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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2016 Volume 36 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review)

Meng Xie, Dafydd Alwyn Dart, Sioned Owen, Xianzi Wen, Jiafu Ji, Wenguo Jiang
Pages: 1191-1198
Published online on: 27 June 2016

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Review

The biological role of epithelial-mesenchymal transition in lung cancer (Review)

Woo Jung Sung, Hongtae Kim, Kwan-Kyu Park
Pages: 1199-1206
Published online on: 21 July 2016

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Review

Long noncoding RNAs in digestive system cancers: Functional roles, molecular mechanisms, and clinical implications (Review)

Min Fu, Chen Zou, Lei Pan, Wei Liang, Hui Qian, Wenrong Xu, Pengcheng Jiang, Xu Zhang
Pages: 1207-1218
Published online on: 11 July 2016

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Review

mTOR signaling in osteosarcoma: Oncogenesis and therapeutic aspects (Review)

Kai Hu, Hai-Bo Dai, Zhi-Long Qiu
Pages: 1219-1225
Published online on: 08 July 2016

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Review

Regulation of the miRNA expression by TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins in acute lymphoblastic leukemia (Review)

Jorge Organista-Nava, Yazmín Gómez-Gómez, Berenice Illades-Aguiar, Marco Antonio Leyva-Vázquez
Pages: 1226-1232
Published online on: 19 July 2016

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Article Open Access

Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells

Yingjian Zeng, Guangyang Weng, Jiaxin Fan, Zhangqiu Li, Jianwei Wu, Yuanming Li, Rong Zheng, Pingfang Xia, Kunyuan Guo
Pages: 1233-1242
Published online on: 15 July 2016

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Article Open Access

Enhancing the treatment effect on melanoma by heat shock protein 70-peptide complexes purified from human melanoma cell lines

Yanwei Gao, Weishi Gao, Xia Chen, Nier Cha, Xiaoli Wang, Xiangdong Jia, Bingping Wang, Meng Ren, Jun Ren
Pages: 1243-1250
Published online on: 19 July 2016

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Article Open Access

Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer

Masafumi Takatsuna, Satoko Morohashi, Tadashi Yoshizawa, Hideaki Hirai, Toshihiro Haga, Rie Ota, Yunyan Wu, Hajime Morohashi, Kenichi Hakamada, Shuji Terai, Hiroshi Kijima
Pages: 1251-1257
Published online on: 11 July 2016

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Article Open Access

Proteomic analysis of imatinib-resistant CML-T1 cells reveals calcium homeostasis as a potential therapeutic target

O. Toman, T. Kabickova, O. Vit, R. Fiser, K. Machova Polakova, J. Zach, J. Linhartova, D. Vyoral, J. Petrak
Pages: 1258-1268
Published online on: 18 July 2016

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Article

Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway

Jing Wang, Li Cui, Liang Feng, Zhenhai Zhang, Jie Song, Dan Liu, Xiaobin Jia
Pages: 1269-1276
Published online on: 20 July 2016

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Article

GFAP expression is regulated by Pax3 in brain glioma stem cells

Xing Su, Xiaojiang Liu, Lanchun Ni, Wei Shi, Hui Zhu, Jinlong Shi, Jian Chen, Zhikai Gu, Yilu Gao, Qing Lan, Qingfeng Huang
Pages: 1277-1284
Published online on: 07 July 2016

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Article

MYO6 knockdown inhibits the growth and induces the apoptosis of prostate cancer cells by decreasing the phosphorylation of ERK1/2 and PRAS40

Dong Wang, Libing Zhu, Min Liao, Tengyue Zeng, Wenli Zhuo, Shunliang Yang, Weizhen Wu
Pages: 1285-1292
Published online on: 29 June 2016

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Article

MicroRNA-497 inhibits the proliferation, migration and invasion of human bladder transitional cell carcinoma cells by targeting E2F3 Corrigendum in /10.3892/or.2020.7466

Yixiao Zhang, Zhe Zhang, Zhenhua Li, Daxin Gong, Bo Zhan, Xiaojun Man, Chuize Kong
Pages: 1293-1300
Published online on: 08 July 2016

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Article

Overexpression of seven in absentia homolog 2 protein in human breast cancer tissues is associated with the promotion of tumor cell malignant behavior in in vitro

Jie Sun, Xiaojuan Zhang, Yanchun Han, Juan Zhen, Yuan Meng, Min Song
Pages: 1301-1312
Published online on: 25 July 2016

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Article

Glycoprotein screening in colorectal cancer based on differentially expressed Tn antigen

Hongyun Wei, Zongyong Cheng, Chunhui Ouyang, Yu Zhang, Yanyan Hu, Shuijiao Chen, Chunlian Wang, Fanggen Lu, Jie Zhang, Yongjun Wang, Xiaowei Liu
Pages: 1313-1324
Published online on: 14 July 2016

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Article

Nutlin-3 reverses the epithelial-mesenchymal transition in gemcitabine-resistant hepatocellular carcinoma cells

Qiong Wu, Xi Wang, Jing Liu, Jiyue Zheng, Yang Liu, Yumei Li, Fang Su, Weili Ou, Rui Wang
Pages: 1325-1332
Published online on: 08 July 2016

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Article

Oxymatrine inhibits epithelial-mesenchymal transition through regulation of NF-κB signaling in colorectal cancer cells

Li Liang, Jiean Huang
Pages: 1333-1338
Published online on: 11 July 2016

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Article

VEGFR-1 targeted DNAzyme via transcatheter arterial delivery influences tumor vasculature assessed through dynamic contrast-enhanced magnetic resonance imaging

Liqing Zhang, Wei Zhao, Chen Liang, Xiaoping Yi, Yigang Pei, Yiting Lin, Jiang He, Wenzheng Li
Pages: 1339-1344
Published online on: 12 July 2016

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Article

Celecoxib suppresses fibroblast growth factor-2 expression in pancreatic ductal adenocarcinoma PANC-1 cells

Jing Li, Miaosha Luo, Yan Wang, Boxin Shang, Lei Dong
Pages: 1345-1352
Published online on: 08 July 2016

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Article

Transcription factor c-jun regulates β3Gn-T8 expression in gastric cancer cell line SGC-7901

Zhi Jiang, Zhenhua Liu, Shitao Zou, Jianlong Ni, Li Shen, Yinghui Zhou, Dong Hua, Shiliang Wu
Pages: 1353-1360
Published online on: 21 July 2016

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Article

Sulforaphane-cysteine suppresses invasion via downregulation of galectin-1 in human prostate cancer DU145 and PC3 cells

Hua Tian, Yan Zhou, Gaoxiang Yang, Yang Geng, Sai Wu, Yabin Hu, Kai Lin, Wei Wu
Pages: 1361-1368
Published online on: 15 July 2016

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Article

Gastrin promotes the metastasis of gastric carcinoma through the β-catenin/TCF-4 pathway

Kun Zhuang, Yuan Yan, Xin Zhang, Jun Zhang, Lingxia Zhang, Kun Han
Pages: 1369-1376
Published online on: 15 July 2016

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Article

Effects of active bufadienolide compounds on human cancer cells and CD4+CD25+Foxp3+ regulatory T cells in mitogen-activated human peripheral blood mononuclear cells

Bo Yuan, Jing He, Keishi Kisoh, Hideki Hayashi, Sachiko Tanaka, Nan Si, Hai-Yu Zhao, Toshihiko Hirano, Baolin Bian, Norio Takagi
Pages: 1377-1384
Published online on: 18 July 2016

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Article

miR-451 acts as a suppressor of angiogenesis in hepatocellular carcinoma by targeting the IL-6R-STAT3 pathway

Xuemin Liu, Anpeng Zhang, Junxi Xiang, Yi Lv, Xufeng Zhang
Pages: 1385-1392
Published online on: 25 July 2016

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Article

Genetically engineered Newcastle disease virus expressing human interferon-λ1 induces apoptosis in gastric adenocarcinoma cells and modulates the Th1/Th2 immune response

Xuefeng Bu, Mi Li, Yinghai Zhao, Sha Liu, Mubin Wang, Jinying Ge, Zhigao Bu, Yulan Yan
Pages: 1393-1402
Published online on: 11 July 2016

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Article

ACE2 overexpression inhibits acquired platinum resistance-induced tumor angiogenesis in NSCLC

Qijian Cheng, Ling Zhou, Jianping Zhou, Huanying Wan, Qingyun Li, Yun Feng
Pages: 1403-1410
Published online on: 22 July 2016

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Article

RNA interference against TRIM29 inhibits migration and invasion of colorectal cancer cells Retraction in /10.3892/or.2025.8908

Weihong Xu, Bin Xu, Yiting Yao, Xiaoling Yu, Hua Cao, Jun Zhang, Jie Liu, Huiming Sheng
Pages: 1411-1418
Published online on: 15 July 2016

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Article

Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells

Lei Zhu, Guangang Tian, Qin Yang, Gejing De, Zhigang Zhang, Yahui Wang, Huizhen Nie, Yanli Zhang, Xiaomei Yang, Jun Li
Pages: 1419-1426
Published online on: 11 July 2016

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Article

ALK ambiguous-positive non-small cell lung cancers are tumors challenged by diagnostic and therapeutic issues

Arnaud Uguen, Sophie Andrieu‑Key, Florence Vergne, Renaud Descourt, Gilles Quéré, Isabelle Quintin‑Roué, Stéphane Key, Paul Guéguen, Matthieu Talagas, Marc De Braekeleer, Pascale Marcorelles
Pages: 1427-1434
Published online on: 21 July 2016

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Article

Establishment and characterization of a novel human cholangiocarcinoma cell line with high metastatic activity

Kwuntida Uthaisar, Kulthida Vaeteewoottacharn, Wunchana Seubwai, Chutima Talabnin, Kanlayanee Sawanyawisuth, Sumalee Obchoei, Ratthaphol Kraiklang, Seiji Okada, Sopit Wongkham
Pages: 1435-1446
Published online on: 25 July 2016

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Article

Platycodin D, a metabolite of Platycodin grandiflorum, inhibits highly metastatic MDA-MB-231 breast cancer growth in vitro and in vivo by targeting the MDM2 oncogene

Ya Kong, Zong-Liang Lu, Jia-Jia Wang, Rui Zhou, Jing Guo, Jie Liu, Hai-Lan Sun, He Wang, Wei Song, Jian Yang, Hong-Xia Xu
Pages: 1447-1456
Published online on: 13 July 2016

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Article

Crocodile blood extract induces the apoptosis of lung cancer cells through PTEN activity

Yuqian Ou, Wing Shing Ho
Pages: 1457-1466
Published online on: 05 July 2016

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Article

miR-338 inhibits the metastasis of lung cancer by targeting integrin β3

Xiao Chen, Li Wei, Song Zhao
Pages: 1467-1474
Published online on: 11 July 2016

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Article

MicroRNA-27a-3p regulates epithelial to mesenchymal transition via targeting YAP1 in oral squamous cell carcinoma cells

Guang Zeng, Wenxing Xun, Kewen Wei, Yongjin Yang, Huan Shen
Pages: 1475-1482
Published online on: 07 July 2016

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Article

Effect of saracatinib on pulmonary metastases from hepatocellular carcinoma

Ju Xiong, Jin-Sheng Wu, Shan-Shan Mao, Xiang-Nan Yu, Xiao-Xi Huang
Pages: 1483-1490
Published online on: 22 July 2016

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Article

Huaier aqueous extract inhibits proliferation and metastasis of tuberous sclerosis complex cell models through downregulation of JAK2/STAT3 and MAPK signaling pathways

Ailin Yang, Haitao Fan, Yunfang Zhao, Xiaojun Zha, Hongbing Zhang, Zhongdong Hu, Pengfei Tu
Pages: 1491-1498
Published online on: 25 July 2016

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Article

Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway

Xingwei Zhao, Qiang Zhang, Liang Chen
Pages: 1499-1505
Published online on: 21 July 2016

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Article

Downregulation of nucleolar and spindle-associated protein 1 expression suppresses cell migration, proliferation and invasion in renal cell carcinoma Corrigendum in /10.3892/or.2020.7875

Lu Fang, Meng Zhang, Lei Chen, Hu Xiong, Yukun Ge, Wei Lu, Xun Wu, Baoli Heng, Dexin Yu, Song Wu
Pages: 1506-1516
Published online on: 20 July 2016

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Article

Coix seed emulsion synergistically enhances the antitumor activity of gemcitabine in pancreatic cancer through abrogation of NF-κB signaling

Yafang Qian, Bo Yang, Yang Xiong, Mancang Gu
Pages: 1517-1525
Published online on: 21 July 2016

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Article

A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway

Bingling Dai, Wenjie Wang, Yujiao Ma, Rui Liu, Yanmin Zhang
Pages: 1526-1534
Published online on: 21 July 2016

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Article

SnoN suppresses TGF-β-induced epithelial-mesenchymal transition and invasion of bladder cancer in a TIF1γ-dependent manner

Xinbao Yin, Chuanshen Xu, Xueping Zheng, Huiyang Yuan, Ming Liu, Yue Qiu, Jun Chen
Pages: 1535-1541
Published online on: 15 July 2016

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Article

Identifying survival-associated ceRNA clusters in cholangiocarcinoma

Ming Wan, Fu-Min Zhang, Zheng-Long Li, Peng-Cheng Kang, Ping-Ming Jiang, Yi-Min Wang, Zhi-Dong Wang, Xiang-Yu Zhong, Chun-Long Li, Hao Wang, Shi-Yong Zhao, Yun-Fu Cui
Pages: 1542-1550
Published online on: 12 July 2016

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Article

TIM-3 promotes the metastasis of esophageal squamous cell carcinoma by targeting epithelial-mesenchymal transition via the Akt/GSK-3β/Snail signaling pathway

Baoen Shan, Hongwei Man, Junfeng Liu, Ling Wang, Tienian Zhu, Ming Ma, Zhili Xv, Xinran Chen, Xingxiao Yang, Pengfei Li
Pages: 1551-1561
Published online on: 14 July 2016

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Article

Classical and atypical resistance of cancer cells as a target for resveratrol

Sylwia Borska, Monika Pedziwiatr, Monika Danielewicz, Katarzyna Nowinska, Bartosz Pula, Malgorzata Drag-Zalesinska, Mateusz Olbromski, Agnieszka Gomulkiewicz, Piotr Dziegiel
Pages: 1562-1568
Published online on: 11 July 2016

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Article

Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4

Yi-Ze Li, Lei Wen, Xu Wei, Qian-Rong Wang, Long-Wen Xu, Hong-Mei Zhang, Wen-Chao Liu
Pages: 1569-1575
Published online on: 05 July 2016

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Article

Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib

Wei-Jun Wei, Chen-Tian Shen, Hong-Jun Song, Zhong-Ling Qiu, Quan-Yong Luo
Pages: 1576-1584
Published online on: 07 July 2016

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Article

GLIPR1 inhibits the proliferation and induces the differentiation of cancer-initiating cells by regulating miR-16 in osteosarcoma

Jian Dong, Binna Bi, Lianhai Zhang, Kaituo Gao
Pages: 1585-1591
Published online on: 19 July 2016

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Article

Analysis of the gene expression profile in response to human epididymis protein 4 in epithelial ovarian cancer cells

Liancheng Zhu, Qian Guo, Shan Jin, Huilin Feng, Huiyu Zhuang, Cong Liu, Mingzi Tan, Juanjuan Liu, Xiao Li, Bei Lin
Pages: 1592-1604
Published online on: 11 July 2016

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Article

Plumbagin reduces chronic lymphocytic leukemia cell survival by downregulation of Bcl-2 but upregulation of the Bax protein level

Chunling Fu, Yanqing Gong, Xuanxuan Shi, Zengtian Sun, Mingshan Niu, Wei Sang, Linyan Xu, Feng Zhu, Ying Wang, Kailin Xu
Pages: 1605-1611
Published online on: 19 July 2016

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Article

The role of PAQR3 gene promoter hypermethylation in breast cancer and prognosis

Jinpeng Chen, Feiran Wang, Junfei Xu, Zhixian He, Yuhua Lu, Zhiwei Wang
Pages: 1612-1618
Published online on: 19 July 2016

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Article

Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma

Yue-Chao Fan, Chen-Chen Cui, Yi-Shuo Zhu, Lei Zhang, Meng Shi, Jin-Song Yu, Jin Bai, Jun-Nian Zheng
Pages: 1619-1625
Published online on: 13 July 2016

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Article

Amyloid precursor protein cooperates with c-KIT mutation/overexpression to regulate cell apoptosis in AML1-ETO-positive leukemia via the PI3K/AKT signaling pathway

Guopan Yu, Changxin Yin, Ling Jiang, Zhongxin Zheng, Zhixiang Wang, Chunli Wang, Hongsheng Zhou, Xuejie Jiang, Qifa Liu, Fanyi Meng
Pages: 1626-1632
Published online on: 21 July 2016

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Article

CCY-1a-E2 induces G2/M phase arrest and apoptotic cell death in HL-60 leukemia cells through cyclin-dependent kinase 1 signaling and the mitochondria-dependent caspase pathway

Chin‑Fen Lin, Jai‑Sing Yang, Chingju Lin, Fuu‑Jen Tsai, Chi‑Cheng Lu, Miau‑Rong Lee
Pages: 1633-1639
Published online on: 25 July 2016

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Article

A novel double carbonyl analog of curcumin induces the apoptosis of human lung cancer H460 cells via the activation of the endoplasmic reticulum stress signaling pathway

Hui Ye, Xiaoyan Wei, Zhankun Wang, Shanshan Zhang, Jiye Ren, Song Yao, Lingyi Shi, Lizhu Yang, Peihong Qiu, Jianzhang Wu, Guang Liang
Pages: 1640-1648
Published online on: 30 June 2016

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Article

Involvement of endoplasmic reticulum stress and p53 in lncRNA MEG3-induced human hepatoma HepG2 cell apoptosis

Rui‑Pei Chen, Zhen‑Lun Huang, Li‑Xuan Liu, Meng‑Qi Xiang, Guo‑Ping Li, Jia‑Lin Feng, Bin Liu, Ling‑Fei Wu
Pages: 1649-1657
Published online on: 08 July 2016

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Article

IKK inhibitor suppresses epithelial-mesenchymal transition and induces cell death in prostate cancer

Hao Ping, Feiya Yang, Mingshuai Wang, Yinong Niu, Nianzeng Xing
Pages: 1658-1664
Published online on: 07 July 2016

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Article

Low expression lncRNA RPLP0P2 is associated with poor prognosis and decreased cell proliferation and adhesion ability in lung adenocarcinoma

Jie Chen, Lijuan Hu, Jian Chen, Fang Wu, Dongwei Hu, Gang Xu, Peiwu Zhu, Yumin Wang
Pages: 1665-1671
Published online on: 22 July 2016

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Article

GATA binding protein 2 overexpression is associated with poor prognosis in KRAS mutant colorectal cancer

Kai Xu, Jiayuan Wang, Jing Gao, Jiabo Di, Beihai Jiang, Lei Chen, Zaozao Wang, Aidong Wang, Fan Wu, Wei Wu, Lin Shen, Xiangqian Su
Pages: 1672-1678
Published online on: 21 July 2016

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Article

The role of lncRNA MALAT1 in bone metastasis in patients with non-small cell lung cancer

Meijuan Liu, Wanli Sun, Yongquan Liu, Xiuhong Dong
Pages: 1679-1685
Published online on: 29 June 2016

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Article

CXCR3A contributes to the invasion and metastasis of gastric cancer cells

Chenggang Yang, Wanlei Zheng, Wenfeng Du
Pages: 1686-1692
Published online on: 19 July 2016

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Article

miR-92b targets DAB2IP to promote EMT in bladder cancer migration and invasion

Jun Huang, Bin Wang, Ke Hui, Jin Zeng, Jinhai Fan, Xinyang Wang, Jer-Tsong Hsieh, Dalin He, Kaijie Wu
Pages: 1693-1701
Published online on: 15 July 2016

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Article

MicroRNA-520a attenuates proliferation of Raji cells through inhibition of AKT1/NF-κB and PERK/eIF2α signaling pathway Retraction in /10.3892/or.2024.8706

Xiaojuan Wang, Pei Wang, Yan Zhu, Zhi Zhang, Jinqian Zhang, Hongwei Wang
Pages: 1702-1708
Published online on: 25 July 2016

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Article

MicroRNA-1207-5p inhibits hepatocellular carcinoma cell growth and invasion through the fatty acid synthase-mediated Akt/mTOR signalling pathway

Gang Zhao, Lei Dong, Haitao Shi, Hong Li, Xiaolan Lu, Xiaoyan Guo, Jinhai Wang
Pages: 1709-1716
Published online on: 19 July 2016

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Article

STC-1 expression is upregulated through an Akt/NF-κB-dependent pathway in triple-negative breast cancer cells

Myeongjin Jeon, Jeonghun Han, Seok Jin Nam, Jeong Eon Lee, Sangmin Kim
Pages: 1717-1722
Published online on: 25 July 2016

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Transglutaminase 3 protein modulates human esophageal cancer cell growth by targeting the NF-κB signaling pathway

Wei Li, Zhongmian Zhang, Wenchao Zhao, Na Han
Pages: 1723-1730
Published online on: 08 July 2016

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Article

Synergistic inhibition of characteristics of liver cancer stem-like cells with a combination of sorafenib and 8-bromo-7-methoxychrysin in SMMC-7721 cell line

Hui Zou, Xiaozheng Cao, Qiao Xiao, Xifeng Sheng, Kaiqun Ren, Meifang Quan, Zhengwei Song, Duo Li, Yu Zheng, Wenbin Zeng, Jianguo Cao, Yaojin Peng
Pages: 1731-1738
Published online on: 25 July 2016

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Article

Breast cancer-associated high-order SNP-SNP interaction of CXCL12/CXCR4-related genes by an improved multifactor dimensionality reduction (MDR-ER)

Ou‑Yang Fu, Hsueh‑Wei Chang, Yu‑Da Lin, Li‑Yeh Chuang, Ming‑Feng Hou, Cheng‑Hong Yang
Pages: 1739-1747
Published online on: 21 July 2016

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Prognostic value of microRNA-203a expression in breast cancer

Bruno Costa Gomes, Manuela Martins, Paulina Lopes, Inês Morujão, Mário Oliveira, António Araújo, José Rueff, António Sebastião Rodrigues
Pages: 1748-1756
Published online on: 05 July 2016

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Article

β2-adrenergic receptor activation promotes the proliferation of A549 lung cancer cells via the ERK1/2/CREB pathway

Ping Hu, Jingjing He, Shiling Liu, Meng Wang, Bingxing Pan, Wenhua Zhang
Pages: 1757-1763
Published online on: 22 July 2016

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Article

Elevated STC‑1 augments the invasiveness of triple‑negative breast cancer cells through activation of the JNK/c‑Jun signaling pathway

Jeonghun Han, Myeongjin Jeon, Incheol Shin, Sangmin Kim
Pages: 1764-1771
Published online on: 26 July 2016

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Journal Cover
January-2026 Volume 55 Issue 1

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Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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