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Article

NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma

  • Authors:
    • Shuang Lin
    • Senjun Zhou
    • Shaojie Jiang
    • Xiaolong Liu
    • Yifan Wang
    • Xueyong Zheng
    • Haimeng Zhou
    • Xuhui Li
    • Xiujun Cai
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China, Department of Radiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China, Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing, Zhejiang, P.R. China
  • Pages: 853-862
    |
    Published online on: June 22, 2016
       https://doi.org/10.3892/or.2016.4896
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Abstract

NEK2 has been estimated to play an important role in cancer progression. However, its relevance in hepatocellular carcinoma (HCC) has not yet been explored. Immunohistochemistry revealed NEK2 expression was upregulated in HCC. NEK2-positive hepatocellular carcinoma patients were associated with poor prognosis after surgery compared with NEK2-negative patients based on Kaplan-Meier curves. Deletion of NEK2 reduced self-renewal properties and chemotherapeutic resistance, and decreased the stemness associated genes in cell lines. NEK2 was associated with unfavorable outcomes in HCC patients, and was revealed to regulate self-renewal property by means of Wnt/β-catenin signaling, and chemotherapeutic resistance by preferential regulation of the expression of ABCG2 and ALDH1A1 in HCC cells.
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Copy and paste a formatted citation
Spandidos Publications style
Lin S, Zhou S, Jiang S, Liu X, Wang Y, Zheng X, Zhou H, Li X and Cai X: NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma. Oncol Rep 36: 853-862, 2016.
APA
Lin, S., Zhou, S., Jiang, S., Liu, X., Wang, Y., Zheng, X. ... Cai, X. (2016). NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma. Oncology Reports, 36, 853-862. https://doi.org/10.3892/or.2016.4896
MLA
Lin, S., Zhou, S., Jiang, S., Liu, X., Wang, Y., Zheng, X., Zhou, H., Li, X., Cai, X."NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma". Oncology Reports 36.2 (2016): 853-862.
Chicago
Lin, S., Zhou, S., Jiang, S., Liu, X., Wang, Y., Zheng, X., Zhou, H., Li, X., Cai, X."NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma". Oncology Reports 36, no. 2 (2016): 853-862. https://doi.org/10.3892/or.2016.4896
Copy and paste a formatted citation
x
Spandidos Publications style
Lin S, Zhou S, Jiang S, Liu X, Wang Y, Zheng X, Zhou H, Li X and Cai X: NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma. Oncol Rep 36: 853-862, 2016.
APA
Lin, S., Zhou, S., Jiang, S., Liu, X., Wang, Y., Zheng, X. ... Cai, X. (2016). NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma. Oncology Reports, 36, 853-862. https://doi.org/10.3892/or.2016.4896
MLA
Lin, S., Zhou, S., Jiang, S., Liu, X., Wang, Y., Zheng, X., Zhou, H., Li, X., Cai, X."NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma". Oncology Reports 36.2 (2016): 853-862.
Chicago
Lin, S., Zhou, S., Jiang, S., Liu, X., Wang, Y., Zheng, X., Zhou, H., Li, X., Cai, X."NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma". Oncology Reports 36, no. 2 (2016): 853-862. https://doi.org/10.3892/or.2016.4896
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