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Article

MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2

  • Authors:
    • Guozhi Yin
    • Huayou Zhou
    • Yumo Xue
    • Bowen Yao
    • Wei Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P.R. China, Department of General Surgery, Hanzhong Central Hospital, Hanzhong 723000, P.R. China, Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P.R. China
  • Pages: 1111-1118
    |
    Published online on: June 15, 2016
       https://doi.org/10.3892/or.2016.4876
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Abstract

Aberrant expression and function of microRNAs (miRNAs) play a critical role in the development and progression of various human cancers including gastric cancer. However, the clinical significance and underlying mechanisms of miR-340 remain largely unknown in gastric cancer. In the present study, we demonstrated that the expression of miR-340 was aberrantly elevated in both gastric cancer tissues and cells. Moreover clinical association analyses disclosed that the elevated level of miR-340 was significantly associated with unfavorable clinicopathological characteristics of the gastric cancer patients, such as poor differentiation, large tumor size and advanced tumor-node-metastasis (TNM) stage. Gastric cancer patients with high expression of miR-340 had prominently shorter overall survival and disease-free survival. Functionally, forced expression of miR-340 promoted cell viability, proliferation, colony formation and cell cycle progression in the SGC-7901 cells, while miR-340 silencing reduced cell viability, proliferation, colony formation and cell cycle progression in MGC-803 cells. Furthermore, in vivo experiments indicated that miR-340 knockdown suppressed the tumor growth of MGC-803 cells. Notably, alteration of miR-340 expression affected the luciferase activity of wild-type 3'-UTR of cyclin G2 (CCNG2) and regulated CCNG2 abundance in gastric cancer cells, indicating that CCNG2 is a direct target of miR-340. Moreover, CCNG2 knockdown eradicated the effects of miR-340 silencing on gastric cancer cells. In conclusion, our data suggest that miR-340 may potentially serve as a novel prognostic biomarker and therapeutic target for gastric cancer.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Kelley JR and Duggan JM: Gastric cancer epidemiology and risk factors. J Clin Epidemiol. 56:1–9. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Crew KD and Neugut AI: Epidemiology of gastric cancer. World J Gastroenterol. 12:354–362. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Mendell JT: MicroRNAs: Critical regulators of development, cellular physiology and malignancy. Cell Cycle. 4:1179–1184. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Jansson MD and Lund AH: MicroRNA and cancer. Mol Oncol. 6:590–610. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Mohammadi-Yeganeh S, Paryan M, Arefian E, Vasei M, Ghanbarian H, Mahdian R, Karimipoor M and Soleimani M: MicroRNA-340 inhibits the migration, invasion, and metastasis of breast cancer cells by targeting Wnt pathway. Tumour Biol. Jan 12–2016.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

9 

Chen CP, Sun ZL, Lu X, Wu WX, Guo WL, Lu JJ, Han C, Huang JQ and Fang Y: miR-340 suppresses cell migration and invasion by targeting MYO10 in breast cancer. Oncol Rep. 35:709–716. 2016.

10 

Huang K, Tang Y, He L and Dai Y: MicroRNA-340 inhibits prostate cancer cell proliferation and metastasis by targeting the MDM2-p53 pathway. Oncol Rep. 35:887–895. 2016.PubMed/NCBI

11 

Wei P, Qiao B, Li Q, Han X, Zhang H, Huo Q and Sun J: microRNA-340 suppresses tumorigenic potential of prostate cancer cells by targeting high-mobility group nucleosome-binding domain 5. DNA Cell Biol. 35:33–43. 2016. View Article : Google Scholar

12 

Yan S, Jiang H, Fang S, Yin F, Wang Z, Jia Y, Sun X, Wu S, Jiang T and Mao A: MicroRNA-340 inhibits esophageal cancer cell growth and invasion by targeting phosphoserine aminotransferase 1. Cell Physiol Biochem. 37:375–386. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Shi L, Chen Z-G, Wu LL, Zheng JJ, Yang JR, Chen XF, Chen ZQ, Liu CL, Chi SY, Zheng JY, et al: miR-340 reverses cisplatin resistance of hepatocellular carcinoma cell lines by targeting Nrf2-dependent antioxidant pathway. Asian Pac J Cancer Prev. 15:10439–10444. 2014. View Article : Google Scholar

14 

Yamashita D, Kondo T, Ohue S, Takahashi H, Ishikawa M, Matoba R, Suehiro S, Kohno S, Harada H, Tanaka J, et al: miR340 suppresses the stem-like cell function of glioma-initiating cells by targeting tissue plasminogen activator. Cancer Res. 75:1123–1133. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Guo J, Miao Y, Xiao B, Huan R, Jiang Z, Meng D and Wang Y: Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues. J Gastroenterol Hepatol. 24:652–657. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Yao Y, Suo AL, Li ZF, Liu LY, Tian T, Ni L, Zhang WG, Nan KJ, Song TS and Huang C: MicroRNA profiling of human gastric cancer. Mol Med Rep. 2:963–970. 2009.PubMed/NCBI

17 

Hou X and Qiao H: Effect of miR-340 on gastric cancer cell proliferation and apoptosis. Int J Clin Exp Pathol. 8:13108–13113. 2015.

18 

Petrocca F, Pilozzi E, Rapazzotti M, Aurello P, Mercantini P, Volinia S, Ruco LP, Croce CM and Vecchione A: MicroRNAs deregulation in gastric cancer. Cancer Res. 66:1338. 2006.

19 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Bates S, Rowan S and Vousden KH: Characterisation of human cyclin G1 and G2: DNA damage inducible genes. Oncogene. 13:1103–1109. 1996.PubMed/NCBI

21 

Shi W, Yu K, Wu G and Zhang H: Expression of CCNG2 in gastric carcinoma and its relationship with prognosis. Chin J Cell Biol. 33:994–997. 2011.

22 

Sun GG, Hu WN, Cui DW and Zhang J: Decreased expression of CCNG2 is significantly linked to the malignant transformation of gastric carcinoma. Tumour Biol. 35:2631–2639. 2014. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yin G, Zhou H, Xue Y, Yao B and Zhao W: MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2. Oncol Rep 36: 1111-1118, 2016.
APA
Yin, G., Zhou, H., Xue, Y., Yao, B., & Zhao, W. (2016). MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2. Oncology Reports, 36, 1111-1118. https://doi.org/10.3892/or.2016.4876
MLA
Yin, G., Zhou, H., Xue, Y., Yao, B., Zhao, W."MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2". Oncology Reports 36.2 (2016): 1111-1118.
Chicago
Yin, G., Zhou, H., Xue, Y., Yao, B., Zhao, W."MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2". Oncology Reports 36, no. 2 (2016): 1111-1118. https://doi.org/10.3892/or.2016.4876
Copy and paste a formatted citation
x
Spandidos Publications style
Yin G, Zhou H, Xue Y, Yao B and Zhao W: MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2. Oncol Rep 36: 1111-1118, 2016.
APA
Yin, G., Zhou, H., Xue, Y., Yao, B., & Zhao, W. (2016). MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2. Oncology Reports, 36, 1111-1118. https://doi.org/10.3892/or.2016.4876
MLA
Yin, G., Zhou, H., Xue, Y., Yao, B., Zhao, W."MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2". Oncology Reports 36.2 (2016): 1111-1118.
Chicago
Yin, G., Zhou, H., Xue, Y., Yao, B., Zhao, W."MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2". Oncology Reports 36, no. 2 (2016): 1111-1118. https://doi.org/10.3892/or.2016.4876
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