryngeal cancer". Oncology Reports 36.2 (2016): 819-826.
Chicago
Yang, L., Zhou, Q., Chen, X., Su, L., Liu, B., Zhang, H."Activation of the FAK/PI3K pathway is crucial for AURKA-induced epithelial-mesenchymal transition in laryngeal cancer". Oncology Reports 36, no. 2 (2016): 819-826. https://doi.org/10.3892/or.2016.4872
Copy and paste a formatted citation
x
Spandidos Publications style
Yang L, Zhou Q, Chen X, Su L, Liu B and Zhang H: Activation of the FAK/PI3K pathway is crucial for AURKA-induced epithelial-mesenchymal transition in laryngeal cancer. Oncol Rep 36: 819-826, 2016.
APA
Yang, L., Zhou, Q., Chen, X., Su, L., Liu, B., & Zhang, H. (2016). Activation of the FAK/PI3K pathway is crucial for AURKA-induced epithelial-mesenchymal transition in laryngeal cancer. Oncology Reports, 36, 819-826. https://doi.org/10.3892/or.2016.4872
MLA
Yang, L., Zhou, Q., Chen, X., Su, L., Liu, B., Zhang, H."Activation of the FAK/PI3K pathway is crucial for AURKA-induced epithelial-mesenchymal transition in laryngeal cancer". Oncology Reports 36.2 (2016): 819-826.
Chicago
Yang, L., Zhou, Q., Chen, X., Su, L., Liu, B., Zhang, H."Activation of the FAK/PI3K pathway is crucial for AURKA-induced epithelial-mesenchymal transition in laryngeal cancer". Oncology Reports 36, no. 2 (2016): 819-826. https://doi.org/10.3892/or.2016.4872
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