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September-2016 Volume 36 Issue 3

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Article

Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma

  • Authors:
    • Yue-Chao Fan
    • Chen-Chen Cui
    • Yi-Shuo Zhu
    • Lei Zhang
    • Meng Shi
    • Jin-Song Yu
    • Jin Bai
    • Jun-Nian Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China, Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China
  • Pages: 1619-1625
    |
    Published online on: July 13, 2016
       https://doi.org/10.3892/or.2016.4936
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Abstract

Adenylate cyclase-associated protein 1 (CAP1), a protein related to the regulation of actin filaments and the Ras/cAMP pathway, is associated with tumor progression. Nevertheless, the expression level and effects of CAP1 in regards to glioma have not been reported. In the present study, we examined the expression of CAP1 in glioma and tumor adjacent normal brain tissues by tissue microarray and immunohistochemistry. Our results showed that CAP1 was overexpressed in glioma tissues in comparison with that noted in the tumor adjacent normal brain tissues and increased staining of CAP1 was found to be correlated with WHO stage. In addition, we discovered that knockdown of CAP1 by specific RNA interference markedly inhibited cell growth and caused downregulation of the proliferation markers, PCNA and cyclin A. We further demonstrated that knockdown of CAP1 inhibited cell metastatic abilities by downregulating N-cadherin and vimentin and upregulating E-cadherin. These findings revealed that CAP1 expression is markedly increased in human glioma and that downregulation of CAP1 in tumors may serve as a treatment for glioma patients.
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Copy and paste a formatted citation
Spandidos Publications style
Fan Y, Cui C, Zhu Y, Zhang L, Shi M, Yu J, Bai J and Zheng J: Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma. Oncol Rep 36: 1619-1625, 2016.
APA
Fan, Y., Cui, C., Zhu, Y., Zhang, L., Shi, M., Yu, J. ... Zheng, J. (2016). Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma. Oncology Reports, 36, 1619-1625. https://doi.org/10.3892/or.2016.4936
MLA
Fan, Y., Cui, C., Zhu, Y., Zhang, L., Shi, M., Yu, J., Bai, J., Zheng, J."Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma". Oncology Reports 36.3 (2016): 1619-1625.
Chicago
Fan, Y., Cui, C., Zhu, Y., Zhang, L., Shi, M., Yu, J., Bai, J., Zheng, J."Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma". Oncology Reports 36, no. 3 (2016): 1619-1625. https://doi.org/10.3892/or.2016.4936
Copy and paste a formatted citation
x
Spandidos Publications style
Fan Y, Cui C, Zhu Y, Zhang L, Shi M, Yu J, Bai J and Zheng J: Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma. Oncol Rep 36: 1619-1625, 2016.
APA
Fan, Y., Cui, C., Zhu, Y., Zhang, L., Shi, M., Yu, J. ... Zheng, J. (2016). Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma. Oncology Reports, 36, 1619-1625. https://doi.org/10.3892/or.2016.4936
MLA
Fan, Y., Cui, C., Zhu, Y., Zhang, L., Shi, M., Yu, J., Bai, J., Zheng, J."Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma". Oncology Reports 36.3 (2016): 1619-1625.
Chicago
Fan, Y., Cui, C., Zhu, Y., Zhang, L., Shi, M., Yu, J., Bai, J., Zheng, J."Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma". Oncology Reports 36, no. 3 (2016): 1619-1625. https://doi.org/10.3892/or.2016.4936
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