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Article

Gastrin promotes the metastasis of gastric carcinoma through the β-catenin/TCF-4 pathway

  • Authors:
    • Kun Zhuang
    • Yuan Yan
    • Xin Zhang
    • Jun Zhang
    • Lingxia Zhang
    • Kun Han
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710003, P.R. China, Division of Gastroenterology, Xi'an Central Hospital, Xi'an, Shaanxi 710003, P.R. China
  • Pages: 1369-1376
    |
    Published online on: July 15, 2016
       https://doi.org/10.3892/or.2016.4943
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Abstract

Gastric cancer is the most common epithelial malignancy and the second leading cause of cancer-related death worldwide; metastasis is a crucial factor in the progression of gastric cancer. The present study applied gastrin-17 amide (G-17) in SGC7901 cells. The results showed that G-17 promoted the cell cycle by accelerating the G0/G1 phase and by increasing the cell proliferation rate by binding to the gastrin receptor. The migratory and invasive abilities of the SGC7901 cells were increased by G-17. The expression levels of matrix metalloproteinase (MMP)-7, MMP-9 and vascular endothelial growth factor (VEGF) were enhanced by G-17 as well. Moreover, G-17 caused the overexpression of β-catenin and TCF-4. G-17 also caused a preferential cytoplasmic and nuclear localization of β-catenin with a high TOP-FLASH activity. Finally, axin reduced the migratory and invasive abilities of the SGC7901 cells, and inhibited the expression of β-catenin, TCF-4, MMP-7, MMP-9 and VEGF; these effects were counteracted by adding G-17. In summary, the present study confirmed the proliferation and metastasis-promoting role of G-17 via binding to the gastrin receptor, and the β-catenin/TCF-4 pathway was found to be essential for mediating G-17-induced metastasis in gastric cancer. These results may provide a novel gene target for the treatment of gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhuang K, Yan Y, Zhang X, Zhang J, Zhang L and Han K: Gastrin promotes the metastasis of gastric carcinoma through the β-catenin/TCF-4 pathway. Oncol Rep 36: 1369-1376, 2016.
APA
Zhuang, K., Yan, Y., Zhang, X., Zhang, J., Zhang, L., & Han, K. (2016). Gastrin promotes the metastasis of gastric carcinoma through the β-catenin/TCF-4 pathway. Oncology Reports, 36, 1369-1376. https://doi.org/10.3892/or.2016.4943
MLA
Zhuang, K., Yan, Y., Zhang, X., Zhang, J., Zhang, L., Han, K."Gastrin promotes the metastasis of gastric carcinoma through the β-catenin/TCF-4 pathway". Oncology Reports 36.3 (2016): 1369-1376.
Chicago
Zhuang, K., Yan, Y., Zhang, X., Zhang, J., Zhang, L., Han, K."Gastrin promotes the metastasis of gastric carcinoma through the β-catenin/TCF-4 pathway". Oncology Reports 36, no. 3 (2016): 1369-1376. https://doi.org/10.3892/or.2016.4943
Copy and paste a formatted citation
x
Spandidos Publications style
Zhuang K, Yan Y, Zhang X, Zhang J, Zhang L and Han K: Gastrin promotes the metastasis of gastric carcinoma through the β-catenin/TCF-4 pathway. Oncol Rep 36: 1369-1376, 2016.
APA
Zhuang, K., Yan, Y., Zhang, X., Zhang, J., Zhang, L., & Han, K. (2016). Gastrin promotes the metastasis of gastric carcinoma through the β-catenin/TCF-4 pathway. Oncology Reports, 36, 1369-1376. https://doi.org/10.3892/or.2016.4943
MLA
Zhuang, K., Yan, Y., Zhang, X., Zhang, J., Zhang, L., Han, K."Gastrin promotes the metastasis of gastric carcinoma through the β-catenin/TCF-4 pathway". Oncology Reports 36.3 (2016): 1369-1376.
Chicago
Zhuang, K., Yan, Y., Zhang, X., Zhang, J., Zhang, L., Han, K."Gastrin promotes the metastasis of gastric carcinoma through the β-catenin/TCF-4 pathway". Oncology Reports 36, no. 3 (2016): 1369-1376. https://doi.org/10.3892/or.2016.4943
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