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Article

Plumbagin reduces chronic lymphocytic leukemia cell survival by downregulation of Bcl-2 but upregulation of the Bax protein level

  • Authors:
    • Chunling Fu
    • Yanqing Gong
    • Xuanxuan Shi
    • Zengtian Sun
    • Mingshan Niu
    • Wei Sang
    • Linyan Xu
    • Feng Zhu
    • Ying Wang
    • Kailin Xu
  • View Affiliations / Copyright

    Affiliations: Blood Diseases Institute, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China, Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China
  • Pages: 1605-1611
    |
    Published online on: July 19, 2016
       https://doi.org/10.3892/or.2016.4950
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Abstract

Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries, and mainly originates from an accumulation of abnormal B cells caused by the dysregulation of cell proliferation and apoptosis rates. The aberration of apoptosis-related genes in CLL cells results in defective apoptosis of CLL cells in response to traditional therapeutic medicine. Plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone), a natural compound from Plumbago zeylinica, has been shown to exhibit pro-apoptotic activities in tumor cells. In the present study, we report that plumbagin effectively inhibited CLL cell viability with a lower dose compared to fludarabine, and inhibited cell proliferation in a dose-dependent manner. In addition, plumbagin promoted accumulation of MEC-1 cells in the S phase, and blocked cell cycle transition of HG3 cells from G0/G1 to S phase. Molecularly, plumbagin markedly induced CLL cell apoptosis through reduction of Bcl-2, but through an increase in the Bax protein level. These results suggest that plumbagin may be considered as a potential anticancer agent for CLL therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Fu C, Gong Y, Shi X, Sun Z, Niu M, Sang W, Xu L, Zhu F, Wang Y, Xu K, Xu K, et al: Plumbagin reduces chronic lymphocytic leukemia cell survival by downregulation of Bcl-2 but upregulation of the Bax protein level. Oncol Rep 36: 1605-1611, 2016.
APA
Fu, C., Gong, Y., Shi, X., Sun, Z., Niu, M., Sang, W. ... Xu, K. (2016). Plumbagin reduces chronic lymphocytic leukemia cell survival by downregulation of Bcl-2 but upregulation of the Bax protein level. Oncology Reports, 36, 1605-1611. https://doi.org/10.3892/or.2016.4950
MLA
Fu, C., Gong, Y., Shi, X., Sun, Z., Niu, M., Sang, W., Xu, L., Zhu, F., Wang, Y., Xu, K."Plumbagin reduces chronic lymphocytic leukemia cell survival by downregulation of Bcl-2 but upregulation of the Bax protein level". Oncology Reports 36.3 (2016): 1605-1611.
Chicago
Fu, C., Gong, Y., Shi, X., Sun, Z., Niu, M., Sang, W., Xu, L., Zhu, F., Wang, Y., Xu, K."Plumbagin reduces chronic lymphocytic leukemia cell survival by downregulation of Bcl-2 but upregulation of the Bax protein level". Oncology Reports 36, no. 3 (2016): 1605-1611. https://doi.org/10.3892/or.2016.4950
Copy and paste a formatted citation
x
Spandidos Publications style
Fu C, Gong Y, Shi X, Sun Z, Niu M, Sang W, Xu L, Zhu F, Wang Y, Xu K, Xu K, et al: Plumbagin reduces chronic lymphocytic leukemia cell survival by downregulation of Bcl-2 but upregulation of the Bax protein level. Oncol Rep 36: 1605-1611, 2016.
APA
Fu, C., Gong, Y., Shi, X., Sun, Z., Niu, M., Sang, W. ... Xu, K. (2016). Plumbagin reduces chronic lymphocytic leukemia cell survival by downregulation of Bcl-2 but upregulation of the Bax protein level. Oncology Reports, 36, 1605-1611. https://doi.org/10.3892/or.2016.4950
MLA
Fu, C., Gong, Y., Shi, X., Sun, Z., Niu, M., Sang, W., Xu, L., Zhu, F., Wang, Y., Xu, K."Plumbagin reduces chronic lymphocytic leukemia cell survival by downregulation of Bcl-2 but upregulation of the Bax protein level". Oncology Reports 36.3 (2016): 1605-1611.
Chicago
Fu, C., Gong, Y., Shi, X., Sun, Z., Niu, M., Sang, W., Xu, L., Zhu, F., Wang, Y., Xu, K."Plumbagin reduces chronic lymphocytic leukemia cell survival by downregulation of Bcl-2 but upregulation of the Bax protein level". Oncology Reports 36, no. 3 (2016): 1605-1611. https://doi.org/10.3892/or.2016.4950
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