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Article

Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer

  • Authors:
    • Yiding Bian
    • Xinwen Chang
    • Yun Liao
    • Jingyun Wang
    • Yiran Li
    • Kai Wang
    • Xiaoping Wan
  • View Affiliations / Copyright

    Affiliations: Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, P.R. China, Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China, Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, P.R. China, Department of Obstetrics and Gynecology, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200080, P.R. China
  • Pages: 803-810
    |
    Published online on: June 17, 2016
       https://doi.org/10.3892/or.2016.4885
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Abstract

The Wnt signaling pathway is essential for embryonic development, and genetic alteration in this network is closely correlated with tumorigenesis and progression. Previous research has shown that Wnt receptor Frizzled2 (Fzd2) is elevated in many metastatic cancer cell lines and high grade tumors. Yet, little is known about the Fzd2 expression and activity in human endometrial cancer (EC). In this study, we present evidence of a direct role of Fzd2 in human EC. We found that Fzd2 expression was higher in EC than that in adjacent normal tissues, and was correlated with epithelial‑mesenchymal transition markers. Next, it was determined that the stable overexpression of Fzd2 in HEC-1B and Ishikawa cells promoted cell migration and induced an EMT phenotype. Conversely, RNA interference-mediated depletion of Fzd2 inhibited EC cell migration. Additionally, mechanistic investigation revealed that elevated Fzd2 expression activated canonical Wnt signaling and was blocked by canonical Wnt signaling inhibitor XAV939. However, Fzd2 did not influence the proliferation of EC cells. Thus, Fzd2 may be a potential marker for EC metastasis and a target for future therapies for this disease.
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Copy and paste a formatted citation
Spandidos Publications style
Bian Y, Chang X, Liao Y, Wang J, Li Y, Wang K and Wan X: Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer. Oncol Rep 36: 803-810, 2016.
APA
Bian, Y., Chang, X., Liao, Y., Wang, J., Li, Y., Wang, K., & Wan, X. (2016). Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer. Oncology Reports, 36, 803-810. https://doi.org/10.3892/or.2016.4885
MLA
Bian, Y., Chang, X., Liao, Y., Wang, J., Li, Y., Wang, K., Wan, X."Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer". Oncology Reports 36.2 (2016): 803-810.
Chicago
Bian, Y., Chang, X., Liao, Y., Wang, J., Li, Y., Wang, K., Wan, X."Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer". Oncology Reports 36, no. 2 (2016): 803-810. https://doi.org/10.3892/or.2016.4885
Copy and paste a formatted citation
x
Spandidos Publications style
Bian Y, Chang X, Liao Y, Wang J, Li Y, Wang K and Wan X: Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer. Oncol Rep 36: 803-810, 2016.
APA
Bian, Y., Chang, X., Liao, Y., Wang, J., Li, Y., Wang, K., & Wan, X. (2016). Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer. Oncology Reports, 36, 803-810. https://doi.org/10.3892/or.2016.4885
MLA
Bian, Y., Chang, X., Liao, Y., Wang, J., Li, Y., Wang, K., Wan, X."Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer". Oncology Reports 36.2 (2016): 803-810.
Chicago
Bian, Y., Chang, X., Liao, Y., Wang, J., Li, Y., Wang, K., Wan, X."Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer". Oncology Reports 36, no. 2 (2016): 803-810. https://doi.org/10.3892/or.2016.4885
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